Development of a Drosophila seizure model for in vivo high-throughput drug screening

European Journal of Neuroscience

Volumn 24, Issue 8, 2006, Pages 2211-2222

  Stilwell, Geoff E ^a   Saraswati, Sudipta ^b   Littleton, J Troy ^b   Chouinard, Scott W ^a  

^a Cambria Pharmaceuticals Inc   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Anti epileptic drugs; Drosophila melanogaster; Epilepsy research; GABA A receptor; Neuronal excitability; Seizure model

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; 4 CHLORODIAZEPAM; 5 CHLOROINDOLE 2 CARBOXYLIC ACID; AMELORIDE; AMITRIPTYLINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLONAZEPAM; DANTROLENE; DIAZEPAM; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; FLUNITRAZEPAM; GABAPENTIN; LAMOTRIGINE; NIFEDIPINE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; PICROTOXIN; PREGABALIN; TIAGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID; VERAPAMIL; VIGABATRIN; ZONISAMIDE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DROSOPHILA; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG EXPOSURE; DRUG INHIBITION; DRUG MECHANISM; DRUG TARGETING; ELECTROPHYSIOLOGY; EPILEPSY; GABAERGIC TRANSMISSION; HIGH THROUGHPUT SCREENING; LARVA; LETHALITY; MOTONEURON; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEIZURE;

AMINO ACID SEQUENCE; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CELL SURVIVAL; CONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; DRUG EVALUATION, PRECLINICAL; ELECTROPHYSIOLOGY; GABA ANTAGONISTS; LARVA; PENTYLENETETRAZOLE; PHENOTYPE; PHENYTOIN; PICROTOXIN; RECEPTORS, GABA-A; SEIZURES;

EID: 33750374340     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05075.x     Document Type: Article

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