메뉴 건너뛰기




Volumn 80, Issue 5, 2004, Pages 589-594

Could a deficiency in growth hormone signaling be beneficial to the aging brain?

Author keywords

Aging; Delayed aging; Growth hormone; Growth hormone deficiency; Knockout mice; Locomotor activity; Open field test; Water maze

Indexed keywords

GROWTH HORMONE;

EID: 1242292288     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2003.10.018     Document Type: Article
Times cited : (66)

References (48)
  • 1
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13:1999;2570-2580.
    • (1999) Genes Dev. , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 2
    • 0028930267 scopus 로고
    • Genes that regulate both development and longevity in Caenorhabditis elegans
    • Larson P.L., Albert P.S., Riddle D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 139:1995;1567-1583.
    • (1995) Genetics , vol.139 , pp. 1567-1583
    • Larson, P.L.1    Albert, P.S.2    Riddle, D.L.3
  • 3
    • 0023627355 scopus 로고
    • Successful selection does increased longevity in Drosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity
    • Arking R. Successful selection does increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity. Exp. Gerontol. 22:1987;199-220.
    • (1987) Exp. Gerontol. , vol.22 , pp. 199-220
    • Arking, R.1
  • 4
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 7
    • 0033657180 scopus 로고    scopus 로고
    • Delayed aging in Ames dwarf mice. Relationship to endocrine function and body size
    • Z. Hekimi. Heidelberg (Germany): Springer
    • Bartke A. Delayed aging in Ames dwarf mice. Relationship to endocrine function and body size. Hekimi Z. The molecular genetics of aging. Results and problems in cell differentiation. 2000;181-202 Springer, Heidelberg (Germany).
    • (2000) The Molecular Genetics of Aging. Results and Problems in Cell Differentiation , pp. 181-202
    • Bartke, A.1
  • 9
    • 10544256602 scopus 로고    scopus 로고
    • Pituitary lineage determination by the prophet of pit-1 homeodomain factor defective in Ames dwarfism
    • Sornson M.W., Wu W., Dasen J.S., et al. Pituitary lineage determination by the prophet of pit-1 homeodomain factor defective in Ames dwarfism. Nature. 384:1996;327-333.
    • (1996) Nature , vol.384 , pp. 327-333
    • Sornson, M.W.1    Wu, W.2    Dasen, J.S.3
  • 10
    • 78651146564 scopus 로고
    • Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf mice
    • Bartke A. Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf mice. Anat. Rec. 149:1964;225-235.
    • (1964) Anat. Rec. , vol.149 , pp. 225-235
    • Bartke, A.1
  • 11
    • 0034884345 scopus 로고    scopus 로고
    • Genes that prolong life: Relationships of growth hormone and growth to aging and life span
    • Bartke A., Coschigano K., Kopchick J., et al. Genes that prolong life: relationships of growth hormone and growth to aging and life span. J. Gerontol. Biol. Sci. 56:2001;B340-B349.
    • (2001) J. Gerontol. Biol. Sci. , vol.56
    • Bartke, A.1    Coschigano, K.2    Kopchick, J.3
  • 12
  • 15
    • 0028788807 scopus 로고
    • Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mice
    • Borg K.E., Brown-Borg H.M., Bartke A. Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mice. Proc. Soc. Exp. Biol. Med. 210:1995;126-133.
    • (1995) Proc. Soc. Exp. Biol. Med. , vol.210 , pp. 126-133
    • Borg, K.E.1    Brown-Borg, H.M.2    Bartke, A.3
  • 16
    • 0036237480 scopus 로고    scopus 로고
    • Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
    • Dominici F.P., Hauck S., Argentino D.P., Bartke A., Turyn D. Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J. Endocrinol. 173(1):2002;81-94.
    • (2002) J. Endocrinol. , vol.173 , Issue.1 , pp. 81-94
    • Dominici, F.P.1    Hauck, S.2    Argentino, D.P.3    Bartke, A.4    Turyn, D.5
  • 17
    • 0032751474 scopus 로고    scopus 로고
    • Antioxidative mechanisms and plasma growth hormone levels
    • Brown-Borg H.M., Bode A.M., Bartke A. Antioxidative mechanisms and plasma growth hormone levels. Endocrine. 11:1999;41-48.
    • (1999) Endocrine , vol.11 , pp. 41-48
    • Brown-Borg, H.M.1    Bode, A.M.2    Bartke, A.3
  • 18
    • 0034653367 scopus 로고    scopus 로고
    • Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase
    • Hauck S., Bartke A. Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase. Free Radic. Biol. Med. 28:2000;970-978.
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 970-978
    • Hauck, S.1    Bartke, A.2
  • 19
    • 0034027841 scopus 로고    scopus 로고
    • Catalase expression in delayed and premature aging mouse models
    • Brown-Borg H.M., Rakoczy S.G. Catalase expression in delayed and premature aging mouse models. Exp. Gerontol. 35:2000;199-212.
    • (2000) Exp. Gerontol. , vol.35 , pp. 199-212
    • Brown-Borg, H.M.1    Rakoczy, S.G.2
  • 20
    • 0025014024 scopus 로고
    • Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
    • Li S., Crenshaw B.E. III, Rawson E.J., Simmons D.M., Swanson L.W., Rosenfeld M.G. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 347:1990;528-533.
    • (1990) Nature , vol.347 , pp. 528-533
    • Li, S.1    Crenshaw III, B.E.2    Rawson, E.J.3    Simmons, D.M.4    Swanson, L.W.5    Rosenfeld, M.G.6
  • 21
    • 0000046781 scopus 로고
    • Genetic models in the study of anterior pituitary hormones
    • J.G.M. Shire. Boca Raton (FL): CRC Press
    • Bartke A. Genetic models in the study of anterior pituitary hormones. Shire J.G.M. Genetic variation in hormone systems. 1979;113-126 CRC Press, Boca Raton (FL).
    • (1979) Genetic Variation in Hormone Systems , pp. 113-126
    • Bartke, A.1
  • 22
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K., Papaconstantinou J., Miller R.A., Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. 98(12):2001;6736-6741.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , Issue.12 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 23
    • 0034455827 scopus 로고    scopus 로고
    • Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    • Coschigano K.T., Clemmons D., Bellush L.L., Kopchick J.J. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 14:2000;2608-2613.
    • (2000) Endocrinology , vol.14 , pp. 2608-2613
    • Coschigano, K.T.1    Clemmons, D.2    Bellush, L.L.3    Kopchick, J.J.4
  • 24
    • 12644257576 scopus 로고    scopus 로고
    • A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (The Laron mouse)
    • Zhou Y., Xu B.C., Maheshwari H.G., et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (The Laron mouse). Proc. Natl. Acad. Sci. U. S. A. 94:1997;13215-13220.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13215-13220
    • Zhou, Y.1    Xu, B.C.2    Maheshwari, H.G.3
  • 25
    • 0027236844 scopus 로고
    • Molecular basis of the little mouse phenotype and implications for cell type-specific growth
    • Lin S.C., Lin C.R., Gukovsky I., Simmons D.M., Swanson L.W., Rosenfeld M.G. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature. 364:1993;208-213.
    • (1993) Nature , vol.364 , pp. 208-213
    • Lin, S.C.1    Lin, C.R.2    Gukovsky, I.3    Simmons, D.M.4    Swanson, L.W.5    Rosenfeld, M.G.6
  • 26
    • 0032958139 scopus 로고    scopus 로고
    • Pituitary and testicular function in growth hormone receptor gene knockout mice
    • Chandrashekar V., Bartke A., Coschigano K.T., Kopchick J.J. Pituitary and testicular function in growth hormone receptor gene knockout mice. Endocrinology. 140:1999;1082-1088.
    • (1999) Endocrinology , vol.140 , pp. 1082-1088
    • Chandrashekar, V.1    Bartke, A.2    Coschigano, K.T.3    Kopchick, J.J.4
  • 28
    • 0034993409 scopus 로고    scopus 로고
    • Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in growth hormone receptor/binding protein knockout mice
    • Hauck S.J., Hunter W.S., Danilovich N., Kopchick J.J., Bartke A. Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in growth hormone receptor/binding protein knockout mice. EBM. 226:2001;552-558.
    • (2001) EBM , vol.226 , pp. 552-558
    • Hauck, S.J.1    Hunter, W.S.2    Danilovich, N.3    Kopchick, J.J.4    Bartke, A.5
  • 29
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin K., Hsin H., Libina N., Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28:2001;139-145.
    • (2001) Nat. Genet. , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 31
    • 0024993193 scopus 로고
    • Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency
    • Degerblad M., Almkvist O., Grunditz R., Hall K., Kaijser L., Knutsson E., et al. Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency. Acta Endocrinol. 123:1990;185-193.
    • (1990) Acta Endocrinol. , vol.123 , pp. 185-193
    • Degerblad, M.1    Almkvist, O.2    Grunditz, R.3    Hall, K.4    Kaijser, L.5    Knutsson, E.6
  • 33
    • 0026767143 scopus 로고
    • The effects of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis as well as on body composition
    • Binnerts A., Swart G.R., Wilson J.H.P., Hoogerbrugge N., Pols H.A.P., Birkenhager J.C., et al. The effects of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis as well as on body composition. Clin. Endocrinol. 37:1992;79-87.
    • (1992) Clin. Endocrinol. , vol.37 , pp. 79-87
    • Binnerts, A.1    Swart, G.R.2    Wilson, J.H.P.3    Hoogerbrugge, N.4    Pols, H.A.P.5    Birkenhager, J.C.6
  • 34
    • 0025079164 scopus 로고
    • Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency
    • McGauley G.A., Cuneo R.C., Salomon F., Sonksen P.H. Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm. Res. 33(Suppl. 4):1990;52-54.
    • (1990) Horm. Res. , vol.33 , Issue.SUPPL. 4 , pp. 52-54
