-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551 (Pubitemid 26413787)
-
(1996)
EMBO Journal
, vol.15
, Issue.23
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
12644301164
-
3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
-
Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M (1997a) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 7:776-789 (Pubitemid 27441832)
-
(1997)
Current Biology
, vol.7
, Issue.10
, pp. 776-789
-
-
Alessi, D.R.1
Deak, M.2
Casamayor, A.3
Caudwell, F.B.4
Morrice, N.5
Norman, D.G.6
Gaffney, P.7
Reese, C.B.8
MacDougall, C.N.9
Harbison, D.10
Ashworth, A.11
Bownes, M.12
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997b) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261-269 (Pubitemid 27176852)
-
(1997)
Current Biology
, vol.7
, Issue.4
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.J.5
Reese, C.B.6
Cohen, P.7
-
4
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
DOI 10.1074/jbc.272.50.31515
-
AndjelkovicM,AlessiDR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA (1997) Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524 (Pubitemid 28013293)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.50
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.C.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
5
-
-
0027432424
-
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
-
Arcaro A, Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296 (Pt 2):297-301 (Pubitemid 23350826)
-
(1993)
Biochemical Journal
, vol.296
, Issue.2
, pp. 297-301
-
-
Arcaro, A.1
Wymann, M.P.2
-
6
-
-
15644362968
-
Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity
-
DOI 10.1074/jbc.273.49.33082
-
Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (1998) Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem 273:33082-33090 (Pubitemid 28557705)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.49
, pp. 33082-33090
-
-
Arcaro, A.1
Volinia, S.2
Zvelebil, M.J.3
Stein, R.4
Watton, S.J.5
Layton, M.J.6
Gout, I.7
Ahmadi, K.8
Downward, J.9
Waterfield, M.D.10
-
7
-
-
0024601010
-
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
-
DOI 10.1016/0092-8674(89)90182-7
-
Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167-175 (Pubitemid 19098878)
-
(1989)
Cell
, vol.57
, Issue.1
, pp. 167-175
-
-
Auger, K.R.1
Serunian, L.A.2
Soltoff, S.P.3
Libby, P.4
Cantley, L.C.5
-
8
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serinethreonine kinase containing an SH2-like region. Science 254:274-277 (Pubitemid 21917339)
-
(1991)
Science
, vol.254
, Issue.5029
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
9
-
-
69349094765
-
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
-
Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG (2009) Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. NatGenet 41:1032-1036
-
(2009)
NatGenet
, vol.41
, pp. 1032-1036
-
-
Bielas, S.L.1
Silhavy, J.L.2
Brancati, F.3
Kisseleva, M.V.4
Al-Gazali, L.5
Sztriha, L.6
Bayoumi, R.A.7
Zaki, M.S.8
Abdel-Aleem, A.9
Rosti, R.O.10
Kayserili, H.11
Swistun, D.12
Scott, L.C.13
Bertini, E.14
Boltshauser, E.15
Fazzi, E.16
Travaglini, L.17
Field, S.J.18
Gayral, S.19
Jacoby, M.20
Schurmans, S.21
Dallapiccola, B.22
Majerus, P.W.23
Valente, E.M.24
Gleeson, J.G.25
more..
-
10
-
-
0141563825
-
Protein targeting to endosomes and phagosomes via FYVE and PX domains
-
Birkeland HC, Stenmark H (2004) Protein targeting to endosomes and phagosomes via FYVE and PX domains. Curr Top Microbiol Immunol 282:89-115
-
(2004)
Curr Top Microbiol Immunol
, vol.282
, pp. 89-115
-
-
Birkeland, H.C.1
Stenmark, H.2
-
11
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
DOI 10.1016/S0968-0004(01)01958-2, PII S0968000401019582
-
Brazil DP, Hemmings BA (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26:657-664 (Pubitemid 33042488)
-
(2001)
Trends in Biochemical Sciences
, vol.26
, Issue.11
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
12
-
-
0031575938
-
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, hsC2-P13K
-
DOI 10.1006/bbrc.1997.6495
-
Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (1997) Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem Biophys Res Commun 233:537-544 (Pubitemid 27226663)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.233
, Issue.2
, pp. 537-544
-
-
Brown, R.A.1
Ho, L.K.F.2
Weber-Hall, S.J.3
Shipley, J.M.4
Fry, M.J.5
-
13
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868 (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
14
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
15
-
-
25444457577
-
HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
DOI 10.1074/jbc.M507201200
-
Byfield MP, Murray JT, Backer JM (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280:33076-33082 (Pubitemid 41368357)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
16
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
DOI 10.1158/0008-5472.CAN-04-2933
-
Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA (2004) Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64:7678-7681 (Pubitemid 39446895)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.F.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
17
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704-19711 (Pubitemid 120013919)
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.32
, pp. 19704-19711
-
-
Carpenter, C.L.1
Duckworth, B.C.2
Auger, K.R.3
Cohen, B.4
Schaffhausen, B.S.5
Cantley, L.C.6
-
18
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
DOI 10.1126/science.276.5320.1848
-
Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK (1997) Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276:1848-1850 (Pubitemid 27443659)
-
(1997)
Science
, vol.276
, Issue.5320
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
Auger, K.R.4
Bellacosa, A.5
Tsichlis, P.N.6
Cantley, L.C.7
Roberts, T.M.8
Vogt, P.K.9
-
19
-
-
0030612144
-
P110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
-
DOI 10.1074/jbc.272.31.19236
-
Chantry D, Vojtek A, Kashishian A, Holtzman DA, Wood C, Gray PW, Cooper JA, Hoekstra MF (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 272:19236-19241 (Pubitemid 27337713)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.31
, pp. 19236-19241
-
-
Chantry, D.1
Vojtek, A.2
Kashishian, A.3
Holtzman, D.A.4
Wood, C.5
Gray, P.W.6
Cooper, J.A.7
Hoekstra, M.F.8
-
20
-
-
0034947026
-
Phox domain interaction with Ptdlns(3)P targets the Vam7 t-SNARE to vacuole membranes
-
DOI 10.1038/35083000
-
Cheever ML, Sato TK, de Beer T, Kutateladze TG, Emr SD, Overduin M (2001) Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 3:613-618 (Pubitemid 32624416)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.7
, pp. 613-618
-
-
Cheever, M.L.1
Sato, T.K.2
De Beer, T.3
Kutateladze, T.G.4
Emr, S.D.5
Overduin, M.6
-
21
-
-
0037119630
-
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med 196: 753-763
-
(2002)
J Exp Med
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
Chantry, D.4
Downes, C.P.5
Gray, A.6
Humphries, L.A.7
Rawlings, D.8
Reynolds, H.9
Vigorito, E.10
Turner, M.11
-
22
-
-
38849208347
-
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
-
Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, Hsueh T, Chen Y, Wang W, Youngkin D, Liau L, Martin N, Becker D, Bergsneider M, Lai A, Green R, Oglesby T, Koleto M, Trent J, Horvath S, Mischel PS, Mellinghoff IK, Sawyers CL (2008) Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5(1):e8
-
(2008)
PLoS Med
, vol.5
, Issue.1
-
-
Cloughesy, T.F.1
Yoshimoto, K.2
Nghiemphu, P.3
Brown, K.4
Dang, J.5
Zhu, S.6
Hsueh, T.7
Chen, Y.8
Wang, W.9
Youngkin, D.10
Liau, L.11
Martin, N.12
Becker, D.13
Bergsneider, M.14
Lai, A.15
Green, R.16
Oglesby, T.17
Koleto, M.18
Trent, J.19
Horvath, S.20
Mischel, P.S.21
Mellinghoff, I.K.22
Sawyers, C.L.23
more..
-
23
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative proteinserine kinase related to the cAMP-dependent and protein kinase C families
-
Coffer PJ, Woodgett JR (1991) Molecular cloning and characterisation of a novel putative proteinserine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem 201:475-481
-
(1991)
Eur J Biochem
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
24
-
-
33845690817
-
Metabolic regulation of Akt: Roles reversed
-
DOI 10.1083/jcb.200610119
-
Coloff JL, Rathmell JC (2006) Metabolic regulation of Akt: roles reversed. J Cell Biol 175: 845-847 (Pubitemid 44969189)
-
(2006)
Journal of Cell Biology
, vol.175
, Issue.6
, pp. 845-847
-
-
Coloff, J.L.1
Rathmell, J.C.2
-
25
-
-
0023665027
-
An 81 kd protein complexed with middle T antigen and pp 60csrc: A possible phosphatidylinositol kinase
-
Courtneidge SA, Heber A (1987) An 81 kd protein complexed with middle T antigen and pp 60csrc: a possible phosphatidylinositol kinase. Cell 50:1031-1037
-
(1987)
Cell
, vol.50
, pp. 1031-1037
-
-
Courtneidge, S.A.1
Heber, A.2
-
26
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
DOI 10.1038/378785a0
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789 (Pubitemid 26004411)
-
(1995)
Nature
, vol.378
, Issue.6559
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
27
-
-
58149295945
-
Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest
-
Dan S, Yoshimi H, Okamura M, Mukai Y, Yamori T (2009) Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest. Biochem Biophys Res Commun 379:104-109
-
(2009)
Biochem Biophys Res Commun
, vol.379
, pp. 104-109
-
-
Dan, S.1
Yoshimi, H.2
Okamura, M.3
Mukai, Y.4
Yamori, T.5
-
28
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
-
DOI 10.1016/S0092-8674(00)80405-5
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241 (Pubitemid 27456390)
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Xu, T.3
Masters, S.4
Haian, F.5
Gotoh, Y.6
Greenberg, M.E.7
-
29
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
DOI 10.1126/science.278.5338.687
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689 (Pubitemid 27464966)
-
(1997)
Science
, vol.278
, Issue.5338
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
30
-
-
33749836234
-
Phosphoinositides in cell regulation and membrane dynamics
-
DOI 10.1038/nature05185, PII NATURE05185
-
Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-657 (Pubitemid 44564702)
-
(2006)
Nature
, vol.443
, Issue.7112
, pp. 651-657
-
-
Di Paolo, G.1
De Camilli, P.2
-
31
-
-
0030884527
-
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
-
Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 326(Pt 1):139-147 (Pubitemid 27386928)
-
(1997)
Biochemical Journal
, vol.326
, Issue.1
, pp. 139-147
-
-
Domin, J.1
Pages, F.2
Volinia, S.3
Rittenhouse, S.E.4
Zvelebil, M.J.5
Stein, R.C.6
Waterfield, M.D.7
-
32
-
-
76249092302
-
Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
-
Edgar KA, Wallin JJ, Berry M, Lee LB, Prior WW, Sampath D, Friedman LS, Belvin M (2010) Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Cancer Res 70:1164-1172
-
(2010)
Cancer Res
, vol.70
, pp. 1164-1172
-
-
Edgar, K.A.1
Wallin, J.J.2
Berry, M.3
Lee, L.B.4
Prior, W.W.5
Sampath, D.6
Friedman, L.S.7
Belvin, M.8
-
33
-
-
42049089732
-
Down-regulation of class II phosphoinositide 3-kinase α expression below a critical threshold induces apoptotic cell death
-
DOI 10.1158/1541-7786.MCR-07-0262
-
Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, Borawski J, Gaither LA, Murphy LO, Finan PM, Mackeigan JP (2008) Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Mol Cancer Res 6:614-623 (Pubitemid 351521843)
-
(2008)
Molecular Cancer Research
, vol.6
, Issue.4
, pp. 614-623
-
-
Elis, W.1
Triantafellow, E.2
Wolters, N.M.3
Sian, K.R.4
Caponigro, G.5
Borawski, J.6
Gaither, L.A.7
Murphy, L.O.8
Finan, P.M.9
MacKeigan, J.P.10
-
34
-
-
0034743311
-
phox
-
DOI 10.1038/35083076
-
Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Gaffney PR, Coadwell J, Chilvers ER, Hawkins PT, Stephens LR (2001) PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol 3:679-682 (Pubitemid 32624425)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.7
, pp. 679-682
-
-
Ellson, C.D.1
Gobert-Gosse, S.2
Anderson, K.E.3
Davidson, K.4
Erdjument-Bromage, H.5
Tempst, P.6
Thuring, J.W.7
Cooper, M.A.8
Lim, Z.-Y.9
Holmes, A.B.10
Gaffney, P.R.J.11
Coadwell, J.12
Chilvers, E.R.13
Hawkins, P.T.14
Stephens, L.R.15
-
35
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garcia-Echeverria C, Weissleder R, Mahmood U, Cantley LC, Wong KK (2008) Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14:1351-1356
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
Chirieac, L.R.11
Kaur, R.12
Lightbown, A.13
Simendinger, J.14
Li, T.15
Padera, R.F.16
Garcia-Echeverria, C.17
Weissleder, R.18
Mahmood, U.19
Cantley, L.C.20
Wong, K.K.21
more..
-
36
-
-
0025727594
-
CDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
-
Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT (1991) cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell 65:75-82 (Pubitemid 121001215)
-
(1991)
Cell
, vol.65
, Issue.1
, pp. 75-82
-
-
Escobedo, J.A.1
Navankasattusas, S.2
Michael Kavanaugh, W.3
Milfay, D.4
Fried, V.A.5
Williams, L.T.6
-
37
-
-
73349129405
-
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
-
Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT, Lifshits E, Chen Z, Maira SM, Garcia-Echeverria C, Wong KK, Engelman JA (2009) Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci USA 106:19503-19508
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19503-19508
-
-
Faber, A.C.1
Li, D.2
Song, Y.3
Liang, M.C.4
Yeap, B.Y.5
Bronson, R.T.6
Lifshits, E.7
Chen, Z.8
Maira, S.M.9
Garcia-Echeverria, C.10
Wong, K.K.11
Engelman, J.A.12
-
38
-
-
72049110528
-
Rethinking phosphatidylinositol 3-monophosphate
-
Falasca M, Maffucci T (2009) Rethinking phosphatidylinositol 3-monophosphate. Biochim Biophys Acta 1793:1795-1803
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1795-1803
-
-
Falasca, M.1
Maffucci, T.2
-
39
-
-
34548596728
-
A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
-
DOI 10.1158/0008-5472.CAN-07-2154
-
Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA (2007) A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 67:7960-7965 (Pubitemid 47395125)
-
(2007)
Cancer Research
, vol.67
, Issue.17
, pp. 7960-7965
-
-
Fan, Q.-W.1
Cheng, C.K.2
Nicolaides, T.P.3
Hackett, C.S.4
Knight, Z.A.5
Shokat, K.M.6
Weiss, W.A.7
-
40
-
-
69949170092
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
-
Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R (2009) Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325:1261-1265
-
(2009)
Science
, vol.325
, pp. 1261-1265
-
-
Fine, B.1
Hodakoski, C.2
Koujak, S.3
Su, T.4
Saal, L.H.5
Maurer, M.6
Hopkins, B.7
Keniry, M.8
Sulis, M.L.9
Mense, S.10
Hibshoosh, H.11
Parsons, R.12
-
41
-
-
84862863970
-
Evidence of clinical activity in a phase 1 study of CAL-101, an oral P110d isoform-selective inhibitor of phosphatidylinositol 3-kinase, in patients with relapsed or refractory B-Cell malignancies
-
Flinn IA, Byrd JC, Furman RR, Brown JR, Benson DM, Coutre SE, Kahl BS, Smith BD, Wagner-Johnston ND, Spurgeon SE, Giese NA, Yu AS (2009) Evidence of clinical activity in a phase 1 study of CAL-101, an oral P110d isoform-selective inhibitor of phosphatidylinositol 3-kinase, in patients with relapsed or refractory B-Cell malignancies. ASH 2009 Abstract
-
(2009)
ASH 2009 Abstract
-
-
Flinn, I.A.1
