메뉴 건너뛰기




Volumn 119, Issue 2, 2011, Pages 346-358

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

Author keywords

BER; EMS; ENU; Genotoxicity; MPG; Threshold dose response

Indexed keywords

6 METHYLPURINE; 7 METHYLGUANINE; DNA GLYCOSYLTRANSFERASE; ETHYLNITROSOUREA; MESSENGER RNA; MESYLIC ACID ETHYL ESTER;

EID: 78751689062     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq341     Document Type: Article
Times cited : (38)

References (96)
  • 1
    • 0032170023 scopus 로고    scopus 로고
    • Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents
    • Allan, J. M., Engelward, B. P., Dreslin, A. J., Wyatt, M. D., Tomasz, M., and Samson, L. D. (1998). Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents. Cancer Res. 58, 3965-3973.
    • (1998) Cancer Res , vol.58 , pp. 3965-3973
    • Allan, J.M.1    Engelward, B.P.2    Dreslin, A.J.3    Wyatt, M.D.4    Tomasz, M.5    Samson, L.D.6
  • 2
    • 0029762067 scopus 로고    scopus 로고
    • Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds
    • Altshuler, K. B., Hodes, C. S., and Essigmann, J. M. (1996). Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds. Chem. Res. Toxicol. 9, 980-987.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 980-987
    • Altshuler, K.B.1    Hodes, C.S.2    Essigmann, J.M.3
  • 3
    • 0025288239 scopus 로고
    • Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
    • Beranek, D. T. (1990). Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231, 11-30.
    • (1990) Mutat. Res. , vol.231 , pp. 11-30
    • Beranek, D.T.1
  • 4
    • 47249087323 scopus 로고    scopus 로고
    • Small-molecule based delivery systems for alkylating antineoplastic compounds
    • Bielawski, K., and Bielawska, A. (2008). Small-molecule based delivery systems for alkylating antineoplastic compounds. ChemMedChem 3, 536-542.
    • (2008) ChemMedChem , vol.3 , pp. 536-542
    • Bielawski, K.1    Bielawska, A.2
  • 5
    • 12844281121 scopus 로고    scopus 로고
    • Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
    • Blagosklonny, M. V. (2004). Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle 3, 1035-1042.
    • (2004) Cell Cycle , vol.3 , pp. 1035-1042
    • Blagosklonny, M.V.1
  • 6
    • 0034665972 scopus 로고    scopus 로고
    • Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene
    • Bouziane, M., Miao, F., Bates, S. E., Somsouk, L., Sang, B. C., Denissenko, M., and O'Connor, T. R. (2000). Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene. Mutat. Res. 461, 15-29.
    • (2000) Mutat. Res. , vol.461 , pp. 15-29
    • Bouziane, M.1    Miao, F.2    Bates, S.E.3    Somsouk, L.4    Sang, B.C.5    Denissenko, M.6    O'Connor, T.R.7
  • 7
    • 69449099359 scopus 로고    scopus 로고
    • The formation and biological significance of N7-guanine adducts
    • Boysen, G., Pachkowski, B. F., Nakamura, J., and Swenberg, J. A. (2009). The formation and biological significance of N7-guanine adducts. Mutat. Res. 678, 76-94.
    • (2009) Mutat. Res. , vol.678 , pp. 76-94
    • Boysen, G.1    Pachkowski, B.F.2    Nakamura, J.3    Swenberg, J.A.4
  • 8
    • 33845987557 scopus 로고    scopus 로고
    • The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice
    • Branda, R. F., O'Neill, J. P., Brooks, E. M., Powden, C., Naud, S. J., and Nicklas, J. A. (2007). The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice. Mutat. Res. 615, 12-17.
    • (2007) Mutat. Res. , vol.615 , pp. 12-17
    • Branda, R.F.1    O'Neill, J.P.2    Brooks, E.M.3    Powden, C.4    Naud, S.J.5    Nicklas, J.A.6
  • 10
    • 0028889093 scopus 로고
    • DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin
    • Broggini, M., Coley, H. M., Mongelli, N., Pesenti, E., Wyatt, M. D., Hartley, J. A., and D'Incalci, M. (1995). DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin. Nucleic Acids Res. 23, 81-87.
    • (1995) Nucleic Acids Res , vol.23 , pp. 81-87
    • Broggini, M.1    Coley, H.M.2    Mongelli, N.3    Pesenti, E.4    Wyatt, M.D.5    Hartley, J.A.6    D'Incalci, M.7
  • 11
    • 0026611091 scopus 로고
    • Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells
    • Bronstein, S. M., Skopek, T. R., and Swenberg, J. A. (1992). Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells. Cancer Res. 52, 2008-2011.