    • McGauley, G.A.1    Cuneo, R.C.2    Salomon, F.3    Sonksen, P.H.4
  • 35
    • 0034523517 scopus 로고    scopus 로고
    • The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
    • Sonntag W.E., Lynch C., Thornton P., Khan A., Bennett S., Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J. Anat. 197(Pt. 4):2000;575-585.
    • (2000) J. Anat. , vol.197 , Issue.PT. 4 , pp. 575-585
    • Sonntag, W.E.1    Lynch, C.2    Thornton, P.3    Khan, A.4    Bennett, S.5    Ingram, R.6
  • 36
    • 0034966342 scopus 로고    scopus 로고
    • Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
    • Kinney B.A., Meliska C.J., Steger R.W., Bartke A. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39:2001;277-284.
    • (2001) Horm. Behav. , vol.39 , pp. 277-284
    • Kinney, B.A.1    Meliska, C.J.2    Steger, R.W.3    Bartke, A.4
  • 37
    • 0035051811 scopus 로고    scopus 로고
    • Evidence that old growth hormone resistant GH-R-KO (Laron) mice have increased memory retention
    • Kinney B.A., Coschigano K.T., Kopchick J.J., Steger R.W., Bartke A. Evidence that old growth hormone resistant GH-R-KO (Laron) mice have increased memory retention. Physiol. Behav. 72:2001;653-660.
    • (2001) Physiol. Behav. , vol.72 , pp. 653-660
    • Kinney, B.A.1    Coschigano, K.T.2    Kopchick, J.J.3    Steger, R.W.4    Bartke, A.5
  • 38
    • 0033047958 scopus 로고    scopus 로고
    • Daily activity and body temperature rhythms do not change simultaneously with age in laboratory mice
    • Weinert D., Waterhouse J. Daily activity and body temperature rhythms do not change simultaneously with age in laboratory mice. Physiol. Behav. 66:1999;605-612.
    • (1999) Physiol. Behav. , vol.66 , pp. 605-612
    • Weinert, D.1    Waterhouse, J.2
  • 41
    • 1242265793 scopus 로고
    • Exploration and fear
    • Hayes K.J. Exploration and fear. Psychol. Rep. 6:1960;91-93.
    • (1960) Psychol. Rep. , vol.6 , pp. 91-93
    • Hayes, K.J.1
  • 42
    • 0026692163 scopus 로고
    • Senescene-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain
    • Miyamoto M., Kiyota Y., Nishiyama M., Nagaoka A. Senescene-accelerated mouse (SAM): age-related reduced anxiety-like behavior in the SAM-P/8 strain. Physiol. Behav. 51:1992;979-985.
    • (1992) Physiol. Behav. , vol.51 , pp. 979-985
    • Miyamoto, M.1    Kiyota, Y.2    Nishiyama, M.3    Nagaoka, A.4
  • 43
    • 0027345682 scopus 로고
    • Premature aging in transgenic mice expressing different growth hormone genes
    • Steger R.W., Bartke A., Cecim M. Premature aging in transgenic mice expressing different growth hormone genes. J. Reprod. Fertil. Suppl. 46:1993;61-75.
    • (1993) J. Reprod. Fertil. Suppl. , vol.46 , pp. 61-75
    • Steger, R.W.1    Bartke, A.2    Cecim, M.3
  • 44
    • 0031193957 scopus 로고    scopus 로고
    • Inhibitory avoidance and appetitive learning in aged normal mice: Comparison with transgenic mice having elevated plasma growth hormone levels
    • Meliska C.J., Burke P.A., Bartke A., Jensen R.A. Inhibitory avoidance and appetitive learning in aged normal mice: comparison with transgenic mice having elevated plasma growth hormone levels. Neurobiol. Learn. Mem. 68:1997;1-12.
    • (1997) Neurobiol. Learn. Mem. , vol.68 , pp. 1-12
    • Meliska, C.J.1    Burke, P.A.2    Bartke, A.3    Jensen, R.A.4
  • 45
    • 0029978498 scopus 로고    scopus 로고
    • Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain
    • Forster M.J., Dubey A., Dawson K.M., Stutts W.A., Lal H., Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. 93:1996;4765-4769.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 4765-4769
    • Forster, M.J.1    Dubey, A.2    Dawson, K.M.3    Stutts, W.A.4    Lal, H.5    Sohal, R.S.6
  • 46
    • 0035117627 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals
    • Lynch C.D., Lyons D., Khan A., Bennett S.A., Sonntag W.E. Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology. 142:2001;506-509.
    • (2001) Endocrinology , vol.142 , pp. 506-509
    • Lynch, C.D.1    Lyons, D.2    Khan, A.3    Bennett, S.A.4    Sonntag, W.E.5
  • 47
    • 0032483062 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 ameliorates age-related behavioral deficits
    • Markowska A.L., Mooney M., Sonntag W.E. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 87(3):1998;559-569.
    • (1998) Neuroscience , vol.87 , Issue.3 , pp. 559-569
    • Markowska, A.L.1    Mooney, M.2    Sonntag, W.E.3
  • 48
    • 0031257758 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury
    • Saatman K.E., Contreras P.C., Smith D.H., et al. Insulin-like growth factor (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Exp. Neurol. 147:1997;418-427.
    • (1997) Exp. Neurol. , vol.147 , pp. 418-427
    • Saatman, K.E.1    Contreras, P.C.2    Smith, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.