Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4654-4661

  Walker, Vernon E ^a,e   Gorelick, Nancy J ^c   Andrews, Julie L ^c   Craft, Teresa R ^b   DeBoer, Johan G ^d   Glickman, Barry W ^d   Skopek, Thomas R ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d UNIVERSITY OF VICTORIA   (Canada)

^e WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER; CHEMICAL CARCINOGENESIS; GENE LOCUS; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE;

ANIMALS; ETHYLNITROSOUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MICE; MICE, TRANSGENIC; MUTAGENESIS; MUTAGENICITY TESTS; MUTAGENS; POINT MUTATION; SPLEEN; T-LYMPHOCYTES; TRANSGENES;

EID: 0029821901     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Loeb, L A Endogenous carcinogenesis: molecular oncology into the twentieth century Cancer Res., 49: 5489-5496, 1989
2. Rao, K S , and Loeb, L. A DNA damage and repair in brain relationship to aging. Mutat Res , 275: 317-329, 1992.
3. Dempsey J. L., and Morley, A. A. Measurement of in vivo mutant frequency in lymphocytes in the mouse Environ Mutagen., 8. 385-391, 1986.
4. Jones, I M , Burkhart-Schultz, K , Strout, C. L., and Crippen, T L. Factors that affect the frequency of thioguanine-resistant lymphocytes in mice following exposure to ethylnitrosourea. Environ. Mutagen., 9: 317-329, 1987.
5. Aidoo, A., Lyn-Cook, L. E., Mittelstaedt, R A., Heflich, R H., and Casciano, D. A. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ Mol Mutagen., 17: 141-151, 1991.
6. Provost, G. S , Kretz, P. L , Hamner, R. T , Matthews, C. D , Rogers, B. J., Lundberg, K. S., Dycaico, M. J , and Short, J. M. Transgenic systems for in vivo mutation analysis. Mutat. Res , 288: 133-150, 1993.
7. Skopek, T. R., Walker, V. E., Cochrane, J. E., Craft, T R., and Cariello, N. F. Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea. Proc. Natl. Acad Sci USA, 89: 7866-7870, 1992.
8. Walker, V. E., and Skopek, T. R. A mouse model for the study of in vivo mutational spectra, sequence specificity of ethylene oxide at the hprt locus. Mutat Res., 288: 151-162, 1993.
9. Tan, R S., Chu, E. H. Y , and Sinsheimer, J E. Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl-1-naphthyl ether in mouse spleen cells in vivo. Environ. Mol. Mutagen , 22: 71-77, 1993.
10. Jansen, J. G., Mohn, G R , Vrieling, H , van Teijlingen, C. M. M , Lohman, P. H. M., and van Zealand, A. A. Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea Cancer Res., 54: 2478-2485, 1994.
11. Zimmer, D. M., Aaron, C. S., O'Neill, J P , and Albertini, R. J. Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (Cynomolgus monkeys). Environ. Mol. Mutagen , 18: 161-167, 1991.
12. Harbach, P. R , Filipunas, A. L., Wang, Y., and Aaron, C S DNA sequence analysis of spontaneous and N-ethyl-N-nitrosourea-induced hprt mutations arising in vivo in Cynomolgus monkey T-lymphocytes. Environ Mol. Mutagen., 20: 96-105, 1922
13. Albertini, R J , Nicklas, J. A., O'Neill, J P., and Robbins. S. H. In vivo somatic mutations in humans: measurement and analysis. Annu. Rev. Genet., 24: 305-326, 1990.
14. Driscoll, K. E., Deyo, L. C., Howard, B W , Poynter, J., and Carter, J. M Characterizing mutagenesis in the hprt gene of rat alveolar epithelial cells. Exp. Lung Res., 21 941-956, 1995
15. Gossen, J. A., DeLeeuw, W. J. F., Tan, C. H. T., Zwarthoff, E. C., Berends, F., Lohman, P H. M , Knook, D L , and Vijg, J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc Natl. Acad Sci. USA, 86: 7971-7975, 1989.
16. Bohr, V. A., Smith, C. A., Okumoto, D. S , and Hanawalt, P. C. Heterogeneous DNA damage and repair in the mammalian genome Cancer Res , 47: 6426-6436, 1987
17. Hu, X., and Worton, R. G Partial gene duplication as a cause of human disease Hum. Mutat , 1: 3-12, 1992.
18. Britten, R. J Evolutionary selection against change in many Alu repeat sequences interspersed throush primate genomes. Proc Natl Acad. Sci. USA, 91: 5992-5996, 1994
19. Kohler, S. W., Provost, G S., Kretz, P. L., Dycaico, M J., Sorge, J. A., and Short, J. M. Development of a short-term, in vivo mutagenesis assay, the effects of methylation on the recovery of a λ phage shuttle vector from transgenic mice. Nucleic Acids Res , 18: 3007-3013, 1990
20. Rideout, W., III, Coetzee, G. A., Olumi, A. F., and Jones, P. A. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science (Washington DC), 249: 1288-1290, 1990
21. Knoll, A., Jacobson, D P., Kretz, P L., Lundberg, K. S., Short, J. M , and Sommer, S S. Spontaneous mutations in lacI-containing λ lysogens derived from transgenic mice: the observed patterns differ in liver and spleen. Mutat. Res , 311: 57-67, 1994.
22. Gorelick, N. J., Andrews, J. A., Gu, M., and Glickman, B. W. Mutational spectra in the lacI gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice. Mol. Carcinogenesis, 14: 53-62, 1995.
23. Farabaugh, P. J. Sequence of the lacI gene. Nature (Lond.), 274: 765-769, 1978.
24. Carr, G. J , and Gorelick, N. J Statistical tests of significance in transgenic mutation assays: considerations on the experimental unit. Environ. Mol. Mutagen , 24. 276-282, 1994
25. Adams, W. T., and Skopek, T. R Statistical test for the comparison of samples from mutational spectra. J Mol. Biol., 194: 391-396, 1987.
26. Piegorsch, W. W , and Bailer, A. J. Statistical approaches for analyzing mutational spectra: some recommendations for categorical data. Genetics, 136: 403-416, 1994.
27. Walker, V. E., and Skopek, T. R. Age-dependent relationships between exposures and phenotypic expression of hprt mutations in T-cells from mice treated with N-ethyl-N-nitrosourea Environ. Mol. Mutagen., 21 (Suppl 22): 75, 1993.
28. Burkhart, J. G , and Malling, H. V. Commentary. Mutagenesis and transgenic systems: perspective from the mutagen, N-ethyl-N-nitrosourea Environ. Mol Mutagen., 22: 1-6, 1993
29. Tao, K. S , Urlando, C , and Heddle, J. A Comparison of somatic mutation in a transgenic versus host locus. Proc Natl. Acad. Sci USA, 90: 10681-10685, 1993
30. Shibuya, T , and Morimoto, K. A review of the genotoxicity of 1-ethyl-1-nitrosourea. Mutat Res , 297: 3-38, 1993.
31. Nakamura, J , Walker, V. E , and Swenberg, J. A DNA adduct formation and persistence N-ethyl-N-nitrosourea-treated adult B6C3F1 mice. The Toxicologist. 13. 108, 1993.
32. 6-alkylguanine-DNA alkyltransferase. Proc. Natl. Acad. Sci USA, 86: 8620-8624, 1989
33. 4-ethylthymine adducts in HeLa cells. Nucleic Acids Res., 18: 4131-4137, 1990.
34. 2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents. Nucleic Acids Res., 20: 587-594, 1992.
35. Kohler, S. W., Provost, G. S , Fieck, A , Kretz, P. L., Bullock, W. O., Sorge, J. A., Putman, D. L , and Short, J. M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. USA, 88: 7958-7962, 1991.
36. Skopek, T. R , Kort, K. L , and Marino, D R. Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice. Environ Mol. Mutagen., 26: 9-15, 1995.
