Opposite effects of Tor1 and Tor2 on nitrogen starvation responses in fission yeast

Genetics

Volumn 175, Issue 3, 2007, Pages 1153-1162

  Weisman, Ronit ^a   Roitburg, Irina ^a   Schonbrun, Miriam ^a   Harari, Rona ^a   Kupiec, Martin ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CANAVANINE; NITROGEN; PROTEIN TUBEROUS SCLEROSIS COMPLEX 1; PROTEIN TUBEROUS SCLEROSIS COMPLEX 2; RAPAMYCIN; RHEB PROTEIN; TARGET OF RAPAMYCIN KINASE; TARGET OF RAPAMYCIN KINASE1; TARGET OF RAPAMYCIN KINASE2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; FUNGUS GROWTH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHIZOSACCHAROMYCES POMBE; SEXUAL DEVELOPMENT; TUBEROUS SCLEROSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID TRANSPORT SYSTEMS; BLOTTING, NORTHERN; CELL CYCLE; DNA PRIMERS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, FUNGAL; LEUCINE; NITROGEN; PROTEIN KINASES; REPRODUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIROLIMUS;

EUKARYOTA; MAMMALIA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 34249054108     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.106.064170     Document Type: Article

References (48)

1. ALVAREZ, B., and S. MORENO, 2006 Fission yeast Tor2 promotes cell growth and represses cell differentiation. J. Cell Sci. 119: 4475-4485.
2. BARBET, N. C., U. SCHNEIDER, S. B. HELLIWELL, I. STANSFIELD, M. F. TUITE et al., 1996 TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7: 25-42.
3. BECK, T., and M. N. HALL, 1999 The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402: 689-692.
4. BOOHER, R., and D. BEACH, 1986 Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol. Cell. Biol. 6: 3523-3530.
5. DI COMO, C. J., and K. T. ARNDT, 1996 Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10: 1904-1916.
6. FANTES, P., and P. NURSE, 1977 Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp. Cell Res. 107: 377-386.
7. GANGLOFF, Y. G., M. MUELLER, S. G. DANN, P. SVOBODA, M. STICKER et al., 2004 Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol. Cell. Biol. 24: 9508-9516.
8. HARRINGTON, L. S., G. M. FINDLAY, A. GRAY, T. TOLKACHEVA, S. WIGFIELD et al., 2004 The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166: 213-223.
9. HAY, N., and N. SONENBERG, 2004 Upstream and downstream of mTOR. Genes Dev. 18: 1926-1945.
10. HOFFMAN, C. S., 2005 Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem. Soc. Trans. 33: 257-260.
11. JACINTO, E., R. LOEWITH, A. SCHMIDT, S. LIN, M. A. RUEGG et al., 2004 Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6: 1122-1128.
12. KAWAI, M., A. NAKASHIMA, M. UENO, T. USHIMARU, K. AIBA et al., 2001 Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr. Genet. 39: 166-174.
13. KIM, D. H., D. SARBASSOV DOS, S. M. ALI, R. R. LATEK, K. V. GUNTUR et al., 2003 GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11: 895-904.
14. LI, Y., M. N. CORRADETTI, K. INOKI and K. L. GUAN, 2004 TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem. Sci. 29: 32-38.
15. LOEWITH, R., E. JACINTO, S. WULLSCHLEGER, A. LORBERG, J. L. CRESPO et al., 2002 Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10: 457-468.
16. LONG, X., C. SPYCHER, Z. S. HAN, A. M. ROSE, F. MULLER et al., 2002 TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr. Biol. 12: 1448-1461.
17. MACH, K. E., K. A. FURGE and C. F. ALBRIGHT, 2000 Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics 155: 611-622.
18. MANNING, B. D., and L. C. CANTLEY, 2003 Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28: 573-576.
19. MATSUMOTO, S., A. BANDYOPADHYAY, D. J. KWIATKOWSKI, U. MAITRA and T. MATSUMOTO, 2002 Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics 161: 1053-1063.
20. MATSUO, T., Y. KUBO, Y. WATANABE and M. YAMAMOTO, 2003 Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J. 22: 3073-3083.