    • (1992) Cancer Res , vol.52 , pp. 2008-2011
    • Bronstein, S.M.1    Skopek, T.R.2    Swenberg, J.A.3
  • 12
    • 0029957245 scopus 로고    scopus 로고
    • XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro
    • Caldecott, K. W., Aoufouchi, S., Johnson, P., and Shall, S. (1996). XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. Nucleic Acids Res. 24, 4387-4394.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4387-4394
    • Caldecott, K.W.1    Aoufouchi, S.2    Johnson, P.3    Shall, S.4
  • 13
    • 0345003994 scopus 로고    scopus 로고
    • Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase
    • Calleja, F., Jansen, J. G., Vrieling, H., Laval, F., and van Zeeland, A. A. (1999). Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase. Mutat. Res. 425, 185-194.
    • (1999) Mutat. Res. , vol.425 , pp. 185-194
    • Calleja, F.1    Jansen, J.G.2    Vrieling, H.3    Laval, F.4    van Zeeland, A.A.5
  • 14
    • 0025949662 scopus 로고
    • Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase
    • Chakravarti, D., Ibeanu, G. C., Tano, K., and Mitra, S. (1991). Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. J. Biol. Chem. 266, 15710-15715.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15710-15715
    • Chakravarti, D.1    Ibeanu, G.C.2    Tano, K.3    Mitra, S.4
  • 15
    • 0018910691 scopus 로고
    • Retention of promutagenic O6-ethylguanine in the DNA of various rat tissues following transplacental inoculation with ethylnitrosourea
    • Chang, M. J., Hart, R. W., and Koestner, A. (1980). Retention of promutagenic O6-ethylguanine in the DNA of various rat tissues following transplacental inoculation with ethylnitrosourea. Cancer Lett. 9, 199-205.
    • (1980) Cancer Lett , vol.9 , pp. 199-205
    • Chang, M.J.1    Hart, R.W.2    Koestner, A.3
  • 16
    • 78751686436 scopus 로고    scopus 로고
    • DNA damage & repair: mechanisms for maintaining DNA integrity
    • Clancy, S. (2008). DNA damage & repair: mechanisms for maintaining DNA integrity. Nat. Educ. 1(1).
    • (2008) Nat. Educ. , vol.1 , Issue.1
    • Clancy, S.1
  • 17
    • 0028801762 scopus 로고
    • Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents-a case of imbalanced DNA repair
    • Coquerelle, T., Dosch, J., and Kaina, B. (1995). Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents-a case of imbalanced DNA repair. Mutat. Res. 336, 9-17.
    • (1995) Mutat. Res. , vol.336 , pp. 9-17
    • Coquerelle, T.1    Dosch, J.2    Kaina, B.3
  • 18
    • 0026323008 scopus 로고
    • Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes
    • Demple, B., Herman, T., and Chen, D. S. (1991). Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. U.S.A. 88, 11450-11454.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 11450-11454
    • Demple, B.1    Herman, T.2    Chen, D.S.3
  • 19
    • 0020679111 scopus 로고
    • The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects
    • den Engelse, L., Floot, B. G., de Brij, R. J., and Tates, A. D. (1983). The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects. Mutat. Res. 107, 153-166.
    • (1983) Mutat. Res. , vol.107 , pp. 153-166
    • den Engelse, L.1    Floot, B.G.2    de Brij, R.J.3    Tates, A.D.4
  • 20
    • 0023006246 scopus 로고
    • Formation and stability of alkylated pyrimidines and purines (including imidazole ring-opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine
    • den Engelse, L., Menkveld, G. J., De Brij, R. J., and Tates, A. D. (1986). Formation and stability of alkylated pyrimidines and purines (including imidazole ring-opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine. Carcinogenesis 7, 393-403.
    • (1986) Carcinogenesis , vol.7 , pp. 393-403
    • den Engelse, L.1    Menkveld, G.J.2    De Brij, R.J.3    Tates, A.D.4
  • 21
    • 0031744963 scopus 로고    scopus 로고
    • Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA
    • Dinglay, S., Gold, B., and Sedgwick, B. (1998). Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA. Mutat. Res. 407, 109-116.
    • (1998) Mutat. Res. , vol.407 , pp. 109-116
    • Dinglay, S.1    Gold, B.2    Sedgwick, B.3
  • 22
    • 34248577471 scopus 로고    scopus 로고
    • Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens
    • Doak, S. H., Jenkins, G. J., Johnson, G. E., Quick, E., Parry, E. M., and Parry, J. M. (2007). Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res. 67, 3904-3911.