Byrd, J.C.2
Furman, R.R.3
Brown, J.R.4
Benson, D.M.5
Coutre, S.E.6
Kahl, B.S.7
Smith, B.D.8
Wagner-Johnston, N.D.9
Spurgeon, S.E.10
Giese, N.A.11
Yu, A.S.12
-
42
-
-
33744990592
-
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
-
DOI 10.1038/nature04694, PII NATURE04694
-
Foukas LC, ClaretM, PearceW, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJ,Withers DJ, Vanhaesebroeck B (2006) Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441:366-370 (Pubitemid 44050203)
-
(2006)
Nature
, vol.441
, Issue.7091
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
Okkenhaug, K.4
Meek, S.5
Peskett, E.6
Sancho, S.7
Smith, A.J.H.8
Withers, D.J.9
Vanhaesebroeck, B.10
-
44
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGFactivated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGFactivated phosphatidylinositol 3-kinase. Cell 81:727-736
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
45
-
-
0030991386
-
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
-
DOI 10.1074/jbc.272.13.8474
-
Frech M, Andjelkovic M, Ingley E, Reddy KK, Falck JR, Hemmings BA (1997) High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem 272:8474-8481 (Pubitemid 27147810)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.13
, pp. 8474-8481
-
-
Frech, M.1
Andjelkovic, M.2
Ingley, E.3
Reddy, K.K.4
Falck, J.R.5
Hemmings, B.A.6
-
46
-
-
0026483185
-
Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns
-
Fry MJ, Panayotou G, Dhand R, Ruiz-Larrea F, Gout I, Nguyen O, Courtneidge SA, Waterfield MD (1992) Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns. Biochem J 288(Pt 2):383-393
-
(1992)
Biochem J
, vol.288
, Issue.PART 2
, pp. 383-393
-
-
Fry, M.J.1
Panayotou, G.2
Dhand, R.3
Ruiz-Larrea, F.4
Gout, I.5
Nguyen, O.6
Courtneidge, S.A.7
Waterfield, M.D.8
-
47
-
-
0032581670
-
FYVE fingers bind PtdIns(3) P
-
Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R (1998) FYVE fingers bind PtdIns(3)P. Nature 394:432-433
-
(1998)
Nature
, vol.394
, pp. 432-433
-
-
Gaullier, J.M.1
Simonsen, A.2
D'Arrigo, A.3
Bremnes, B.4
Stenmark, H.5
Aasland, R.6
-
48
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16:115-125
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
Bowtell, D.6
Barretina, J.7
Lin, W.M.8
Rameh, L.9
Salmena, L.10
Pandolfi, P.P.11
Cantley, L.C.12
-
49
-
-
44349119736
-
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
-
DOI 10.1038/nature06892, PII NATURE06892
-
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B (2008) Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature 453:662-666 (Pubitemid 351769296)
-
(2008)
Nature
, vol.453
, Issue.7195
, pp. 662-666
-
-
Graupera, M.1
Guillermet-Guibert, J.2
Foukas, L.C.3
Phng, L.-K.4
Cain, R.J.5
Salpekar, A.6
Pearce, W.7
Meek, S.8
Millan, J.9
Cutillas, P.R.10
Smith, A.J.H.11
Ridley, A.J.12
Ruhrberg, C.13
Gerhardt, H.14
Vanhaesebroeck, B.15
-
50
-
-
59449092539
-
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
-
Guillard S, Clarke PA, Te Poele R, Mohri Z, Bjerke L, Valenti M, Raynaud F, Eccles SA, Workman P (2009) Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. Cell Cycle 8:443-453
-
(2009)
Cell Cycle
, vol.8
, pp. 443-453
-
-
Guillard, S.1
Clarke, P.A.2
Te Poele, R.3
Mohri, Z.4
Bjerke, L.5
Valenti, M.6
Raynaud, F.7
Eccles, S.A.8
Workman, P.9
-
52
-
-
0028021882
-
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
-
DOI 10.1038/371168a0
-
Harlan JE, Hajduk PJ, Yoon HS, Fesik SW (1994) Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371:168-170 (Pubitemid 24284017)
-
(1994)
Nature
, vol.371
, Issue.6493
, pp. 168-170
-
-
Harlan, J.E.1
Hajduk, P.J.2
Yoon, H.S.3
Fesik, S.W.4
-
54
-
-
0026654026
-
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase
-
Hawkins PT, Jackson TR, Stephens LR (1992) Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase. Nature 358:157-159
-
(1992)
Nature
, vol.358
, pp. 157-159
-
-
Hawkins, P.T.1
Jackson, T.R.2
Stephens, L.R.3
-
55
-
-
0025200830
-
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
-
Herman PK, Emr SD (1990) Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 10:6742-6754 (Pubitemid 120004619)
-
(1990)
Molecular and Cellular Biology
, vol.10
, Issue.12
, pp. 6742-6754
-
-
Herman, P.K.1
Emr, S.D.2
-
56
-
-
0026720350
-
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
-
Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R, Panayotou G, Ruiz-Larrea F, Thompson A, Totty NF et al (1992) Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419-429
-
(1992)
Cell
, vol.70
, pp. 419-429
-
-
Hiles, I.D.1
Otsu, M.2
Volinia, S.3
Fry, M.J.4
Gout, I.5
Dhand, R.6
Panayotou, G.7
Ruiz-Larrea, F.8
Thompson, A.9
Totty, N.F.10
-
57
-
-
0034635434
-
Specific requirement for the p85-p110α phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
-
DOI 10.1074/jbc.275.6.3741
-
Hill K, Welti S, Yu J, Murray JT, Yip SC, Condeelis JS, Segall JE, Backer JM (2000) Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. J Biol Chem 275:3741-3744 (Pubitemid 30094592)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.6
, pp. 3741-3744
-
-
Hill, K.1
Welti, S.2
Yu, J.3
Murray, J.T.4
Yip, S.-C.5
Condeelis, J.S.6
Segall, J.E.7
Backer, J.M.8
-
58
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-1053
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
59
-
-
0027361002
-
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3- kinase and identification of its binding site on p85
-
Hu P, Mondino A, Skolnik EY, Schlessinger J (1993) Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol Cell Biol 13:7677-7688 (Pubitemid 23354292)
-
(1993)
Molecular and Cellular Biology
, vol.13
, Issue.12
, pp. 7677-7688
-
-
Hu, P.1
Mondino, A.2
Skolnik, E.Y.3
Schlessinger, J.4
-
61
-
-
0032530384
-
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
-
DOI 10.1093/emboj/17.18.5374
-
Isakoff SJ, Cardozo T, Andreev J, Li Z, Ferguson KM, Abagyan R, Lemmon MA, Aronheim A, Skolnik EY (1998) Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J 17:5374-5387 (Pubitemid 28427051)
-
(1998)
EMBO Journal
, vol.17
, Issue.18
, pp. 5374-5387
-
-
Isakoff, S.J.1
Cardozo, T.2
Andreev, J.3
Li, Z.4
Ferguson, K.M.5
Abagyan, R.6
Lemmon, M.A.7
Aronheim, A.8
Skolnik, E.Y.9
-
62
-
-
0026674617
-
Receptor specificity of growth factorstimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells
-
Jackson TR, Stephens LR, Hawkins PT (1992) Receptor specificity of growth factorstimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells. J Biol Chem 267:16627-16636
-
(1992)
J Biol Chem
, vol.267
, pp. 16627-16636
-
-
Jackson, T.R.1
Stephens, L.R.2
Hawkins, P.T.3
-
63
-
-
21044454703
-
PI 3-kinase p110β: A new target for antithrombotic therapy
-
DOI 10.1038/nm1232
-
Jackson SP, Schoenwaelder SM, Goncalves I,NesbittWS,Yap CL,Wright CE, Kenche V, Anderson KE,Dopheide SM, Yuan Y, SturgeonSA, PrabaharanH, Thompson PE, SmithGD, Shepherd PR, Daniele N, Kulkarni S, Abbott B, Saylik D, Jones C, Lu L, Giuliano S, Hughan SC, Angus JA, Robertson AD, Salem HH (2005) PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 11:507-514 (Pubitemid 40685973)
-
(2005)
Nature Medicine
, vol.11
, Issue.5
, pp. 507-514
-
-
Jackson, S.P.1
Schoenwaelder, S.M.2
Goncalves, I.3
Nesbitt, W.S.4
Yap, C.L.5
Wright, C.E.6
Kenche, V.7
Anderson, K.E.8
Dopheide, S.M.9
Yuan, Y.10
Sturgeon, S.A.11
Prabaharan, H.12
Thompson, P.E.13
Smith, G.D.14
Shepherd, P.R.15
Daniele, N.16
Kulkarni, S.17
Abbott, B.18
Saylik, D.19
Jones, C.20
Lu, L.21
Giuliano, S.22
Hughan, S.C.23
Angus, J.A.24
Robertson, A.D.25
Salem, H.H.26
more..
