Novel approaches to plant drug discovery based on high throughput pharmacological screening and genetic manipulation

Life Sciences

Volumn 78, Issue 5, 2005, Pages 467-475

  Littleton, John ^a   Rogers, Trent ^a   Falcone, Deane ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

Author keywords

Drug discovery; Nicotinic acetylcholine receptors; Plants; Radioligand binding

Indexed keywords

ACTINOMERIS ALTERNIFOLIA EXTRACT; AMPHICARPA BRACTEATA EXTRACT; ANABASINE; ANATABINE; CACALIA ATRIPLICAFOLIA EXTRACT; CAREX LURIDA EXTRACT; CAREX MEADII EXTRACT; CLINTONIA UMBELLATA EXTRACT; COTININE; DELPHINIUM TRICORNE EXTRACT; EPIGEA RIPENS EXTRACT; EQUISETUM ARVENSIS EXTRACT; EUONYMOUS AMERICANUS EXTRACT; FAGUS GRANDIFOLIA EXTRACT; LIATRIS SPICATA EXTRACT; LOBELIA INFLATA EXTRACT; LOBELINE; LYSIMACHIA LANCEOLATA EXTRACT; MEDEOLA VIRGINIANA EXTRACT; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR; NORNICOTINE; OXYDENDRUM ARBORETUM EXTRACT; PLANT EXTRACT; SCUTELLARIA OVATA EXTRACT; SOLIDAGO NEMORALIS EXTRACT; SPIGELIA MARILANDICA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIOLA SORORIA EXTRACT;

ACTINOMERIS ALTERNIFOLIA; AMPHICARPA BRACTEATA; ANIMAL CELL; ANIMAL TISSUE; BIODIVERSITY; CACALIA ATRIPLICAFOLIA; CAREX LURIDA; CAREX MEADII; CLINTONIA UMBELLATA; CONFERENCE PAPER; CONTROLLED STUDY; DELPHINIUM TRICORNE; DRUG INDUSTRY; DRUG RECEPTOR BINDING; DRUG SCREENING; EPIGEA RIPENS; EQUISETUM ARVENSIS; EUONYMOUS AMERICANUS; FAGUS GRANDIFOLIA; GAS CHROMATOGRAPHY; GENETIC MANIPULATION; GENOMICS; GEOGRAPHIC DISTRIBUTION; HIGH THROUGHPUT SCREENING; LIATRIS SPICATA; LOBELIA INFLATA; LYSIMACHIA LANCEOLATA; MASS SPECTROMETRY; MEDEOLA VIRGINIANA; MEDICINAL PLANT; MOLECULAR CLONING; MUTANT; NATURAL SELECTION; NEUROPROTECTION; NONHUMAN; OXYDENDRUM ARBORETUM; PLANT CELL CULTURE; PLANT GENETICS; RADIOASSAY; RAT; SCUTELLARIA OVATA; SOLIDAGO NEMORALIS; SPIGELIA MARILANDICA; TOBACCO; VIOLA SORORIA;

DRUG EVALUATION, PRECLINICAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOME, PLANT; INDICATORS AND REAGENTS; KENTUCKY; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RADIOLIGAND ASSAY; RECEPTORS, NICOTINIC; REFERENCE STANDARDS; TOBACCO;

AMPHICARPAEA BRACTEATA; ANIMALIA; CACALIA; CAREX LURIDA; CAREX MEADII; CLINTONIA; DELPHINIUM TRICORNE; EQUISETUM; FAGUS GRANDIFOLIA; LIATRIS SPICATA; LOBELIA INFLATA; LYSIMACHIA LANCEOLATA; MAMMALIA; MEDEOLA VIRGINIANA; NICOTIANA TABACUM; OXYDENDRUM; SCUTELLARIA OVATA; SOLIDAGO NEMORALIS; SPIGELIA MARILANDICA; VERBESINA ALTERNIFOLIA; VIOLA SORORIA;

EID: 27844536497     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.09.013     Document Type: Conference Paper

References (33)