    • (2007) Cancer Res , vol.67 , pp. 3904-3911
    • Doak, S.H.1    Jenkins, G.J.2    Johnson, G.E.3    Quick, E.4    Parry, E.M.5    Parry, J.M.6
  • 23
    • 0025294590 scopus 로고
    • Comparative efficiency of forming m4T.G versus m4T. A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase alpha-primase complex
    • Dosanjh, M. K., Essigmann, J. M., Goodman, M. F., and Singer, B. (1990). Comparative efficiency of forming m4T.G versus m4T.A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase alpha-primase complex. Biochemistry 29, 4698-4703.
    • (1990) Biochemistry , vol.29 , pp. 4698-4703
    • Dosanjh, M.K.1    Essigmann, J.M.2    Goodman, M.F.3    Singer, B.4
  • 24
    • 0029665878 scopus 로고    scopus 로고
    • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct
    • Duckett, D. R., Drummond, J. T., Murchie, A. I., Reardon, J. T., Sancar, A., Lilley, D. M., and Modrich, P. (1996). Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl. Acad. Sci. U.S.A. 93, 6443-6447.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 6443-6447
    • Duckett, D.R.1    Drummond, J.T.2    Murchie, A.I.3    Reardon, J.T.4    Sancar, A.5    Lilley, D.M.6    Modrich, P.7
  • 26
    • 0032570769 scopus 로고    scopus 로고
    • A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome
    • Engelward, B. P., Allan, J. M., Dreslin, A. J., Kelly, J. D., Wu, M. M., Gold, B., and Samson, L. D. (1998). A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome. J. Biol. Chem. 273, 5412-5418.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5412-5418
    • Engelward, B.P.1    Allan, J.M.2    Dreslin, A.J.3    Kelly, J.D.4    Wu, M.M.5    Gold, B.6    Samson, L.D.7
  • 27
    • 0030041960 scopus 로고    scopus 로고
    • Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylationinduced chromosome damage and cell killing
    • Engelward, B. P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., and Samson, L. (1996). Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylationinduced chromosome damage and cell killing. EMBO J. 15, 945-952.
    • (1996) EMBO J , vol.15 , pp. 945-952
    • Engelward, B.P.1    Dreslin, A.2    Christensen, J.3    Huszar, D.4    Kurahara, C.5    Samson, L.6
  • 29
    • 0033858808 scopus 로고    scopus 로고
    • A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division
    • Fenech, M. (2000). A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division. Mutagenesis 15, 329-336.
    • (2000) Mutagenesis , vol.15 , pp. 329-336
    • Fenech, M.1
  • 30
    • 33846330178 scopus 로고    scopus 로고
    • Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide
    • Fishel, M. L., He, Y., Smith, M. L., and Kelley, M. R. (2007). Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. Clin. Cancer Res. 13, 260-267.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 260-267
    • Fishel, M.L.1    He, Y.2    Smith, M.L.3    Kelley, M.R.4
  • 31
    • 0037309710 scopus 로고    scopus 로고
    • Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing
    • Fishel, M. L., Seo, Y. R., Smith, M. L., and Kelley, M. R. (2003). Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. Cancer Res. 63, 608-615.
    • (2003) Cancer Res , vol.63 , pp. 608-615
    • Fishel, M.L.1    Seo, Y.R.2    Smith, M.L.3    Kelley, M.R.4
  • 32
    • 0016832582 scopus 로고
    • Cell cycle studies of mononucleate and cytochalasin-B-induced binucleate fibroblasts
    • Fournier, R. E., and Pardee, A. B. (1975). Cell cycle studies of mononucleate and cytochalasin-B-induced binucleate fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 72, 869-873.
    • (1975) Proc. Natl. Acad. Sci. U. S. A. , vol.72 , pp. 869-873
    • Fournier, R.E.1    Pardee, A.B.2
  • 33
    • 3242727654 scopus 로고    scopus 로고
    • Biologically relevant chemical reactions of N7-alkylguanine residues in DNA
    • Gates, K. S., Nooner, T., and Dutta, S. (2004). Biologically relevant chemical reactions of N7-alkylguanine residues in DNA. Chem. Res. Toxicol. 17, 839-856.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 839-856
    • Gates, K.S.1    Nooner, T.2    Dutta, S.3
  • 35
    • 69449085094 scopus 로고    scopus 로고
    • MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU
    • Gocke, E., Ballantyne, M., Whitwell, J., and Muller, L. (2009). MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU. Toxicol. Lett. 190, 286-297.
    • (2009) Toxicol. Lett. , vol.190 , pp. 286-297
    • Gocke, E.1    Ballantyne, M.2    Whitwell, J.3    Muller, L.4
  • 36
    • 69449108362 scopus 로고    scopus 로고
    • In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU
    • Gocke, E., and Muller, L. (2009). In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU. Mutat. Res 678, 101-107.