-
64
-
-
69349095810
-
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
-
Jacoby M, Cox JJ, Gayral S, Hampshire DJ, Ayub M, Blockmans M, Pernot E, Kisseleva MV, Compere P, Schiffmann SN, Gergely F, Riley JH, Perez-Morga D, Woods CG, Schurmans S (2009) INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 41:1027-1031
-
(2009)
Nat Genet
, vol.41
, pp. 1027-1031
-
-
Jacoby, M.1
Cox, J.J.2
Gayral, S.3
Hampshire, D.J.4
Ayub, M.5
Blockmans, M.6
Pernot, E.7
Kisseleva, M.V.8
Compere, P.9
Schiffmann, S.N.10
Gergely, F.11
Riley, J.H.12
Perez-Morga, D.13
Woods, C.G.14
Schurmans, S.15
-
65
-
-
70749140937
-
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
-
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S (2009) Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell 16:463-474
-
(2009)
Cancer Cell
, vol.16
, pp. 463-474
-
-
Jaiswal, B.S.1
Janakiraman, V.2
Kljavin, N.M.3
Chaudhuri, S.4
Stern, H.M.5
Wang, W.6
Kan, Z.7
Dbouk, H.A.8
Peters, B.A.9
Waring, P.10
Dela Vega, T.11
Kenski, D.M.12
Bowman, K.K.13
Lorenzo, M.14
Li, H.15
Wu, J.16
Modrusan, Z.17
Stinson, J.18
Eby, M.19
Yue, P.20
Kaminker, J.S.21
De Sauvage, F.J.22
Backer, J.M.23
Seshagiri, S.24
more..
-
66
-
-
61849135453
-
Tumor suppressors and cell metabolism: A recipe for cancer growth
-
Jones RG, Thompson CB (2009) Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 23:537-548
-
(2009)
Genes Dev
, vol.23
, pp. 537-548
-
-
Jones, R.G.1
Thompson, C.B.2
-
67
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA (1991) Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci USA 88:4171-4175 (Pubitemid 21914501)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.10
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
68
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex
-
DOI 10.1128/MCB.22.24.8580-8591.2002
-
Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Wang D, Ihle JN (2002) Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 22:8580-8591 (Pubitemid 35397173)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.24
, pp. 8580-8591
-
-
Jou, S.-T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.-R.5
Carpino, N.6
Wang, D.7
Ihle, J.N.8
-
69
-
-
0034946472
-
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K
-
DOI 10.1038/35083070
-
Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB (2001) The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol 3:675-678 (Pubitemid 32624424)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.7
, pp. 675-678
-
-
Kanai, F.1
Liu, H.2
Field, S.J.3
Akbary, H.4
Matsuo, T.5
Brown, G.E.6
Cantley, L.C.7
Yaffe, M.B.8
-
70
-
-
0023665111
-
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
-
Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM (1987) Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021-1029
-
(1987)
Cell
, vol.50
, pp. 1021-1029
-
-
Kaplan, D.R.1
Whitman, M.2
Schaffhausen, B.3
Pallas, D.C.4
White, M.5
Cantley, L.6
Roberts, T.M.7
-
71
-
-
0030975196
-
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and sec7 homology domains
-
DOI 10.1126/science.275.5308.1927
-
Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP (1997) Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-1930 (Pubitemid 27148813)
-
(1997)
Science
, vol.275
, Issue.5308
, pp. 1927-1930
-
-
Klarlund, J.K.1
Guilherme, A.2
Holik, J.J.3
Virbasius, J.V.4
Chawla, A.5
Czech, M.P.6
-
72
-
-
0033560896
-
Direct control of the forkhead transcription faotor AFX by protein kinase B
-
DOI 10.1038/19328
-
Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630-634 (Pubitemid 29183692)
-
(1999)
Nature
, vol.398
, Issue.6728
, pp. 630-634
-
-
Kops, G.J.P.L.1
De Ruiter, N.D.2
De Vries-Smits, A.M.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.Th.6
-
73
-
-
18244392475
-
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
-
DOI 10.1016/S1097-2765(02)00434-3
-
Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P,ManifavaM,KtistakisN, Painter G, Thuring JW, Cooper MA, Lim ZY,Holmes AB,Dove SK, MichellRH, Grewal A, NazarianA, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (2002) Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell 9:95-108 (Pubitemid 34127774)
-
(2002)
Molecular Cell
, vol.9
, Issue.1
, pp. 95-108
-
-
Krugmann, S.1
Anderson, K.E.2
Ridley, S.H.3
Risso, N.4
McGregor, A.5
Coadwell, J.6
Davidson, K.7
Eguinoa, A.8
Ellson, C.D.9
Lipp, P.10
Manifava, M.11
Ktistakis, N.12
Painter, G.13
Thuring, J.W.14
Cooper, M.A.15
Lim, Z.-Y.16
Holmes, A.B.17
Dove, S.K.18
Michell, R.H.19
Grewal, A.20
Nazarian, A.21
Erdjument-Bromage, H.22
Tempst, P.23
Stephens, L.R.24
Hawkins, P.T.25
more..
-
74
-
-
0029830237
-
The drosophila phosphoinositide 3-kinase Dp 110 promotes cell growth
-
Leevers SJ, Weinkove D, MacDougall LK, Hafen E, Waterfield MD (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J 15:6584-6594 (Pubitemid 26413791)
-
(1996)
EMBO Journal
, vol.15
, Issue.23
, pp. 6584-6594
-
-
Leevers, S.J.1
Weinkove, D.2
MacDougall, L.K.3
Hafen, E.4
Waterfield, M.D.5
-
75
-
-
38549092474
-
Membrane recognition by phospholipid-binding domains
-
DOI 10.1038/nrm2328, PII NRM2328
-
Lemmon MA (2008) Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 9:99-111 (Pubitemid 351158910)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.2
, pp. 99-111
-
-
Lemmon, M.A.1
-
76
-
-
0034635221
-
Roles of PLC-β2 and -β3 and PI3kγ in chemoattractant- mediated signal transduction
-
DOI 10.1126/science.287.5455.1046
-
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049 (Pubitemid 30094361)
-
(2000)
Science
, vol.287
, Issue.5455
, pp. 1046-1049
-
-
Li, Z.1
Jiang, H.2
Xie, W.3
Zhang, Z.4
Smrcka, A.V.5
Wu, D.6
-
78
-
-
0029612196
-
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
-
DOI 10.1016/S0960-9822(95)00278-8
-
MacDougall LK, Domin J, Waterfield MD (1995) A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr Biol 5:1404-1415 (Pubitemid 3008923)
-
(1995)
Current Biology
, vol.5
, Issue.12
, pp. 1404-1415
-
-
MacDougall, L.K.1
Domin, J.2
Waterfield, M.D.3
-
79
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
DOI 10.1074/jbc.273.22.13375
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378 (Pubitemid 28268370)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.22
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
80
-
-
70350126139
-
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
-
Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM (2009) A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci USA 106:16996-17001
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 16996-17001
-
-
Mandelker, D.1
Gabelli, S.B.2
Schmidt-Kittler, O.3
Zhu, J.4
Cheong, I.5
Huang, C.H.6
Kinzler, K.W.7
Vogelstein, B.8
Amzel, L.M.9
-
81
-
-
0027288910
-
A putative modular domain present in diverse signaling proteins
-
DOI 10.1016/0092-8674(93)90244-K
-
Mayer BJ, Ren R, Clark KL, Baltimore D (1993) A putative modular domain present in diverse signaling proteins. Cell 73:629-630 (Pubitemid 23159003)
-
(1993)
Cell
, vol.73
, Issue.4
, pp. 629-630
-
-
Mayer, B.J.1
Ren, R.2
Clark, K.L.3
Baltimore, D.4
-
82
-
-
34447503808
-
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
-
DOI 10.1126/science.1135394
-
Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL (2007) Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Pubitemid 47076198)
-
(2007)
Science
, vol.317
, Issue.5835
, pp. 239-242
-
-
Miled, N.1
Yan, Y.2
Hon, W.-C.3
Perisic, O.4
Zvelebil, M.5
Inbar, Y.6
Schneidman-Duhovny, D.7
Wolfson, H.J.8
Backer, J.M.9
Williams, R.L.10
-
83
-
-
0032539734
-
Cloning and characterization of a Novel class II phosphoinositide 3-kinase containing C2 domain
-
DOI 10.1006/bbrc.1998.8294
-
Misawa H, Ohtsubo M, Copeland NG, Gilbert DJ, Jenkins NA, Yoshimura A (1998) Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun 244:531-539 (Pubitemid 28414116)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.244
, Issue.2
, pp. 531-539
-
-
Misawa, H.1
Ohtsubo, M.2
Copeland, N.G.3
Gilbert, D.J.4
Jenkins, N.A.5
Yoshimura, A.6
-
84
-
-
0025105970
-
Purification and characterization of bovine brain type I phosphatidylinositol kinase
-
DOI 10.1111/j.1432-1033.1990.tb19185.x
-
Morgan SJ, Smith AD, Parker PJ (1990) Purification and characterization of bovine brain type I phosphatidylinositol kinase. Eur J Biochem 191:761-767 (Pubitemid 20265787)
-
(1990)
European Journal of Biochemistry
, vol.191
, Issue.3
, pp. 761-767
-
-
Morgan, S.J.1
Smith, A.D.2
Parker, P.J.3
-
85
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
DOI 10.1038/382536a0
-
Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:536-539 (Pubitemid 26260694)
-
(1996)
Nature
, vol.382
, Issue.6591
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
86
-
-
24944536147
-
Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
-
DOI 10.1016/j.febslet.2005.07.096, PII S0014579305010033
-
Morrow CJ, Gray A, Dive C (2005) Comparison of phosphatidylinositol-3- kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA. FEBS Lett 579:5123-5128 (Pubitemid 41318079)
-
(2005)
FEBS Letters
, vol.579
, Issue.23
, pp. 5123-5128
-
-
Morrow, C.J.1
Gray, A.2
Dive, C.3
-
87
-
-
0029030937
-
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif
-
Mu FT, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL, McCluskey J, Yeo JP, Tock EP, Toh BH (1995) EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem 270:13503-13511
-
(1995)
J Biol Chem
, vol.270
, pp. 13503-13511
-
-
Mu, F.T.1
Callaghan, J.M.2
Steele-Mortimer, O.3
Stenmark, H.4
Parton, R.G.5
Campbell, P.L.6
McCluskey, J.7
Yeo, J.P.8
Tock, E.P.9
Toh, B.H.10
-
88
-
-
47649106149
-
Endosomal phosphoinositides and human diseases
-
DOI 10.1111/j.1600-0854.2008.00754.x
-
Nicot AS, Laporte J (2008) Endosomal phosphoinositides and human diseases. Traffic 9: 1240-1249 (Pubitemid 352016284)
-
(2008)
Traffic
, vol.9
, Issue.8
, pp. 1240-1249
-
-
Nicot, A.-S.1
Laporte, J.2
-
89
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
DOI 10.1073/pnas.0506925102
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci USA 102:14238-14243 (Pubitemid 41429682)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.T.11
Thomas, G.12
-
90
-
-
77954755623
-
Predictive biomarkers of sensitivity to the phosphatidylinositol 30 kinase inhibitor GDC-0941 in breast cancer preclinical models
-
[Epub ahead of print]
-
O'Brien C, Wallin JJ, Sampath D, Guhathakurta D, Savage H, Punnoose EA, Guan J, Berry L, Prior WW, Amler LC, Belvin M, Friedman L, Lackner M (2010) Predictive biomarkers of sensitivity to the phosphatidylinositol 30 kinase inhibitor GDC-0941 in breast cancer preclinical models. Clin Cancer Res [Epub ahead of print]
-
(2010)
Clin Cancer Res
-
-
O'Brien, C.1
Wallin, J.J.2
Sampath, D.3
Guhathakurta, D.4
Savage, H.5
Punnoose, E.A.6
Guan, J.7
Berry, L.8
Prior, W.W.9
Amler, L.C.10
Belvin, M.11
Friedman, L.12
Lackner, M.13
-
91
-
-
0030659557
-
The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
DOI 10.1038/40194
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994-999 (Pubitemid 27485694)
-
(1997)
Nature
, vol.389
, Issue.6654
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
92
-
-
0028146616
-
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
-
Okada T, Sakuma L, Fukui Y, Hazeki O, Ui M (1994) Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J Biol Chem 269:3563-3567
-
(1994)
J Biol Chem
, vol.269
, pp. 3563-3567
-
-
Okada, T.1
Sakuma, L.2
Fukui, Y.3
Hazeki, O.4
Ui, M.5
-
93
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice
-
DOI 10.1126/science.1073560
-
OkkenhaugK, BilancioA, FarjotG, Priddle H, Sancho S, Peskett E, PearceW,Meek SE, Salpekar A, Waterfield MD, Smith AJ, Vanhaesebroeck B (2002) Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297:1031-1034 (Pubitemid 34856039)
-
(2002)
Science
, vol.297
, Issue.5583
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
Pearce, W.7
Meek, S.E.8
Salpekar, A.9
Waterfield, M.D.10
Smith, A.J.H.11
Vanhaesebroeck, B.12
-
94
-
-
0032571317
-
A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration
-
DOI 10.1074/jbc.273.13.7731
-
Ono F, Nakagawa T, Saito S, Owada Y, Sakagami H, Goto K, Suzuki M, Matsuno S, Kondo H (1998) A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. J Biol Chem 273:7731-7736 (Pubitemid 28152804)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.13
, pp. 7731-7736
-
-
Ono, F.1
Nakagawa, T.2
Saito, S.3
Owada, Y.4
Sakagami, H.5
Goto, K.6
Suzuki, M.7
Matsuno, S.8
Kondo, H.9
-
95
-
-
62749155738
-
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
-
Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA (2009) The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J 419:29-49
-
(2009)
Biochem J
, vol.419
, pp. 29-49
-
-
Ooms, L.M.1
Horan, K.A.2
Rahman, P.3
Seaton, G.4
Gurung, R.5
Kethesparan, D.S.6
Mitchell, C.A.7
-
96
-
-
0025755422
-
c-src complexes, and PI3-kinase
-
Otsu M, Hiles I, Gout I, Fry MJ, Ruiz-Larrea F, Panayotou G, Thompson A, Dhand R, Hsuan J, Totty N et al (1991) Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp 60c-src complexes, and PI3-kinase. Cell 65:91-104 (Pubitemid 121001217)
-
(1991)
Cell
, vol.65
, Issue.1
, pp. 91-104
-
-
Otsu, M.1
Hiles, I.2
Gout, I.3
Fry, M.J.4
Ruiz-Larrea, F.5
Panayotou, G.6
Thompson, A.7
Dhand, R.8
Hsuan, J.9
Totty, N.10
Smith, A.D.11
Morgan, S.J.12
Courtneidge, S.A.13
Parker, P.J.14
Waterfield, M.D.15
-
97
-
-
71549166652
-
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase
-
Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET,WuH, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM (2009) Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res 69:8868-8876
-
(2009)
Cancer Res
, vol.69
, pp. 8868-8876
-
-
Pang, H.1
Flinn, R.2
Patsialou, A.3
Wyckoff, J.4
Roussos, E.T.5
Wu, H.6
Pozzuto, M.7
Goswami, S.8
Condeelis, J.S.9
Bresnick, A.R.10
Segall, J.E.11
Backer, J.M.12
-
98
-
-
34447299716
-
The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN
-
DOI 10.1038/sj.emboj.7601763, PII 7601763
-
Papakonstanti EA, Ridley AJ, Vanhaesebroeck B (2007) The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J 26:3050-3061 (Pubitemid 47057501)
-
(2007)
EMBO Journal
, vol.26
, Issue.13
, pp. 3050-3061
-
-
Papakonstanti, E.A.1
Ridley, A.J.2
Vanhaesebroeck, B.3
-
99
-
-
59349095075
-
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
-
Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B (2008) Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci 121:4124-4133
-
(2008)
J Cell Sci
, vol.121
, pp. 4124-4133
-
-
Papakonstanti, E.A.1
Zwaenepoel, O.2
Bilancio, A.3
Burns, E.4
Nock, G.E.5
Houseman, B.6
Shokat, K.7
Ridley, A.J.8
Vanhaesebroeck, B.9
-
100
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from age-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12:2488-2498 (Pubitemid 28406952)
-
(1998)
Genes and Development
, vol.12
, Issue.16
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
101
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr., Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
Olivi, A.11
McLendon, R.12
Rasheed, B.A.13
Keir, S.14
Nikolskaya, T.15
Nikolsky, Y.16
Busam, D.A.17
Tekleab, H.18
Diaz Jr., L.A.19
Hartigan, J.20
Smith, D.R.21
Strausberg, R.L.22
Marie, S.K.23
Shinjo, S.M.24
Yan, H.25
Riggins, G.J.26
Bigner, D.D.27
Karchin, R.28
Papadopoulos, N.29
Parmigiani, G.30
Vogelstein, B.31
Velculescu, V.E.32
Kinzler, K.W.33
more..
