Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: A comparison of the mutagenicities of O4- methylthymine and O6-methylguanine in cells with different DNA repair backgrounds

Chemical Research in Toxicology

Volumn 9, Issue 6, 1996, Pages 980-987

  Altshuler, Kara B ^a   Hodes, Colette S ^a   Essigmann, John M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER; CHO CELL; DNA ALKYLATION; DNA REPAIR; DNA REPLICATION; GENE MUTATION; GENETIC ANALYSIS; MUTAGENESIS; NONHUMAN;

ANIMALS; CHO CELLS; CRICETINAE; DNA; DNA REPAIR; GENETIC MARKERS; GENETIC VECTORS; GUANINE; METHYLTRANSFERASES; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SEQUENCE ANALYSIS; THYMINE; TRANSFECTION;

EID: 0029762067     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960062w     Document Type: Article

References (45)

1. 6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc. Natl. Acad. Sci. U.S.A. 71, 639-643.
2. Singer, B., Spengler, S., and Bodell, W. J. (1981) Tissue-dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats. Carcinogenesis 2, 1069-1073.
3. 6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc. Natl. Acad. Sci. U.S.A. 81, 1692-1695.
4. Zarbl, H., Sukumar, S., Arthur, A. V., Martin-Zanca, D., and Barbacid, M. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitro-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315, 382-385.
5. 4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine. Carcinogenesis 7, 241-246.
6. 6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions. Int. J. Cancer 41, 762-766.
7. Belinsky, S. A., Devereux, T. R., Maronpot, R. R., Stoner, G. D., and Anderson, M. W. (1989) Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res. 49, 5305-5311.
8. Basu, A. K., and Essigmann, J. M. (1990) Site-specifically alkylated oligodeoxynucleotides: probes for mutagenesis, DNA repair and the structural effects of DNA damage. Mutat. Res. 233, 189-201.
9. 6-methylguanine from DNA. J. Natl. Cancer Inst. 53, 1839-1841.
10. Nicoll, J. W., Swann, P. F., and Pegg, A. E. (1975) Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA. Nature 254, 261-262.
11. Sukumar, S., Notario, V., Martin-Zanca, D., and Barbacid, M. (1983) Induction of mammary carcinomas in rats by nitrosom-ethylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature 306, 658-661.
12. 6 of guanine is only one of many chemical events that may initiate carcinogenesis. Cancer Invest. 2, 233-238.
13. 4-methylthymidine as a pro-mutagenic base. Nucleic Acids Res. 4, 761-769.
14. 4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 83, 8501-8505.
15. 4-methylthymine in Escherichia coli. Biochemistry 30, 7027-7033.
16. 4-ethylthymine preferentially form alkyl T-G pairs that do not block in vitro replication in a defined sequence, Carcinogenesis 14, 1915-1919.
17. 4-ethylthymine adducts in HeLa cells. Nucleic Acids Res. 18, 4131-4136.
18. 4-alkylthymines in human cells. J. Biol. Chem. 269, 25521-25528.
19. 4T-A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase α-primase complex. Biochemistry 29, 4698-4703.
20. Gait, M. J. (1990) Oligonucleotide Synthesis. A Practical Approach, IRL Press, Washington, DC.
21. 6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used. Proc. Natl. Acad. Sci. U.S.A. 86, 8271-8274.
22. 6Me)GCG]. Nucleic Acids Res. 11, 3393-3407.
23. 6-methylguanine: A probe for mutagenesis in mammalian cells. Mutat. Res. 220, 93-100.
24. Kunkel, T. A. (1985) Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. U.S.A. 82, 488-492.
25. Maniatis, T., Fritsch, E. F., and Sambrook, J. (1989) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
26. 6-methylguanine into viral and plasmid genomes. Proc. Natl. Acad. Sci. U.S.A. 81, 13-17.
27. 6-methylguanine. Mol. Cell. Biol. 5, 3293-3296.
28. Samson, L., Derfler, B., and Waldstein, E. A. (1986) Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes. Proc. Natl. Acad. Sci. U.S.A. 83, 5607-5610.
29. 6-methylguanine residues in DNA. Nature 280, 76-77.
30. Graham, F. L., and van der Eb, A. J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
31. Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., and Chasin, L. (1979) DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 76, 1373-1376.
32. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. L., Higuch, R., Horn, G. T., Mullis, K. B., and Erlich, H. A. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.
33. 6-alkylguanine-DNA alkyltransferase. Proc. Natl. Acad. Sci. U.S.A. 86, 8620-8624.
34. 6-alkylguanine. Cancer Res. 40, 2623-2624.
35. 6-methylguanine-DNA-methyltransferase in Chinese hamster ovary cells transfected with human DNA. Mutat. Res. 255, 175-182.
36. Dolan, M. E., Scicchitano, D., Singer, B., and Pegg, A. E. (1984) Comparison of repair of methylated pyrimidines in poly (dT) by extracts from rat liver and Escherichia coli. Biochem. Biophys. Res. Commun. 123, 324-330.
37. 6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitroso-guanidine. Carcinogenesis 6, 1641-1649.
38. Brent, T. P., Dolan, M. E., Frankael-Conrat, H., Hall, J., Karran, P., Laval, F., Margison, G. P., Montesano, R., Pegg, A. E., Potter, P. M., Singer, B., Swenberg, J. A., and Yarosh, D. B. (1988) Repair of O-alkylpyrimidines in mammalian cells: A present consensus. Proc. Natl. Acad. Sci. U.S.A. 85, 1759-1762.
39. 6-alkylguanine alkyltransferase. Carcinogenesis 6, 949-953.
40. Hall, J., and Karran, P. (1986) O-methylated pyrimidines-Important lesions in cytotoxicity and mutagenicity in mammalian cells. In Repair of DNA Lesions Introduced by N-Nitroso Compounds (Myrnes, B., and Krokan, H., Eds.) pp 73-88, Norwegian University Press, Oslo, Norway.
41. 4-methylthymine lesion. Mutat. Res. 193, 131-137.
42. 4-ethylthymidine in alkylated DNA: repair of minor miscoding base in human cells. Carcinogenesis 8, 1137-1144.
43. Koike, G., Maki, H., Takeya, H., Hayakawa, H., and Sekiguchi, M. (1990) Purification, structure, and biochemical properties of human O-methylguanine-DNA methyltransferase. J. Biol. Chem. 265, 14754-14762.
44. 6-benzylguanine. Cancer Res. 53, 3895-3898.
45. 6-methylguanine-DNA methyltransferases. J. Biol. Chem. 261, 730-733.