1. N. Belluardo, G. Mudo, M. Blum, and K. Fuxe Central nicotinic receptors, neurotrophic factors and neuroprotection Behavioural Brain Research 113 2000 21 34
2. E.L. Braun Deciduous Forests of Eastern North America 1950 Blakiston Philadelphia PA
3. R.B. Barlow, and O. Johnson Relations between structure and nicotine-like activity: x-ray crystal structure analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds British Journal of Pharmacology 98 3 1989 799 808
4. J. Brioni, M. Decker, J. Sullivan, and S. Arneric The pharmacology of (-)-nicotine and novel cholinergic channel modulator Advances in Pharmacology 37 1997 153 214
5. J.P. Changeux, D. Bertrand, P.J. Corringer, S. Dehaene, S. Edelstein, C. Lena, N. La Novere, L. Marubio, M. Picciotto, and M. Zoli Brain nicotinic receptors: structure and regulation, role in learning and reinforcement Brain Research Reviews 26 1998 198 216
6. P.B.S. Clarke, R.D. Schwartz, S.M. Paul, C.B. Pert, and A. Pert Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine and [125I] α-bungarotoxin Journal of Neuroscience 5 1985 1307 1315
7. J.R. Copeland, A. Adem, P. Jacob III, and A. Nordberg A comparison of the binding of nicotine and nornicotine stereoisomers to nicotinic binding sites in rat brain cortex Naunyn-Schmiedeberg's Archives of Pharmacology 343 2 1991 123 127
8. A.R. Davies, D.J. Hardick, I.S. Blagbrough, B.V. Potter, A.J. Wolstenholme, and S. Wonnacott Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors Neuropharmacology 38 5 1999 679 690
9. M.W. Decker, J.D. Brioni, A.W. Bannon, and S.P. Arneric Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics Life Sciences 56 8 1995 545 570
10. L.P. Dwoskin, and P.A. Crooks Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery Journal of Pharmacology and Experimental Therapeutics 298 2001 395 402
11. L.C. Gahring, E.L. Meyer, and S.W. Rogers Nicotine-induced neuroprotection against N-methyl-d-aspartic acid or β-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines Journal of Neurochemistry 87 2003 1125 1136
12. M. Gattu, A.V. Terry, and J.J. Buccafusco A rapid microtechnique for the estimation of muscarinic and nicotinic receptor binding parameters using 96 well filtration plates Journal of Neuroscience Methods 63 1995 121 125
13. V. Gerzanich, X. Peng, F. Wang, G. Wells, R. Anand, S. Fletcher, and J. Lindstrom Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors Molecular Pharmacology 48 4 1995 774 782
14. D. Gradisch, E.D. London, P. Terry, G. Hill, and A. Muhkin High affinity binding of [3H]epibatidine to rat brain membranes Neuroreport 10 1999 1631 1636
15. M. Hall, L. Zerbe, S. Leonard, and R. Freedman Characterization of [3H]cytisine binding to human brain membrane preparations Brain Research 600 1993 127 133
16. M.W. Holladay, M.J. Dart, and J.K. Lynch Neuronal nicotinic acetylcholine receptors as targets for drug discovery Journal of Medicinal Chemistry 40 26 1997 4169 4194
17. E. Koylu, S. Demirgoren, E.D. London, and P. Sakire Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain Life Sciences 61 12 1997 185 190
18. M. Lourenco, A. Matos, and M. Oliviera Gas-liquid chromatographic determination of major tobacco alkaloids Journal of Chromatography A 898 2000 235 242
19. R.J. Lukas, J.P. Changeux, N. Le Novere, E.X. Albuquerque, D.J. Balfour, D.K. Berg, D. Bertrand, V.A. Chiappinelli, P.B. Clarke, A.C. Collins, J.A. Dani, S.R. Grady, K.J. Kellar, J.M. Lindstrom, M.J. Marks, M. Quik, P.W. Taylor, and S. Wonnacott International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits Pharmacological Reviews 51 2 1999 397 401 (Jun)
20. M.J. Marks, J.A. Stitzel, E. Romm, J.M. Wehner, and A.C. Collins Nicotine binding sites in rat and mouse brain: comparison of acetylcholine, nicotine and alpha-bungarotoxin Molecular Pharmacology 30 1986 427 436
21. S. Mihailescu, and R. Drucker-Colin Nicotine, brain nicotinic receptors and neuropsychiatric disorders Archives of Medical Research 31 2 2000 131 144
22. D.M. Morens, A. Grandinetti, D. Reed, L.R. White, and G.W. Ross Cigarette smoking and protection from Parkinson's disease: false association or etiologic clue? Neurology 45 6 1995 1041 1051
23. P.A. Newhouse, A. Potter, M. Kelton, and J. Corwin Nicotinic treatment of Alzheimer's disease Biological Psychology 49 3 2001 268 278
24. M.R. Piccioto, M. Zoli, R. Rimondini, C. Lena, L.M. Marubio, E.M. Pich, K. Fuxe, and J.P. Changeux Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine Nature 391 1998 173 177
25. D.T. Rogers, D.F. Falcone, and J.M. Littleton A functional genomics strategy for plant drug discovery Pharmagenomics 14 2003 26 34
26. F. Saitoh, M. Noma, and N. Kawashima The alkaloid contents of sixty Nicotiana species Phytochemistry 24 3 1985 477 480
27. M. Schapira, R. Abagyan, and M. Totrov Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine BMC Structural Biology 2 1 2002 1
28. V.A. Sisson, and R.F. Severson Alkaloid composition of the Nicotiana species Beitrage zur Tabakforschung International 14 6 1990 326 339
29. P. Vainio, and R.K. Tuominen Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cells and rat brain membranes Nicotine and Tobacco Research 3 2001 177 182
30. C.M. Van Duijn, and A. Hoffman Relation between nicotine intake and Alzheimer's disease British Medical Journal 302 6791 1991 1491 1494
31. L. Yum, K.M. Wolf, and V.A. Chiappinelli Nicotinic acetylcholine receptors in separate brain regions exhibit different affinities for methyllycaconitine Neuroscience 72 2 1996 545 555
32. M. Williams, and S.P. Arneric Tobacco: beyond the smokescreen. Dissecting out the therapeutic potential of nicotine Expert Opinion on Investigational Drugs 5 1996 1035 1045
33. J. Zhang, and J.H. Steinbach Cytisine binds with similar affinity to nicotinic α4β2 receptors on the cell surface and in homogenates Brain Research 959 2003 98 102