MNT and Muta™Mouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU

Toxicology Letters

Volumn 190, Issue 3, 2009, Pages 286-297

  Gocke, Elmar ^a   Ballantyne, Mark ^b   Whitwell, James ^b   Müller, Lutz ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Department of Genetic and Molecular Toxicology   (United Kingdom)

Author keywords

Alkylating agents; Dose response; In vivo genotoxicity; lacZ; Micronucleus; Threshold

Indexed keywords

BETA GALACTOSIDASE; MESYLIC ACID ETHYL ESTER; DNA; DRUG DERIVATIVE; ETHYLNITROSOUREA; MUTAGENIC AGENT; VALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE MUTATION; GENOTOXICITY; IN VIVO STUDY; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REFERENCE VALUE; TOXICOKINETICS; ANIMAL; BONE MARROW; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG CONTAMINATION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; HUMAN; LACTOSE OPERON; LYMPHOCYTE; MUTATION; ORAL DRUG ADMINISTRATION; RISK ASSESSMENT; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; BONE MARROW; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CONTAMINATION; ENVIRONMENTAL EXPOSURE; ETHYL METHANESULFONATE; ETHYLNITROSOUREA; HUMANS; LAC OPERON; LYMPHOCYTES; MICE; MICE, TRANSGENIC; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; MUTATION; RISK ASSESSMENT; VALINE;

EID: 69449085094     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.03.021     Document Type: Article

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