High throughput screening for bioactive components from traditional Chinese medicine

Combinatorial Chemistry and High Throughput Screening

Volumn 13, Issue 10, 2010, Pages 837-848

  Zhu, Yanhui ^a   Zhang, Zhiyun ^a   Zhang, Meng ^a   Mais, Dale E ^b   Wang, Ming Wei ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b MPI RESEARCH   (United States)

Author keywords

Drug discovery; High throughput screening; Natural products; Traditional Chinese medicine

Indexed keywords

NATURAL PRODUCT;

ARTICLE; BIOASSAY; CAPILLARY ELECTROPHORESIS; CELL ASSAY; CHINESE MEDICINE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICRODIALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; ULTRAFILTRATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ANIMALS; BIOLOGICAL PRODUCTS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MEDICINE, CHINESE TRADITIONAL; PLANTS, MEDICINAL;

EID: 79951597391     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620710793360257     Document Type: Article

References (134)

1. Wang, M.W.; Hao, X.J.; Chen, K.X. Biological screening of natural products and drug innovation in China. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2007, 362, 1093-1105.
2. Yao, X.; Hu, K.; Liu, J.; Wang, N.; Cui, C.; He, X. In Herbs: Challenges in Chemistry and Biology; Wang, M. F.; Sang, S. M.; Hwang, L. S.; Ho, C. T., Eds.; American Chemical Society: Washington, DC, 2006; pp 14-24.
3. Koehn, F.E.; Carter, G.T. The evolving role of natural products in (Pubitemid 40372555)
4. Quinn, R.J.; Carroll, A.R.; Pham, N.B.; Baron, P.; Palframan, M.E.; Suraweera, L.; Pierens, G.K.; Muresan, S.J. Developing a Drug-like Natural Product Library. Nat. Prod., 2008, 71, 464-468. (Pubitemid 351549376)
5. Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 1997, 23, 3-25. (Pubitemid 27046991)
6. Foungbe, S.; Kouassi, G.; Kablan, J.B.; Marcy, R. Study of Costus lucanusianus: plant juice, fraction combinations and pharmacologie estimation of natural product total activity. J. Ethnopharmacol., 1991, 33, 221-226.
7. Turner, D.M. Natural product source material use in the pharmaceutical industry: the Glaxo experience. J. Ethnopharmacol, 1996, 51, 39-44. (Pubitemid 26093349)
8. Schuster, B.G. A new integrated program for natural product development and the value of an ethnomedical approach. J. Altern. Complement. Med., 2001, 7, 61-72.
9. Cardellina, II J.H.; Fuller, R.W.; Gamble, W.R.; Westergaard, C.; Boswell, J.; Munro, M.H.G.; Currens, M.; Boyd, M.R. In Bioassay methods in natural product research and drug development; Bohlin L., Bruhn J. G., Eds.; Kluwer Academic Publishers: Dordrecht, The Netherlands, 1999; pp 25-35.
10. Strohl, W.R. The role of natural products in a modern drug discovery program. Drug Discov. Today, 2000, 5, 39-41. (Pubitemid 30084700)
11. Koehn, F.E. High impact technologies for natural products screening. Prog. Drug Res., 2008, 65, 175, 177-210.
12. Eldridge, G.R.; Vervoort, H.C.; Lee, C.M.; Cremin, P.A.; Williams, C.T.; Hart, S.M.; Goering, M.G.; O'Neil-Johnson, M.; Zeng, L. High throughput method for the production and analysis of large natural product libraries for drug discovery. Anal. Chem., 2002, 74, 3963-3971. (Pubitemid 34912891)
13. Cremin, P.A.; Zeng, L. High throughput analysis of natural product compound libraries by parallel LC- MS evaporative light scattering detection. Anal. Chem., 2002, 74, 5492-5500. (Pubitemid 35253110)
14. Wagenaar, M.M. Pre-fractionated microbial samples - the second generation natural products library at Wyeth. Molecules, 2008, 13, 1406-1426.
15. Potterat, O.; Hamburger, M. Natural products in drug discovery- Concepts and approaches for tracking bioactivity. Curr. Org. Chem., 2006, 10, 899-920.
