Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 102-106

  Negi, Geeta ^a   Kumar, Ashutosh ^a   Sharma, Shyam S ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

4 ANI; Diabetic neuropathy; FeTMPyP; Oxidative nitrosative stress; PARP

Indexed keywords

(5,10,15,20 TETRA(N METHYL 4 PYRIDYL)PORPHYRINATO IRON III; 3 NITROTYROSINE; 4 AMINO 1,8 NAPTHALIMIDE; GLUCOSE; IRON DERIVATIVE; MALONALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PEROXYNITRITE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; CATALYST; CONTROLLED STUDY; DIABETIC NEUROPATHY; DRUG TARGETING; ENZYME ACTIVATION; FUNCTIONAL ASSESSMENT; GLUCOSE BLOOD LEVEL; HEAT SENSITIVITY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MONOTHERAPY; MOTOR NERVE CONDUCTION; NERVE FUNCTION; NITROSATIVE STRESS; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL CIRCULATION; PERIPHERAL NERVE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN TARGETING; RAT; SCIATIC NERVE; TISSUE LEVEL; TISSUE SECTION;

1-NAPHTHYLAMINE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DNA DAMAGE; MALE; METALLOPORPHYRINS; NAPHTHALIMIDES; OXIDATIVE STRESS; PERIPHERAL NERVES; PEROXYNITROUS ACID; POLY(ADP-RIBOSE) POLYMERASES; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 72949103912     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.010     Document Type: Article

References (28)

1. Tomlinson D.R., and Gardiner N.J. Glucose neurotoxicity. Nat. rev. 9 (2008) 36-45
2. Cameron N.E., and Cotter M.A. Pro-inflammatory mechanism in diabetic neuropathy: focus on the nuclear factor kappa B pathway. Curr. Drug Targets 9 (2008) 60-67
3. Obrosova I.G., Drel V.R., Pacher P., Ilnytska O., Wang Z.Q., Stevens M.J., and Yorek M.A. Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited. Diabetes 54 (2005) 3435-3441
4. Nangle M.R., Cotter M.A., and Cameron N.E. Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice. Eur. J. Pharmacol. 502 (2004) 143-148
5. Pacher P., Obrosova I.G., Mabley J.G., and Szabo C. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr. Med. Chem. 12 (2005) 267-275
6. Bartosz G. Peroxynitrite: mediator of the toxic action of nitric oxide. Acta Biochim. Pol. 43 (1996) 645-659
7. Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 140-141 (2003) 105-112
8. Turko I.V., and Murad F. Protein nitration in cardiovascular diseases. Pharmacol. Rev. 54 (2002) 619-634
9. Arora M., Kumar A., Kaundal R.K., and Sharma S.S. Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabeic neuropathy. Eur. J. Pharmacol. 596 (2008) 77-83
10. Pacher P., and Szabo C. Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc. Drug Rev. 25 (2007) 235-260
11. Szabo C. Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. Pharmacol. Res. 52 (2005) 60-71
12. D'Amours D., Desnoyers S., D'Silva I., and Poirier G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 342 (1999) 249-268
13. Gan L., Anton K.E., Masterson B.A., Vincent V.A., Ye S., and Gonzalez-Zulueta M. Specific interference with gene expression and gene function mediated by long dsRNA in neural cells. J. Neurosci. Methods 121 (2002) 151-157
14. Stevens M.J., Li F., Drel V.R., Abatan O.I., Kim H., Burnett D., Larkin D., and Obrosova I.G. Nicotinamide reverses neurological and neurovascular deficits in Streptozotocin diabetic rats. J. Pharmacol. Exp. Ther. 320 (2007) 458-464
15. Ilnytska O., Lyzogubov V.V., Stevens M.J., Drel V.R., Mashtalir N., Pacher P., Yorek M.A., and Obrosova I.G. Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. Diabetes 55 (2006) 1686-1694
16. Obrosova I.G., Li F., Abatan O.I., Forsell M.A., Komjati K., Pacher P., Szabo C., and Stevens M.J. Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. Diabetes 53 (2004) 711-720
17. Obrosova I.G., Xu W., Lyzogubov V.V., Ilnytska O., Mashtalir N., Vareniuk I., Pavlov I.A., Zhang J., Slusher B., and Drel V.R. PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. Free Radic. Biol. Med. 44 (2008) 972-981
18. Sharma S.S., and Sayyed S.G. Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy. Clin. Exp. Pharmacol. Physiol. 33 (2006) 1022-1028
19. Sayyed S.G., Kumar A., and Sharma S.S. Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci. 79 (2006) 777-783
20. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
21. Kumar A., Kaundal R.K., Iyer S., and Sharma S.S. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy. Life Sci. 80 (2007) 1236-1244
22. Nisselbaum J.S., and Green S. A simple ultramicro method for determination of pyridine nucleotides in tissue. Anal. Biochem. 27 (1969) 212-217
23. Mabley J.G., and Soriano F.G. Role of nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic vascular dysfunction. Curr. Vasc. Pharmacol. 3 (2005) 247-252
24. Obrosova I.G., Drel V.R., Oltman C.L., Mashtalir N., Tibrewala J., Groves J.T., and Yorek M.A. Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am. J. Physiol. Endocrinol. Metab. 293 (2007) E1645-E1655
25. Sharma S.S., Kumar A., Arora M., and Kaundal R.K. Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes. Free Radic. Res. 43 (2009) 400-408
26. Sweitzer S.M., Medicherla S., Almirez R., Dugar S., Chakravarty S., Shumilla J.A., Yeomans D.C., and Protter A.A. Antinociceptive action of a p38alpha MAPK inhibitor, SD-282, in a diabetic neuropathy model. Pain 109 (2004) 409-419
27. Salvemini D., Wang Z.Q., Stern M.K., Currie M.G., and Misko T.P. Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology. Proc. Natl. Acad. Sci. USA 95 (1998) 2659-2663
28. Hoeldtke R.D., Bryner K.D., McNeill D.R., Hobbs G.R., Riggs J.E., Warehime S.S., Christie I., Ganser G., and Van Dyke K. Nitrosative stress, uric acid, and peripheral nerve function in early type1 diabetes. Diabetes 51 (2002) 2817-2825