-
102
-
-
0035886016
-
The phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors
-
Philp AJ, Campbell IG, Leet C, Vincan E, Rockman SP, Whitehead RH, Thomas RJ, Phillips WA (2001) The phosphatidylinositol 30-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 61:7426-7429 (Pubitemid 32995029)
-
(2001)
Cancer Research
, vol.61
, Issue.20
, pp. 7426-7429
-
-
Philp, A.J.1
Campbell, I.G.2
Leet, C.3
Vincan, E.4
Rockman, S.P.5
Whitehead, R.H.6
Thomas, R.J.S.7
Phillips, W.A.8
-
103
-
-
27844526600
-
Akt-dependent transformation: There is more to growth than just surviving
-
DOI 10.1038/sj.onc.1209097, PII 1209097
-
Plas DR, Thompson CB (2005) Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24:7435-7442 (Pubitemid 41637983)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7435-7442
-
-
Plas, D.R.1
Thompson, C.B.2
-
104
-
-
0028217223
-
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3- kinase
-
PowisG,Bonjouklian R, BerggrenMM,GallegosA,AbrahamR, Ashendel C, Zalkow L,MatterWF, Dodge J, Grindey G et al (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res 54:2419-2423
-
(1994)
Cancer Res
, vol.54
, pp. 2419-2423
-
-
Powis, G.1
Bonjouklian, R.2
Berggren, M.M.3
Gallegos, A.4
Abraham, R.5
Ashendel, C.6
Zalkow, L.7
Matter, W.F.8
Dodge, J.9
Grindey, G.10
-
105
-
-
34250823572
-
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
-
DOI 10.1158/0008-5472.CAN-06-4615
-
Raynaud FI, Eccles S, Clarke PA, Hayes A, Nutley B, Alix S, Henley A, Di-Stefano F, Ahmad Z, Guillard S, BjerkeLM,Kelland L, ValentiM, Patterson L,Gowan S, deHavenBA,HayakawaM, Kaizawa H, Koizumi T, Ohishi T, Patel S, Saghir N, Parker P,Waterfield M, Workman P (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res 67:5840-5850 (Pubitemid 46985018)
-
(2007)
Cancer Research
, vol.67
, Issue.12
, pp. 5840-5850
-
-
Raynaud, F.I.1
Eccles, S.2
Clarke, P.A.3
Hayes, A.4
Nutley, B.5
Alix, S.6
Henley, A.7
Di-Stefano, F.8
Ahmad, Z.9
Guillard, S.10
Bjerke, L.M.11
Kelland, L.12
Valenti, M.13
Patterson, L.14
Gowan, S.15
Brandon, A.D.H.16
Hayakawa, M.17
Kaizawa, H.18
Koizumi, T.19
Ohishi, T.20
Patel, S.21
Saghir, N.22
Parker, P.23
Waterfield, M.24
Workman, P.25
more..
-
106
-
-
0028584245
-
The phosphatidylinositol 3-kinase alpha is required for DNAsynthesis induced by some, but not all, growth factors
-
Roche S, Koegl M, Courtneidge SA (1994) The phosphatidylinositol 3-kinase alpha is required for DNAsynthesis induced by some, but not all, growth factors. Proc Natl Acad SciUSA91:9185-9189
-
(1994)
Proc Natl Acad SciUSA
, vol.91
, pp. 9185-9189
-
-
Roche, S.1
Koegl, M.2
Courtneidge, S.A.3
-
107
-
-
0031725052
-
A function for phosphatidylinositol 3-kinase β (p85α- p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
-
Roche S, Downward J, Raynal P, Courtneidge SA (1998) A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulinand lysophosphatidic acid-mediated signal transduction. Mol Cell Biol 18:7119-7129 (Pubitemid 28533031)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.12
, pp. 7119-7129
-
-
Roche, S.1
Downward, J.2
Raynal, P.3
Courtneidge, S.A.4
-
108
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
DOI 10.1038/370527a0
-
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532 (Pubitemid 24264918)
-
(1994)
Nature
, vol.370
, Issue.6490
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
109
-
-
33847239467
-
PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
-
Rommel C, Camps M, Ji H (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7:191-201
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 191-201
-
-
Rommel, C.1
Camps, M.2
Ji, H.3
-
110
-
-
33750525089
-
PI3Kgamma inhibition: Towards an 'aspirin of the 21st century'?