16. Bindseil, K.U.; Jakupovic, J.; Wolf, D.; Lavayre, J.; Leboul, J.; van der Pyl, D. Pure compound libraries; a new perspective for natural product based drug discovery. Drug Discov. Today, 2001, 6, 840-847. (Pubitemid 32734512)
17. Anonymous. Chemical studies on qinghaosu (artemisinine). China Cooperative Research Group on qinghaosu and its derivatives as antimalarials. J. Tradit. Chin. Med., 1982, 2, 3-8.
18. Wang, Y.P.; Xuan, L.J. An achievement on the modernization of Chinese traditional medicine: research and development of depsides salts from Salvia Miltiorrhiza and its preparatons. Bull. Chin. Acad. Sci., 2005, 20, 377-380.
19. Corley, D.G.; Durley, R.C. Strategies for database dereplication of natural products. J. Nat. Prod., 1994, 57, 1484-1490.
20. Mishra, K.P.; Ganju, L.; Sairam, M.; Banerjee, P.K.; Sawhney, R.C. A review of high throughput technology for the screening of natural products. Biomed. Pharmacother., 2008, 62, 94-98. (Pubitemid 351215811)
21. Soumyanath, A.; Srijayanta, S. In Traditional medicines for modern times: antidiabetic plants; Soumyanath, A., Ed.; CRC Press LLC: Boca Raton, Fla., 2006; pp 99-116.
22. Balunas, M.J.; Su, B.; Landini, S.; Brueggemeier, R.W.; Kinghorn, A.D. Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. J. Nat. Prod., 2006, 69, 700-703. (Pubitemid 43798133)
23. van Middlesworth, F.; Cannell, R.J.P. In Natural products isolation. Humana Press Inc: Totowa, New Jersey, 1998; Vol. 4, pp. 279-327.
24. Rishton, G.M. Nonleadlikeness and leadlikeness in biochemical screening. Drug Discov. Today, 2003, 8, 86-96. (Pubitemid 36139902)
25. Hagerman, A.E.; Klucher, K.M. In Phenolic Compounds in Food and Their Effects on Health; American Chemical Society: Washington, DC, 1992; pp 236-247.
26. Sashidhara, K.V.; Rosaiah, J.N. Various dereplication strategies using LC-MS for rapid natural product lead identification and drug discovery. Nat. Prod. Commun., 2007, 2, 193-202.
27. O'Neil-Johnson, M. In Can I get a structure on 50 micrograms? Metabolites, natural products and proteins using a CapNMR probe., Abstracts of Papers, 226th ACS National Meeting, New York, United States, September 7-11, 2003; New York; American Chemical Society: Washington, DC, 2003; p 123.
28. Liu, L.; Li, Y.; Cheng, Y. A method for the production and characterization of fractionated libraries from Chinese herbal formulas. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 2008, 862, 196-204.
29. Lang, G.; Mayhudin, N.A.; Mitova, M.I.; Sun, L.; van der Sar, S.; Blunt, J.W.; Cole, A.L.J.; Ellis, G.; Laatsch, H.; Munro, M.H.G. Evolving trends in the dereplication of natural product extracts: New methodology for rapid, small-scale investigation of natural product extracts. J. Nat. Prod., 2008, 71, 1595-1599.
30. Bitzer, J.; Koepcke, B.; Stadler, M.; Hellwig, V.; Ju, Y.; Seip, S.; Henkel, T. Accelerated dereplication of natural products, supported by reference libraries. Chimia, 2007, 61, 332-338.
31. Nielsen, N.; Carstensen, J.M.; Smedsgaard, J. Aligning of single and multiple wavelength chromatographic profiles for chemometric data analysis using correlation optimised warping. J. Chromatogr. A, 1998, 805, 17-35. (Pubitemid 28231183)
32. Tormo, J.R.; García, J.B. Automated analyses of HPLC profiles of microbial extracts. Nat. Prod., 2005, 57-75.
33. van Nederkassel, A.M.; Daszykowski, M.; Eilers, P.; Heyden, Y.V. A comparison of three algorithms for chromatograms alignment. J. Chromatogr. A, 2006, 1118, 199-210. (Pubitemid 43794995)
34. Bradshaw, J.; Butina, D.; Dunn, A.J.; Green, R.H.; Hajek, M.; Jones, M.M.; Lindon, J.C.; Sidebottom, P.J. A rapid and facile method for the dereplication of purified natural products. J. Nat. Prod., 2001, 64, 1541-1544. (Pubitemid 34051975)
35. Quinn, R.J. QPRI's system for screening of natural products. Proc. Phytochem. Soc. Eur., 1999, 43, 151-157.
36. Quinn, R.J. High throughput screening in natural product drug discovery in Australia utilising Australia's biodiversity. Drug Develop. Res., 1999, 46, 250-254. (Pubitemid 29258922)
37. Glauser, G.; Guillarme, D.; Grata, E.; Boccard, J.; Thiocone, A.; Carrupt, P.A.; Veuthey, J.L.; Rudaz, S.; Wolfender, J.L. Optimized liquid chromatography-mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance. J. Chromatogr. A, 2008, 1180, 90-98.