    • (2009) Mutat. Res , vol.678 , pp. 101-107
    • Gocke, E.1    Muller, L.2
  • 37
    • 0026734634 scopus 로고
    • In vitro mispairing specificity of O2-ethylthymidine
    • Grevatt, P. C., Solomon, J. J., and Bhanot, O. S. (1992). In vitro mispairing specificity of O2-ethylthymidine. Biochemistry 31, 4181-4188.
    • (1992) Biochemistry , vol.31 , pp. 4181-4188
    • Grevatt, P.C.1    Solomon, J.J.2    Bhanot, O.S.3
  • 38
    • 0023893127 scopus 로고
    • Alkylating activity in food products-especially sauerkraut and sour fermented dairy products-after incubation with nitrite under quasi-gastric conditions
    • Groenen, P. J., and Busink, E. (1988). Alkylating activity in food products-especially sauerkraut and sour fermented dairy products-after incubation with nitrite under quasi-gastric conditions. Food Chem. Toxicol. 26, 215-225.
    • (1988) Food Chem. Toxicol. , vol.26 , pp. 215-225
    • Groenen, P.J.1    Busink, E.2
  • 39
    • 0023175747 scopus 로고
    • Determination of volatile nitrosamines in cheese and cured meat products. Model study of a temperature- and pH-dependent artefact formation phenomenon in alkaline medium
    • Groenen, P. J., Busink, E., and van Wandelen, M. (1987). Determination of volatile nitrosamines in cheese and cured meat products. Model study of a temperature- and pH-dependent artefact formation phenomenon in alkaline medium. Z. Lebensm. Unters. Forsch. 185, 24-30.
    • (1987) Z. Lebensm. Unters. Forsch. , vol.185 , pp. 24-30
    • Groenen, P.J.1    Busink, E.2    van Wandelen, M.3
  • 40
    • 0027398114 scopus 로고
    • Increased resistance of the Chinese hamster mutant irsl cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes
    • Habraken, Y., and Laval, F. (1993). Increased resistance of the Chinese hamster mutant irsl cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes. Mutat. Res. 293, 187-195.
    • (1993) Mutat. Res. , vol.293 , pp. 187-195
    • Habraken, Y.1    Laval, F.2
  • 41
    • 0030707950 scopus 로고    scopus 로고
    • Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1, N6-ethenoadenine and hypoxanthine but not of 3, N4-ethenocytosine or 8-oxoguanine
    • Hang, B., Singer, B., Margison, G. P., and Elder, R. H. (1997). Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1, N6-ethenoadenine and hypoxanthine but not of 3, N4-ethenocytosine or 8-oxoguanine. Proc. Natl. Acad. Sci. U.S.A. 94, 12869-12874.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 12869-12874
    • Hang, B.1    Singer, B.2    Margison, G.P.3    Elder, R.H.4
  • 42
    • 0030296814 scopus 로고    scopus 로고
    • DNA damage by filtered, tarand aerosolfree cigarette smoke in rodent cells: a novel evaluation
    • Hess, R. D., and Brandner, G. (1996). DNA damage by filtered, tarand aerosolfree cigarette smoke in rodent cells: a novel evaluation. Toxicol. Lett. 88, 9-13.
    • (1996) Toxicol. Lett. , vol.88 , pp. 9-13
    • Hess, R.D.1    Brandner, G.2
  • 43
    • 0032851842 scopus 로고    scopus 로고
    • Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
    • Hickman, M. J., and Samson, L. D. (1999). Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl. Acad. Sci. U.S.A. 96, 10764-10769.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 10764-10769
    • Hickman, M.J.1    Samson, L.D.2
  • 44
    • 0023884151 scopus 로고
    • Mutants of Aspergillus nidulans with increased resistance to the alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine
    • Hooley, P., Shawcross, S. G., and Strike, P. (1988). Mutants of Aspergillus nidulans with increased resistance to the alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine. Mutat. Res. 193, 247-254.
    • (1988) Mutat. Res. , vol.193 , pp. 247-254
    • Hooley, P.1    Shawcross, S.G.2    Strike, P.3
  • 45
    • 0026465075 scopus 로고
    • Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells
    • Ibeanu, G., Hartenstein, B., Dunn, W. C., Chang, L. Y., Hofmann, E., Coquerelle, T., Mitra, S., and Kaina, B. (1992). Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells. Carcinogenesis 13, 1989-1995.
    • (1992) Carcinogenesis , vol.13 , pp. 1989-1995
    • Ibeanu, G.1    Hartenstein, B.2    Dunn, W.C.3    Chang, L.Y.4    Hofmann, E.5    Coquerelle, T.6    Mitra, S.7    Kaina, B.8
  • 48
    • 2642574948 scopus 로고    scopus 로고
    • Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go
    • Kaina, B. (2004). Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. Cytogenet. Genome Res. 104, 77-86.
    • (2004) Cytogenet. Genome Res. , vol.104 , pp. 77-86
    • Kaina, B.1
  • 49
    • 0036064451 scopus 로고    scopus 로고
    • Expression of p53 and its transcriptional target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nervous system
    • Katayama, K., Ohtsuka, R., Takai, H., Nakayama, H., and Doi, K. (2002a). Expression of p53 and its transcriptional target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nervous system. Histol. Histopathol. 17, 715-720.
    • (2002) Histol. Histopathol. , vol.17 , pp. 715-720
    • Katayama, K.1    Ohtsuka, R.2    Takai, H.3    Nakayama, H.4    Doi, K.5
  • 50
    • 0035992833 scopus 로고    scopus 로고
    • Ethylnitrosourea induces apoptosis and growth arrest in the trophoblastic cells of rat placenta
    • Katayama, K., Ueno, M., Takai, H., Ejiri, N., Uetsuka, K., Nakayama, H., and Doi, K. (2002b). Ethylnitrosourea induces apoptosis and growth arrest in the trophoblastic cells of rat placenta. Biol. Reprod. 67, 431-435.
    • (2002) Biol. Reprod. , vol.67 , pp. 431-435
    • Katayama, K.1    Ueno, M.2    Takai, H.3    Ejiri, N.4    Uetsuka, K.5    Nakayama, H.6    Doi, K.7
  • 51
    • 0033603438 scopus 로고    scopus 로고
    • Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent
    • Kelly, J. D., Inga, A., Chen, F. X., Dande, P., Shah, D., Monti, P., Aprile, A., Burns, P. A., Scott, G., Abbondandolo, A., et al. (1999). Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent. J. Biol. Chem. 274, 18327-18334.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18327-18334
    • Kelly, J.D.1    Inga, A.2    Chen, F.X.3    Dande, P.4    Shah, D.5    Monti, P.6    Aprile, A.7    Burns, P.A.8    Scott, G.9    Abbondandolo, A.10
  • 52
    • 10044282525 scopus 로고    scopus 로고
    • The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways
    • Kim, W. J., Beardsley, D. I., Adamson, A. W., and Brown, K. D. (2005). The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. Toxicol. Appl. Pharmacol. 202, 84-98.
    • (2005) Toxicol. Appl. Pharmacol. , vol.202 , pp. 84-98
    • Kim, W.J.1    Beardsley, D.I.2    Adamson, A.W.3    Brown, K.D.4
  • 54
    • 77949543799 scopus 로고    scopus 로고
    • Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase
    • Klapacz, J., Lingaraju, G. M., Guo, H. H., Shah, D., Moar-Shoshani, A., Loeb, L. A., and Samson, L. D. (2010). Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol. Cell 37, 843-853.
    • (2010) Mol. Cell , vol.37 , pp. 843-853
    • Klapacz, J.1    Lingaraju, G.M.2    Guo, H.H.3    Shah, D.4    Moar-Shoshani, A.5    Loeb, L.A.6    Samson, L.D.7
  • 55
    • 0032538337 scopus 로고    scopus 로고
    • Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision
    • Lau, A. Y., Scharer, O. D., Samson, L., Verdine, G. L., and Ellenberger, T. (1998). Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. Cell 95, 249-258.
    • (1998) Cell , vol.95 , pp. 249-258
    • Lau, A.Y.1    Scharer, O.D.2    Samson, L.3    Verdine, G.L.4    Ellenberger, T.5
  • 56
    • 64549102042 scopus 로고    scopus 로고
    • Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG)
    • Lee, C. Y., Delaney, J. C., Kartalou, M., Lingaraju, G. M., Maor-Shoshani, A., Essigmann, J. M., and Samson, L. D. (2009). Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). Biochemistry 48, 1850-1861.
    • (2009) Biochemistry , vol.48 , pp. 1850-1861
    • Lee, C.Y.1    Delaney, J.C.2    Kartalou, M.3    Lingaraju, G.M.4    Maor-Shoshani, A.5    Essigmann, J.M.6    Samson, L.D.7
  • 57
    • 69449107550 scopus 로고    scopus 로고
    • Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data
    • Lutz, W. K., and Lutz, R. W. (2009). Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data. Mutat. Res. 678, 118-122.
    • (2009) Mutat. Res. , vol.678 , pp. 118-122
    • Lutz, W.K.1    Lutz, R.W.2
  • 58
    • 0037818408 scopus 로고    scopus 로고
    • Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity
    • Lynch, A., Harvey, J., Aylott, M., Nicholas, E., Burman, M., Siddiqui, A., Walker, S., and Rees, R. (2003). Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity. Mutagenesis 18, 345-353.
