-
2
-
-
6344233662
-
Prevalence and clinical characteristics of metabolic syndrome in a rural population of South Korea
-
Kim ES, Han SM, Kim YI, et al. Prevalence and clinical characteristics of metabolic syndrome in a rural population of South Korea. Diabet Med 2004; 21:1141-1143.
-
(2004)
Diabet Med
, vol.21
, pp. 1141-1143
-
-
Kim, E.S.1
Han, S.M.2
Kim, Y.I.3
-
3
-
-
0037021505
-
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
-
Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002; 288:2709-2716.
-
(2002)
JAMA
, vol.288
, pp. 2709-2716
-
-
Lakka, H.M.1
Laaksonen, D.E.2
Lakka, T.A.3
-
4
-
-
0033864163
-
Features of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: A prospective study in Mauritius
-
Boyko EJ, de Courten M, Zimmet PZ, et al. Features of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: A prospective study in Mauritius. Diabetes Care 2000; 23:1242-1248.
-
(2000)
Diabetes Care
, vol.23
, pp. 1242-1248
-
-
Boyko, E.J.1
de Courten, M.2
Zimmet, P.Z.3
-
5
-
-
0030969532
-
Skeletal muscle triglyceride levels are inversely related to insulin action
-
Pan DA, Lillioja S, Storlien LH, et al. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997; 46:983-988.
-
(1997)
Diabetes
, vol.46
, pp. 983-988
-
-
Pan, D.A.1
Lillioja, S.2
Storlien, L.H.3
-
6
-
-
0033991180
-
Cytosolic triglycerides and oxidative stress in central obesity: The missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?
-
Bakker SJ, IJzerman RG, Teerlink T, et al. Cytosolic triglycerides and oxidative stress in central obesity: The missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? Atherosclerosis 2000; 148:17-21.
-
(2000)
Atherosclerosis
, vol.148
, pp. 17-21
-
-
Bakker, S.J.1
Ijzerman, R.G.2
Teerlink, T.3
-
7
-
-
9644252751
-
Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats
-
Song KH, Lee WJ, Koh JM, et al. Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun 2005; 326:197-202.
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 197-202
-
-
Song, K.H.1
Lee, W.J.2
Koh, J.M.3
-
8
-
-
0035125917
-
Lipotoxicity of beta-cells in obesity and in other causes offatty acid spillover
-
Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes offatty acid spillover. Diabetes 2001; 50:S118-S121.
-
(2001)
Diabetes
, vol.50
, pp. S118-S121
-
-
Unger, R.H.1
Zhou, Y.T.2
-
9
-
-
19744372144
-
Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
-
Lee WJ, Song KH, Koh EH, et al. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 2005; 332:885-891.
-
(2005)
Biochem Biophys Res Commun
, vol.332
, pp. 885-891
-
-
Lee, W.J.1
Song, K.H.2
Koh, E.H.3
-
10
-
-
33644802810
-
Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase
-
Lee WJ, Lee IK, Kim HS, et al. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol 2005; 25:2488-2494.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2488-2494
-
-
Lee, W.J.1
Lee, I.K.2
Kim, H.S.3
-
11
-
-
3142677140
-
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
-
Kim MS, Park JY, Namkoong C, et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 2004; 10:727-733.
-
(2004)
Nat Med
, vol.10
, pp. 727-733
-
-
Kim, M.S.1
Park, J.Y.2
Namkoong, C.3
-
12
-
-
0024160877
-
Banting lecture 1988. Role of insulin resistance in human disease
-
Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37:1595-1607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
13
-
-
0028987309
-
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
-
Simoneau JA, Colberg SR, Thaete FL, et al. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 1995; 9:273-278
-
(1995)
FASEB J
, vol.9
, pp. 273-278
-
-
Simoneau, J.A.1
Colberg, S.R.2
Thaete, F.L.3
-
14
-
-
0029134591
-
Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures
-
Henry RR, Abrams L, Nikoulina S, et al. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 1995; 44:936-946.
-
(1995)
Diabetes
, vol.44
, pp. 936-946
-
-
Henry, R.R.1
Abrams, L.2
Nikoulina, S.3
-
15
-
-
0023939293
-
Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM
-
Wright KS, Beck-Nielsen H, Kolterman OG, et al. Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM. Diabetes 1998; 37:436-440.
-
(1998)
Diabetes
, vol.37
, pp. 436-440
-
-
Wright, K.S.1
Beck-Nielsen, H.2
Kolterman, O.G.3
-
16
-
-
0032698470
-
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
-
Kim YB, Nikoulina SE, Ciaraldi TP, et al. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 1999; 104:733-741.
-
(1999)
J Clin Invest
, vol.104
, pp. 733-741
-
-
Kim, Y.B.1
Nikoulina, S.E.2
Ciaraldi, T.P.3
-
17
-
-
0028903232
-
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
-
Goodyear LJ, Giorgino F, Sherman LA, et al. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 1995; 95:2195-2204.
-
(1995)
J Clin Invest
, vol.95
, pp. 2195-2204
-
-
Goodyear, L.J.1
Giorgino, F.2
Sherman, L.A.3
-
18
-
-
0031057526
-
Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
-
Bjornholm M, Kawano Y, Lehtihet M, et al. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 1997; 46:524-527.
