메뉴 건너뛰기




Volumn 29, Issue 18, 2009, Pages 5926-5937

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SERINE THREONINE KINASE; TUBERIN;

EID: 65949106140     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0778-09.2009     Document Type: Article
Times cited : (142)

References (65)
  • 3
    • 0032504710 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • DOI 10.1016/S0005-2728(98)00114-5, PII S0005272898001145
    • Beal MF (1998) Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta 1366:211-223. (Pubitemid 28467033)
    • (1998) Biochimica et Biophysica Acta - Bioenergetics , vol.1366 , Issue.1-2 , pp. 211-223
    • Beal, M.F.1
  • 4
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326-332.
    • (2000) Nat Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 7
    • 0026511824 scopus 로고
    • Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells
    • Dorner AJ, Wasley LC, Kaufman RJ (1992) Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells. EMBO J 11:1563-1571.
    • (1992) EMBO J , vol.11 , pp. 1563-1571
    • Dorner, A.J.1    Wasley, L.C.2    Kaufman, R.J.3
  • 9
    • 0033118409 scopus 로고    scopus 로고
    • Complexes containing activating transcription factor (ATF)/cAMP- responsive-element-binding protein (CREB) interact with the CCAAT/enhancer- binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
    • DOI 10.1042/0264-6021:3390135
    • Fawcett TW, Martindale JL, Guyton KZ, Hai T, Holbrook NJ (1999) Complexes containing activating transcription factor (ATF)/cAMP-responsive-element- binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem J 339:135-141. (Pubitemid 29179300)
    • (1999) Biochemical Journal , vol.339 , Issue.1 , pp. 135-141
    • Fawcett, T.W.1    Martindale, J.L.2    Guyton, K.Z.3    Hai, T.4    Holbrook, N.J.5
  • 10
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri KF, Kroemer G (2001) Organelle-specific initiation of cell death pathways. Nat Cell Biol 3:E255-E263.
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 11
    • 28244468650 scopus 로고    scopus 로고
    • Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin
    • DOI 10.1158/0008-5472.CAN-05-1394
    • Finlay GA, Thannickal VJ, Fanburg BL, Kwiatkowski DJ (2005) Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin. Cancer Res 65:10881-10890. (Pubitemid 41713356)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10881-10890
    • Finlay, G.A.1    Thannickal, V.J.2    Fanburg, B.L.3    Kwiatkowski, D.J.4
  • 13
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6:1099-1108.
    • (2000) Mol Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5    Schapira, M.6    Ron, D.7
  • 15
    • 4444265582 scopus 로고    scopus 로고
    • Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death
    • DOI 10.1016/j.molcel.2004.08.025, PII S1097276504005118
    • Haynes CM, Titus EA, Cooper AA (2004) Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell 15:767-776. (Pubitemid 39194906)
    • (2004) Molecular Cell , vol.15 , Issue.5 , pp. 767-776
    • Haynes, C.M.1    Titus, E.A.2    Cooper, A.A.3
  • 16
    • 33750599989 scopus 로고    scopus 로고
    • A new paradigm of channelopathy in epilepsy syndromes: Intracellular trafficking abnormality of channel molecules
    • Hirose S (2006) A new paradigm of channelopathy in epilepsy syndromes: intracellular trafficking abnormality of channel molecules. Epilepsy Res 70 [Suppl 1]:S206-S217.
    • (2006) Epilepsy Res , vol.70 , Issue.SUPPL. 1
    • Hirose, S.1
  • 17
    • 34249016897 scopus 로고    scopus 로고
    • Akt up- And down-regulation in response to endoplasmic reticulum stress
    • DOI 10.1016/j.brainres.2007.03.052, PII S0006899307006543
    • Hosoi T, Hyoda K, Okuma Y, Nomura Y, Ozawa K (2007) Akt up- and down-regulation in response to endoplasmic reticulum stress. Brain Res 1152:27-31. (Pubitemid 46802507)
    • (2007) Brain Research , vol.1152 , Issue.1 , pp. 27-31
    • Hosoi, T.1    Hyoda, K.2    Okuma, Y.3    Nomura, Y.4    Ozawa, K.5
  • 18
    • 10344253840 scopus 로고    scopus 로고
    • Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
    • DOI 10.1074/jbc.M407700200
    • Hu P, Han Z, Couvillon AD, Exton JH (2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279:49420-49429. (Pubitemid 39625828)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49420-49429
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Exton, J.H.4
  • 20
    • 0036853914 scopus 로고    scopus 로고
    • Orchestrating the unfolded protein response in health and disease
    • DOI 10.1172/JCI200216886
    • Kaufman RJ (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110:1389-1398. (Pubitemid 35396907)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.10 , pp. 1389-1398
    • Kaufman, R.J.1
  • 21
    • 0036710984 scopus 로고    scopus 로고
    • Analysis of mitochondrial free radical generation in animal models of neuronal disease
    • DOI 10.1016/S0891-5849(02)00968-1, PII S0891584902009681
    • Kim DY, Won SJ, Gwag BJ (2002) Analysis of mitochondrial free radical generation in animal models of neuronal disease. Free Radic Biol Med 33:715-723. (Pubitemid 35245844)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.5 , pp. 715-723
    • Kim, D.Y.1    Won, S.J.2    Gwag, B.J.3
  • 22
    • 33646167400 scopus 로고    scopus 로고
    • ER stress, hypoxia tolerance and tumor progression
    • Koumenis C (2006) ER stress, hypoxia tolerance and tumor progression. Curr Mol Med 6:55-69.
    • (2006) Curr Mol Med , vol.6 , pp. 55-69
    • Koumenis, C.1
  • 23
    • 27744588780 scopus 로고    scopus 로고
    • Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
    • DOI 10.1093/hmg/ddi260
    • Kwiatkowski DJ, Manning BD (2005) Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 14 [Suppl 2]:R251-R258. (Pubitemid 41631882)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SUPPL. 2
    • Kwiatkowski, D.J.1    Manning, B.D.2
  • 24
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    • DOI 10.1101/gad.964702
    • Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ (2002) IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 16:452-466. (Pubitemid 34165102)
    • (2002) Genes and Development , vol.16 , Issue.4 , pp. 452-466
    • Lee, K.1    Tirasophon, W.2    Shen, X.3    Michalak, M.4    Prywes, R.5    Okada, T.6    Yoshida, H.7    Mori, K.8    Kaufman, R.J.9
  • 25
    • 0033920261 scopus 로고    scopus 로고
    • ATF6 as a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
    • DOI 10.1128/MCB.20.14.5096-5106.2000
    • Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000) ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol Cell Biol 20:5096-5106. (Pubitemid 30431563)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.14 , pp. 5096-5106
    • Li, M.1    Baumeister, P.2    Roy, B.3    Phan, T.4    Foti, D.5    Luo, S.6    Lee, A.S.7
  • 26
    • 0034637605 scopus 로고    scopus 로고
    • Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
    • DOI 10.1074/jbc.M004454200
    • Liu CY, Schröder M, Kaufman RJ (2000) Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 275:24881-24885. (Pubitemid 30626593)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.32 , pp. 24881-24885
    • Chuan Yin, L.1    Schroder, M.2    Kaufman, R.J.3
  • 27
    • 0038043221 scopus 로고    scopus 로고
    • Structure and intermolecular interactions of the luminal dimerization domain of human IRE1α
    • DOI 10.1074/jbc.M300418200
    • Liu CY, Xu Z, Kaufman RJ (2003) Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J Biol Chem 278:17680-17687. (Pubitemid 36799370)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.20 , pp. 17680-17687
    • Liu, C.Y.1    Xu, Z.2    Kaufman, R.J.3
  • 29
    • 0036314984 scopus 로고    scopus 로고
    • Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
    • DOI 10.1016/S0022-2836(02)00234-6
    • Ma Y, Brewer JW, Diehl JA, Hendershot LM (2002) Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318:1351-1365. (Pubitemid 34754003)
    • (2002) Journal of Molecular Biology , vol.318 , Issue.5 , pp. 1351-1365
    • Ma, Y.1    Brewer, J.W.2    Alan Diehl, J.3    Hendershot, L.M.4
  • 30
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162.
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 32
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
    • DOI 10.1128/MCB.21.4.1249-1259.2001
    • McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21:1249-1259. (Pubitemid 32114973)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.4 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.-O.3    Aw, T.-Y.4    Holbrook, N.J.5
  • 33
    • 34250626014 scopus 로고    scopus 로고
    • A mouse model of tuberous sclerosis: Neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival
    • DOI 10.1523/JNEUROSCI.5540-06.2007
    • Meikle L, Talos DM, Onda H, Pollizzi K, Rotenberg A, Sahin M, Jensen FE, Kwiatkowski DJ (2007) A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci 27:5546-5558. (Pubitemid 350021088)
    • (2007) Journal of Neuroscience , vol.27 , Issue.21 , pp. 5546-5558
    • Meikle, L.1    Talos, D.M.2    Onda, H.3    Pollizzi, K.4    Rotenberg, A.5    Sahin, M.6    Jensen, F.E.7    Kwiatkowski, D.J.8
  • 34
    • 45849110311 scopus 로고    scopus 로고
    • Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function
    • Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ (2008) Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci 28:5422-5432.
