Dissociation of AMPK activity and ACCβ phosphorylation in human muscle during prolonged exercise

Biochemical and Biophysical Research Communications

Volumn 298, Issue 3, 2002, Pages 309-316

  Wojtaszewski, Jorgen F P ^a   Mourtzakis, Marina ^b   Hillig, Thore ^a   Saltin, Bengt ^c   Pilegaard, Henriette ^d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF GUELPH   (Canada)

^c Rigshospitalet   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

5 AMP activated protein kinase; Acetyl CoA carboxylase ; FA uptake; Glucose uptake; Glycogenolysis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; FATTY ACID; SERINE; THREONINE;

ADULT; ARTICLE; COMBUSTION; CONTROLLED STUDY; CYCLING; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; EXERCISE; EXHAUSTION; FATTY ACID TRANSPORT; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE; MUSCLE METABOLISM; NORMAL HUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; THIGH;

ACETYL-COA CARBOXYLASE; ADULT; AMINO ACID SEQUENCE; BLOOD GLUCOSE; ENERGY METABOLISM; ENZYME ACTIVATION; EXERCISE; FATTY ACIDS; GLYCOGEN; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0036430469     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02465-8     Document Type: Article

References (41)

1. W.W. Winder, D.G. Hardie, AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes, Am. J. Physiol. 277 (1999) E1-E10.
2. W.W. Winder, D.G. Hardie, Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise, Am. J. Physiol. 270 (1996) E299-E304.
3. J.F.P. Wojtaszewski, P. Nielsen, B.F. Hansen, E.A. Richter, B. Kiens, Isoform specific and exercise intensity dependent activation of 5′AMP-activated protein kinase in human skeletal muscle, J. Physiol. 528 (2000) 221-226.
4. C.A. Hutber, D.G. Hardie, W.W. Winder, Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase, Am. J. Physiol. 272 (1997) E262-E266.
5. D.G. Hardie, D. Carling, M. Carlson, The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67 (1998) 821-855.
6. N. Fujii, T. Hayashi, M.F. Hirshman, T.J. Smith, S.A. Habinowski, L. Kaijser, J. Mu, O. Ljungqvist, M.J. Birnbaum, L.A. Witters, A. Thorell, L.J. Goodyear, Exercise induces isoform specific increase in 5′AMP-activated protein kinase activity in human skeletal muscle, Biochem. Biophys. Res. Commun. 273 (2000) 1150-1155.
7. N. Musi, N. Fujii, M.F. Hirshman, I. Ekberg, S. Fröberg, O. Ljungqvist, A. Thorell, L.J. Goodyear, AMP activated protein kinase is activated in muscle of subjects with type 2 diabetes during exercise, Diabetes 50 (2001) 921-927.
8. Z.P. Chen, G.K. McConell, B.J. Michell, R.J. Snow, B.J. Canny, B.E. Kemp, AMPK signaling in contracting human skeletal muscle: Acetyl-CoA carboxylase and NO synthase phosphorylation, Am. J. Physiol. 279 (2000) E1202-E1206.
9. T.J. Stephens, Z.P. Chen, B.J. Canny, B.J. Michell, B.E. Kemp, G.K. McConell, Progressive increase in human skeletal muscle AMPK α2 activity and ACC phosphorylation during exercise, Am. J. Physiol. 282 (2002) E688-E694.
10. G.F. Merrill, E.J. Kurth, D.G. Hardie, W.W. Winder, Fatty acid oxidation, and glucose uptake in rat muscle, Am. J. Physiol. 273 (1997) E1107-E1112.
11. J. Mu, J.T. Brozinick Jr., O. Valladares, M. Bucan, M. Birnbaum, A role for AMP activated protein kinase in contraction and hypoxia regulated glucose transport in skeletal muscle, Mol. Cell 7 (2001) 1085-1094.
12. L.G. Fryer, F. Foufelle, K. Barnes, S.A. Baldwin, A. Woods, D. Carling, Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells, Biochem. J. 363 (2002) 167-174.
13. T. Hayashi, M.F. Hirshman, E.J. Kurth, W.W. Winder, L.J. Goodyear, Evidence for 5′AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport, Diabetes 47 (1998) 1369-1373.
14. Z. Yan, M.K. Spencer, A. Katz, ELect of low glycogen on glycogen synthase in human muscle during and after exercise, Acta Physiol. Scand. 145 (1992) 345-352.
15. D. Carling, D.G. Hardie, The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase, Biochim. Biophys. Acta 1012 (1989) 81-86.
16. I.P. Salt, G. Johnson, S.J. Ashcroft, D.G. Hardie, AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release, Biochem. J. 335 (1998) 533-539.
17. S.J. Yeaman, J.L. Armstrong, S.M. Bonavaud, D. Poinasamy, L. Pickersgill, R. Halse, Regulation of glycogen synthesis in human muscle cells, Biochem. Soc. Trans. 29 (2001) 537-541.
