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Volumn 8, Issue 12, 2005, Pages 1727-1734

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; COFILIN; HAMARTIN; LIM PROTEIN; PROTEIN KINASE; TUBERIN;

EID: 28044456974     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1566     Document Type: Article
Times cited : (408)

References (50)
  • 2
    • 0033582748 scopus 로고    scopus 로고
    • Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito, N. & Rubin, G.M. Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96, 529-539 (1999).
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 3
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter, C.J., Huang, H. & Xu, T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105, 357-368 (2001).
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 4
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon, N., Ito, N., Dickson, B.J., Treisman, J.E. & Hariharan, I.K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105, 345-355 (2001).
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hariharan, I.K.5
  • 5
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao, X. & Pan, D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15, 1383-1392 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 6
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C.J., Pedraza, L.G. & Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658-665 (2002).
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 7
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. & Cantley, L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10, 151-162 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 8
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657 (2002).
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 9
    • 0038304516 scopus 로고    scopus 로고
    • Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    • Stocker, H. et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5, 559-565 (2003).
    • (2003) Nat. Cell Biol. , vol.5 , pp. 559-565
    • Stocker, H.1
  • 10
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami, A. et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 1457-1466
    • Garami, A.1
  • 11
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 12
    • 0029826812 scopus 로고    scopus 로고
    • Loss of heterozygosity in tuberous sclerosis hamartomas
    • Sepp, T., Yates, J.R. & Green, A.J. Loss of heterozygosity in tuberous sclerosis hamartomas. J. Med. Genet. 33, 962-964 (1996).
    • (1996) J. Med. Genet. , vol.33 , pp. 962-964
    • Sepp, T.1    Yates, J.R.2    Green, A.J.3
  • 13
    • 0037864533 scopus 로고    scopus 로고
    • Aspects of tuberous sclerosis complex (TSC) protein function in the brain
    • Ramesh, V. Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem. Soc. Trans. 31, 579-583 (2003).
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 579-583
    • Ramesh, V.1
  • 14
    • 11844272669 scopus 로고    scopus 로고
    • BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways
    • Dijkhuizen, P.A. & Ghosh, A. BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways. J. Neurobiol. 62, 278-288 (2005).
    • (2005) J. Neurobiol. , vol.62 , pp. 278-288
    • Dijkhuizen, P.A.1    Ghosh, A.2
  • 15
    • 0037039358 scopus 로고    scopus 로고
    • A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    • Tang, S.J. et al. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc. Natl. Acad. Sci. USA 99, 467-472 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 467-472
    • Tang, S.J.1
  • 16
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    • Hou, L. & Klann, E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J. Neurosci. 24, 6352-6361 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 6352-6361
    • Hou, L.1    Klann, E.2
  • 17
    • 0034685813 scopus 로고    scopus 로고
    • Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
    • Huber, K.M., Kayser, M.S. & Bear, M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288, 1254-1257 (2000).
    • (2000) Science , vol.288 , pp. 1254-1257
    • Huber, K.M.1    Kayser, M.S.2    Bear, M.F.3
  • 18
    • 0036713644 scopus 로고    scopus 로고
    • Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
    • Uhlmann, E.J. et al. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann. Neurol. 52, 285-296 (2002).
    • (2002) Ann. Neurol. , vol.52 , pp. 285-296
    • Uhlmann, E.J.1
  • 19
    • 0032496239 scopus 로고    scopus 로고
    • Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
    • Kohn, A.D. et al. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J. Biol. Chem. 273, 11937-11943 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 11937-11943
    • Kohn, A.D.1
  • 20
    • 0141963351 scopus 로고    scopus 로고
    • Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton
    • Meng, Y., Zhang, Y., Tregoubov, V., Falls, D.L. & Jia, Z. Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton. Rev. Neurosci. 14, 233-240 (2003).
    • (2003) Rev. Neurosci. , vol.14 , pp. 233-240
    • Meng, Y.1    Zhang, Y.2    Tregoubov, V.3    Falls, D.L.4    Jia, Z.5
  • 21
    • 9644278075 scopus 로고    scopus 로고
    • Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
    • Zhou, Q., Homma, K.J. & Poo, M.M. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44, 749-757 (2004).
    • (2004) Neuron , vol.44 , pp. 749-757
    • Zhou, Q.1    Homma, K.J.2    Poo, M.M.3
  • 22
    • 0347988005 scopus 로고    scopus 로고
    • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-AW signaling through downregulation of PDGFR
    • Zhang, H. et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-AW signaling through downregulation of PDGFR. J. Clin. Invest. 112, 1223-1233 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1223-1233
    • Zhang, H.1
  • 23
    • 0031586755 scopus 로고    scopus 로고
    • Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, TSC-36, in human cancer cells
    • Mashimo, J., Maniwa, R., Sugino, H. & Nose, K. Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, TSC-36, in human cancer cells. Cancer Lett. 113, 213-219 (1997).
    • (1997) Cancer Lett. , vol.113 , pp. 213-219
    • Mashimo, J.1    Maniwa, R.2    Sugino, H.3    Nose, K.4
  • 24
    • 0034781057 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
    • Tuttle, R.L. et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 7, 1133-1137 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 1133-1137
    • Tuttle, R.L.1
  • 25
    • 0033258521 scopus 로고    scopus 로고
    • Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
    • Verdu, J., Buratovich, M.A., Wilder, E.L. & Birnbaum, M.J. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1, 500-506 (1999).
    • (1999) Nat. Cell Biol. , vol.1 , pp. 500-506
    • Verdu, J.1    Buratovich, M.A.2    Wilder, E.L.3    Birnbaum, M.J.4
  • 26
    • 0035734381 scopus 로고    scopus 로고
    • Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
    • Kwon, C.H. et al. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404-411 (2001).
    • (2001) Nat. Genet. , vol.29 , pp. 404-411
    • Kwon, C.H.1
  • 27
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • Backman, S.A. et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403 (2001).
    • (2001) Nat. Genet. , vol.29 , pp. 396-403
    • Backman, S.A.1
  • 28
    • 5444233787 scopus 로고    scopus 로고
    • Tsc2 is not a critical target of Akt during normal Drosophila development
    • Dong, J. & Pan, D. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18, 2479-2484 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2479-2484
    • Dong, J.1    Pan, D.2
  • 29
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D.D., Guertin, D.A., Ali, S.M. & Sabatini, D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 30
    • 0033775869 scopus 로고    scopus 로고
    • The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    • Lamb, R.F. et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2, 281-287 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 281-287
    • Lamb, R.F.1
  • 31
    • 1842455769 scopus 로고    scopus 로고
    • The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
    • Govek, E.E. et al. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat. Neurosci. 7, 364-372 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 364-372
    • Govek, E.E.1
  • 32
    • 0035139220 scopus 로고    scopus 로고
    • The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis
    • Penzes, P. et al. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 29, 229-242 (2001).
    • (2001) Neuron , vol.29 , pp. 229-242
    • Penzes, P.1
  • 33
    • 0037461752 scopus 로고    scopus 로고
    • Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
    • Penzes, P. et al. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37, 263-274 (2003).
    • (2003) Neuron , vol.37 , pp. 263-274
    • Penzes, P.1
  • 34
    • 0037160104 scopus 로고    scopus 로고
    • Regulation of TSC2 by 14-3-3 binding
    • Li, Y., Inoki, K., Yeung, R. & Guan, K.L. Regulation of TSC2 by 14-3-3 binding. J. Biol. Chem. 277, 44593-44596 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 44593-44596
    • Li, Y.1    Inoki, K.2    Yeung, R.3    Guan, K.L.4
  • 36
    • 0037718525 scopus 로고    scopus 로고
    • ER export: Call 14-3-3
    • Nufer, O. & Hauri, H.P. ER export: call 14-3-3. Curr. Biol. 13, R391-R393 (2003).