-
Ruckle T, Schwarz MK, Rommel C (2006) PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5:903-918
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 903-918
-
-
Ruckle, T.1
Schwarz, M.K.2
Rommel, C.3
-
111
-
-
0037369696
-
Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
-
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE (2003) Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 170:2647-2654 (Pubitemid 36245657)
-
(2003)
Journal of Immunology
, vol.170
, Issue.5
, pp. 2647-2654
-
-
Sadhu, C.1
Masinovsky, B.2
Dick, K.3
Sowell, C.G.4
Staunton, D.E.5
-
112
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
DOI 10.1126/science.1096502
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554 (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
113
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/ PKB by the rictor-mTOR complex. Science 307:1098-1101 (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
114
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM (2000) Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-Dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
Joza, N.11
Mak, T.W.12
Ohashi, P.S.13
Suzuki, A.14
Penninger, J.M.15
-
115
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260:88-91 (Pubitemid 23122750)
-
(1993)
Science
, vol.259
, Issue.5104
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
116
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
DOI 10.1038/nature05474, PII NATURE05474
-
Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM (2007) Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445:437-441 (Pubitemid 46160912)
-
(2007)
Nature
, vol.445
, Issue.7126
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
Blair, J.4
Hann, B.5
Shokat, K.M.6
Moasser, M.M.7
-
117
-
-
0025896083
-
Two types of phosphatidylinositol 3-kinase from bovine thymus: Monomer and heterodimer form
-
Shibasaki F, Homma Y, Takenawa T (1991) Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J Biol Chem 266:8108-8114 (Pubitemid 21906483)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.13
, pp. 8108-8114
-
-
Shibasaki, F.1
Homma, Y.2
Takenawa, T.3
-
118
-
-
77953719346
-
Progress in the design and development of phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of chronic diseases
-
Shuttleworth S, Silva F, Tomassi C, Cecil A, Hill T, Rogers H, Townsend P (2009) Progress in the design and development of phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of chronic diseases. Prog Med Chem 48:81-131
-
(2009)
Prog Med Chem
, vol.48
, pp. 81-131
-
-
Shuttleworth, S.1
Silva, F.2
Tomassi, C.3
Cecil, A.4
Hill, T.5
Rogers, H.6
Townsend, P.7
-
120
-
-
0025921611
-
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
-
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J (1991) Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/ cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90 (Pubitemid 121001216)
-
(1991)
Cell
, vol.65
, Issue.1
, pp. 83-90
-
-
Skolnik, E.Y.1
Margolis, B.2
Mohammadi, M.3
Lowenstein, E.4
Fischer, R.5
Drepps, A.6
Ullrich, A.7
Schlessinger, J.8
-
121
-
-
0035979372
-
Phox homology domains specifically bind phosphatidylinositol phosphates
-
DOI 10.1021/bi0155100
-
Song X, Xu W, Zhang A, Huang G, Liang X, Virbasius JV, Czech MP, Zhou GW (2001) Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry 40:8940-8944 (Pubitemid 32709527)
-
(2001)
Biochemistry
, vol.40
, Issue.30
, pp. 8940-8944
-
-
Song, X.1
Xu, W.2
Zhang, A.3
Huang, G.4
Liang, X.5
Virbasius, J.V.6
Czech, M.P.7
Wayne Zhou, G.8
-
122
-
-
77950457187
-
PI3K p110{delta} regulates T cell cytokine production during primary and secondary immune responses in mice and humans
-
Soond DR, Bjorgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JH, Tasken K, Bunyard P, Okkenhaug K (2010) PI3K p110{delta} regulates T cell cytokine production during primary and secondary immune responses in mice and humans. Blood 115:2203-2213
-
(2010)
Blood
, vol.115
, pp. 2203-2213
-
-
Soond, D.R.1
Bjorgo, E.2
Moltu, K.3
Dale, V.Q.4
Patton, D.T.5
Torgersen, K.M.6
Galleway, F.7
Twomey, B.8
Clark, J.9
Gaston, J.H.10
Tasken, K.11
Bunyard, P.12
Okkenhaug, K.13
-
123
-
-
70449995469
-
Identifying genotype-dependent efficacy of single and combined PI3K-and MAPK-pathway inhibition in cancer
-
Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stuckrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansen S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK (2009) Identifying genotype-dependent efficacy of single and combined PI3K-and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci USA 106:18351-18356
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 18351-18356
-
-
Sos, M.L.1
Fischer, S.2
Ullrich, R.3
Peifer, M.4
Heuckmann, J.M.5
Koker, M.6
Heynck, S.7
Stuckrath, I.8
Weiss, J.9
Fischer, F.10
Michel, K.11
Goel, A.12
Regales, L.13
Politi, K.A.14
Perera, S.15
Getlik, M.16
Heukamp, L.C.17
Ansen, S.18
Zander, T.19
Beroukhim, R.20
Kashkar, H.21
Shokat, K.M.22
Sellers, W.R.23
Rauh, D.24
Orr, C.25
Hoeflich, K.P.26
Friedman, L.27
Wong, K.K.28
Pao, W.29
Thomas, R.K.30
more..
-
124
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT (2008) An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 68:6084-6091
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
Neve, R.M.4
Kuo, W.L.5
Davies, M.6
Carey, M.7
Hu, Z.8
Guan, Y.9
Sahin, A.10
Symmans, W.F.11
Pusztai, L.12
Nolden, L.K.13
Horlings, H.14
Berns, K.15
Hung, M.C.16
Van De Vijver, M.J.17
Valero, V.18
Gray, J.W.19
Bernards, R.20
Mills, G.B.21
Hennessy, B.T.22
more..
-
125
-
-
0029846518
-
Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
-
Stenmark H, Aasland R, Toh BH, D'Arrigo A (1996) Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J Biol Chem 271:24048-24054
-
(1996)
J Biol Chem
, vol.271
, pp. 24048-24054
-
-
Stenmark, H.1
Aasland, R.2
Toh, B.H.3
D'Arrigo, A.4
-
126
-
-
0028334738
-
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
-
DOI 10.1016/0092-8674(94)90237-2
-
Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 77:83-93 (Pubitemid 24184690)
-
(1994)
Cell
, vol.77
, Issue.1
, pp. 83-93
-
-
Stephens, L.1
Smrcka, A.2
Cooke, F.T.3
Jackson, T.R.4
Sternweis, P.C.5
Hawkins, P.T.6
-
127
-
-
0030887632
-
The Gβγ/sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT (1997) The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89:105-114 (Pubitemid 27180590)
-
(1997)
Cell
, vol.89
, Issue.1
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
Lui, M.4
Cooke, F.5
Coadwell, J.6
Smrcka, A.S.7
Thelen, M.8
Cadwallader, K.9
Tempst, P.10
Hawkins, P.T.11
-
128
-
-
0032578999
-
Prohtein kinase B kinases that mediate phosphatidylinositol 3,4,5- trisphosphate-dependent activation of protein kinase B
-
DOI 10.1126/science.279.5351.710
-
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate- dependent activation of protein kinase B. Science 279:710-714 (Pubitemid 28144551)
-
(1998)
Science
, vol.279
, Issue.5351
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
Gaffney, P.R.J.7
Reese, C.B.8
McCormick, F.9
Tempst, P.10
Coadwell, J.11
Hawkins, P.T.12
-
129
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
DOI 10.1126/science. 1068094
-
Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA, Hafen E (2002) Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295:2088-2091 (Pubitemid 34229473)
-
(2002)
Science
, vol.295
, Issue.5562
, pp. 2088-2091
-
-
Stocker, H.1
Andjelkovic, M.2
Oldham, S.3
Laffargue, M.4
Wymann, M.P.5
Hemmings, B.A.6
Hafen, E.7
-
130
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
DOI 10.1126/science.277.5325.567
-
Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT (1997) Dual role of phosphatidylinositol-3,4, 5-trisphosphate in the activation of protein kinase B. Science 277:567-570 (Pubitemid 27369005)
-
(1997)
Science
, vol.277
, Issue.5325
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.J.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormick, F.8
Hawkins, P.T.9
-
131
-
-
0029090212
-
Cloning and characterization of a G proteinactivated human phosphoinositide-3 kinase
-
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B et al (1995) Cloning and characterization of a G proteinactivated human phosphoinositide-3 kinase. Science 269:690-693
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesebroeck, B.8
Dhand, R.9
Nurnberg, B.10
-
132
-
-
0011168670
-
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglyercol
-
Sugimoto Y, Whitman M, Cantley LC, Erikson RL (1984) Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci USA 81:2117-2121 (Pubitemid 14146614)
-
(1984)
Proceedings of the National Academy of Sciences of the United States of America
, vol.81
, Issue.7
, pp. 2117-2121
-
-
Sugimoto, Y.1
Whitman, M.2
Cantley, L.C.3
Erikson, R.L.4
-
133
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
TGCA
-
TGCA (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
134
-
-
33847293670
-
High-throughput oncogene mutation profiling in human cancer
-
DOI 10.1038/ng1975, PII NG1975
-
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA (2007) High-throughput oncogene mutation profiling in human cancer. Nat Genet 39:347-351 (Pubitemid 46328493)
-
(2007)
Nature Genetics
, vol.39
, Issue.3
, pp. 347-351
-
-
Thomas, R.K.1
Baker, A.C.2
DeBiasi, R.M.3
Winckler, W.4
LaFramboise, T.5
Lin, W.M.6
Wang, M.7
Feng, W.8
Zander, T.9
MacConnaill, L.E.10
Lee, J.C.11
Nicoletti, R.12
Hatton, C.13
Goyette, M.14
Girard, L.15
Majmudar, K.16
Ziaugra, L.17
Wong, K.-K.18
Gabriel, S.19
Beroukhim, R.20
Peyton, M.21
Barretina, J.22
Dutt, A.23
Emery, C.24
Greulich, H.25
Shah, K.26
Sasaki, H.27
Gazdar, A.28
Minna, J.29
Armstrong, S.A.30
Mellinghoff, I.K.31
Hodi, F.S.32
Dranoff, G.33
Mischel, P.S.34
Cloughesy, T.F.35
Nelson, S.F.36
Liau, L.M.37
Mertz, K.38
Rubin, M.A.39
Moch, H.40
Loda, M.41
Catalona, W.42
Fletcher, J.43
Signoretti, S.44
Kaye, F.45
Anderson, K.C.46
Demetri, G.D.47
Dummer, R.48
Wagner, S.49
Herlyn, M.50
Sellers, W.R.51
Meyerson, M.52
Garraway, L.A.53
more..