38. Gronquist, M.; Meinwald, J.; Eisner, T.; Schroeder, F.C. Exploring uncharted terrain in nature's structure space using capillary NMR spectroscopy: 13 steroids from 50 fireflies. J. Am. Chem. Soc., 2005, 127, 10810-10811. (Pubitemid 41129839)
39. Hu, J.F.; Garo, E.; Yoo, H.D.; Cremin, P.A.; Zeng, L.; Goering, M.G.; O'Neil-Johnson, M.; Eldridge, G.R. Application of capillaryscale NMR for the structure determination of phytochemicals. Phytochem. Anal., 2005, 16, 127-133. (Pubitemid 40533161)
40. Elyashberg, M.E.; Blinov, K.A.; Williams, A.J.; Martirosian, E.R.; Molodtsov, S.G. Application of a new expert system for the structure elucidation of natural products from their 1D and 2D NMR data. J. Nat. Prod., 2002, 65, 693-703. (Pubitemid 34547412)
41. Austin, C.P.; Brady, L.S.; Insel, T.R.; Collins, F.S. Molecular biology: NIH molecular libraries initiative. Science, 2004, 306, 1138-1139. (Pubitemid 39488980)
42. Tomiki, T.; Saito, T.; Ueki, M.; Konno, H.; Asaoka, T.; Suzuki, R.; Uramoto, M.; Kakeya, H.; Osada, H. RIKEN natural products encyclopedia (RIKEN NPEdia), a chemical database of RIKEN natural products depository (RIKEN NPDepo). J. Comput. Aided. Chem., 2006, 7, 157-162.
43. Efferth, T.; Konkimalla, V.B. Anti-cancer natural product library from traditional Chinese medicine. Comb. Chem. High Throughput Screen., 2008, 11, 7-15.
44. Littleton, J.; Rogers, T.; Falcone, D. Novel approaches to plant drug discovery based on high throughput pharmacological screening and genetic manipulation. Life Sci., 2005, 78, 467-475. (Pubitemid 41653496)
45. Cordell, G.A.; Shin, Y.G. Finding the needle in the haystack. The dereplication of natural product extracts. Pure Appl. Chem., 1999, 71, 1089-1094.
46. Dittmann, K.; Riese, U.; Hamburger, M. HPLC-based bioactivity profiling of plant extracts: a kinetic assay for the identification of monoamine oxidase-A inhibitors using human recombinant monoamine oxidase-A. Phytochemistry, 2004, 65, 2885-2891. (Pubitemid 40292120)
47. Adams, M.; Zimmermann, S.; Kaiser, M.; Brun, R.; Hamburger, M. A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites. Nat. Prod. Commun., 2009, 4, 1377-1381.
48. Danz, H.; Stoyanova, S.; Wippich, P.; Brattstrom, A.; Hamburger, M. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Med., 2001, 67, 411-416. (Pubitemid 32652575)
49. Kim, H.J.; Baburin, I.; Khom, S.; Hering, S.; Hamburger, M. HPLC-Based activity profiling approach for the discovery of GABA∼ A receptor ligands using an automated Two microelectrode voltage clamp assay on xenopus oocytes. Planta Med., 2008, 74, 521-526. (Pubitemid 351655969)
50. Buss, A.D.; Butler, M.S. A new model for utilising chemical diversity from natural sources. Drug Develop. Res., 2004, 62, 362-370. (Pubitemid 40076270)
51. Mallender, W.D.; Bembenek, M.; Dick, L.R.; Kuranda, M.; Li, P.; Menon, S.; Pardo, E.; Parsons, T. In High throughput Screening in Drug Discovery; Hüser, J., Ed.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, 2006; pp 93-128.
