AMPK activation by long chain fatty acyl analogs

Biochemical Pharmacology

Volumn 76, Issue 10, 2008, Pages 1263-1275

  Za'tara, Ghadeer ^a   Bar Tana, Jacob ^a   Kalderon, Bella ^a   Suter, Marianne ^b   Morad, Etedal ^a   Samovski, Dmitry ^a   Neumann, Dietbert ^b   Hertz, Rachel ^a  

^a HEBREW UNIVERSITY   (Israel)

^b ETH ZURICH   (Switzerland)

Author keywords

Acyl CoA; AMPK; Diabetes; Fatty acids; MEDICA

Indexed keywords

ACYL COENZYME A; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA,ALPHA' TETRAMETHYLHEXADECANEDIOIC ACID; BETA,BETA' TETRAMETHYLHEXADECANEDIOIC ACID; CARBON; DICARBOXYLIC ACID DERIVATIVE; GAMMA,GAMMA TETRAMETHYLHEXADECANEDIOIC ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LONG CHAIN FATTY ACID; METFORMIN; PROTEIN KINASE LKB1; RECOMBINANT PROTEIN; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ESTERIFICATION; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERINSULINEMIA; LIVER CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT;

3T3-L1 CELLS; ANIMALS; CELL LINE; ENZYME ACTIVATION; FATTY ACIDS; HELA CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIENZYME COMPLEXES; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 54249111313     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.08.028     Document Type: Article

References (49)

