High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells

Cellular Signalling

Volumn 22, Issue 5, 2010, Pages 791-800

  Venieratos, Panagiotis D ^a   Drossopoulou, Garyfalia I ^a   Kapodistria, Katerina D ^a   Tsilibary, Effie C ^a   Kitsiou, Paraskevi V ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

TC 6 cells; Apoptosis; IL 1 ; Insulin signalling; Pancreatic beta cell glucotoxicity; SOCS 1

Indexed keywords

CASPASE 3; CYTOKINE; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR FOXO; FORKHEAD TRANSCRIPTION FACTOR; INSULIN RECEPTOR SUBSTRATE; PHOSPHOTYROSINE; SOCS1 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; UP-REGULATION;

EID: 77949350953     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.01.003     Document Type: Article

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