18. J.F.P. Wojtaszewski, S.B. Jørgensen, Y. Hellsten, D.G. Hardie, E.A. Richter, Glycogen dependent eLects of AICAR on 5′AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle, Diabetes 51 (2002) 284-292.
19. W. Derave, J. Ihlemann, L. Witters, S. Kristiansen, E.A. Richter, T. Ploug, Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle, Diabetes 49 (2000) 1281-1287.
20. K. Kawanaka, L.A. Nolte, D.H. Han, P.A. Hansen, J.O. Holloszy, Mechanisms underlying impaired GLUT-4 translocation in glycogen supercompensated muscles of exercised rats, Am. J. Physiol. 279 (2000) E1311-E1318.
21. E.A. Richter, C. Macdonald, B. Kiens, D.G. Hardie, J.F.P. Wojtaszewski, Dissociation of 5′AMP-activated protein kinase activity and glucose clearance in human skeletal muscle during exercise, Diabetes 50 (2001) A62.
22. N.B. Ruderman, A.K. Saha, D. Vavvas, T. Kurowski, D.R. Laybutt, C. Schmitz-peiLer, T. Biden, E.W. Kraegen, Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity, Adv. Exp. Med. Biol. 441 (1998) 263-270.
23. J. Ha, S. Daniel, S.S. Broyles, K.-H. Kim, Critical phosphorylation sites for acetyl-CoA carboxylase activity, J. Biol. Chem. 269 (1994) 22162-22168.
24. S.P. Davies, A.T. Sim, D.G. Hardie, Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase, Eur. J. Biochem. 187 (2001) 183-190.
25. A.K. Saha, A.J. Schwarsin, R. Roduit, F. Masse, V. Kaushik, K. Tornheim, M. Prentki, N.B. Ruderman, Activation of malonyl CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, J. Biol. Chem. (2001) 24279-24283.
26. S.A. Habinowski, M.F. Hirshman, K. Sakamoto, B.E. Kemp, S.L. Gould, L.J. Goodyear, L.A. Witters, Manolyl-CoA decar-boxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or islet cell line, Arch. Biochem. Biophys. 396 (2001) 71-79.
27. D. Chien, D. Dean, A.K. Saha, J.P. Flatt, N.B. Ruderman, Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo, Am. J. Physiol. (2001) E259-E265.
28. N. Alam, E.D. Saggerson, Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle, Biochem. J. 334 (1998) 233-241.
29. D.J. Dean, J.R. Daugaard, M.E. Young, A. Saha, D. Vavvas, S. Asp, B. Kiens, K.-H. Kim, L.A. Witters, E.A. Richter, N.B. Ruderman, Exercise diminishes the activity of acetyl CoA carboxylase in human muscle, Diabetes 49 (2000) 1295-1300.
30. L.M. Odland, R.A. Howlett, G.J. Heigenhauser, E. Hultman, L.L. Spriet, Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans, Am. J. Physiol. 274 (2001) E1080-E1085.
31. L.M. Odland, G.J. Heigenhauser, G.D. Lopaschuk, L.L. Spriet, Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise, Am. J. Physiol. 270 (1996) E541-E544.
32. G. Radegran, Ultrasound Doppler estimate of femoral artery blood flow during dynamic extensor exercise in human, J. Appl. Physiol. 83 (1997) 1383-1388.
33. O.L. Wade, J.M. Bishop, Cardiac Output and Regional Blood Flow, Blackwell, Oxford, 1962.
34. O.H. Lowry, J.V. Passonneau, A flexible system of enzymatic analysis, Academic Press, London, 1972.
35. S. Smhimizu, K. Inoue, Y. Tani, H. Yamada, Enzymatic microdetermination of serum free fatty acids, Anal. Biochem. 98 (1979) 341-345.
36. P.C. Tullson, D.M. Whitlock, R.L. Terjung, Adenine nucleotide degradation in slow-twitch red muscle, J. Physiol. 520 (1990) 909-920.
37. J.F. Markuns, J.F.P. Wojtaszewski, L.J. Goodyear, Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle, J. Biol. Chem. 274 (1999) 24896-24900.
38. K. Frayn, Calculation of substrate oxidation rates in vivo from gaseous exchange, J. Appl. Physiol. 55 (1983) 628-634.
39. S.H. Park, S.R. Gammon, J.D. Knippers, S.R. Paulsen, D.S. Rubink, W.W. Winder, Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle, J. Appl. Physiol. 92 (2002) 2475-2482.
40. J.N. Nielsen, J.F.P. Wojtaszewski, R.G. Haller, D.G. Hardie, B.E. Kemp, E.A. Richter, J. Vissing, Role of 5′AMP-activated protein kinase in exercise regulation of glucose utilization and glycogen synthase activity in skeletal muscle; insights from patients with McArdles3s disease, J. Physiol. 541 (2002) 979-989.
41. G. Ahlborg, P. Felig, L. Hagenfeldt, R. Hendler, J. Wahren, Substrate turnover during prolonged exercise in man, J. Clin. Invest. 53 (1973) 1080-1090.