    • (2003) Mutagenesis , vol.18 , pp. 345-353
    • Lynch, A.1    Harvey, J.2    Aylott, M.3    Nicholas, E.4    Burman, M.5    Siddiqui, A.6    Walker, S.7    Rees, R.8
  • 59
    • 42749095519 scopus 로고    scopus 로고
    • Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model
    • Mahabir, A. G., van Benthem, J., Korsten, H., Lynch, A. M., Bailey, L., de Vries, A., Hendriksen, C. F., and van Steeg, H. (2008). Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model. Mutat. Res. 652, 151-157.
    • (2008) Mutat. Res. , vol.652 , pp. 151-157
    • Mahabir, A.G.1    van Benthem, J.2    Korsten, H.3    Lynch, A.M.4    Bailey, L.5    de Vries, A.6    Hendriksen, C.F.7    van Steeg, H.8
  • 60
    • 0024255832 scopus 로고
    • Tests for biologic markers of genotoxic exposure and effect
    • Mendelsohn, M. L. (1988). Tests for biologic markers of genotoxic exposure and effect. Stat. Sci. 3, 346-349.
    • (1988) Stat. Sci. , vol.3 , pp. 346-349
    • Mendelsohn, M.L.1
  • 62
    • 0027351670 scopus 로고
    • Regulation of repair of alkylation damage in mammalian genomes
    • Mitra, S., and Kaina, B. (1993). Regulation of repair of alkylation damage in mammalian genomes. Prog. Nucleic Acid Res. Mol. Biol. 44, 109-142.
    • (1993) Prog. Nucleic Acid Res. Mol. Biol. , vol.44 , pp. 109-142
    • Mitra, S.1    Kaina, B.2
  • 63
    • 2442616388 scopus 로고    scopus 로고
    • Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-Lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair
    • Monti, P., Iannone, R., Campomenosi, P., Ciribilli, Y., Varadarajan, S., Shah, D., Menichini, P., Gold, B., and Fronza, G. (2004). Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-Lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair. Biochemistry 43, 5592-5599.
    • (2004) Biochemistry , vol.43 , pp. 5592-5599
    • Monti, P.1    Iannone, R.2    Campomenosi, P.3    Ciribilli, Y.4    Varadarajan, S.5    Shah, D.6    Menichini, P.7    Gold, B.8    Fronza, G.9
  • 64
    • 1642411206 scopus 로고    scopus 로고
    • Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase
    • O'Brien, P. J., and Ellenberger, T. (2004a). Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase. J. Biol. Chem. 279, 9750-9757.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9750-9757
    • O'Brien, P.J.1    Ellenberger, T.2
  • 65
    • 3042686671 scopus 로고    scopus 로고
    • The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site
    • O'Brien, P. J., and Ellenberger, T. (2004b). The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site. J. Biol. Chem. 279, 26876-26884.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26876-26884
    • O'Brien, P.J.1    Ellenberger, T.2
  • 66
    • 0025784273 scopus 로고
    • Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine
    • O'Connor, T. R., and Laval, J. (1991). Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine. Biochem. Biophys. Res. Commun. 176, 1170-1177.
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 1170-1177
    • O'Connor, T.R.1    Laval, J.2
  • 67
    • 0030961096 scopus 로고    scopus 로고
    • Specificity of DNA repair methyltransferases determined by competitive inactivation with oligonucleotide substrates: evidence that Escherichia coli Ada repairs O6-methylguanine and O4-methylthymine with similar efficiency
    • Paalman, S. R., Sung, C., and Clarke, N. D. (1997). Specificity of DNA repair methyltransferases determined by competitive inactivation with oligonucleotide substrates: evidence that Escherichia coli Ada repairs O6-methylguanine and O4-methylthymine with similar efficiency. Biochemistry 36, 11118-11124.
    • (1997) Biochemistry , vol.36 , pp. 11118-11124
    • Paalman, S.R.1    Sung, C.2    Clarke, N.D.3
  • 68
    • 28544446417 scopus 로고    scopus 로고
    • Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase
    • Paik, J., Duncan, T., Lindahl, T., and Sedgwick, B. (2005). Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res. 65, 10472-10477.
    • (2005) Cancer Res , vol.65 , pp. 10472-10477
    • Paik, J.1    Duncan, T.2    Lindahl, T.3    Sedgwick, B.4
  • 69
    • 17844365289 scopus 로고    scopus 로고
    • APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine
    • Parsons, J. L., Dianova, I. I., and Dianov, G. L. (2005). APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine. Nucleic Acids Res. 33, 2204-2209.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2204-2209
    • Parsons, J.L.1    Dianova, I.I.2    Dianov, G.L.3
  • 70
    • 0034937377 scopus 로고    scopus 로고
    • Mutagenesis by O(6)-methyl-, O(6)ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair
    • Pauly, G. T., and Moschel, R. C. (2001). Mutagenesis by O(6)-methyl-, O(6)ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair. Chem. Res. Toxicol. 14, 894-900.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 894-900
    • Pauly, G.T.1    Moschel, R.C.2
  • 71
    • 0021944394 scopus 로고
    • Epidemiological reservations about risk assessment
    • Peto, R. (1985). Epidemiological reservations about risk assessment. Basic Life Sci. 33, 3-16.
