Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 29930-29937

  Karbowniczek, Magdalena ^a   Cash, Timothy ^a   Cheung, Mitchell ^b   Robertson, Gavin P ^b   Astrinidis, Aristotelis ^a   Henske, Elizabeth Petri ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; SKIN; TUMORS;

TUBERIN; TUBEROUS SCLEROSIS COMPLEX (TSC);

GENES;

B RAF KINASE; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; HAMARTIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN; RAS PROTEIN; RHEB PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTISM; BRAIN TUMOR; CONTROLLED STUDY; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART TUMOR; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY TUMOR; MENTAL DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RETINA TUMOR; SEIZURE; SKIN TUMOR; TUBEROUS SCLEROSIS; WILD TYPE;

CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DIMERIZATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE TRANSFERASE; GUANOSINE DIPHOSPHATE; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; MUTATION; NEUROPEPTIDES; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN ISOPRENYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RNA; RNA, SMALL INTERFERING; SIROLIMUS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 3142757865     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402591200     Document Type: Article

References (48)

1. van Slegtenhorst, M., de Hoogt, R., Hermans, C., Nellist, M., Janssen, B., Verhoef, S., Lindhout, D., van den Ouweland, A., Halley, D., Young, J., Burley, M., Jeremiah, S., Woodward, K., Nahmias, J., Fox, M., Ekong, R., Osborne, J., Wolfe, J., Povey, S., Snell, R., Cheadle, J., Jones, A., Tachataki, M., Ravine, D., Sampson, J., Reeve, M., Richardson, P., Wilmer, R., Munro, C. Hawkins, T., Sepp, T., Ali, J., Ward, S., Green, A., Yates, J., Kwiatkowska, J., Henske, E., Short, M., Haines, J., Jozwiak, S., and Kwiatkowski, D. (1997) Science 277, 805-808
2. The European Chromosome 16 Tuberous Sclerosis Consortium (1993) Cell 75, 1305-1315
3. Plank, T. L., Yeung, R. S., and Henske, E. P. (1998) Cancer Res. 58, 4766-4770
4. van Slegtenhorst, M., Nellist, M., Nagelkerken, B., Cheadle, J., Snell, R., van den Ouweland, A., Reuser, A., Sampson, J., Halley, D., and van der Sluijs, P. (1998) Hum. Mol. Genet. 7, 1053-1057
5. Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A., and Yeung, R. S. (1997) J. Biol. Chem. 272, 6097-6100
6. Ito, N., and Rubin, G. M. (1999) Cell 96, 529-539
7. Soucek, T., Pusch, O., Wienecke, R., DeClue, J. E., and Hengstschlager, M. (1997) J. Biol. Chem. 272, 29301-29308
8. Miloloza, A., Rosner, M., Nellist, M., Halley, D., Bernaschek, G., and Hengstschlager, M. (2000) Hum. Mol. Genet. 9, 1721-1727
9. Potter, C. J., Huang, H., and Xu, T. (2001) Cell 105, 357-368
10. Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E., and Hariharan, I. K. (2001) Cell 105, 345-355
11. Henry, K. W., Yuan, X., Koszewski, N. J., Onda, H., Kwiatkowski, D. J., and Noonan, D. J. (1998) J. Biol. Chem. 273, 20535-20539
12. Lamb, R. F., Roy, C., Diefenbach, T. J., Vinters, H. V., Johnson, M. W., Jay, D. G., and Hall, A. (2000) Nat. Cell Biol. 2, 281-287
13. Astrinidis, A., Cash, T. P., Hunter, D. S., Walker, C. L., Chernoff, J., and Henske, E. P. (2002) Oncogene 21, 8470-8476
14. Kwiatkowski, D. J., Zhang, H., Bandura, J. L., Heiberger, K. M., Glogauer, M., el-Hashemite, N., and Onda, H. (2002) Hum. Mol. Genet. 11, 525-534
15. Goncharova, E. A., Goncharov, D. A., Eszterhas, A., Hunter, D. S., Glassberg, M. K., Yeung, R. S., Walker, C. L., Noonan, D., Kwiatkowski, D. J., Chou, M. M., Panettieri, R. A., Jr., and Krymskaya, V. P. (2002) J. Biol. Chem. 277, 30958-30967
