Detecting genotoxic effects of potential clastogens: An in vivo study using the transgenic lacZ plasmid and the Muta™Mouse model

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 652, Issue 2, 2008, Pages 151-157

  Mahabir, Anuska G ^a,c   van Benthem, Jan ^a   Korsten, Hanneke ^a   Lynch, Anthony M ^d   Bailey, Lorna ^d   de Vries, Annemieke ^a   Hendriksen, Coenradus F M ^b,c   van Steeg, Harry ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b NETHERLANDS VACCINE INSTITUTE   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Clastogens; LacZ mutations; Micronucleus assay; Mouse DNA; pUR288; Rearrangements

Indexed keywords

AMSACRINE; BETA GALACTOSIDASE; BLEOMYCIN; CAMPTOTHECIN; CLASTOGEN; ETHYLNITROSOUREA; METHYLCELLULOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; COMPARATIVE STUDY; CONTROLLED STUDY; DNA HYBRIDIZATION; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL MODEL; GENOTOXICITY; IN VIVO STUDY; MALE; MICRONUCLEUS TEST; MOUSE; MOUSE MUTANT; MUTATION RATE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TOXICITY TESTING; TRANSGENIC MOUSE;

AMSACRINE; ANIMALS; BLEOMYCIN; CAMPTOTHECIN; ETHYLNITROSOUREA; GENES, REPORTER; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; PLASMIDS;

MUS;

EID: 42749095519     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.01.007     Document Type: Article

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