    • (1985) Basic Life Sci , vol.33 , pp. 3-16
    • Peto, R.1
  • 73
    • 0032747178 scopus 로고    scopus 로고
    • Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli
    • Posnick, L. M., and Samson, L. D. (1999). Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli. J. Bacteriol. 181, 6763-6771.
    • (1999) J. Bacteriol. , vol.181 , pp. 6763-6771
    • Posnick, L.M.1    Samson, L.D.2
  • 74
    • 69449092971 scopus 로고    scopus 로고
    • Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU
    • Pottenger, L. H., Schisler, M. R., Zhang, F., Bartels, M. J., Fontaine, D. D., McFadden, L. G., and Bhaskar Gollapudi, B. (2009). Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU. Mutat. Res. 678, 138-147.
    • (2009) Mutat. Res. , vol.678 , pp. 138-147
    • Pottenger, L.H.1    Schisler, M.R.2    Zhang, F.3    Bartels, M.J.4    Fontaine, D.D.5    McFadden, L.G.6    Bhaskar Gollapudi, B.7
  • 75
    • 0023645664 scopus 로고
    • Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA
    • Preston, B. D., Singer, B., and Loeb, L. A. (1987). Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA. J. Biol. Chem. 262, 13821-13827.
    • (1987) J. Biol. Chem. , vol.262 , pp. 13821-13827
    • Preston, B.D.1    Singer, B.2    Loeb, L.A.3
  • 77
    • 4444381880 scopus 로고    scopus 로고
    • Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells
    • Rinne, M., Caldwell, D., and Kelley, M. R. (2004). Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Mol. Cancer Ther. 3, 955-967.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 955-967
    • Rinne, M.1    Caldwell, D.2    Kelley, M.R.3
  • 78
    • 20144386176 scopus 로고    scopus 로고
    • N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
    • Rinne, M. L., He, Y., Pachkowski, B. F., Nakamura, J., and Kelley, M. R. (2005). N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts. Nucleic Acids Res. 33, 2859-2867.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2859-2867
    • Rinne, M.L.1    He, Y.2    Pachkowski, B.F.3    Nakamura, J.4    Kelley, M.R.5
  • 79
    • 0036468545 scopus 로고    scopus 로고
    • 3-Methyladenine DNA glycosylasedeficient Aag null mice display unexpected bone marrow alkylation resistance
    • Roth, R. B., and Samson, L. D. (2002). 3-Methyladenine DNA glycosylasedeficient Aag null mice display unexpected bone marrow alkylation resistance. Cancer Res. 62, 656-660.
    • (2002) Cancer Res , vol.62 , pp. 656-660
    • Roth, R.B.1    Samson, L.D.2
  • 80
    • 43449137572 scopus 로고    scopus 로고
    • Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates
    • Rusyn, I., Fry, R. C., Begley, T. J., Klapacz, J., Svensson, J. P., Ambrose, M., and Samson, L. D. (2007). Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. PloS ONE 2, e1252.
    • (2007) PloS ONE , vol.2
    • Rusyn, I.1    Fry, R.C.2    Begley, T.J.3    Klapacz, J.4    Svensson, J.P.5    Ambrose, M.6    Samson, L.D.7
  • 81
    • 0025990209 scopus 로고
    • Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16
    • Samson, L., Derfler, B., Boosalis, M., and Call, K. (1991). Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. Proc. Natl. Acad. Sci. U.S.A. 88, 9127-9131.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 9127-9131
    • Samson, L.1    Derfler, B.2    Boosalis, M.3    Call, K.4
  • 82
    • 0035852863 scopus 로고    scopus 로고
    • Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair
    • Shah, D., Kelly, J., Zhang, Y., Dande, P., Martinez, J., Ortiz, G., Fronza, G., Tran, H., Soto, A. M., Marky, L., et al. (2001). Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair. Biochemistry 40, 1796-1803.
    • (2001) Biochemistry , vol.40 , pp. 1796-1803
    • Shah, D.1    Kelly, J.2    Zhang, Y.3    Dande, P.4    Martinez, J.5    Ortiz, G.6    Fronza, G.7    Tran, H.8    Soto, A.M.9    Marky, L.10
  • 83
    • 74049108712 scopus 로고    scopus 로고
    • Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
    • Shrivastav, N., Li, D., and Essigmann, J. M. (2010). Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation. Carcinogenesis 31, 59-70.