21. MAUNDRELL, K., 1993 Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 123: 127-130.
22. MORENO, S., A. KLAR and P. NURSE, 1991 Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194: 795-823.
23. MURAKAMI, M., T. ICHISAKA, M. MAEDA, N. OSHIRO, K. HARA et al., 2004 mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol. Cell. Biol. 24: 6710-6718.
24. +, a homolog of the human gene predisposing tuberous sclerosis complex. Genetics 173: 569-578.
25. NODA, T., and Y. OHSUMI, 1998 Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273: 3963-3966.
26. OLDHAM, S., J. MONTAGNE, T. RADIMERSKI, G. THOMAS and E. HAFEN, 2000 Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14: 2689-2694.
27. PRENTICE, H. L., 1992 High efficiency transformation of Schizosaccharomyces pombe by electroporation. Nucleic Acids Res. 20: 621.
28. SARBASSOV, D. D., S. M. ALI, D. H. KIM, D. A. GUERTIN, R. R. LATEK et al., 2004 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14: 1296-1302.
29. SARBASSOV, D. D., D. A. GUERTIN, S. M. ALI and D. M. SABATINI, 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
30. SHAH, O. J., Z. WANG and T. HUNTER, 2004 Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14: 1650-1656.
31. SNAITH, H. A., and S. L. FORSBURG, 1999 Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes. Genetics 152: 839-851.
32. STETTLER, S., E. WARBRICK, S. PROCHNIK, S. MACKIE and P. FANTES, 1996 The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. J. Cell Sci. 109(7): 1927-1935.
33. STIEFEL, J., L. WANG, D. A. KELLY, R. T. JANOO, J. SEITZ et al., 2004 Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe. Eukaryot. Cell 3: 610-619.
34. TEE, A. R., and J. BLENIS, 2005 mTOR, translational control and human disease. Semin. Cell Dev. Biol. 16: 29-37.
35. UM, S. H., F. FRIGERIO, M. WATANABE, F. PICARD, M. JOAQUIN et al., 2004 Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431: 200-205.
36. URANO, J., M. J. COMISO, L. GUO, P. J. ASPURIA, R. DENISKIN et al., 2005 Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Mol. Microbiol. 58: 1074-1086.
37. URITANI, M., H. HIDAKA, Y. HOTTA, M. UENO, T. USHIMARU et al., 2006 Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells 11: 1367-1379.
38. VAN SLEGTENHORST, M., E. CARR, R. STOYANOVA, W. KRUGER and E. P. HENSKE, 2004 Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J. Biol. Chem. 279: 12706-12713.
39. WEISMAN, R., 2004 The fission yeast TOR proteins and the rapamycin response: an unexpected tale. Curr. Top. Microbiol. Immunol. 279: 85-95.
40. WEISMAN, R., and M. CHODER, 2001 The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276: 7027-7032.
41. WEISMAN, R., M. CHODER and Y. KOLTIN, 1997 Rapamycin specifically interferes with the developmental response of fission yeast to starvation. J. Bacteriol. 179: 6325-6334.
42. + in Schizosaccharomyces pombe is sensitive to rapamycin. Genetics 169: 539-550.
43. WULLSCHLEGER, S., R. LOEWITH and M. N. HALL, 2006 TOR signaling in growth and metabolism. Cell 124: 471-484.
44. YANG, Q., K. INOKI, E. KIM and K. L. GUAN, 2006 TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc. Natl. Acad. Sci. USA 103: 6811-6816.
45. YANG, W., A. P. TABANCAY, JR., J. URANO and F. TAMANOI, 2001 Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant. Mol. Microbiol. 41: 1339-1347.
46. YOUNG, P. G., and P. A. FANTES, 1987 Schizosaccharomyces pombe mutants affected in their division response to starvation. J. Cell Sci. 88(3): 295-304.
47. ZARAGOZA, D., A. GHAVIDEL, J. HEITMAN and M. C. SCHULTZ, 1998 Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol. Cell. Biol. 18: 4463-4470.
48. ZHANG, H., J. P. STALLOCK, J. C. NG, C. REINHARD and T. P. NEUFELD, 2000 Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14: 2712-2724.