Hypoglycaemic effect of AICAriboside in mice

Diabetologia

Volumn 39, Issue 10, 1996, Pages 1148-1155

  Vincent, M F ^a,c   Erion, M D ^b   Gruber, H E ^b   Van Den Berghe, G ^a  

^a International Institute of Cellular and Molecular Pathology   (Belgium)

^b Gensia Inc   (United States)

^c Laboratory of Medicinal Chemistry   (Belgium)

Author keywords

AICAriboside; Fructose 1,6 bisphosphatase; Gluconeogenesis; Z nucleotides

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE PHOSPHATE; FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLYCOGEN; INSULIN; LACTIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG METABOLISM; DRUG TISSUE LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER FUNCTION; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029775873     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02658500     Document Type: Article

References (33)

1. Vincent MF, Marangos PJ, Gruber HE, Van den Berghe G (1991) Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes. Diabetes 40: 1259-1266
2. Sabina RL, Holmes EW, Becker MA (1984) The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP). Science 223:1193-1195
3. Sherratt HS (1981) Inhibition of gluconeogenesis by nonhormonal hypoglycaemic compounds. In: Hue L, van de Werve G (eds) Short-term regulation of liver metabolism. Elsevier/North-Holland, Amsterdam, pp 199-227
4. Wollenberger A, Ristau O, Schoffa G (1960) A simple technique for extremely rapid freezing of large pieces of tissue. Arch Ges Physiol 270:399-412
5. Hohorst HJ (1965) L-(+)-Lactate. Determination with lactic dehydrogenase and DPN. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 266-270
6. Lamprecht W, Heinz F (1985) D-Glycerate 2-phosphate and phosphoenol-pyruvate. In: Bergmeyer HU (ed) Methods of enzymatic analysis, 3rd edn, vol 6. Chemi, Weinheim, pp 555-561
7. Czok R (1985) D-Glycerate 3-phosphate. In: Bergmeyer HU (ed) Methods of enzymatic analysis, 3rd edn, vol 6. Chemie, Weinheim, pp 537-541
8. Michal G (1985) D-fructose-1,6-diphosphate, dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. In: Bergmeyer HU (ed) Methods of enzymatic analysis, 3rd edn, vol 6. Chemie, Weinheim, pp 342-350
9. Huggett A St G, Nixon DA (1957) Enzymic determination of blood glucose. Biochem J 66:12P
10. Maes M, Ketelslegers JM, Underwood LE (1983) Low plasma somatomedin-C in streptozotocin-induced diabetes mellitus. Correlation with changes in somatogenic and lactogenic liver binding sites. Diabetes 32:1060-1069
11. Elliott J, Hems DA, Beloff-Chain A (1971) Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese-hyperglycaemic (ob/ob) mice. Biochem J 125:773-780
12. Assimacopoulos-Jeannet F, Exton JH, Jeanrenaud B (1973) Control of gluconeogenesis and glycogenolysis in perfused livers of normal mice. Am J Physiol 225:25-32
13. Claus TH, EI-Maghrabi MR, Pilkis SJ (1979) Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin. J Biol Chem 254:7855-7864
14. Van Schaftingen E, Hue L, Hers HG (1980) Study of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in the liver in vivo. Biochem J 192:263-271
15. Dixon R, Gourzis J, McDermott D, Fujitaki J, Dewland P, Gruber H (1991) AICA-riboside: safety, tolerance and pharmacokinetics of a novel adenosine-regulating agent. J Clin Pharmacol 31:342-347
16. Menasché P, Jamieson WRE, Flameng W, Davies MK (1995) Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. J Thorac Cardiovasc Surg 110:1096-1106
17. Akkan AG, Malaisse WJ (1994) Insulinotropic action of AICAriboside. I. Insulin release by isolated islets and the perfused pancreas. Diabetes Res 25:13-23
18. Vincent MF, Bontemps F, Van den Berghe G (1992) Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes. Biochem J 281:267-272
19. Henin N, Vincent MF, Gruber HE, Van den Berghe G (1995) Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J 9:541-546
20. Salmon DMW, Bowen NL, Hems DA (1974) Synthesis of fatty acids in the perfused mouse liver. Biochem J 142:611-618
21. Buchalter SE, Crain MR, Kreisberg R (1989) Regulation of lactate metabolism in vivo. Diabet Metab Rev 5:379-391
22. 13C NMR. Science 254:573-576
23. Yki-Järvinen H, Helve E, Sane T, Nurjhan N, Taskinen M-R (1989) Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM. Am J Physiol 256:E732-E739
24. Blackshear PJ, Holloway PAH, Alberti KGMM (1975) Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis. Studies on whole animals and after functional hepatectomy. Biochem J 146:447-456
25. Pagliara AS, Karl IE, Keating JP, Brown BI, Kipnis DM (1972) Hepatic fructose-1,6-diphosphatase deficiency. A cause of lactic acidosis in infancy. J Clin Invest 51:2115-2123
26. Morris AAM, Deshpande S, Ward-Platt MP et al. (1995) Impaired ketogenesis in fructose-1,6-bisphosphatase deficiency: a pitfall in the investigation of hypoglycaemia. J Inner Metab Dis 18:28-32
27. Gitzelmann R, Steinmann B, Van den Berghe G (1995) Disorders of fructose metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 7th edn. McGraw-Hill, New York, pp 905-934
28. Sabina RL, Patterson D, Holmes EW (1985) 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells. J Biol Chem 260:6107-6114
29. Shafrir E, Berman M, Felig P (1986) The endocrine pancreas: diabetes mellitus. In: Felig P, Baxter JD, Broadus AE, Frohman LA (eds) Endocrinology and metabolism. 2nd edn. McGraw-Hill, New York, pp 1043-1178
30. Consoli A, Nurjhan N, Capani F, Gerich J (1989) Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38:550-557
31. Mitrakou A, Kelley D, Mokan M et al. (1992) Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. New Engl J Med 326:22-29
32. Nurjhan N, Consoli A, Gerich J (1992) Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 89:169-175
33. 13C nuclear magnetic resonance study. J Clin Invest 90:1323-1327