16. Kenerson, H. L., Aicher, L. D., True, L. D., and Yeung, R. S. (2002) Cancer Res. 62, 5645-5650
17. Karbowniczek, M., Yu, J., and Henske, E. P. (2003) Am. J. Pathol. 162, 491-500
18. El-Hashemite, N., Zhang, H., Henske, E. P., and Kwiatkowski, D. J. (2003) Lancet 361, 1348-1349
19. Radimerski, T., Montagne, J., Hemmings-Mieszczak, M., and Thomas, G. (2002) Genes Dev. 16, 2627-2632
20. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) Nat. Cell Biol. 4, 648-657
21. Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B., and Pan, D. (2002) Nat. Cell Biol. 4, 699-704
22. Wienecke, R., Konig, A., and DeClue, J. E. (1995) J. Biol. Chem. 270, 16409-16414
23. Yamagata, K., Sanders, L. K., Kaufmann, W. E., Yee, W., Barnes, C. A., Nathans, D., and Worley, P. F. (1994) J. Biol. Chem. 269, 16333-16339
24. Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., and Hafen, E. (2003) Nat. Cell Biol. 5, 559-566
25. Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003) Nat. Cell Biol. 5, 566-571
26. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003) Nat. Cell Biol. 5, 578-581
27. Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Curr. Biol. 13, 1259-1268
28. Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Genes Dev. 17, 1829-1834
29. Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., and Thomas, G. (2003) Mol. Cell. 11, 1457-1466
30. Castro, A. F., Rebhun, J. F., Clark, G. J., and Quilliam, L. A. (2003) J. Biol. Chem. 278, 32493-32496
31. Im, E., von Lintig, F. C., Chen, J., Zhuang, S., Qui, W., Chowdhury, S., Worley, P. F., Boss, G. R., and Pilz, R. B. (2002) Oncogene 21, 6356-6365
32. Zhang, H., Cicchetti, G., Onda, H., Koon, H. B., Asrican, K., Bajraszewski, N., Vazquez, F., Carpenter, C. L., and Kwiatkowski, D. J. (2003) J. Clin. Investig. 112, 1223-1233
33. Yoon, H. S., Ramachandiran, S., Chacko, M. A., Monks, T. J., and Lau, S. S. (2004) Am. J. Physiol. 286, F417-F424
34. Howe, S. R., Gottardis, M. M., Everitt, J. I., Goldsworthy, T. L., Wolf, D. C., and Walker, C. (1995) Am. J. Pathol. 146, 1568-1579
35. Scheele, J. S., Rhee, J. M., and Boss, G. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1097-1100
36. Liu, M. Y., Cai, S., Espejo, A., Bedford, M. T., and Walker, C. L. (2002) Cancer Res. 62, 6475-6480
37. Zhang, B. H., and Guan, K. L. (2000) EMBO J. 19, 5429-5439
38. Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Nature 417, 949-954
39. Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D., and Der, C. J. (1997) J. Biol. Chem. 272, 10608-10615
40. Stacey, D. W., Feig, L. A., and Gibbs, J. B. (1991) Mol. Cell. Biol. 11, 4053-4064
41. Urano, J., Tabancay, A. P., Yang, W., and Tamanoi, F. (2000) J. Biol. Chem. 275, 11198-11206
42. Yee, W. M., and Worley, P. F. (1997) Mol. Cell. Biol. 17, 921-933
43. Mercer, K., Chiloeches, A., Huser, M., Kiernan, M., Marais, R., and Pritchard, C. (2002) Oncogene 21, 347-355
44. Huser, M., Luckett, J., Chiloeches, A., Mercer, K., Iwobi, M., Giblett, S., Sun, X. M., Brown, J., Marais, R., and Pritchard, C. (2001) EMBO J 20, 1940-1951
45. Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R., and Kaelin, W. G., Jr. (2003) Cancer Cell 4, 147-158
46. Wojnowski, L., Zimmer, A. M., Beck, T. W., Hahn, H., Bernal, R., Rapp, U. R., and Zimmer, A. (1997) Nat. Genet. 16, 293-297
47. Niida, Y., Stemmer-Rachamimov, A. O., Logrip, M., Tapon, D., Perez, R., Kwiatkowski, D. J., Sims, K., MacCollin, M., Louis, D. N., and Ramesh, V. (2001) Am. J. Hum. Genet. 69, 493-503
48. Hirose, T., Scheithauer, B. W., Lopes, M. B., Gerber, H. A., Altermatt, H. J., Hukee, M. J., VandenBerg, S. R., and Charlesworth, J. C. (1995) Acta Neuropathol. (Berl.) 90, 387-399