52. Liu, B.; Li, S.; Hu, J. Technological advances in high throughput screening. Am. J. Pharmacogenomics, 2004, 4, 263-276. (Pubitemid 39145474)
53. Cook, N.D. Scintillation proximity assay: a versatile high throughput screening technology. Drug Discov. Today, 1996, 1, 287-294. (Pubitemid 126380364)
54. Jayasuriya, H.; Herath, K.B.; Ondeyka, J.G.; Guan, Z.; Borris, R.P.; Tiwari, S.; de Jong, W.; Chavez, F.; Moss, J.; Stevenson, D.W. Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. J. Nat. Prod., 2005, 68, 1247-1252. (Pubitemid 41291272)
55. Owicki, J.C. Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer. Screening, 2000, 5, 297-306.
56. Turek-Etienne, T.C.; Small, E.C.; Soh, S.C.; Xin, T.A.; Gaitonde, P.V.; Barrabee, E.B.; Hart, R.F.; Bryant, R.W. Evaluation of fluorescent compound interference in 4 fluorescence polarization assays: 2 kinases, 1 protease, and 1 phosphatase. J. Biomol. Screen., 2003, 8, 176-184.
57. Do, E.U.; Piao, L.Z.; Choi, G.; Choi, Y.B.; Kang, T.M.; Shin, J.; Chang, Y.J.; Nam, H.Y.; Kim, H.J.; Kim, S. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Peptides, 2006, 27, 997-1004.
58. Diamandis, E.P. Immunoassays with time-resolved fluorescence spectroscopy: principles and applications. Clin. Biochem., 1988, 21, 139-150.
59. McMahon, J.B.; Beutler, J.A.; O'Keefe, B.R.; Goodrum, C.; Myers, M.A.; Boyd, M.R. Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence. J. Biomol. Screen., 2000, 5, 169-176. (Pubitemid 30436620)
60. Roda, A.; Guardigli, M.; Pasini, P.; Mirasoli, M. Bioluminescence and chemiluminescence in drug screening. Anal. Bioanal. Chem., 2003, 377, 826-833. (Pubitemid 40877848)
61. Kricka, L.J. Chemiluminescent and bioluminescent techniques. Clin. Chem., 1991, 37, 1472-1481. (Pubitemid 21905200)
62. Sasiela, C.A.; Stewart, D.H.; Kitagaki, J.; Safiran, Y.J.; Yang, Y.; Weissman, A.M.; Oberoi, P.; Davydov, I.V.; Goncharova, E.; Beutler, J.A. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high throughput electrochemiluminescent screen. J. Biomol. Screen., 2008, 13, 229-237. (Pubitemid 351322873)
63. Clemons, P.A.; Tolliday, N.J.; Wagner, B.K. In Cell-based assays for high throughput screening. Humana Press Inc.: Totowa, New Jersey, 2009.
64. Fowler, A.; Seifert, N.; Acker, V.; Woehrle, T.; Kilpert, C.; de Saizieu, A. A nonradioactive high throughput/high-content assay for measurement of the human serotonin reuptake transporter function in vitro. J. Biomol. Screen., 2006, 11, 1027-1034. (Pubitemid 44847157)
65. Tsai, C.C.; Chen, C.J.; Tseng, H.W.; Hua, K.F.; Tsai, R.Y.; Lai, M.H.; Chao, L.K.; Chen, S.T. Cytomic screening of immunomodulating activity compounds from calocedrus formosana. Comb. Chem. High Throughput Screen., 2008, 11, 834-842.
66. Tian, H.; Ip, L.; Luo, H.; Chang, D.C.; Luo, K.Q. A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. Brit. J. Pharmacol., 2007, 150, 321-334. (Pubitemid 46221041)
67. Durocher, Y.; Perret, S.; Thibaudeau, E.; Gaumond, M.H.; Kamen, A.; Stocco, R.; Abramovitz, M. A reporter gene assay for high throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture. Anal. Biochem., 2000, 284, 316-326.
68. Eglen, R.M. Functional G protein-coupled receptor assays for primary and secondary screening. Comb. Chem. High Throughput Screen., 2005, 8, 311-318. (Pubitemid 40694867)
69. New, D.C.; Miller-Martini, D.M.; Wong, Y.H. Reporter gene assays and their applications to bioassays of natural products. Phytother. Res., 2003, 17, 439-448. (Pubitemid 36605891)
70. Crisman, T.J.; Parker, C.N.; Jenkins, J.L.; Scheiber, J.; Thoma, M.; Bin Kang, Z.; Kim, R.; Bender, A.; Nettles, J.H.; Davies, J.W.; Glick, M. Understanding false positives in reporter gene assays: in silico chemogenomics approaches to prioritize cell-based HTS data. J. Chem. Inf. Model., 2007, 47, 1319-1327. (Pubitemid 47210036)
71. Gao, P.; Guan, Y.; Song, D.Q.; Xiao, C.L. A cell-based screening system for detection of inhibitors toward mycobacterial cell wall core. J. Antibiot. (Tokyo), 2009, 62, 315-318.
