N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts

Nucleic Acids Research

Volumn 33, Issue 9, 2005, Pages 2859-2867

  Rinne, M L ^a   He, Y ^a   Pachkowski, B F ^b   Nakamura, J ^b   Kelley, M R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLGUANINE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CARMUSTINE; CISPLATIN; DNA GLYCOSYLTRANSFERASE; ETHYLNITROSOUREA; ETOPOSIDE; LEXITROPSIN; MESYLIC ACID METHYL ESTER; MITOMYCIN C; N METHYLPURINE DNA GLYCOSYLTRANSFERASE; TEMOZOLOMIDE; THIOTEPA; UNCLASSIFIED DRUG; 7-METHYLGUANINE; DNA 3 METHYLADENINE GLYCOSIDASE II; DNA-3-METHYLADENINE GLYCOSIDASE II; DRUG DERIVATIVE; GUANINE;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; DNA MODIFICATION; DNA STRAND BREAKAGE; DRUG SENSITIVITY; ENZYME ACTIVITY; EXCISION REPAIR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SITE DIRECTED MUTAGENESIS; GENE EXPRESSION; GENETICS; KINETICS; METABOLISM; TUMOR CELL LINE;

ALKYLATING AGENTS; CELL LINE, TUMOR; DNA ADDUCTS; DNA DAMAGE; DNA GLYCOSYLASES; GENE EXPRESSION; GUANINE; HUMANS; KINETICS; METHYL METHANESULFONATE;

EID: 20144386176     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki601     Document Type: Article

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