Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 63, Issue 8, 2008, Pages 813-824

  Treuting, Piper M ^a,d   Linford, Nancy J ^a,c   Knoblaugh, Sue E ^b   Emond, M J ^a   Morton, John F ^a   Martin, George M ^a   Rabinovitch, Peter S ^a   Ladiges, Warren C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Health Sciences Center   (United States)

Author keywords

Free radicals; Oxidative stress; Pathology

Indexed keywords

CATALASE;

AGING; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CAUSE OF DEATH; COMORBIDITY; CONTROLLED STUDY; HEART INJURY; HISTOPATHOLOGY; INFLAMMATION; LIFESPAN; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME; WILD TYPE;

MUS;

EID: 53349153165     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/63.8.813     Document Type: Article

References (23)

1. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci. 2006;1067:10-21.
2. Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004;125:811-826.
3. Sun J, Folk D, Bradley TJ, Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult drosophila melanogaster. Genetics. 2002;161:661-672.
4. Orr WC, Radyuk SN, Prabhudesai L, et al. Overexpression of glutamate-cysteine ligase extends life span in drosophila melanogaster. J Biol Chem. 2005;280:37331-37338.
5. Linford NJ, Schriner SE, Rabinovitch PS. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006;66:2497-2499.
6. Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005;308:1909-1911.
7. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci. 2003;58:291-296.
8. Kodell RL, Blackwell BN, Bucci TJ, Greenman DL. Cause-of-death assignment at the National Center for Toxicological Research. Toxicol Pathol. 1995;23:241-247.
9. Blackwell BN, Bucci TJ, Hart RW, Turturro A. Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. Toxicol Pathol. 1995;23:570-582.
10. Ward JM. Lymphomas and leukemias in mice. Exp Toxicol Pathol. 2006;57:377-381.
11. Porter DD, Porter HG, Cox NA. Immune complex glomerulonephritis in one-year-old C57BL-6 mice induced by endogenous murine leukemia virus and erythrocyte antigens. J Immunol. 1973;111:1626-1633.
12. Ward JM, Anver MR, Mahler JF, Devor-Henneman DE. Pathology of mice commonly used in genetic engineering (C57Bl/6; 129; B6, 129; and FVB/N). In: Ward JM, Mahler JF, Maronpot RR, Sundberg JP, Frederickson RM. Pathology of Genetically Engineered Mice. First edition. Ames: Iowa State Press; 2000:161-179.
13. Lipman RD, Gaillard ET, Harrison DE, Bronson RT. Husbandry factors and the prevalence of age-related amyloidosis in mice. Lab Anim Sci. 1993;43:439-444.
14. Lipman RD, Bronson RT, Wu D, et al. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice. Mech Ageing Dev. 1998;103:269-284.
15. Lipman RD, Dallal GE, Bronson RT. Lesion biomarkers of aging in B6C3F1 hybrid mice. J Gerontol Biol Sci. 1999;54A:B466-B477.
16. Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol. 2003;15:247-254.
17. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-247.
18. Gayama S, Vaupel BA, Kanagawa O. Sequence heterogeneity of murine acquired immunodeficiency syndrome virus: the role of endogenous virus. Int Immunol. 1995;7:861-868.
19. Kubo Y, Nakagawa Y, Kakimi K, et al. Molecular cloning and characterization of a murine AIDS virus-related endogenous transcript expressed in C57BL/6 mice. J Gen Virol. 1994;75:881-888.
20. Kastenmayer RJ, Fain MA, Perdue KA. A retrospective study of idiopathic ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci. 2006;45:8-12.
21. Miller RA, Nadon NL. Principles of animal use for gerontological research. J Gerontol Biol Sci. 2000;55A:B117-B123.
22. Miller RA, Burke D, Nadon N. Announcement: four-way cross mouse stocks: a new, genetically heterogeneous resource for aging research. J Gerontol Biol Sci. 1999;54A:B358-B360.
23. Bronson RT, Lipman RD. Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. Growth Dev Aging. 1991;55:169-184.