3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance

Cancer Research

Volumn 62, Issue 3, 2002, Pages 656-660

  Roth, Richard B ^a   Samson, Leona D ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE DNA GLYCOSYLTRANSFERASE; ALKYLATING AGENT; CARMUSTINE; CLASTOGEN; DNA GLYCOSYLTRANSFERASE; LEXITROPSIN; MESYLIC ACID METHYL ESTER; METHYLLEXITROPSIN; MITOMYCIN C; TEMOZOLOMIDE; THIOTEPA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG RESISTANCE; ENZYME DEFICIENCY; EXCISION REPAIR; FLOW CYTOMETRY; MICRONUCLEUS TEST; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; STEM CELL;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; BONE MARROW CELLS; CELL LINEAGE; DNA GLYCOSYLASES; DRUG RESISTANCE; MICE; MICE, INBRED C57BL; N-GLYCOSYL HYDROLASES;

EID: 0036468545     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. The suicidal DNA repair methyltransferases of microbes
2. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase
3. Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11
4. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16
5. 3-Methyladenine DNA glycosylases: Structure, function, and biological importance
6. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
7. Measurement of nucleic acid concentrations using the DyNA Quant and the GeneQuant
8. Comparison of Acridine Orange and Giemsa stains in several mouse bone marrow micronucleus assays, including a triple dose study
9. Determination of approximate lethal dose with about six animals
10. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat, and mouse tissues
11. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
12. Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins
13. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
14. Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents
15. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
16. Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli
17. In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells
18. Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate
19. Lessons learned from structural results on uracil-DNA glycosylase
20. Passing the baton in base excision repair
21. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe
22. DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions
23. Acute nonlymphocytic leukemia, preleukemia, and solid tumours following intensive chemotherapy of small cell carcinoma of the lung
24. Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for nonHodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents
25. Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent