-
1
-
-
0004102014
-
-
Oxford Univ. Press, New York
-
Gomez, M.R., Sampson, J.R. & Whittemore, V.H. (eds.) Tuberous Sclerosis Complex (Oxford Univ. Press, New York, 1999).
-
(1999)
Tuberous Sclerosis Complex
-
-
Gomez, M.R.1
Sampson, J.R.2
Whittemore, V.H.3
-
2
-
-
0033582748
-
Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
-
Ito, N. & Rubin, G.M. Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96, 529-539 (1999).
-
(1999)
Cell
, vol.96
, pp. 529-539
-
-
Ito, N.1
Rubin, G.M.2
-
3
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter, C.J., Huang, H. & Xu, T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105, 357-368 (2001).
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
4
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon, N., Ito, N., Dickson, B.J., Treisman, J.E. & Hariharan, I.K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105, 345-355 (2001).
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
5
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao, X. & Pan, D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15, 1383-1392 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
6
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C.J., Pedraza, L.G. & Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658-665 (2002).
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
7
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. & Cantley, L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10, 151-162 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
8
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657 (2002).
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
9
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H. et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5, 559-565 (2003).
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
-
10
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A. et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
-
11
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
12
-
-
0029826812
-
Loss of heterozygosity in tuberous sclerosis hamartomas
-
Sepp, T., Yates, J.R. & Green, A.J. Loss of heterozygosity in tuberous sclerosis hamartomas. J. Med. Genet. 33, 962-964 (1996).
-
(1996)
J. Med. Genet.
, vol.33
, pp. 962-964
-
-
Sepp, T.1
Yates, J.R.2
Green, A.J.3
-
13
-
-
0037864533
-
Aspects of tuberous sclerosis complex (TSC) protein function in the brain
-
Ramesh, V. Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem. Soc. Trans. 31, 579-583 (2003).
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 579-583
-
-
Ramesh, V.1
-
14
-
-
11844272669
-
BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways
-
Dijkhuizen, P.A. & Ghosh, A. BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways. J. Neurobiol. 62, 278-288 (2005).
-
(2005)
J. Neurobiol.
, vol.62
, pp. 278-288
-
-
Dijkhuizen, P.A.1
Ghosh, A.2
-
15
-
-
0037039358
-
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
-
Tang, S.J. et al. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc. Natl. Acad. Sci. USA 99, 467-472 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 467-472
-
-
Tang, S.J.1
-
16
-
-
3242724040
-
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
-
Hou, L. & Klann, E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J. Neurosci. 24, 6352-6361 (2004).
-
(2004)
J. Neurosci.
, vol.24
, pp. 6352-6361
-
-
Hou, L.1
Klann, E.2
-
17
-
-
0034685813
-
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
-
Huber, K.M., Kayser, M.S. & Bear, M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288, 1254-1257 (2000).
-
(2000)
Science
, vol.288
, pp. 1254-1257
-
-
Huber, K.M.1
Kayser, M.S.2
Bear, M.F.3
-
18
-
-
0036713644
-
Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
-
Uhlmann, E.J. et al. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann. Neurol. 52, 285-296 (2002).
-
(2002)
Ann. Neurol.
, vol.52
, pp. 285-296
-
-
Uhlmann, E.J.1
-
19
-
-
0032496239
-
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
-
Kohn, A.D. et al. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J. Biol. Chem. 273, 11937-11943 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11937-11943
-
-
Kohn, A.D.1
-
20
-
-
0141963351
-
Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton
-
Meng, Y., Zhang, Y., Tregoubov, V., Falls, D.L. & Jia, Z. Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton. Rev. Neurosci. 14, 233-240 (2003).
-
(2003)
Rev. Neurosci.
, vol.14
, pp. 233-240
-
-
Meng, Y.1
Zhang, Y.2
Tregoubov, V.3
Falls, D.L.4
Jia, Z.5
-
21
-
-
9644278075
-
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
-
Zhou, Q., Homma, K.J. & Poo, M.M. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44, 749-757 (2004).
-
(2004)
Neuron
, vol.44
, pp. 749-757
-
-
Zhou, Q.1
Homma, K.J.2
Poo, M.M.3
-
22
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-AW signaling through downregulation of PDGFR
-
Zhang, H. et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-AW signaling through downregulation of PDGFR. J. Clin. Invest. 112, 1223-1233 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
-
23
-
-
0031586755
-
Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, TSC-36, in human cancer cells
-
Mashimo, J., Maniwa, R., Sugino, H. & Nose, K. Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, TSC-36, in human cancer cells. Cancer Lett. 113, 213-219 (1997).
-
(1997)
Cancer Lett.
, vol.113
, pp. 213-219
-
-
Mashimo, J.1
Maniwa, R.2
Sugino, H.3
Nose, K.4
-
24
-
-
0034781057
-
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
-
Tuttle, R.L. et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 7, 1133-1137 (2001).
-
(2001)
Nat. Med.
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
-
25
-
-
0033258521
-
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
-
Verdu, J., Buratovich, M.A., Wilder, E.L. & Birnbaum, M.J. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1, 500-506 (1999).
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 500-506
-
-
Verdu, J.1
Buratovich, M.A.2
Wilder, E.L.3
Birnbaum, M.J.4
-
26
-
-
0035734381
-
Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
-
Kwon, C.H. et al. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404-411 (2001).
-
(2001)
Nat. Genet.
, vol.29
, pp. 404-411
-
-
Kwon, C.H.1
-
27
-
-
0035733762
-
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
-
Backman, S.A. et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403 (2001).
-
(2001)
Nat. Genet.
, vol.29
, pp. 396-403
-
-
Backman, S.A.1
-
28
-
-
5444233787
-
Tsc2 is not a critical target of Akt during normal Drosophila development
-
Dong, J. & Pan, D. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18, 2479-2484 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2479-2484
-
-
Dong, J.1
Pan, D.2
-
29
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D.D., Guertin, D.A., Ali, S.M. & Sabatini, D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
30
-
-
0033775869
-
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
-
Lamb, R.F. et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2, 281-287 (2000).
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 281-287
-
-
Lamb, R.F.1
-
31
-
-
1842455769
-
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
-
Govek, E.E. et al. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat. Neurosci. 7, 364-372 (2004).
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 364-372
-
-
Govek, E.E.1
-
32
-
-
0035139220
-
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis
-
Penzes, P. et al. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 29, 229-242 (2001).
-
(2001)
Neuron
, vol.29
, pp. 229-242
-
-
Penzes, P.1
-
33
-
-
0037461752
-
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
-
Penzes, P. et al. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37, 263-274 (2003).
-
(2003)
Neuron
, vol.37
, pp. 263-274
-
-
Penzes, P.1
-
34
-
-
0037160104
-
Regulation of TSC2 by 14-3-3 binding
-
Li, Y., Inoki, K., Yeung, R. & Guan, K.L. Regulation of TSC2 by 14-3-3 binding. J. Biol. Chem. 277, 44593-44596 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44593-44596
-
-
Li, Y.1
Inoki, K.2
Yeung, R.3
Guan, K.L.4
-
35
-
-
0344121246
-
Tuberous sclerosis genes regulate cellular 14-3-3 protein levels
-
Hengstschlager, M., Rosner, M., Fountoulakis, M. & Lubec, G. Tuberous sclerosis genes regulate cellular 14-3-3 protein levels. Biochem. Biophys. Res. Commun. 312, 676-683 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, pp. 676-683
-
-
Hengstschlager, M.1
Rosner, M.2
Fountoulakis, M.3
Lubec, G.4
-
36
-
-
0037718525
-
ER export: Call 14-3-3
-
Nufer, O. & Hauri, H.P. ER export: call 14-3-3. Curr. Biol. 13, R391-R393 (2003).
-
(2003)
Curr. Biol.
, vol.13
-
-
Nufer, O.1
Hauri, H.P.2
-
37
-
-
0036794093
-
14-3-3 Regulates actin dynamics by stabilizing phosphorylated cofilin
-
Gohla, A. & Bokoch, G.M. 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr. Biol. 12, 1704-1710 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1704-1710
-
-
Gohla, A.1
Bokoch, G.M.2
-
38
-
-
17844369428
-
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
-
Benvenuto, G. et al. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19, 6306-6316 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 6306-6316
-
-
Benvenuto, G.1
-
39
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D.D. et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
-
40
-
-
0032565962
-
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
-
Arber, S. et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393, 805-809 (1998).
-
(1998)
Nature
, vol.393
, pp. 805-809
-
-
Arber, S.1
-
41
-
-
0029949025
-
LIM-kinase deleted in Williams syndrome
-
Tassabehji, M. et al. LIM-kinase deleted in Williams syndrome. Nat. Genet. 13, 272-273 (1996).
-
(1996)
Nat. Genet.
, vol.13
, pp. 272-273
-
-
Tassabehji, M.1
-
42
-
-
2942583823
-
Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice
-
Hayashi, M.L. et al. Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42, 773-787 (2004).
-
(2004)
Neuron
, vol.42
, pp. 773-787
-
-
Hayashi, M.L.1
-
43
-
-
8544267258
-
GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation
-
Bryan, B. et al. GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J. Biol. Chem. 279, 45824-45832 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45824-45832
-
-
Bryan, B.1
-
44
-
-
18444372636
-
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice
-
Meng, Y. et al. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35, 121-133 (2002).
-
(2002)
Neuron
, vol.35
, pp. 121-133
-
-
Meng, Y.1
-
45
-
-
0030583146
-
Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues
-
Chang, H. et al. Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues. Biochem. Biophys. Res. Commun. 223, 324-328 (1996).
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.223
, pp. 324-328
-
-
Chang, H.1
-
46
-
-
0028821190
-
MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment
-
Shepherd, C.W., Houser, O.W. & Gomez, M.R. MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. AJNR Am. J. Neuroradiol. 16, 149-155 (1995).
-
(1995)
AJNR Am. J. Neuroradiol.
, vol.16
, pp. 149-155
-
-
Shepherd, C.W.1
Houser, O.W.2
Gomez, M.R.3
-
47
-
-
0032527884
-
Comparison of hippocampal dendritic spines in culture and in brain
-
Boyer, C., Schikorski, T. & Stevens, C.F. Comparison of hippocampal dendritic spines in culture and in brain. J. Neurosci. 18, 5294-5300 (1998).
-
(1998)
J. Neurosci.
, vol.18
, pp. 5294-5300
-
-
Boyer, C.1
Schikorski, T.2
Stevens, C.F.3
-
48
-
-
0025805120
-
A simple method for organotypic cultures of nervous tissue
-
Stoppini, L., Buchs, P.A. & Muller, D.A. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182 (1991).
-
(1991)
J. Neurosci. Methods
, vol.37
, pp. 173-182
-
-
Stoppini, L.1
Buchs, P.A.2
Muller, D.A.3
-
49
-
-
7044220658
-
State dependent calcium signaling in dendritic spines of striatal medium spiny neurons
-
Carter, A.G. & Sabatini, B.L. State dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron (2004).
-
(2004)
Neuron
-
-
Carter, A.G.1
Sabatini, B.L.2
-
50
-
-
0037180832
-
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
-
Trachtenberg, J.T. et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420, 788-794 (2002).
-
(2002)
Nature
, vol.420
, pp. 788-794
-
-
Trachtenberg, J.T.1
|