1. Hardie D.G. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47 (2007) 185-210
2. Viollet B., Mounier R., Leclerc J., Yazigi A., Foretz M., and Andreelli F. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 33 (2007) 395-402
3. Scott J.W., Hawley S.A., Green K.A., Anis M., Stewart G., Scullion G.A., et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest 113 (2004) 274-284
4. Suter M., Riek U., Tuerk R., Schlattner U., Wallimann T., and Neumann D. Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 281 (2006) 32207-32216
5. Sanders M.J., Grondin P.O., Hegarty B.D., Snowden M.A., and Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403 (2007) 139-148
6. Corton J.M., Gillespie J.G., Hawley S.A., and Hardie D.G. 5-Aminoimidazole-4-carboxamide ribonucleoside: a specific method for activating AMP-activated protein kinase in intact cells. Eur J Biochem 229 (1995) 558-565
7. Hardie D.G., and Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23 (2001) 1112-1119
8. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 11 (2002) 1288-1295
9. Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
10. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108 (2001) 1167-1174
11. Fryer L.G., Parbu-Patel A., and Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277 (2002) 25226-25232
12. Carling D., Zammit V.A., and Hardie D.G. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223 (1987) 217-222
13. Clark H., Carling D., and Saggerson D. Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. Eur J Biochem 271 (2004) 2215-2224
14. de Lange P., Farina P., Moreno M., Ragni M., Lombardi A., Silvestri E., et al. Sequential changes in the signal transduction responses of skeletal muscle following food deprivation. FASEB J 20 (2006) 2579-2581
15. Suchankova G., Tekle M., Saha A.K., Ruderman N.B., Clarke S.D., and Gettys T.W. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem Biophys Res Commun 326 (2005) 851-858
16. Fediuc S., Gaidhu M.P., and Ceddia R.B. Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. J Lipid Res 47 (2006) 412-420
17. Watt M.J., Steinberg G.R., Chen Z.P., Kemp B.E., and Febbraio M.A. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol 574 (2006) 139-147
18. Kawaguchi T., Osatomi K., Yamashita H., Kabashima T., and Uyeda K. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem 277 (2002) 3829-3835
19. Wang X., Zhou L., Li G., Luo T., Gu Y., and Qian L. Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells. Biochem Biophys Res Commun 352 (2007) 463-468
20. Sakakibara S., Yamauchi T., Oshima Y., Tsukamoto Y., and Kadowaki T. Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice. Biochem Biophys Res Commun. 344 (2006) 597-604
21. Pelletier A., and Coderre L. Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes. Am J Physiol Endocrinol Metab 292 (2007) E1325-E1332
22. Wu Y., Song P., Xu J., Zhang M., and Zou M.H. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem 282 (2007) 9777-9788
23. Di Paola M., and Lorusso M. Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transition. Biochim Biophys Acta 1757 (2006) 1330-1337
24. Klumpp S., Thissen M.C., and Krieglstein J. Protein phosphatases types 2Calpha and 2Cbeta in apoptosis. Biochem Soc Trans 34 (2006) 1370-1375
25. Taylor E.B., Ellingson W.J., Lamb J.D., Chesser D.G., and Winder W.W. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. Am J Physiol Endocrinol Metab 288 (2005) E1055-E1061
26. Bar-Tana J., Kahn-Rose G., and Srebnik B. Inhibition of lipid synthesis by β,β′ tetramethyl-substituted C14-C22 α,ω dicarboxylic acids in the rat in vivo. J Biol Chem 260 (1985) 8404-8410
27. Kalderon B., Sheena V., Shachrur S., Hertz R., and Bar-Tana J. Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry. J Lipid Res 43 (2002) 1125-1132
28. Yang M.S., and Gupta R.C. Determination of energy charge potential in the C-6 glioma and the HepG-2 cell culture. Toxicol Mech Meth 13 (2003) 97-101
29. Qian T., Cai Z., and Yang M.S. Determination of adenosine nucleotides in cultured cells by ion-pairing liquid chromatography-electrospray ionization mass spectrometry. Anal Biochem 325 (2004) 77-84
30. Atkinson D.E. The energy charge of the adenylate pool as a regulatory parameter: interaction with feedback modifiers. Biochemistry 7 (1968) 4030-4034
31. 2+ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J Biol Chem 254 (1979) 6528-6537
32. Bronner M., Hertz R., and Bar-Tana J. Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. Biochem J 384 (2004) 295-305
33. Zufferey R., Nagy D., Mandel R.J., Naldini L., and Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 9 (1997) 871-875
34. Naldini L., Blomer U., Gage F.H., Trono D., and Verma I.M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 21 (1996) 11382-11388
35. Neumann D., Woods A., Carling D., Wallimann T., and Schlattner U. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr Purif 30 (2003) 230-237
36. Bar-Tana J., Ben-Shoshan S., Blum J., Migron Y., Hertz R., Pill J., et al. Synthesis, hypolipidemic and antidiabetogenic activities of β,β′-tetra-substituted, long chain dioic acids. J Med Chem 32 (1989) 2072-2084
37. Kawaguchi A., Yoshimura T., and Okuda S. A new method for the preparation of acyl-CoA thioesters. J Biochem 2 (1981) 337-339
38. Hertz R., Kalderon B., Byk T., Berman I., Za'tara G., Mayer R., et al. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4α. J Biol Chem 280 (2005) 24451-24461
39. Hawley S.A., Pan D.A., Mustard K.J., Ross L., Bain J., and Edelman A.M. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2 (2005) 9-19
40. Hermesh O., Kalderon B., and Bar-Tana J. Mitochondria uncoupling by a long chain fatty acyl analogue. J Biol Chem 273 (1998) 4237-4244
41. Kalderon B., Hertz R., and Bar-Tana J. Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid. Endocrinology 131 (1992) 1629-1635
42. Hawley S.A., Gadalla A.E., Olsen G.S., and Hardie D.G. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 51 (2002) 2420-2425
43. Cramer C.T., Goetz B., Hopson K.L., Fici G.J., Ackermann R.M., Brown S.C., et al. Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome. J Lipid Res 45 (2004) 1289-1301
44. Bar-Tana J., Rose-Kahn G., Frenke B., Shafer Z., and Fainaru M. The hypolipidemic effect of β,β′-methyl-substituted hexadecanedioic acid in normal and nephrotic rats. J Lipid Res 29 (1988) 431-441
45. Mayorek N., Kalderon B., Itach E., and Bar-Tana J. Sensitization to insulin induced by β,β′-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. Diabetes 46 (1997) 1958-1964
46. Leclerc I., Lenzner C., Gourdon L., Vaulont S., Kahn A., and Viollet B. Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes 50 (2001) 1515-1521
47. Barthel A., Schmoll D., Krüger K.D., Roth R.A., and Joost H.G. Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Endocrinology 143 (2002) 3183-3186
48. Shaw R.J., Lamia K.A., Vasquez D., Koo S.H., Bardeesy N., Depinho R.A., et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 (2005) 1642-1646
49. Foster G.D., Wyatt H.R., Hill J.O., McGuckin B.G., Brill C., Mohammed B.S., et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 348 (2003) 2082-2090