37. Skopek, T. R. Of mice and mutants: target size and sensitivity Mutat Res., 331: 225-228, 1995.
38. 4-ethylthymine preferentially form alkyl T-G pairs that do not block in vitro replication in a define sequence. Carcinogenesis (Lond), 14 1915-1919, 1993.
39. Miller J. H., and Schmeissner, U. Genetic studies of the lac repressor. 10. Analysis of missense mutations in the lacI gene. J. Mol. Biol., 131: 223-248, 1979.
40. Schaaper, R. M , Danforth, B. N., and Glickman, B. W. Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene. J Mol. Biol , 189: 273-284, 1986.
41. Schaaper, R. M., and Dunn, R. L. Spontaneous mutation in the Escherichia coli lacI gene. Genetics, 129: 317-326, 1991
42. 6-alkylguanine in defined segments of genomic DNA Proc. Am. Assoc. Cancer Res., 51: A48, 1991
43. Provost, G. S , and Short, J. M. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc Natl. Acad Sci USA, 91. 6564-6568, 1994.
44. Favor, J Toward an understanding of the mechanisms of mutation induction by ethylnitrosourea in germ cells of the mouse. In: Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis, pp. 221-235. Cold Spnng Harbor, NY Cold Spring Harbor Laboratory Press, 1990.
45. Mittelstaedt, R. A , Smith, B. A , and Heflich, R. H. Analysis of in viro mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes Environ. Mol. Mutagen , 26: 261-269, 1995
46. Richardson, K. K., Richardson, F. C., Crosby, R. M., Swenberg, J. A., and Skopek, T. R. DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea. Proc Natl Acad Sci. USA, 84: 344-348, 1987
47. Burns, P. A., Gordon, A. J. E , Kunsman, K., and Glickman, B. Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesion in Escherichia coli. Cancer Res , 48 4455-4458, 1988
48. Eckert, K. A., Ingle, C. A., Klinedinst, D. K , and Drinkwater, N. R. Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea. Mol. Carcinogenesis (Lond.), 1, 50-56, 1988.
49. Pastink, A , Vreeken, C., Nivard, M. J M , Searles, L L., and Vogel, E. W. Sequence analysis of N-ethyl-N-introsourea-induced vermilion mutations in Drosophila melangoaster Genetics, 123: 123-129, 1989.
50. Lee, G S-F , Blonsky, K S., Van On, D L , Savage, E. A., Morgan, A. R., and von Borstel, R. C. Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants J. Mol. Biol , 223: 617-626, 1992.
51. Walker, V E., Recio, L , Sisk, S C., and Skopek, T R Mutagenicity at the hprt locus of T-cells following inhalation exposures of Big Blue® mice to ethylene oxide The Toxicologist, 14 318, 1994
52. Sisk, S. C , Preston, R. J., and Recio, L. Determination of circulating micronuclei and mutant frequency in lung, spleen, and germ cells of male B6C3F1 lacI transgenic mice after inhalation exposure to ethylene oxide. Environ. Mol. Mutagen., 23 (Suppl.): 23:62, 1994
53. Walker, V E., Gorelick, N J., Upton, P. B., and Skopek, T. R. Mutagenicity at the hprt locus of splenic T-lymphocytes following in vivo exposure of B6C3F1 mice to cyclophosphamide Environ Mol. Mutagen , 23 (Suppl.): 23:71, 1994.
54. Andrews, J. L. Walker, V E , Upton, P B., deBoer, J. G., and Gorelick, N. J. Cyclophosphamide-induced mutations are detected at the hprt but not the lacI loci in splenic T-cells of exposed Big Blue® mice Environ. Mol. Mutagen., 27 (Suppl.): 27:4, 1996.
55. Tao, K. S , and Meddle, J. A The accumulation and persistence of somatic mutations. Mutagenesis, 9: 187-191, 1994
56. Gorelick, N J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol Mutagen., 25: 218-230, 1995
57. Melton, D. W , Konecki, D. S , Brennand, J , and Caskey, C. T. Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene Proc Natl. Acad. Sci USA, 81. 2147-2151, 1984