Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance

Diabetes

Volumn 49, Issue 11, 2000, Pages 1761-1765

  Thompson, A L ^a   Cooney, G J ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; GLUCOSE; GLUCOSE 6 PHOSPHATE; HEXOKINASE; INSULIN; LIPID; OLEOYL COENZYME A; PALMITOYL COENZYME A;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIPID STORAGE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0033755148     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.11.1761     Document Type: Article

References (32)

1. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis
2. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
3. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
4. Mechanism of free fatty acid-induced insulin resistance in humans
5. 31P NMR studies on the mechanism of insulin resistance in obesity
6. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate
7. 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat
8. 1H NMR spectroscopy study
9. Skeletal muscle triglyceride levels are inversely related to insulin action
10. Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
11. Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
12. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
13. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
14. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
15. The glucose-fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
16. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
17. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
18. Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
19. 12 skeletal muscle cells pretreated with palmitate
20. Fatty acyl-CoA thioesters are lignads of hepatic nuclear factor 4α
21. Mechanism of palmitoyl coenzyme A inhibition of liver glycogen synthase
22. Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling
23. An allosteric model for the inhibition of glucokinase by long chain acyl Coenzyme A
24. Specific inhibition of glucokinase by long chain acyl coenzyme A below the critical micelle concentration
25. Regulation of mammalian hexokinase activity
26. The localization of hexokinase isoenzymes in red and white skeletal muscles of the rat
27. Regulation of hexokinase II and glycogen synthase mRNA, protein and activity in human muscle
28. Competitive inhibition of liver glucokinase by its regulatory protein
29. Acyl-CoA binding proteins: Multiplicity and function
30. Study of the regulatory properties of glucokinase by site directed mutagenesis: Conversion of glucokinase to an enzyme with high affinity for glucose
31. Glycogen synthase activity in skeletal muscle: Interconversion of two forms and control of glycogen synthesis
32. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle