HPLC-based bioactivity profiling of plant extracts: A kinetic assay for the identification of monoamine oxidase-A inhibitors using human recombinant monoamine oxidase-A

Phytochemistry

Volumn 65, Issue 21 SPEC. ISS., 2004, Pages 2885-2891

  Dittmann, Kathrin ^a   Riese, Ulrike ^a   Hamburger, Matthias ^a,b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Activity profiling; GST fusion protein; HPLC; Human recombinant; Lead discovery; Monoamine oxidase A; Plant extract

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; ENZYME; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; KYNURAMINE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE INHIBITOR; PLANT EXTRACT; QUINOLINOL DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE; YEAST; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; REPRODUCIBILITY; SACCHAROMYCES CEREVISIAE; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

GYMNOMYZA SAMOENSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PLANT EXTRACTS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SACCHAROMYCES CEREVISIAE; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 14344261179     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2004.07.024     Document Type: Article

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