    • (2003) Curr. Biol. , vol.13
    • Nufer, O.1    Hauri, H.P.2
  • 37
    • 0036794093 scopus 로고    scopus 로고
    • 14-3-3 Regulates actin dynamics by stabilizing phosphorylated cofilin
    • Gohla, A. & Bokoch, G.M. 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr. Biol. 12, 1704-1710 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1704-1710
    • Gohla, A.1    Bokoch, G.M.2
  • 38
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • Benvenuto, G. et al. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19, 6306-6316 (2000).
    • (2000) Oncogene , vol.19 , pp. 6306-6316
    • Benvenuto, G.1
  • 39
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D.D. et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1
  • 40
    • 0032565962 scopus 로고    scopus 로고
    • Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
    • Arber, S. et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393, 805-809 (1998).
    • (1998) Nature , vol.393 , pp. 805-809
    • Arber, S.1
  • 41
    • 0029949025 scopus 로고    scopus 로고
    • LIM-kinase deleted in Williams syndrome
    • Tassabehji, M. et al. LIM-kinase deleted in Williams syndrome. Nat. Genet. 13, 272-273 (1996).
    • (1996) Nat. Genet. , vol.13 , pp. 272-273
    • Tassabehji, M.1
  • 42
    • 2942583823 scopus 로고    scopus 로고
    • Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice
    • Hayashi, M.L. et al. Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42, 773-787 (2004).
    • (2004) Neuron , vol.42 , pp. 773-787
    • Hayashi, M.L.1
  • 43
    • 8544267258 scopus 로고    scopus 로고
    • GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
    • Bryan, B. et al. GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J. Biol. Chem. 279, 45824-45832 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 45824-45832
    • Bryan, B.1
  • 44
    • 18444372636 scopus 로고    scopus 로고
    • Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice
    • Meng, Y. et al. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35, 121-133 (2002).
    • (2002) Neuron , vol.35 , pp. 121-133
    • Meng, Y.1
  • 45
    • 0030583146 scopus 로고    scopus 로고
    • Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues
    • Chang, H. et al. Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues. Biochem. Biophys. Res. Commun. 223, 324-328 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 324-328
    • Chang, H.1
  • 46
    • 0028821190 scopus 로고
    • MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment
    • Shepherd, C.W., Houser, O.W. & Gomez, M.R. MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. AJNR Am. J. Neuroradiol. 16, 149-155 (1995).
    • (1995) AJNR Am. J. Neuroradiol. , vol.16 , pp. 149-155
    • Shepherd, C.W.1    Houser, O.W.2    Gomez, M.R.3
  • 47
    • 0032527884 scopus 로고    scopus 로고
    • Comparison of hippocampal dendritic spines in culture and in brain
    • Boyer, C., Schikorski, T. & Stevens, C.F. Comparison of hippocampal dendritic spines in culture and in brain. J. Neurosci. 18, 5294-5300 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 5294-5300
    • Boyer, C.1    Schikorski, T.2    Stevens, C.F.3
  • 48
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini, L., Buchs, P.A. & Muller, D.A. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182 (1991).
    • (1991) J. Neurosci. Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.A.3
  • 49
    • 7044220658 scopus 로고    scopus 로고
    • State dependent calcium signaling in dendritic spines of striatal medium spiny neurons
    • Carter, A.G. & Sabatini, B.L. State dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron (2004).
    • (2004) Neuron
    • Carter, A.G.1    Sabatini, B.L.2
  • 50
    • 0037180832 scopus 로고    scopus 로고
    • Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    • Trachtenberg, J.T. et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420, 788-794 (2002).
    • (2002) Nature , vol.420 , pp. 788-794
    • Trachtenberg, J.T.1


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