    • (2008) J Neurosci , vol.28 , pp. 5422-5432
    • Meikle, L.1    Pollizzi, K.2    Egnor, A.3    Kramvis, I.4    Lane, H.5    Sahin, M.6    Kwiatkowski, D.J.7
  • 35
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori K (2000) Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 36
    • 19444378586 scopus 로고    scopus 로고
    • Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation
    • DOI 10.1016/j.ymthe.2005.01.005, PII S1525001605000146
    • Mostoslavsky G, Kotton DN, Fabian AJ, Gray JT, Lee JS, Mulligan RC (2005) Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation. Mol Ther 11:932-940. (Pubitemid 40724112)
    • (2005) Molecular Therapy , vol.11 , Issue.6 , pp. 932-940
    • Mostoslavsky, G.1    Kotton, D.N.2    Fabian, A.J.3    Gray, J.T.4    Lee, J.-S.5    Mulligan, R.C.6
  • 37
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • DOI 10.1038/sj.cdd.4401373
    • Oyadomari S, Mori M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11:381-389. (Pubitemid 38489416)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.4 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 38
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29:541-551.
    • (2008) Mol Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Düvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 40
    • 0030052530 scopus 로고    scopus 로고
    • Requirement for superoxide in excitotoxic cell death
    • DOI 10.1016/S0896-6273(00)80052-5
    • Patel M, Day BJ, Crapo JD, Fridovich I, McNamara JO (1996) Requirement for superoxide in excitotoxic cell death. Neuron 16:345-355. (Pubitemid 26072367)
    • (1996) Neuron , vol.16 , Issue.2 , pp. 345-355
    • Patel, M.1    Day, B.J.2    Crapo, J.D.3    Fridovich, I.4    McNamara, J.O.5
  • 41
    • 0036827635 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial dysfunction, and epilepsy
    • DOI 10.1080/1071576021000016391
    • Patel MN (2002) Oxidative stress, mitochondrial dysfunction, and epilepsy. Free Radic Res 36:1139-1146. (Pubitemid 35230233)
    • (2002) Free Radical Research , vol.36 , Issue.11 , pp. 1139-1146
    • Patel, M.N.1
  • 42
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4:658-665.
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 44
    • 34547307366 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of neurodegenerative disorders
    • Reynolds A, Laurie C, Mosley RL, Gendelman HE (2007) Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol 82:297-325.
    • (2007) Int Rev Neurobiol , vol.82 , pp. 297-325
    • Reynolds, A.1    Laurie, C.2    Mosley, R.L.3    Gendelman, H.E.4
  • 45
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529. (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 46
    • 0347285295 scopus 로고    scopus 로고
    • A trip to the ER: Coping with stress
    • DOI 10.1016/j.tcb.2003.11.001
    • Rutkowski DT, Kaufman RJ (2004) A trip to the ER: coping with stress. Trends Cell Biol 14:20-28. (Pubitemid 38076857)
    • (2004) Trends in Cell Biology , vol.14 , Issue.1 , pp. 20-28
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 47
    • 0033973712 scopus 로고    scopus 로고
    • The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- And antioxidant properties
    • Ryter SW, Tyrrell RM (2000) The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 28:289-309.