72. Blanka, R.; O, L. T.; H, C. M.; H, R. M.; Harald, L.; D, H. A.; Alwin, K. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Res., 2007, 67, 6342-6350.
73. Li, J.W.H.; Vederas, J.C. Drug discovery and natural products: end of an era or an endless frontier? Science, 2009, 325, 161-165.
74. Young, K.; Jayasuriya, H.; Ondeyka, G.J.; Herath, K.; Zhang, C.; Kodali, S.; Galgoci, A.; Painter, R.; Brown-Driver, V.; Yamamoto, R.; Lynn, L.S.; Zheng, Y.; Ventura J.I.; Sigmund, J.; Ha, S.; Basilio, A.; Vicente, F.; Tormo J.R.; Pelaez, F.; Youngman, P.; Cully, D.F.; Barrett J.F.; Schmatz, D.; Singh S.B.; Wang, J. Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity. Antimicrob. Agents Chemother., 2006, 50, 519-526.
75. Wang, J.; Kodali, S.; Lee, S.H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S.L.; Herath, K.; Cummings, R.; Salazar, O.; Gonzalez, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D.F.; Singh S.B. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc. Natl. Acad. Sci. USA, 2007, 104, 7612-7616. (Pubitemid 47185954)
76. Mandrekar, N.; Thakur, N.L. Significance of the zebrafish model in the discovery of bioactive molecules from nature. Biotechnol. Lett., 2009, 31, 171-179.
77. Crawford, A.D.; Esguerra, C.V.; de Witte, P.A.M. Fishing for drugs from nature: Zebrafish as a technology platform for natural product discovery. Planta Med., 2008, 74, 624-632. (Pubitemid 351846776)
78. He M.F., But P.P.H., Shaw P.C., Jiang R.W., Xu H.X.. In Antiangiogenic agents from tripterygium wilfordii, American Society of Pharmacognosy 47th Annual Meeting, Arlington, Virginia, August 5-9: 2006.
79. Moy, T.I.; Conery, A.L.; Larkins-Ford, J.; Wu, G.; Mazitschek, R.; Casadei, G.; Lewis, K.; Carpenter, A.E.; Ausubel, F.M. High throughput screen for novel antimicrobials using a whole animal infection model. ACS Chem. Biol., 2009, 4, 527-533.
80. Okoli, I.; Coleman, J.J.; Tempakakis, E.; An, W.F.; Holson, E.; Wagner, F.; Conery, A.L.; Larkins-Ford, J.; Wu, G.; Stern, A.; Ausubel, F.M.; Mylonakis, E. Identification of antifungal compounds active against Candida albicans using an improved high throughput caenorhabditis elegans assay. PLoS One, 2009, 4, e7025.
81. Moy, T.I.; Ball, A.R.; Anklesaria, Z.; Casadei, G.; Lewis, K.; Ausubel, F.M. Identification of novel antimicrobials using a liveanimal infection model. Proc. Natl. Acad. Sci. USA, 2006, 103, 10414-10419. (Pubitemid 44051181)
82. Rohde, C.B.; Zeng, F.; Gonzalez-Rubio, R.; Angel, M.; Yanik, M.F. Microfluidic system for on-chip high throughput wholeanimal sorting and screening at subcellular resolution. Proc. Natl. Acad. Sci. USA, 2007, 104, 13891-13895. (Pubitemid 350003307)
83. Stilwell, G.E.; Saraswati, S.; Littleton, J.T.; Chouinard, S.W. Development of a Drosophila seizure model for in vivo high throughput drug screening. Eur. J. Neurosci., 2006, 24, 2211-2222. (Pubitemid 44622342)
84. Inglese, J.; Auld, D.S.; Jadhav, A.; Johnson, R.L.; Simeonov, A.; Yasgar, A.; Zheng, W.; Austin, C.P. Quantitative high throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. USA, 2006, 103, 11473-11478. (Pubitemid 44182476)
85. Ryan, A.J.; Gray, N.M.; Lowe, P.N.; Chung, C.W. Effect of Detergent on "Promiscuous" Inhibitors. J. Med. Chem., 2003, 46, 3448-3451.
86. Feng, B.Y.; Shoichet, B.K. A detergent-based assay for the detection of promiscuous inhibitors. Nat. Protoc., 2006, 1, 550-553.
87. Li, H.; An, J.; Zhou, J.; Li, P. Target molecule affinity coupled with mass spectrometry for the screening of bioactive compounds in complex matrices. Zhongguo Yaoke Daxue Xuebao, 2009, 40, 97-103.
88. Smith, D.L.; Zhang, Z. Probing noncovalent structural features of proteins by mass spectrometry. Mass Spectrom. Rev., 1994, 13, 411-429. (Pubitemid 24974685)
89. Sannes-Lowery, K.A.; Drader, J.J.; Griffey, R.H.; Hofstadler, S.A. Fourier transform ion cyclotron resonance mass spectrometry as a high throughput affinity screen to identify RNA binding ligands. Trends Analyt. Chem., 2000, 19, 481-491. (Pubitemid 30460068)
90. Daniel, J.M.; McCombie, G.; Wendt, S.; Zenobi, R. Mass spectrometric determination of association constants of adenylate kinase with two noncovalent inhibitors. J. Am. Soc. Mass Spectr., 2003, 14, 442-448. (Pubitemid 36871625)
91. Marani, M.M.; Oliveira, E.; Cote, S.; Camperi, S.A.; Albericio, F.; Cascone, O. Identification of protein-binding peptides by direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of peptide beads selected from the screening of one bead-one peptide combinatorial libraries. Anal. Biochem., 2007, 370, 215-222. (Pubitemid 47496117)
92. Cummins, L.L.; Chen, S.; Blyn, L.B.; Sannes-Lowery, K.A.; Drader, J.J.; Griffey, R.H.; Hofstadler, S.A. Multitarget affinity/specificity screening of natural products: finding and characterizing high-affinity ligands from complex mixtures by using high-performance mass spectrometry. J. Nat. Prod., 2003, 66, 1186-1190. (Pubitemid 37204216)
93. Liu, D.; Guo, J.; Luo, Y.; Broderick, D.J.; Schimerlik, M.I.; Pezzuto, J.M.; van Breemen, R.B. Screening for ligands of human retinoid X receptor-α using ultrafiltration mass spectrometry. Anal. Chem., 2007, 79, 9398-9402. (Pubitemid 350276318)
94. Wan, H.; Rehngren, M. High throughput screening of protein binding by equilibrium dialysis combined with liquid chromatography and mass spectrometry. J. Chromatogr. A, 2006, 1102, 125-134. (Pubitemid 41790342)
95. Kariv, I.; Cao, H.; Oldenburg, K.R. Development of a high throughput equilibrium dialysis method. J. Pharm. Sci., 2001, 90, 580-587. (Pubitemid 32378379)
96. Qi, L.; Li, P.; Li, S.; Sheng, L.; Li, R.; Song, Y.; Li, H. Screening and identification of permeable components in a combined prescription of Danggui Buxue decoction using a liposome equilibrium dialysis system followed by HPLC and LC-MS. J. Sep. Sci., 2006, 29, 2211-2220. (Pubitemid 44480053)
97. Wen, X.D.; Qi, L.W.; Chen, J.; Song, Y.; Yi, L.; Yang, X.W.; Li, P. Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS. J. Chromatogr. B, 2007, 852, 598-604. (Pubitemid 46830165)
98. Herrera, A.M.; Scott, D.O.; Lunte, C.E. Microdialysis sampling for determination of plasma protein binding of drugs. Pharm. Res., 1990, 7, 1077-1081. (Pubitemid 20366738)
99. Muckenschnabel, I.; Falchetto, R.; Mayr, L.M.; Filipuzzi, I. SpeedScreen: label-free liquid chromatography-mass spectrometrybased high throughput screening for the discovery of orphan protein ligands. Anal. Biochem., 2004, 324, 241-249. (Pubitemid 38028520)
100. Li, H.; An, J.; Zhou, J.; Li, P. Target molecule affinity coupled with mass spectrometry for the screening of bioactive compounds in complex matrices. Zhongguo Yaoke Daxue Xuebao, 2009, 40, 97-103.
101. Huhn, C.; Neusüß, C.; Pelzing, M.; Pyell, U.; Mannhardt, J.; Pütz, M. Capillary electrophoresis-laser induced fluorescenceelectrospray ionization-mass spectrometry: A case study. Electrophoresis, 2005, 26, 1389-1397. (Pubitemid 40645456)
102. Zou, H.; Zhang, Q.; Guo, Z.; Guo, B.; Zhang, Q.; Chen, X. A mass spectrometry based direct-binding assay for screening binding partners of proteins. Angew. Chem. Int. Ed., 2002, 41, 646-648. (Pubitemid 34174804)
103. Arai, A. M.; Eiji, K.; Takashi, K.; Thaworn, K.; Shigeaki, K.; Masami, I. A method for the rapid discovery of naturally occurring products by proteins immobilized on magnetic beads and reverse affinity chromatography. Chem. Asian J, 2009, 4, 1802-1808.
104. Bertucci, C.; Bartolini, M.; Gotti, R.; Andrisano, V. Drug affinity to immobilized target bio-polymers by high-performance liquid chromatography and capillary electrophoresis. J.. Chromatogr. B, 2003, 797, 111-129. (Pubitemid 37421303)
105. Huang, X.; Kong, L.; Li, X.; Chen, X.; Guo, M.; Zou, H. Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines. J. Chromatogr. B, 2004, 812, 71-84. (Pubitemid 39535402)
106. Hu, L.; Chen, X.; Kong, L.; Su, X.; Ye, M.; Zou, H. Improved performance of comprehensive two-dimensional HPLC separation of traditional Chinese medicines by using a silica monolithic column and normalization of peak heights. J. Chromatogr., A, 2005, 1092, 191-198. (Pubitemid 41393927)
107. Wang, H.; Zou, H.; Kong, L.; Ni, J.; Zhang, Y. Screening and analysis of biologically active components in Traditional Chinese medicine by molecular biochromatography. Se Pu, 1999, 17, 123-127.
108. Wang, Y.; Kong, L.; Hu, L.; Lei, X.; Yang, L.; Chou, G.; Zou, H.; Wang, C.; Bligh, S. W.A.; Wang, Z. Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 2007, 860, 185-194. (Pubitemid 350181633)
109. Hu, F.; Deng, C.; Zhang, X. Development of high performance liquid chromatography with immobilized enzyme onto magnetic nanospheres for screening enzyme inhibitor. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 2008, 871, 67-71.
110. Ward, R. S.; Davies, J.; Hodges, G.; Roberts, D. W. Applications of immobilised artificial membrane chromatography to quaternary alkylammonium sulfobetaines and comparison of chromatographic methods for estimating the octanol-water partition coefficient. J. Chromatogr. A, 2003, 1007, 67-75. (Pubitemid 38352602)
111. Beigi, F.; Yang, Q.; Lundahl, P. Immobilized-liposome chromatographic analysis of drug partitioning into lipid bilayers. J. Chromatogr. A, 1995, 704, 315-321.
112. Wang, Y.; Kong, L.; Lei, X.Y.; Hu, L.H.; Zou, H.F.; Welbeck, E.; Bligh, S.W.A.; Wang, Z.T. Comprehensive two-dimensional highperformance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan decoction. J. Chromatogr. A, 2009, 1216, 2185-2191.
113. He, L. C.; Wang, S.; Geng, X. Coating and fusing cell membranes onto a silica surface and their chromatographic characteristics. Chromatographia, 2001, 54, 71-76. (Pubitemid 32652805)
114. Liang, M.; He, L.C.; Yang, G. Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong. Life Sci., 2005, 78, 128-133. (Pubitemid 41568335)
115. Wang, C.; He, L.C.; Wang, N.; Liu, F. Screening anti-inflammatory components from Chinese traditional medicines using a peritoneal macrophage/cell membrane chromatography-offline-GC/MS method. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 2009, 877, 3019-3024.
116. Li, C.Q.; He, L.C.; Dong, H.Y.; Jin, J.Q. Screening for the antiinflammatory activity of fractions and compounds from Atractylodes macrocephala koidz. J. Ethnopharmacol., 2007, 114, 212-217.
117. Hou, X.F.; Zhou, M.Z.; Jiang, Q.; Wang, S.C.; He, L.C. A vascular smooth muscle/cell membrane chromatography-offline-gas chromatography/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines. J. Chromatogr. A, 2009, 1216, 7081-7087.
