Discovery of FabH/FabF inhibitors from natural products

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 2, 2006, Pages 519-526

  Young, Katherine ^a   Jayasuriya, Hiranthi ^a   Ondeyka, John G ^a   Herath, Kithsiri ^a   Zhang, Chaowei ^a   Kodali, Srinivas ^a   Galgoci, Andrew ^a   Painter, Ronald ^a   Brown Driver, Vickie ^a,b   Yamamoto, Robert ^a   Silver, Lynn L ^a,c   Zheng, Yingcong ^a   Ventura, Judith I ^a   Sigmund, Janet ^a   Ha, Sookhee ^a   Basilio, Angela ^a   Vicente, Francisca ^a   Tormo, José Rubén ^a   Pelaez, Fernando ^a   Youngman, Phil ^a   Cully, Doris ^a   Barrett, John F ^a   Schmatz, Dennis ^a   Singh, Sheo B ^a   Wang, Jun ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Rx3 Pharmaceuticals   (United States)

^c LL Silver Consulting LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERULENIN; COMPLEMENTARY RNA; FABF INHIBITOR; FABH INHIBITOR; NATURAL PRODUCT; PHOMALLENIC ACID A; PHOMALLENIC ACID B; PHOMALLENIC ACID C; PROTEIN; PROTEIN FABF; PROTEIN FABH; PROTEIN INHIBITOR; THIOLACTOMYCIN; THIOTETROMYCIN; TU 3010; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; FATTY ACID SYNTHESIS; HAEMOPHILUS INFLUENZAE TYPE A; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; NORTHERN BLOTTING; PLASMID; PRIORITY JOURNAL; RNA TRANSCRIPTION; STAPHYLOCOCCUS AUREUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BACTERIA; BIOLOGICAL PRODUCTS; DRUG DESIGN; ENZYME INHIBITORS; FATTY ACIDS; MICROBIAL SENSITIVITY TESTS; RNA, ANTISENSE; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 31944450795     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.2.519-526.2006     Document Type: Article

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