    • (2000) Free Radic Biol Med , vol.28 , pp. 289-309
    • Ryter, S.W.1    Tyrrell, R.M.2
  • 49
    • 1842608814 scopus 로고    scopus 로고
    • Heme oxygenase-1: Transducer of pathological brain iron sequestration under oxidative stress
    • DOI 10.1196/annals.1306.007
    • Schipper HM (2004a) Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann N Y Acad Sci 1012:84-93. (Pubitemid 38453517)
    • (2004) Annals of the New York Academy of Sciences , vol.1012 , pp. 84-93
    • Schipper, H.M.1
  • 50
    • 8544257019 scopus 로고    scopus 로고
    • Heme oxygenase expression in human central nervous system disorders
    • DOI 10.1016/j.freeradbiomed.2004.09.015, PII S0891584904007403
    • Schipper HM (2004b) Heme oxygenase expression in human central nervous system disorders. Free Radic Biol Med 37:1995-2011. (Pubitemid 39491319)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.12 , pp. 1995-2011
    • Schipper, H.M.1
  • 51
    • 41449116766 scopus 로고    scopus 로고
    • Ero1 and redox homeostasis in the endoplasmic reticulum
    • Sevier CS, Kaiser CA (2008) Ero1 and redox homeostasis in the endoplasmic reticulum. Biochim Biophys Acta 1783:549-556.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 549-556
    • Sevier, C.S.1    Kaiser, C.A.2
  • 53
    • 0027296209 scopus 로고
    • Reversal of long-term potentiation by inhibitors of haem oxygenase
    • DOI 10.1038/364147a0
    • Stevens CF, Wang Y (1993) Reversal of long-term potentiation by inhibitors of haem oxygenase. Nature 364:147-149. (Pubitemid 23238196)
    • (1993) Nature , vol.364 , Issue.6433 , pp. 147-149
    • Stevens, C.F.1    Wang, Y.2
  • 54
    • 2942555358 scopus 로고    scopus 로고
    • Heme oxygenase-1: A novel therapeutic target in oxidative tissue injuries
    • Takahashi T, Morita K, Akagi R, Sassa S (2004) Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr Med Chem 11:1545-1561. (Pubitemid 38735796)
    • (2004) Current Medicinal Chemistry , vol.11 , Issue.12 , pp. 1545-1561
    • Takahashi, T.1    Morita, K.2    Akagi, R.3    Sassa, S.4
  • 55
    • 28044456974 scopus 로고    scopus 로고
    • Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
    • DOI 10.1038/nn1566, PII N1566
    • Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8:1727-1734. (Pubitemid 41683201)
    • (2005) Nature Neuroscience , vol.8 , Issue.12 , pp. 1727-1734
    • Tavazoie, S.F.1    Alvarez, V.A.2    Ridenour, D.A.3    Kwiatkowski, D.J.4    Sabatini, B.L.5
  • 56
    • 34247158550 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
    • DOI 10.1016/j.neuroscience.2006.10.056, PII S0306452206014333, Genome Dynamics and DNA Repair in the CNS
    • Trushina E, McMurray CT (2007) Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 145:1233-1248. (Pubitemid 46602738)
    • (2007) Neuroscience , vol.145 , Issue.4 , pp. 1233-1248
    • Trushina, E.1    McMurray, C.T.2
  • 57
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • DOI 10.1126/science.287.5453.664
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-666. (Pubitemid 30070916)
    • (2000) Science , vol.287 , Issue.5453 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 58
    • 0037025272 scopus 로고    scopus 로고
    • The endoplasmic reticulum as an integrating signalling organelle: From neuronal signalling to neuronal death
    • Verkhratsky A, Petersen OH (2002) The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. Eur J Pharmacol 447:141-154.
    • (2002) Eur J Pharmacol , vol.447 , pp. 141-154
    • Verkhratsky, A.1    Petersen, O.H.2
  • 62
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M (2008) Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 63:444-453.
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 63
    • 33750040886 scopus 로고    scopus 로고
    • S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
    • DOI 10.1016/j.molcel.2006.09.019, PII S1097276506006678
    • Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD (2006) S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 24:185-197. (Pubitemid 44574477)
    • (2006) Molecular Cell , vol.24 , Issue.2 , pp. 185-197
    • Zhang, H.H.1    Lipovsky, A.I.2    Dibble, C.C.3    Sahin, M.4    Manning, B.D.5
  • 64
    • 33644858343 scopus 로고    scopus 로고
    • The unfolded protein response: A stress signaling pathway critical for health and disease
    • PII 0000611420060124100018
    • Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66:S102-S109. (Pubitemid 43739994)
    • (2006) Neurology , vol.66 , Issue.2 SUPPL. 1
    • Zhang, K.1    Kaufman, R.J.2
  • 65
    • 0027267817 scopus 로고
    • Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus
    • Zhuo M, Small SA, Kandel ER, Hawkins RD (1993) Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science 260:1946-1950. (Pubitemid 23258276)
    • (1993) Science , vol.260 , Issue.5116 , pp. 1946-1950
    • Zhuo, M.1    Small, S.A.2    Kandel, E.R.3    Hawkins, R.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.