-
(1997)
Diabetes
, vol.46
, pp. 524-527
-
-
Bjornholm, M.1
Kawano, Y.2
Lehtihet, M.3
-
19
-
-
50549202600
-
The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle PJ, Garland PB, Hales CN, et al. The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1:785-789.
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
-
20
-
-
0035345532
-
Skeletal muscle triglyceride: An aspect of regional adiposity and insulin resistance
-
Kelly DE, Goodpaster BH. Skeletal muscle triglyceride: An aspect of regional adiposity and insulin resistance. Diabetes Care 2001; 4:933-941.
-
(2001)
Diabetes Care
, vol.4
, pp. 933-941
-
-
Kelly, D.E.1
Goodpaster, B.H.2
-
21
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type-2 diabetes
-
Petersen KF, Dufour S, Befroy D, et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type-2 diabetes. N Engl J Med 2004; 350:664-671.
-
(2004)
N Engl J Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
-
22
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type-2 diabetes
-
Kelley DE, He J, Menshikova EV, et al. Dysfunction of mitochondria in human skeletal muscle in type-2 diabetes. Diabetes 2002; 51:2944-2950.
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
-
23
-
-
0017375420
-
Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis
-
Newsholme EA, Sugden PH, Williams T. Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis. Biochem J 1977; 166:123-129.
-
(1977)
Biochem J
, vol.166
, pp. 123-129
-
-
Newsholme, E.A.1
Sugden, P.H.2
Williams, T.3
-
24
-
-
0021032715
-
Effect of fatty acids on glucose production and utilization in man
-
Ferrannini E, Barrett EJ, Bevilacqua S, et al. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 1983; 72:1737-1747.
-
(1983)
J Clin Invest
, vol.72
, pp. 1737-1747
-
-
Ferrannini, E.1
Barrett, E.J.2
Bevilacqua, S.3
-
25
-
-
0023706040
-
Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man
-
Lee KU, Lee HK, Koh CS, et al. Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man. Diabetologia 1988; 31:285-290.
-
(1988)
Diabetologia
, vol.31
, pp. 285-290
-
-
Lee, K.U.1
Lee, H.K.2
Koh, C.S.3
-
26
-
-
0022628695
-
In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: Assessment by euglycemic clamp plus deoxyglucose administration
-
Kraegen EW, James DE, Storlien LH, et al. In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: Assessment by euglycemic clamp plus deoxyglucose administration. Diabetologia 1986; 29:192-198.
-
(1986)
Diabetologia
, vol.29
, pp. 192-198
-
-
Kraegen, E.W.1
James, D.E.2
Storlien, L.H.3
-
27
-
-
0029962282
-
Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats
-
Kim JK, Wi JK, Youn JH. Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats. Diabetes 1996; 45:651-658.
-
(1996)
Diabetes
, vol.45
, pp. 651-658
-
-
Kim, J.K.1
Wi, J.K.2
Youn, J.H.3
-
28
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996; 97:2859-2865.
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
-
29
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46:3-10.
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
30
-
-
0033938601
-
Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats
-
Kim CH, Youn JH, Lee KU, et al. Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab 2000; 278: 1E977-E984.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
, pp. 1E977-1E984
-
-
Kim, C.H.1
Youn, J.H.2
Lee, K.U.3
-
31
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A, Laurent D, Shulman GI, et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 1999; 103:253-259.
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Shulman, G.I.3
-
32
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
Itani SI, Ruderman NB, Schmieder F, et al. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002; 51:2005-2011.
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
-
33
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Shulman GI, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999; 48:1270-1274.
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Shulman, G.I.3
-
34
-
-
0025195689
-
Effect of central obesity on regulation of carbohydrate metabolism in obese patients with varying degrees of glucose tolerance
-
Golay A, Chen N, Chen YD, et al. Effect of central obesity on regulation of carbohydrate metabolism in obese patients with varying degrees of glucose tolerance. J Clin Endocrinol Metab 1990; 71:1299-1304.
-
(1990)
J Clin Endocrinol Metab
, vol.71
, pp. 1299-1304
-
-
Golay, A.1
Chen, N.2
Chen, Y.D.3
-
35
-
-
0027946529
-
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
-
Kelley DE, Simoneau JA. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest 1994; 94:2349-2356.
-
(1994)
J Clin Invest
, vol.94
, pp. 2349-2356
-
-
Kelley, D.E.1
Simoneau, J.A.2
-
36
-
-
0027184935
-
Relationship between skeletal muscle lipoprotein lipase activity and 24-h macronutrient oxidation
-
Ferro R, Eckel R, Larson E, et al. Relationship between skeletal muscle lipoprotein lipase activity and 24-h macronutrient oxidation. J Clin Invest 1993; 92:441-445.
-
(1993)
J Clin Invest
, vol.92
, pp. 441-445
-
-
Ferro, R.1
Eckel, R.2
Larson, E.3
-
37
-
-
0030689043
-
Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
-
Oakes ND, Cooney GJ, Camilleri S, et al. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 1997; 46: 1768-1774.
