Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins

Journal of Chromatography A

Volumn 1216, Issue 12, 2009, Pages 2394-2403

  Zhou, Jian Liang ^a   An, Jing Jing ^a   Li, Ping ^a   Li, Hui Jun ^a   Jiang, Yan ^a   Cheng, Jie Fei ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

Author keywords

AChE; BChE; Ligand screening; On line bioseparation chemical analysis strategy; Turbulent flow chromatography; Two dimensional

Indexed keywords

ACETYLCHOLINESTERASE; ACHE; BCHE; BINDING AFFINITIES; BOUND LIGANDS; BUTYRYLCHOLINESTERASE; CONVENTIONAL APPROACHES; DISSOCIATION PROCESS; FREE MOLECULES; HIGH-THROUGHPUT SCREENINGS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; LOW TO HIGHS; MIXED MODES; ON-LINE BIOSEPARATION/CHEMICAL ANALYSIS STRATEGY; RETENTION TIME; REVERSED-PHASE; STRUCTURE-ACTIVITY RELATIONSHIPS; TARGET PROTEINS; ULTRA FASTS;

BINDING ENERGY; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DISSOCIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PROTEINS; SPECTRUM ANALYSIS; TURBULENCE; TURBULENT FLOW; TWO DIMENSIONAL;

LIGANDS;

ACETYLCHOLINESTERASE; CHOLINESTERASE; INORGANIC SALT;

AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; BIOSEPARATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHROMATOGRAPHY; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; ION EXCHANGE CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ONLINE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN TARGETING; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCREENING; SENSITIVITY ANALYSIS; STRUCTURE ACTIVITY RELATION; TWO DIMENSIONAL TURBULENT FLOW CHROMATOGRAPHY;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, LIQUID; EQUIPMENT DESIGN; GALANTAMINE; LIGANDS; MASS SPECTROMETRY; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60649122005     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.01.010     Document Type: Article

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