-
1
-
-
17144373303
-
Druggability indices for protein targets derived from NMR-based screening data
-
Hajduk, P.J., Huth, J.R. & Fesik, S.W. Druggability indices for protein targets derived from NMR-based screening data. J. Med. Chem. 48 2518-2525 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 2518-2525
-
-
Hajduk, P.J.1
Huth, J.R.2
Fesik, S.W.3
-
2
-
-
0030756360
-
Reactive compounds and in vitro false positives in HTS
-
Rishton, G.M. Reactive compounds and in vitro false positives in HTS. Drug Discov. Today 2, 382-384 (1997).
-
(1997)
Drug Discov. Today
, vol.2
, pp. 382-384
-
-
Rishton, G.M.1
-
3
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters, W.P. & Namchuk, M. Designing screens: How to make your hits a hit. Nat. Rev. Drug Discov. 2, 259-266 (2003).
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
4
-
-
33645665186
-
Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures
-
Feng, B. & Shoichet, B.K. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures. J. Med. Chem. 49, 2151-2154 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 2151-2154
-
-
Feng, B.1
Shoichet, B.K.2
-
5
-
-
23844500772
-
High-throughput assays for promiscuous inhibitors
-
Feng, B.Y. et al. High-throughput assays for promiscuous inhibitors. Nat. Chem. Biol. 1, 146-148 (2005).
-
(2005)
Nat. Chem. Biol
, vol.1
, pp. 146-148
-
-
Feng, B.Y.1
-
6
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern, S.L., Caselli, E., Grigorieff, N. & Shoichet, B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45, 1712-1722 (2002).
-
(2002)
J. Med. Chem
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
7
-
-
0141792701
-
A specific mechanism of nonspecific inhibition
-
McGovern, S.L., Helfand, B.T., Feng, B.Y. & Shoichet, B.K. A specific mechanism of nonspecific inhibition. J. Med. Chem. 46, 4265-4272 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 4265-4272
-
-
McGovern, S.L.1
Helfand, B.T.2
Feng, B.Y.3
Shoichet, B.K.4
-
8
-
-
0037431421
-
Kinase inhibitors: Not just for kinases anymore
-
McGovern, S.L. & Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. J. Med. Chem. 46, 1478-1483 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 1478-1483
-
-
McGovern, S.L.1
Shoichet, B.K.2
-
9
-
-
0141923641
-
Identification and prediction of promiscuous aggregating inhibitors among known drugs
-
Seidler, J., McGovern, S.L., Doman, T. & Shoichet, B.K. Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 46, 4477-4486 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 4477-4486
-
-
Seidler, J.1
McGovern, S.L.2
Doman, T.3
Shoichet, B.K.4
-
10
-
-
0141923641
-
Identification and prediction of promiscuous drugs
-
Seidler, J., McGovern, S.L., Doman, T.N. & Shoichet, B.K. Identification and prediction of promiscuous drugs. J. Med. Chem. 46, 4477-4486 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 4477-4486
-
-
Seidler, J.1
McGovern, S.L.2
Doman, T.N.3
Shoichet, B.K.4
-
11
-
-
0032487847
-
Structure-based enhancement of boronic acid-based inhibitors of AmpC β-lactamase
-
Weston, G.S., Blazquez, J., Baquero, F. & Shoichet, B.K. Structure-based enhancement of boronic acid-based inhibitors of AmpC β-lactamase. J. Med. Chem. 41, 4577-4586 (1998).
-
(1998)
J. Med. Chem
, vol.41
, pp. 4577-4586
-
-
Weston, G.S.1
Blazquez, J.2
Baquero, F.3
Shoichet, B.K.4
-
12
-
-
0041842684
-
Effect of detergent on "promiscuous" inhibitors
-
Ryan, A.J., Gray, N.M., Lowe, P.N. & Chung, C. Effect of detergent on "promiscuous" inhibitors. J. Med. Chem. 46, 3448-3451 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 3448-3451
-
-
Ryan, A.J.1
Gray, N.M.2
Lowe, P.N.3
Chung, C.4
-
13
-
-
84940137432
-
Zone behavior of enzymes: Illustrated by the effect of dissociation constant and dilution on the system cholinesterase-physostigmine
-
Straus, O.H. & Goldstein, A. Zone behavior of enzymes: Illustrated by the effect of dissociation constant and dilution on the system cholinesterase-physostigmine. J. Gen. Physiol. 26, 559-585 (1943).
-
(1943)
J. Gen. Physiol
, vol.26
, pp. 559-585
-
-
Straus, O.H.1
Goldstein, A.2
|