A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine

British Journal of Pharmacology

Volumn 150, Issue 3, 2007, Pages 321-334

  Tian, H ^a   Ip, L ^a   Luo, H ^b   Chang, D C ^a   Luo, K Q ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer drugs; Apoptosis; Caspase; Drug discovery; FRET; Green fluorescent protein; Herbal medicine; HTS; Podophyllotoxin; Tanshinone

Indexed keywords

1BETA,2BETA,3BETA, 4' DEMETHYLPICROPODOPHYLLONE; 4' NORPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; CRYPTOTANSHINONE; DEHYDROPODOPHYLLOTOXIN; DEOXYPODOPHYLLOTOXIN; ETOPOSIDE; FLUORESCENT DYE; HERBACEOUS AGENT; HYDROXYUREA; METHYLENETANSHINQUINONE; NOCODAZOLE; PACLITAXEL; PODOPHYLLOTOXIN; PODOPHYLLOTOXONE; TANSHINONE I; TANSHINONE IIA; TANSHINONE IIA SULFONIC ACID; TANSHINONE IIB; UNCLASSIFIED DRUG; VINCRISTINE;

ACCURACY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOSENSOR; CELL ASSAY; CELL CULTURE; CELL DEATH; CELL LINE; CELL VIABILITY; CHINESE MEDICINE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVATION; FIELD EMISSION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HERBAL MEDICINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; METHODOLOGY; NITROBLUE TETRAZOLIUM TEST; PODOPHYLLUM; PODOPHYLLUM EMODI; PRIORITY JOURNAL; SALVIA MILTIORRHIZA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOSENSING TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELLS; HUMANS; PODOPHYLLUM; SALVIA MILTIORRHIZA;

EID: 33846860595     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706988     Document Type: Article

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