118. van Elswijk, D.A.; Irth, H. Analytical tools for the detection and characterization of biologically active compounds from nature. Phytochem. Rev., 2002, 1, 427-439. (Pubitemid 41413237)
119. Schobel, U.; Frenay, M.; van Elswijk, D.A.; McAndrews, J.M.; Long, K.R.; Olson, L.M.; Bobzin, S.C.; Irth, H. High resolution screening of plant natural product extracts for estrogen receptor alpha and beta binding activity using an online HPLC-MS biochemical detection system. J. Biomol. Screen., 2001, 6, 291-303. (Pubitemid 33027496)
120. Zhou, J.L.; An, J.J.; Li, P.; Li, H.J.; Jiang, Y.; Cheng, J.F. Twodimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins. J. Chromatogr. A, 2009, 1216, 2394-2403.
121. de Boer, A.R.; Alcaide-Hidalgo, J.M.; Krabbe, J.G.; Kolkman, J.; van Emde, B.; Niessen, W.M.; Lingeman, H.; Irth, H. Hightemperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection. Anal. Chem., 2005, 77, 7894-7900. (Pubitemid 41831974)
122. Carlomagno, T. Ligand-target interactions: What can we learn from NMR? Annu. Rev., 2005, 34, 245-266. (Pubitemid 40847725)
123. Shuker, S.B.; Hajduk, P.J.; Meadows, R.P.; Fesik, S.W. Discovering high-affinity ligands for proteins: SAR by NMR. Science, 1996, 274, 1531-1534. (Pubitemid 26403929)
124. Johnson, E.C.; Feher, V.A.; Peng, J.W.; Moore, J.M.; Williamson, J.R. Application of NMR SHAPES screening to an RNA target. J. Am. Chem. Soc., 2003, 125, 15724-15725. (Pubitemid 37553672)
125. Lin, K.J.; You, Q.D.; Lin, D.H.; Wu, W.T.; Ye, B.P. Biol. NMR in drug design. Zhongguo Yaoke Daxue Xuebao, 2004, 35, 387-392.
126. Villar, H.O.; Yan, J.; Hansen, M.R. Using NMR for ligand discovery and optimization. Curr. Opin. Chem. Biol., 2004, 8, 387-391. (Pubitemid 38993731)
127. Politi, M.; Chávez, M.I. Screening by NMR: A new approach for the study of bioactive natural products? The example of Pleurotus ostreatus hot water extract. Eur. J. Org. Chem., 2005, 2005, 1392-1396. (Pubitemid 40477409)
128. Blundell, T.L.; Jhoti, H.; Abell, C. High throughput crystallography for lead discovery in drug design. Nat. Rev. Drug Discov., 2002, 1, 45-54. (Pubitemid 37361403)
129. Manjasetty, B.A.; Turnbull, A.P.; Panjikar, S.; Büssow, K.; Chance, M.R. Automated technologies and novel techniques to accelerate protein crystallography for structural genomics. Proteomics, 2008, 8, 612-625. (Pubitemid 351362926)
130. Orita, M.; Warizaya, M.; Amano, Y.; Ohno, K.; Niimi, T. Advances in fragment-based drug discovery platforms. Expert. Opin. Drug Discov., 2009, 4, 1125-1144.
131. Rao, Z.H. History of protein crystallography in China. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2007, 362, 1035-1042.
132. Yang, H.T.; Yang, M.J.; Ding, Y.; Liu, Y.W.; Lou, Z.Y.; Zhou, Z.; Sun, L.; Mo, L.J.; Ye, S.; Pang, H. Gao, G.F.; Anand, K.; Bartlam, M.; Hilgenfeld, R.; Rao, Z.H. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 13190-13195. (Pubitemid 37444717)
133. Rao, Z.H.; Lou, Z.Y.; Sun, Y.N.; Ma, M.; Zhang, Y.; Guo, Y.; Zhang, C.; Xue, F. Screening natural products targeting a protein by evaluation of x-ray tertiary structure of protein-drug complex. CN 101,063,682, October 31, 2007.
134. Rao, Z.H.; Sun, Y.N.; Lou, Z.Y.; Xiang, K.H. Method for screening main protease inhibitor against severe acute respiratory syndrome coronavirus from backup bank of mixture of natural product such as traditional chinese medicine. CN 101,063,234, October 31, 2007.