    • (2010) Carcinogenesis , vol.31 , pp. 59-70
    • Shrivastav, N.1    Li, D.2    Essigmann, J.M.3
  • 85
    • 13844269360 scopus 로고    scopus 로고
    • Detection of DNA damage derived from a direct acting ethylating agent present in cigarette smoke by use of liquid chromatography-tandem mass spectrometry
    • Singh, R., Kaur, B., and Farmer, P. B. (2005). Detection of DNA damage derived from a direct acting ethylating agent present in cigarette smoke by use of liquid chromatography-tandem mass spectrometry. Chem. Res. Toxicol. 18, 249-256.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 249-256
    • Singh, R.1    Kaur, B.2    Farmer, P.B.3
  • 86
    • 0031013464 scopus 로고    scopus 로고
    • Detection and characterization of two major ethylated deoxyguanosine adducts by high performance liquid chromatography, electrospray mass spectrometry, and 32P-postlabeling. Development of an approach for detection of phosphotriesters
    • Singh, R., Sweetman, G. M., Farmer, P. B., Shuker, D. E., and Rich, K. J. (1997). Detection and characterization of two major ethylated deoxyguanosine adducts by high performance liquid chromatography, electrospray mass spectrometry, and 32P-postlabeling. Development of an approach for detection of phosphotriesters. Chem. Res. Toxicol. 10, 70-77.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 70-77
    • Singh, R.1    Sweetman, G.M.2    Farmer, P.B.3    Shuker, D.E.4    Rich, K.J.5
  • 88
    • 0032516831 scopus 로고    scopus 로고
    • Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps
    • Srivastava, D. K., Berg, B. J., Prasad, R., Molina, J. T., Beard, W. A., Tomkinson, A. E., and Wilson, S. H. (1998). Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. J. Biol. Chem. 273, 21203-21209.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21203-21209
    • Srivastava, D.K.1    Berg, B.J.2    Prasad, R.3    Molina, J.T.4    Beard, W.A.5    Tomkinson, A.E.6    Wilson, S.H.7
  • 90
    • 33750065724 scopus 로고    scopus 로고
    • Effects of lowdose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells
    • Sudprasert, W., Navasumrit, P., and Ruchirawat, M. (2006). Effects of lowdose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells. Int. J. Hyg. Environ. Health 209, 503-511.
    • (2006) Int. J. Hyg. Environ. Health , vol.209 , pp. 503-511
    • Sudprasert, W.1    Navasumrit, P.2    Ruchirawat, M.3
  • 91
    • 0018954840 scopus 로고
    • Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 Chinese hamster cells, independence of cytotoxic and mutagenic responses
    • Suter, W., Brennand, J., McMillan, S., and Fox, M. (1980). Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 Chinese hamster cells, independence of cytotoxic and mutagenic responses. Mutat. Res. 73, 171-181.
    • (1980) Mutat. Res. , vol.73 , pp. 171-181
    • Suter, W.1    Brennand, J.2    McMillan, S.3    Fox, M.4
  • 92
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., and Speleman, F. (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 93
    • 0029821901 scopus 로고    scopus 로고
    • Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in spenic lymphocytes of exposed lacI transgenic mice
    • Walker, V. E., Gorelick, N. J., Andrews, J. L., Craft, T. R., deBoer, J. G., Glickman, B. W., and Skopek, T. R. (1996). Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in spenic lymphocytes of exposed lacI transgenic mice. Cancer Res. 56, 4654-4661.
    • (1996) Cancer Res , vol.56 , pp. 4654-4661
    • Walker, V.E.1    Gorelick, N.J.2    Andrews, J.L.3    Craft, T.R.4    deBoer, J.G.5    Glickman, B.W.6    Skopek, T.R.7
  • 94
    • 0025008357 scopus 로고
    • The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-yl carbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate
    • Whittaker, S. G., Moser, S. F., Maloney, D. H., Piegorsch, W. W., Resnick, M. A., and Fogel, S. (1990). The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-yl carbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate. Mutat. Res. 242, 231-258.
    • (1990) Mutat. Res. , vol.242 , pp. 231-258
    • Whittaker, S.G.1    Moser, S.F.2    Maloney, D.H.3    Piegorsch, W.W.4    Resnick, M.A.5    Fogel, S.6
  • 95
    • 0028177755 scopus 로고
    • Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyl-transferases
    • Zak, P., Kleibl, K., and Laval, F. (1994). Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyl-transferases. J. Biol. Chem. 269, 730-733.
    • (1994) J. Biol. Chem. , vol.269 , pp. 730-733
    • Zak, P.1    Kleibl, K.2    Laval, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.