-
(1997)
Diabetes
, vol.46
, pp. 1768-1774
-
-
Oakes, N.D.1
Cooney, G.J.2
Camilleri, S.3
-
38
-
-
0027424423
-
Interstitial glucose and lactate balance in human skeletal muscle and adipose tissue studied by microdialysis
-
Rosdahl H, Ungerstedt U, Jorfeldt L, et al. Interstitial glucose and lactate balance in human skeletal muscle and adipose tissue studied by microdialysis. J Physiol 1993; 471:637-657.
-
(1993)
J Physiol
, vol.471
, pp. 637-657
-
-
Rosdahl, H.1
Ungerstedt, U.2
Jorfeldt, L.3
-
39
-
-
0347629107
-
Lipolysis in skeletal muscle is decreased in high-fat-fed rats
-
Kim CH, Kim MS, Lee KU, et al. Lipolysis in skeletal muscle is decreased in high-fat-fed rats. Metabolism 2003; 52:1586-1592.
-
(2003)
Metabolism
, vol.52
, pp. 1586-1592
-
-
Kim, C.H.1
Kim, M.S.2
Lee, K.U.3
-
40
-
-
0032752951
-
Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
-
Simoneau JA, Veerkamp JH, Turcotte LP, et al. Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss. FASEB J 1999; 13:2051-2060.
-
(1999)
FASEB J
, vol.13
, pp. 2051-2060
-
-
Simoneau, J.A.1
Veerkamp, J.H.2
Turcotte, L.P.3
-
41
-
-
0017717091
-
Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase
-
Wititsuwannakul D, Kim KH. Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase. J Biol Chem 1977; 252:7812-7817.
-
(1977)
J Biol Chem
, vol.252
, pp. 7812-7817
-
-
Wititsuwannakul, D.1
Kim, K.H.2
-
42
-
-
0033755148
-
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance
-
Thompson AL, Cooney GJ. Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance. Diabetes 2000;49:1761-1765.
-
(2000)
Diabetes
, vol.49
, pp. 1761-1765
-
-
Thompson, A.L.1
Cooney, G.J.2
-
43
-
-
0030914330
-
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
-
Schmitz-Peiffer C, Browne CL, Biden TJ, et al. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 1997; 46:169-178.
-
(1997)
Diabetes
, vol.46
, pp. 169-178
-
-
Schmitz-Peiffer, C.1
Browne, C.L.2
Biden, T.J.3
-
44
-
-
0030784947
-
Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
-
Oakes ND, Bell KS, Kraegen EW, et al. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 1997; 46:2022-2028.
-
(1997)
Diabetes
, vol.46
, pp. 2022-2028
-
-
Oakes, N.D.1
Bell, K.S.2
Kraegen, E.W.3
-
45
-
-
0032946302
-
Malonyl-CoA, fuel sensing, and insulin resistance
-
Ruderman NB, Saha AK, Vavvas D, et al. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 1999; 276:E1-E18.
-
(1999)
Am J Physiol
, vol.276
, pp. E1-E18
-
-
Ruderman, N.B.1
Saha, A.K.2
Vavvas, D.3
-
46
-
-
3042821172
-
Muscle fat oxidative capacity is not impaired by age but by physical inactivity: Association with insulin sensitivity
-
Rimbert V, Boirie Y, Bedu M, et al. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: Association with insulin sensitivity. FASEB J 2004; 18:737-739.
-
(2004)
FASEB J
, vol.18
, pp. 737-739
-
-
Rimbert, V.1
Boirie, Y.2
Bedu, M.3
-
47
-
-
7044220612
-
A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance
-
Iossa S, Mollica MP, Lionetti L, et al. A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance. Diabetes 2004; 53:2861-2866.
-
(2004)
Diabetes
, vol.53
, pp. 2861-2866
-
-
Iossa, S.1
Mollica, M.P.2
Lionetti, L.3
-
48
-
-
0035344913
-
Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type-2 diabetic patients
-
Song J, Oh JY, Sung YA, et al. Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type-2 diabetic patients. Diabetes Care 2001; 24:865-869.
-
(2001)
Diabetes Care
, vol.24
, pp. 865-869
-
-
Song, J.1
Oh, J.Y.2
Sung, Y.A.3
-
49
-
-
0042266366
-
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
-
Short KR, Vittone JL, Nair KS, et al. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 2003; 52:1888-1896.
-
(2003)
Diabetes
, vol.52
, pp. 1888-1896
-
-
Short, K.R.1
Vittone, J.L.2
Nair, K.S.3
-
50
-
-
12144275294
-
Deficiency of subsarcolemmal mitochondria in obesity and type-2 diabetes
-
Ritov VB, Menshikova EV, He J, et al. Deficiency of subsarcolemmal mitochondria in obesity and type-2 diabetes. Diabetes 2005; 54:8-14.
-
(2005)
Diabetes
, vol.54
, pp. 8-14
-
-
Ritov, V.B.1
Menshikova, E.V.2
He, J.3
-
51
-
-
0015864346
-
Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol
-
Beg ZH, Allmann DW, Gibson DM. Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol. Biochem Biophys Res Commun 1973; 54:1362-1369.