-
135
-
-
0023810588
-
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
-
Traynor-Kaplan AE, Harris AL, Thompson BL, Taylor P, Sklar LA (1988) An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334:353-356
-
(1988)
Nature
, vol.334
, pp. 353-356
-
-
Traynor-Kaplan, A.E.1
Harris, A.L.2
Thompson, B.L.3
Taylor, P.4
Sklar, L.A.5
-
136
-
-
0024436756
-
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils
-
Traynor-Kaplan AE, Thompson BL, Harris AL, Taylor P, Omann GM, Sklar LA (1989) Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. J Biol Chem 264:15668-15673 (Pubitemid 19242949)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.26
, pp. 15668-15673
-
-
Traynor-Kaplan, A.E.1
Thompson, B.L.2
Harris, A.L.3
Taylor Omann, P.G.M.4
Sklar, L.A.5
-
137
-
-
0030805703
-
Phosphoinositide 3-kinases: A conserved family of signal transducers
-
DOI 10.1016/S0968-0004(97)01061-X, PII S096800049701061X
-
Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD (1997a) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22:267-272 (Pubitemid 27310948)
-
(1997)
Trends in Biochemical Sciences
, vol.22
, Issue.7
, pp. 267-272
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Panayotou, G.3
Waterfield, M.D.4
Waterfield, M.D.5
-
138
-
-
0030611198
-
P110δ, A novel phosphoinositide 3-kinase in leukocytes
-
DOI 10.1073/pnas.94.9.4330
-
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (1997b) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci USA 94:4330-4335 (Pubitemid 27194241)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.9
, pp. 4330-4335
-
-
Vanhaesebroeck, B.1
Welham, M.J.2
Kotani, K.3
Stein, R.4
Warne, P.H.5
Zvelebil, M.J.6
Higashi, K.7
Volinia, S.8
Downward, J.9
Waterfield, M.D.10
-
139
-
-
0033128166
-
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
-
Vanhaesebroeck B, Jones GE, Allen WE, Zicha D, Hooshmand-Rad R, Sawyer C, Wells C, Waterfield MD, Ridley AJ (1999) Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nat Cell Biol 1:69-71 (Pubitemid 129495013)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.1
, pp. 69-71
-
-
Vanhaesebroeck, B.1
Jones, G.E.2
Allen, W.E.3
Zicha, D.4
Hooshmand-Rad, R.5
Sawyer, C.6
Wells, C.7
Waterfield, M.D.8
Ridley, A.J.9
-
140
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
DOI 10.1146/annurev.biochem.70.1.535
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC,Woscholski R, Parker PJ, Waterfield MD (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70:535-602 (Pubitemid 32662219)
-
(2001)
Annual Review of Biochemistry
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
Driscoll, P.C.6
Woscholski, R.7
Parker, P.J.8
Waterfield, M.D.9
-
142
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
VasudevanKM, BarbieDA,DaviesMA, Rabinovsky R,McNear CJ,KimJJ,HennessyBT, TsengH, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA (2009) AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16:21-32
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
143
-
-
0029884657
-
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
-
Virbasius JV, Guilherme A, Czech MP (1996) Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem 271:13304-13307
-
(1996)
J Biol Chem
, vol.271
, pp. 13304-13307
-
-
Virbasius, J.V.1
Guilherme, A.2
Czech, M.P.3
-
144
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
145
-
-
0033581886
-
Structural insights into phosphoinositide 3-kinase catalysis and signalling
-
Walker EH, Perisic O, Ried C, Stephens L, Williams RL (1999) Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402:313-320 (Pubitemid 129516270)
-
(1999)
Nature
, vol.402
, Issue.6759
, pp. 313-320
-
-
Walker, E.H.1
Perisic, O.2
Ried, C.3
Stephens, L.4
Williams, R.L.5
-
146
-
-
0037155727
-
3- and gβγ-regulated guanine-nucleotide exchange factor for Rac
-
DOI 10.1016/S0092-8674(02)00663-3
-
Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, Stephens LR (2002) P-Rex1, a PtdIns(3,4,5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809-821 (Pubitemid 34327532)
-
(2002)
Cell
, vol.108
, Issue.6
, pp. 809-821
-
-
Welch, H.C.E.1
Coadwell W.John2
Ellson, C.D.3
Ferguson G.John4
Andrews, S.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Hawkins, P.T.8
Stephens, L.R.9
-
147
-
-
0021828496
-
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
-
DOI 10.1038/315239a0
-
Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM (1985) Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 315:239-242 (Pubitemid 15064453)
-
(1985)
Nature
, vol.315
, Issue.6016
, pp. 239-242
-
-
Whitman, M.1
Kaplan, D.R.2
Schaffhausen, B.3
-
148
-
-
0023897684
-
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
-
Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988) Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644-646
-
(1988)
Nature
, vol.332
, pp. 644-646
-
-
Whitman, M.1
Downes, C.P.2
Keeler, M.3
Keller, T.4
Cantley, L.5
-
149
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
DOI 10.1126/science.1145720
-
Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R,Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108-1113 (Pubitemid 350134889)
-
(2007)
Science
, vol.318
, Issue.5853
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
Silliman, N.11
Szabo, S.12
Dezso, Z.13
Ustyanksky, V.14
Nikolskaya, T.15
Nikolsky, Y.16
Karchin, R.17
Wilson, P.A.18
Kaminker, J.S.19
Zhang, Z.20
Croshaw, R.21
Willis, J.22
Dawson, D.23
Shipitsin, M.24
Willson, J.K.V.25
Sukumar, S.26
Polyak, K.27
Ben, H.P.28
Pethiyagoda, C.L.29
Pant, P.V.K.30
Ballinger, D.G.31
Sparks, A.B.32
Hartigan, J.33
Smith, D.R.34
Suh, E.35
Papadopoulos, N.36
Buckhaults, P.37
Markowitz, S.D.38
Parmigiani, G.39
Kinzler, K.W.40
Velculescu, V.E.41
Vogelstein, B.42
more..
-
150
-
-
0034944422
-
SNX3 regulates endosomal function through its PX-domain-mediated interaction with Ptdlns(3)P
-
DOI 10.1038/35083051
-
Xu Y, Hortsman H, Seet L, Wong SH, Hong W (2001) SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol 3:658-666 (Pubitemid 32624422)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.7
, pp. 658-666
-
-
Xu, Y.1
Hortsman, H.2
Seet, L.3
Wong, S.H.4
Hong, W.5
-
151
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846-25856 (Pubitemid 23358203)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.34
, pp. 25846-25856
-
-
Yano, H.1
Nakanishi, S.2
Kimura, K.3
Hanai, N.4
Saitoh, Y.5
Fukui, Y.6
Nonomura, Y.7
Matsuda, Y.8
-
152
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao R, Cooper GM (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
153
-
-
0029147402
-
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: Biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development
-
Zhou K, Takegawa K, Emr SD, Firtel RA (1995) A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol 15:5645-5656
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5645-5656
-
-
Zhou, K.1
Takegawa, K.2
Emr, S.D.3
Firtel, R.A.4
-
154
-
-
0030605392
-
Structural and functional diversity of phosphoinositide 3-kinases
-
Zvelebil MJ, MacDougall L, Leevers S, Volinia S, Vanhaesebroeck B, Gout I, Panayotou G, Domin J, Stein R, Pages F et al (1996) Structural and functional diversity of phosphoinositide 3-kinases. Philos Trans R Soc Lond B Biol Sci 351:217-223 (Pubitemid 126745332)
-
(1996)
Philosophical Transactions of the Royal Society B: Biological Sciences
, vol.351
, Issue.1336
, pp. 217-223
-
-
Zvelebil, M.J.1
|