High resolution screening of plant natural product extracts for estrogen receptor α and β binding activity using an online HPLC-MS biochemical detection system

Journal of Biomolecular Screening

Volumn 6, Issue 5, 2001, Pages 291-303

  Schobel, Uwe ^a   Frenay, Michel ^a   Van Elswijk, Danny A ^a   McAndrews, Joanne M ^b   Long, Kelly R ^b   Olson, Lisa M ^b   Bobzin, Steven C ^b   Irth, Hubertus ^a  

^a ZF screens BV   (Netherlands)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ALPHA ZEARALENOL; BIOCHANIN A; COUMESTROL; DAIDZEIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; IPRIFLAVONE; PLANT EXTRACT; PROGESTERONE; QUERCETIN; RALOXIFENE; TAMOXIFEN;

ANALYTIC METHOD; ARTICLE; DEVICE; DOSE RESPONSE; DRUG SCREENING; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MASS SPECTROMETRY; MOLECULAR WEIGHT; PRIORITY JOURNAL; RECEPTOR BINDING; RELIABILITY;

BIOLOGICAL FACTORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MASS SPECTROMETRY; PLANT EXTRACTS; PROTEIN BINDING; RECEPTORS, ESTROGEN; REPRODUCIBILITY OF RESULTS;

EID: 0034757192     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1089/108705701753200509     Document Type: Article

References (24)

1. Hormone therapy to prevent disease and prolong life in postmenopausal women
2. Effects of hormone therapy on bone mineral density: Results from the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial
3. Estrogen replacement therapy and fractures in older women
4. Effects of hormone replacement therapy on the endometrium and lipid parameters: A review of randomized clinical trials, 1985-1995
5. Effect of age for initiation and discontinuation of hormone replacement therapy
6. Why do postmenopausal woman discontinue hormone replacement therapy?
7. Dietary isoflavones: Biological effects and relevance to human health
8. Dietary phytoestrogens
9. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
10. Approaches to automating the dereplication of bioactive natural products - The key step in high throughput screening of bioactive materials from natural sources
11. Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents
12. Strategies for database dereplication of natural products
13. Comparison of liquid chromatography electrospray, atmospheric pressure chemical ionization, thermospray and continuous-flow fast atom bombardment mass spectrometry for the determination of secondary metabolites in crude plant extracts
14. Dereplication of natural products using LC/MS
15. Increased speed and accuracy of structural determination of natural products using LC-MS
16. Reversed-phase liquid chromatography coupled online to receptor affinity detection based on the human estrogen receptor
17. Guidelines for immunoassay data processing
18. Estrogenicity of coumestrol in the mouse: Fluorescence detection of interaction with estrogen receptors
19. Development of high throughput screening assays using fluorescence polarization: Nuclear receptor-ligand-binding and kinase/phosphatase assays
20. Limit of detection: A closer look at the IUPAC definition
21. Rapid screening of environmental chemicals for estrogen receptor binding capacity
22. Multi-residue screening of bovine urine on xenobiotic oestrogens with an oestrogen radioreceptor assay
23. A simple statistical parameter for use in evaluation and validation of high throughput assays
24. Determination of zeranol, taleranol, zearalenone, alpha- and beta-zearalenol in urine and tissue by high-performance liquid chromatography-tandem mass spectrometry