-
(1973)
Biochem Biophys Res Commun
, vol.54
, pp. 1362-1369
-
-
Beg, Z.H.1
Allmann, D.W.2
Gibson, D.M.3
-
52
-
-
0015918822
-
Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation
-
Carlson CA, Kim KH. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J Biol Chem 1973; 248:378-390.
-
(1973)
J Biol Chem
, vol.248
, pp. 378-390
-
-
Carlson, C.A.1
Kim, K.H.2
-
53
-
-
0018963044
-
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge
-
Yeh LA, Lee KH, Kim KH. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge. J Biol Chem 1980; 255:2308-2314.
-
(1980)
J Biol Chem
, vol.255
, pp. 2308-2314
-
-
Yeh, L.A.1
Lee, K.H.2
Kim, K.H.3
-
54
-
-
0030792297
-
AMP-activated protein kinase isoenzyme family: Subunit structure and chromosomal location
-
Stapleton D, Woollatt E, Mitchelhill KI, et al. AMP-activated protein kinase isoenzyme family: Subunit structure and chromosomal location. FEBS Lett 1997; 409:452-456.
-
(1997)
FEBS Lett
, vol.409
, pp. 452-456
-
-
Stapleton, D.1
Woollatt, E.2
Mitchelhill, K.I.3
-
55
-
-
0034636006
-
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression
-
da Silva Xavier G, Leclerc I, Salt IP, et al. Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci USA2000; 97:4023-4028.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4023-4028
-
-
da Silva Xavier, G.1
Leclerc, I.2
Salt, I.P.3
-
56
-
-
0033815967
-
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
-
Woods A, Azzout-Marniche D, Foretz M, et al. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol 2000; 20:6704-6711.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6704-6711
-
-
Woods, A.1
Azzout-Marniche, D.2
Foretz, M.3
-
57
-
-
0032728266
-
Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle
-
Chen Z, Heierhorst J, Mann RJ, et al. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. FEBS Lett 1999; 460:343-348.
-
(1999)
FEBS Lett
, vol.460
, pp. 343-348
-
-
Chen, Z.1
Heierhorst, J.2
Mann, R.J.3
-
58
-
-
0038199737
-
Management of cellular energy by the AMP-activated protein kinase system
-
Hardie DG, Scott JW, Pan DA, et al. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 2003; 546:113-120.
-
(2003)
FEBS Lett
, vol.546
, pp. 113-120
-
-
Hardie, D.G.1
Scott, J.W.2
Pan, D.A.3
-
59
-
-
33745815985
-
AMP-activated protein kinase signaling in metabolic regulation
-
Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 2006; 116:1776-1783.
-
(2006)
J Clin Invest
, vol.116
, pp. 1776-1783
-
-
Long, Y.C.1
Zierath, J.R.2
-
60
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley SA, Pan DA, Mustard KJ, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005; 2:9-19.
-
(2005)
Cell Metab
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
-
61
-
-
12844281251
-
AMPK, the metabolic syndrome and cancer
-
Luo Z, Saha AK, Xiang X, et al. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 2005; 26:69-76.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 69-76
-
-
Luo, Z.1
Saha, A.K.2
Xiang, X.3
-
62
-
-
0035665594
-
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
-
Bergeron R, Ren JM, Cadman KS, et al. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 2001; 281:E1340-E1346.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.281
, pp. E1340-E1346
-
-
Bergeron, R.1
Ren, J.M.2
Cadman, K.S.3
-
63
-
-
0037058977
-
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
-
Zong H, Ren JM, Young LH, et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 2002; 99:15983-15987.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15983-15987
-
-
Zong, H.1
Ren, J.M.2
Young, L.H.3
-
64
-
-
1542373685
-
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
-
Kelly DP, Scarpullar RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004; 18:357-368.
-
(2004)
Genes Dev
, vol.18
, pp. 357-368
-
-
Kelly, D.P.1
Scarpullar, R.C.2
-
65
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98:115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
-
66
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310:1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
-
67
-
-
0037067666
-
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
-
Fryer LG, Parbu-Patel A, Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002; 277:25226-25232.
-
(2002)
J Biol Chem
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
Carling, D.3
-
68
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8:1288-1295.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
-
69
-
-
0242581695
-
Adiponectin stimulates production of nitric oxide in vascular endothelial cells
-
Chen H, Montagnani M, Funahashi T, et al. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003; 278:45021-45026.
-
(2003)
J Biol Chem
, vol.278
, pp. 45021-45026
-
-
Chen, H.1
Montagnani, M.2
Funahashi, T.3
-
70
-
-
33644869305
-
Chronic rosiglitazone treatment restores AMPK alpha 2 activity in insulin-resistant rat skeletal muscle
-
Lessard SJ, Chen ZP, Watt MJ, et al. Chronic rosiglitazone treatment restores AMPK alpha 2 activity in insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab 2006; 290:E251-E257.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.290
, pp. E251-E257
-
-
Lessard, S.J.1
Chen, Z.P.2
Watt, M.J.3
-
71
-
-
0017375420
-
Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis
-
Newsholme EA, Sugden PH, Williams T. Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis. Biochem J 1977; 166:123-129.
