SpeedScreen: Label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands

Analytical Biochemistry

Volumn 324, Issue 2, 2004, Pages 241-249

  Muckenschnabel, I ^a   Falchetto, R ^a   Mayr, L M ^a   Filipuzzi, I ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Affinity selection; Deconvolution of mixtures; Drug discovery; High throughput screening; Lead finding; Orphan proteins

Indexed keywords

BINDERS; COMPLEXATION; DRUG PRODUCTS; LIGANDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MIXTURES; PROTEINS; SCREENING;

AFFINITY SELECTION; DETECTION AND IDENTIFICATIONS; DRUG DISCOVERY; HIGH THROUGHPUT SCREENING; HIGH-AFFINITY BINDERS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; PROTEIN FRACTIONS; SCREENING METHODS;

SIZE EXCLUSION CHROMATOGRAPHY;

BUFFER; DORZOLAMIDE; LIGAND; OLOMOUCINE; PROTEIN; SORAPHEN; STAUROSPORINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; AUTOMATION; BINDING AFFINITY; CHEMICAL LABELING; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; GEL PERMEATION CHROMATOGRAPHY; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICAL TECHNOLOGY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; SCREENING; VALIDATION PROCESS;

EID: 0347694626     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2003.09.040     Document Type: Article

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