-
(1977)
Biochem J
, vol.166
, pp. 123-129
-
-
Newsholme, E.A.1
Sugden, P.H.2
Williams, T.3
-
72
-
-
0037163076
-
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
-
Marsin AS, Bouzin C, Bertrand L, et al. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 2002; 277:30778-83.
-
(2002)
J Biol Chem
, vol.277
, pp. 30778-30783
-
-
Marsin, A.S.1
Bouzin, C.2
Bertrand, L.3
-
73
-
-
0031849916
-
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
-
Hayashi T, Hirshman MF, Kurth EJ, et al. Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 1998;47:1369-1373.
-
(1998)
Diabetes
, vol.47
, pp. 1369-1373
-
-
Hayashi, T.1
Hirshman, M.F.2
Kurth, E.J.3
-
74
-
-
0034637538
-
Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside
-
Saha AK, Schwarsin AJ, Ruderman NB, et al. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside. J Biol Chem 2000; 275:24279-24283.
-
(2000)
J Biol Chem
, vol.275
, pp. 24279-24283
-
-
Saha, A.K.1
Schwarsin, A.J.2
Ruderman, N.B.3
-
75
-
-
0345374578
-
Minireview: Malonyl-CoA, AMP-activated protein kinase, and adiposity
-
Ruderman NB, Saha AK, Kraegen EW. Minireview: Malonyl-CoA, AMP-activated protein kinase, and adiposity. Endocrinology 2003; 144:5166-5171.
-
(2003)
Endocrinology
, vol.144
, pp. 5166-5171
-
-
Ruderman, N.B.1
Saha, A.K.2
Kraegen, E.W.3
-
76
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415:339-343.
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
-
77
-
-
0037059013
-
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
-
Tomas E, Tsao TS, Saha AK, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A 2002; 99:16309-16313.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16309-16313
-
-
Tomas, E.1
Tsao, T.S.2
Saha, A.K.3
-
78
-
-
0036430469
-
Dissociation of AMPK activity and ACC beta phosphorylation in human muscle during prolonged exercise
-
Wojtaszewski JF, Mourtzakis M, Hillig T, et al. Dissociation of AMPK activity and ACC beta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun 2002; 98:309-316.
-
(2002)
Biochem Biophys Res Commun
, vol.98
, pp. 309-316
-
-
Wojtaszewski, J.F.1
Mourtzakis, M.2
Hillig, T.3
-
79
-
-
0037031840
-
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
-
Park H, Kaushik VK, Saha AK, et al. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem 2002; 277:32571-32577.
-
(2002)
J Biol Chem
, vol.277
, pp. 32571-32577
-
-
Park, H.1
Kaushik, V.K.2
Saha, A.K.3
-
80
-
-
0042423598
-
Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles
-
Suwa M, Nakano H, Kumagai S. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J Appl Physiol 2003; 95:960-968.
-
(2003)
J Appl Physiol
, vol.95
, pp. 960-968
-
-
Suwa, M.1
Nakano, H.2
Kumagai, S.3
-
81
-
-
0036288154
-
Exercise training increases lipid metabolism gene expression in human skeletal muscle
-
Tunstall RJ, Mehan KA, Cameron-Smith D, et al. Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab 2002; 283:E66-E72.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
, pp. E66-E72
-
-
Tunstall, R.J.1
Mehan, K.A.2
Cameron-Smith, D.3
-
82
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108:1167-1174.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
-
83
-
-
0035406121
-
Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase
-
Leclerc I, Lenzner C, Gourdon L, et al. Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes 2001; 50:1515-1521.
-
(2001)
Diabetes
, vol.50
, pp. 1515-1521
-
-
Leclerc, I.1
Lenzner, C.2
Gourdon, L.3
-
84
-
-
0015918822
-
Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation
-
Carlson CA, Kim KH. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J Biol Chem 1973; 248:378-80.
-
(1973)
J Biol Chem
, vol.248
, pp. 378-380
-
-
Carlson, C.A.1
Kim, K.H.2
-
85
-
-
10644256593
-
Role of the liver in the control of carbohydrate and lipid homeostasis
-
Postic C, Dentin R, Girard J. Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes Metab 2004; 30:398-408.
-
(2004)
Diabetes Metab
, vol.30
, pp. 398-408
-
-
Postic, C.1
Dentin, R.2
Girard, J.3
-
86
-
-
0029775873
-
Hypoglycemic effect of AICA riboside in mice
-
Vincent MF, Erion MD, Gruber HE, et al. Hypoglycemic effect of AICA riboside in mice. Diabetologia 1996; 39:1148-1155.
-
(1996)
Diabetologia
, vol.39
, pp. 1148-1155
-
-
Vincent, M.F.1
Erion, M.D.2
Gruber, H.E.3
-
87
-
-
0042330251
-
Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
-
Rajala MW, Scherer PE. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144: 3765-3773.
-
(2003)
Endocrinology
, vol.144
, pp. 3765-3773
-
-
Rajala, M.W.1
Scherer, P.E.2
-
88
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo SH, Flechner L, Qi L, et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 2005; 437:1109-1111.
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
Flechner, L.2
Qi, L.3
-
89
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310:1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
-
90
-
-
0033036636
-
AMP-activated protein kinase phosphorylation of endothelial NO synthase
-
Chen ZP, Mitchelhill KI, Michell BJ, et al. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 1999; 443:285-289.
-
(1999)
FEBS Lett
, vol.443
, pp. 285-289
-
-
Chen, Z.P.1
Mitchelhill, K.I.2
Michell, B.J.3
-
91
-
-
0035933369
-
Acute regulation of fatty acid oxidation and AMP-activated protein kinase in human umbilical vein endothelial cells
-
Dagher Z, Ruderman N, Tornheim K, et al. Acute regulation of fatty acid oxidation and AMP-activated protein kinase in human umbilical vein endothelial cells. Circ Res 2001; 88:1276-1282.
-
(2001)
Circ Res
, vol.88
, pp. 1276-1282
-
-
Dagher, Z.1
Ruderman, N.2
Tornheim, K.3
-
92
-
-
0037328928
-
Malonyl-CoA and AMP-activated protein kinase (AMPK): Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
-
Ruderman NB, Cacicedo JM, Itani S, et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans 2003; 31:202-206.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 202-206
-
-
Ruderman, N.B.1
Cacicedo, J.M.2
Itani, S.3
-
93
-
-
0036095269
-
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation
-
Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation. Diabetes 2002; 51:159-167.
-
(2002)
Diabetes
, vol.51
, pp. 159-167
-
-
Ido, Y.1
Carling, D.2
Ruderman, N.3
-
94
-
-
0038584871
-
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
-
da Silva Xavier G, Leclerc I, Varadi A, et al. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 2003; 371:761-774.
-
(2003)
Biochem J
, vol.371
, pp. 761-774
-
-
da Silva Xavier, G.1
Leclerc, I.2
Varadi, A.3
-
95
-
-
0037301056
-
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
-
Kefas BA, Heimberg H, Vaulont S, et al. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia 2003; 46:250-254.
-
(2003)
Diabetologia
, vol.46
, pp. 250-254
-
-
Kefas, B.A.1
Heimberg, H.2
Vaulont, S.3
-
96
-
-
1642546212
-
Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
-
Diraison F, Parton L, Ferre P, et al. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J 2004; 378:769-778.
-
(2004)
Biochem J
, vol.378
, pp. 769-778
-
-
Diraison, F.1
Parton, L.2
Ferre, P.3
-
97
-
-
0019505898
-
Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats
-
Davis JD, Wirtshafter D, Asin KE, et al. Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats. Science 1981; 212:81-3.
-
(1981)
Science
, vol.212
, pp. 81-83
-
-
Davis, J.D.1
Wirtshafter, D.2
Asin, K.E.3
-
98
-
-
0036065628
-
Central administration of oleic acid inhibits glucose production and food intake
-
Obici S, Feng Z, Morgan K, et al. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002; 51:271-5.
-
(2002)
Diabetes
, vol.51
, pp. 271-275
-
-
Obici, S.1
Feng, Z.2
Morgan, K.3
-
99
-
-
0017663816
-
Hunger in humans induced by 2-deoxy-d-glucose: Glucoprivic control of taste preference and food intake
-
Thompson DA, Campbell RG. Hunger in humans induced by 2-deoxy-d-glucose: Glucoprivic control of taste preference and food intake. Science 1977; 198: 1065-1068.
-
(1977)
Science
, vol.198
, pp. 1065-1068
-
-
Thompson, D.A.1
Campbell, R.G.2
-
100
-
-
0034677059
-
Effect of 2-mercaptoacetate and 2-deoxy-d-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus
-
Sergeyev V, Broberger C, Gorbatyuk O, et al. Effect of 2-mercaptoacetate and 2-deoxy-d-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus. Neuroreport 2000; 11:117-121.
-
(2000)
Neuroreport
, vol.11
, pp. 117-121
-
-
Sergeyev, V.1
Broberger, C.2
Gorbatyuk, O.3
-
101
-
-
0034733730
-
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
-
Loftus TM, Jaworsky DE, Frehywot GL, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 2379-2381.
-
(2000)
Science
, vol.288
, pp. 2379-2381
-
-
Loftus, T.M.1
Jaworsky, D.E.2
Frehywot, G.L.3
-
102
-
-
0038037734
-
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
-
Obici S, Feng Z, Arduini A, Conti R, et al. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 2003; 9:756-761.
-
(2003)
Nat Med
, vol.9
, pp. 756-761
-
-
Obici, S.1
Feng, Z.2
Arduini, A.3
Conti, R.4
-
103
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428:569-574.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
-
104
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
Andersson U, Filipsson K, Abbott CR, et al. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004; 279:12005-12008.
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
-
105
-
-
2442631468
-
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
-
Kim EK, Miller I, Aja S, et al. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 2004; 279:19970-19976.
-
(2004)
J Biol Chem
, vol.279
, pp. 19970-19976
-
-
Kim, E.K.1
Miller, I.2
Aja, S.3
-
106
-
-
9144219529
-
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism
-
Landree LE, Hanlon AL, Strong DW, et al. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. J Biol Chem 2004; 279:3817-3827.
-
(2004)
J Biol Chem
, vol.279
, pp. 3817-3827
-
-
Landree, L.E.1
Hanlon, A.L.2
Strong, D.W.3
-
107
-
-
19944426367
-
Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats
-
Namkoong C, Kim MS, Jang PG, et al. Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 2005; 54:63-68.
-
(2005)
Diabetes
, vol.54
, pp. 63-68
-
-
Namkoong, C.1
Kim, M.S.2
Jang, P.G.3
-
108
-
-
11144242445
-
Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior
-
Lee K, Li B, Xi X, Suh Y, et al. Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 2005; 146:3-10.
-
(2005)
Endocrinology
, vol.146
, pp. 3-10
-
-
Lee, K.1
Li, B.2
Xi, X.3
Suh, Y.4
-
109
-
-
0037461107
-
Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes
-
Light PE, Wallace CH, Dyck JR. Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes. Circulation 2003; 107:1962-1965.
-
(2003)
Circulation
, vol.107
, pp. 1962-1965
-
-
Light, P.E.1
Wallace, C.H.2
Dyck, J.R.3
-
110
-
-
0033933777
-
Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase
-
Hallows KR, Raghuram V, Kemp BE, et al. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest 2000; 105:1711-1721.
-
(2000)
J Clin Invest
, vol.105
, pp. 1711-1721
-
-
Hallows, K.R.1
Raghuram, V.2
Kemp, B.E.3
-
111
-
-
22044443268
-
The molecular basis for oxidative stress-induced insulin resistance
-
Evans JL, Maddux BA, Goldfine ID. The molecular basis for oxidative stress-induced insulin resistance. Antioxid Redox Signal 2005; 7:1040-1052.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1040-1052
-
-
Evans, J.L.1
Maddux, B.A.2
Goldfine, I.D.3
-
112
-
-
0037219409
-
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
-
Evans JL, Goldfine ID, Maddux BA, et al. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003; 52:1-8.
-
(2003)
Diabetes
, vol.52
, pp. 1-8
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
-
113
-
-
0035140346
-
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of alpha-lipoic acid
-
Maddux BA, See W, Lawrence JC Jr, et al. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of alpha-lipoic acid. Diabetes 2001; 50:404-410.
-
(2001)
Diabetes
, vol.50
, pp. 404-410
-
-
Maddux, B.A.1
See, W.2
Lawrence, J.C.3
-
114
-
-
0031683542
-
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes
-
Rudich A, Tirosh A, Potashnik R, et al. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 1998; 47:1562-1569.
-
(1998)
Diabetes
, vol.47
, pp. 1562-1569
-
-
Rudich, A.1
Tirosh, A.2
Potashnik, R.3
-
115
-
-
0141679355
-
Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells
-
Gardner CD, Eguchi S, Reynolds CM, et al. Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells. Exp Biol Med (Maywood) 2003; 228: 836-842.
-
(2003)
Exp Biol Med (Maywood)
, vol.228
, pp. 836-842
-
-
Gardner, C.D.1
Eguchi, S.2
Reynolds, C.M.3
-
116
-
-
0032799487
-
Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes
-
Rudich A, Tirosh A, Potashnik R, et al. Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. Diabetologia 1999; 42:949-957.
-
(1999)
Diabetologia
, vol.42
, pp. 949-957
-
-
Rudich, A.1
Tirosh, A.2
Potashnik, R.3
-
117
-
-
0029742327
-
The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle
-
Jacob S, Streeper RS, Fogt DL, et al. The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 1996; 45:1024-1029.
-
(1996)
Diabetes
, vol.45
, pp. 1024-1029
-
-
Jacob, S.1
Streeper, R.S.2
Fogt, D.L.3
-
118
-
-
4143080212
-
Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats
-
Saengsirisuwan V, Perez FR, Sloniger JA, et al. Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats. Am J Physiol Endocrinol Metab 2004; 287:E529-E536.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
, pp. E529-E536
-
-
Saengsirisuwan, V.1
Perez, F.R.2
Sloniger, J.A.3
-
119
-
-
0034968005
-
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats
-
Saengsirisuwan V, Kinnick TR, Schmit MB, et al. Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats. J Appl Physiol 2001; 91:145-153.
-
(2001)
J Appl Physiol
, vol.91
, pp. 145-153
-
-
Saengsirisuwan, V.1
Kinnick, T.R.2
Schmit, M.B.3
-
120
-
-
0029978685
-
Improvement of insulin-stimulated glucose-disposal in type-2 diabetes after repeated parenteral administration of thioctic acid
-
Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type-2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes 1996; 104:284-288.
-
(1996)
Exp Clin Endocrinol Diabetes
, vol.104
, pp. 284-288
-
-
Jacob, S.1
Henriksen, E.J.2
Tritschler, H.J.3
-
121
-
-
0026757632
-
Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
-
Robertson RP, Zhang HJ, Pyzdrowski KL, et al. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest 1992; 90:320-325.
-
(1992)
J Clin Invest
, vol.90
, pp. 320-325
-
-
Robertson, R.P.1
Zhang, H.J.2
Pyzdrowski, K.L.3
-
122
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994; 93:870-876.
-
(1994)
J Clin Invest
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
-
123
-
-
0027414370
-
Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack
-
Burkart V, Koike T, Brenner HH, et al. Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack. Agents Actions 1993; 38:60-65.
-
(1993)
Agents Actions
, vol.38
, pp. 60-65
-
-
Burkart, V.1
Koike, T.2
Brenner, H.H.3
-
124
-
-
15244343075
-
Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets
-
Schroeder MM, Belloto RJ Jr, Hudson RA, et al. Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets. Immunopharmacol Immunotoxicol 2005; 27:109-122.
-
(2005)
Immunopharmacol Immunotoxicol
, vol.27
, pp. 109-122
-
-
Schroeder, M.M.1
Belloto, R.J.2
Hudson, R.A.3
-
125
-
-
0033570271
-
Oxidative stress as a regulator of gene expression in the vasculature
-
Kunsch C, Medford RM. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 1999; 85:753-766.
-
(1999)
Circ Res
, vol.85
, pp. 753-766
-
-
Kunsch, C.1
Medford, R.M.2
-
126
-
-
0034843965
-
Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis
-
Choy JC, Granville DJ, Hunt DW, et al. Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 2001; 33:1673-1690.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 1673-1690
-
-
Choy, J.C.1
Granville, D.J.2
Hunt, D.W.3
-
127
-
-
0033552883
-
Atherosclerosis-an inflammatory disease
-
Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-126.
-
(1999)
N Engl J Med
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
128
-
-
0022640297
-
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
-
Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986; 320:454-456.
-
(1986)
Nature
, vol.320
, pp. 454-456
-
-
Gryglewski, R.J.1
Palmer, R.M.2
Moncada, S.3
-
129
-
-
0035158577
-
Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
-
Zhang WJ, Frei B. Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. FASEB J 2001; 15:2423-2432.
-
(2001)
FASEB J
, vol.15
, pp. 2423-2432
-
-
Zhang, W.J.1
Frei, B.2
-
130
-
-
33747770115
-
Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery
-
Lee KM, Park KG, Kim YD, et al. Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery. Atherosclerosis 2006; 189:106-114.
-
(2006)
Atherosclerosis
, vol.189
, pp. 106-114
-
-
Lee, K.M.1
Park, K.G.2
Kim, Y.D.3
-
131
-
-
9644308047
-
Prevention and treatment of macroangiopathy: Focusing on oxidative stress
-
Park KG, Kim MJ, Kim HS, et al. Prevention and treatment of macroangiopathy: Focusing on oxidative stress. Diabetes Res Clin Pract 2004; 66:S57-S62.
-
(2004)
Diabetes Res Clin Pract
, vol.66
, pp. S57-S62
-
-
Park, K.G.1
Kim, M.J.2
Kim, H.S.3
-
132
-
-
33744933422
-
Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells
-
Targonsky ED, Dai F, Koshkin V, et al. Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 2006; 49:1587-1598.
-
(2006)
Diabetologia
, vol.49
, pp. 1587-1598
-
-
Targonsky, E.D.1
Dai, F.2
Koshkin, V.3
-
133
-
-
0033042929
-
R-Alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
-
Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. R-Alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 1999; 13:411-418.
-
(1999)
FASEB J
, vol.13
, pp. 411-418
-
-
Hagen, T.M.1
Ingersoll, R.T.2
Lykkesfeldt, J.3
-
134
-
-
2342544918
-
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress
-
Smith AR, Shenvi SV, Widlansky M, et al. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004; 11:1135-1146.
-
(2004)
Curr Med Chem
, vol.11
, pp. 1135-1146
-
-
Smith, A.R.1
Shenvi, S.V.2
Widlansky, M.3
-
135
-
-
0038025936
-
Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia
-
Schafer M, Schafer C, Ewald N, et al. Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia. Circ Res 2003; 92:1010-1015.
-
(2003)
Circ Res
, vol.92
, pp. 1010-1015
-
-
Schafer, M.1
Schafer, C.2
Ewald, N.3
-
136
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000; 26:435-439.
-
(2000)
Nat Genet
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
Onuma, H.2
Pecqueur, C.3
-
137
-
-
20044391092
-
The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells
-
Park JY, Park KG, Kim HJ, et al. The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells. Diabetologia 2005; 48: 1022-1028.
-
(2005)
Diabetologia
, vol.48
, pp. 1022-1028
-
-
Park, J.Y.1
Park, K.G.2
Kim, H.J.3
-
138
-
-
20444437554
-
Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis
-
Lee KU, Lee IK, Han J, et al. Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circ Res 2005; 96:1200-1207.
-
(2005)
Circ Res
, vol.96
, pp. 1200-1207
-
-
Lee, K.U.1
Lee, I.K.2
Han, J.3
-
139
-
-
0036845661
-
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons
-
Russell JW, Golovoy D, Vincent AM, et al. High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J 2002; 16:1738-1748.
-
(2002)
FASEB J
, vol.16
, pp. 1738-1748
-
-
Russell, J.W.1
Golovoy, D.2
Vincent, A.M.3
-
140
-
-
0032796613
-
Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinemia
-
Niimi M, Sato M, Yokote R, et al. Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinemia. J Neuroendocrinol 1999; 11:605-611.
-
(1999)
J Neuroendocrinol
, vol.11
, pp. 605-611
-
-
Niimi, M.1
Sato, M.2
Yokote, R.3
-
141
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1:1155-1161.
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
|