The antioxidant α-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle

Diabetes

Volumn 45, Issue 8, 1996, Pages 1024-1029

  Jacob, Stephan ^a,b,c   Streeper, Ryan S ^a   Fogt, Donovan L ^a   Hokama, Jason Y ^a   Tritschler, Hans J ^d   Dietze, Günther J ^b   Henriksen, Erik J ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b Max Grundig Klinik   (Germany)

^c Stadtklinik ^*  (Germany)

^d ASTA MEDICA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CITRATE SYNTHASE; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOGEN; HEXOKINASE; INSULIN; THIOCTIC ACID;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT SYSTEM; INSULIN RESISTANCE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0029742327     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.45.8.1024     Document Type: Article

References (42)

1. Kolterman OG, Gray RS, Griffin J, Insel J, Scarlett JA, Olefsky JM: J Clin Invest 68:957-969, 1981
2. Olefsky JM, Kolterman OG, Scarlett JA: Insulin action and resistance in obesity and non-insulin-dependent type II diabetes mellitus. Am J Physiol 243:E15-E30, 1982
3. Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K: Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. J Clin Invest 84:205-213, 1989
4. Alberti KGMM, Gries FA: Management in non-insulin-dependent diabetes mellitus in Europe: a consensus view. Diabetic Med 5:275-281, 1988
5. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:32-45, 1983
6. Hughes TA, Gwynne JT, Switzer BR, Herbst C, White G: Effects of caloricrestriction and weight loss on glycemic control, insulin release and resistance, and atherosclerotic risk in obese patients with type II diabetes mellitus. Am J Med 77:7-17, 1984
7. Laakso M, Uusitupa M, Takala J, Majander H, Reijonen T, Penttllá I: Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms in obese non-insulin-dependent diabetic subjects. Metabolism 37:1092-1100, 1988
8. Johnson AB, Argyraki M, Thow JC, Jones IR, Broughton D, Miller M, Taylor: The effect of sulfonylurea therapy in skeletal muscle glycogen synthase activity and insulin secretion in newly presenting type 2 (non-insulin-dependent) diabetes mellitus. Diabetic Med 8:243-252, 1901
9. DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J: Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest 68:1468-1474, 1981
10. Holloszy JO, Schultz J, Kuznierkiewicz J, Hagberg JM, Ehsani AA: Effects of exercise on glucose tolerance and insulin resistance. Acta Med Scand 711 (Suppl.):55-65, 1985
11. Rogers MA, Yamamoto C, King DS, Hagberg JM, Ehsani AA, Holloszy JO: Improvements in glucose tolerance after 1 week of exercise in patients with mild NIDDM. Diabetes Care 11:013-618, 1988
12. Helmrick SP, Ragland DR, Leung RW, Paffenbarger RS: Physical activity and reduced occurence of non-insulin-dependent diabetes. N Engl J Med 325:147-152, 1991
13. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, Speizer FE: Physical activity and the incidence of non-insulin-dependent diabetes mellitus in women. Lanect 338: 774-778, 1991
14. Packer L, Witt EH, Tritschler HJ: alpha-Lipoic acid as a biological antioxidant. Free Rad Biol Med 19:227-250, 1995
15. Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA: Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160-1167, 1995
16. Haugaard N, Haugaard ES: Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro. Biochem Biophys Acta 222:583- 586, 1970
17. Singh HPP, Bowman RH: Effect of D,L-alpha lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats. Biochem Biophys Res Commun 41:555-561, 1970
18. Klip A, Volchuk A, Ramlal T, Ackerley C, Mitsumoto Y: Glucose transporters of muscle cells in culture: developmental regulation and modulation by lipoic acid, an anti-hyperglycemic agent. In Molecular Biology of Diabetes. Draznin B, LeRoith D, Eds. Totowa, NJ, Humana Press, 1994, p. 511-528
19. Henriksen EJ, Ritter LS: Effect of soleus unweighting on stimulation of insulin-independent glucose transport activity. J Appl Physiol 74:1653- 1657, 1993
20. Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, Holloszy JO: Glucose transporters and glucose transport in skeletal muscles of 1 to 25 month old rats. Am J Physiol 264:E319-E327, 1993
21. Henriksen EJ, Tischler ME: Time course of the response of carbohydrate metabolism to unloading of the soleus. Metabolism 37:201-208, 1988
22. Hassid WZ, Abraham S: Chemical procedure for analysis of polysaccharides: determination of glycogen and starch. Methods Enzymol 3:34-37, 1957
23. Henriksen EJ, Halseth AE: Early adaptations in soleus GLUT4, glucose transport, and glycogen in voluntary running rats. J Appl Physiol 76:1862-1867, 1994
24. Uyeda K, Racker E: Regulatory mechanisms in carbohydrate metabolism. VII. Hexokinase and phosphofructokinase. J Biol Chem. 240:4682-4688, 1965
25. Srere PA: Citrate synthase. Methods Enzymol 13:3-5, 1969
26. Henriksen EJ, Holloszy JO: Effect of diffusion distance on measurement of glucose transport in rat skeletal muscles in vitro. Acta Physiol Scand 143:381-386, 1991
27. Jacob S, Henriksen EJ, Tritschler HJ, Clancy DE, Simon I, Schiemann AL, Ulrich H, Jung WI, Dietze GJ, Augustin HJ: Thioctic acid enhances glucose disposal in patients with type 2 diabetes. Drug Res 45:872-874, 1995
28. Jacob S, Henriksen EJ, Tritschler HJ, Augustin HJ, Dietze GJ:Improvement of insulin-stimulated glucose disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes 104:284-288, 1996
29. Del Prato S, Bonadonna RC, Bonora E, Gulli G, Solini A, Shank M, DeFronzo RA: Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus. J Clin Invest 91:484- 494, 1993
30. Henriksen EJ, Jacob S, Tritschler HJ, Wessel K, Augustin HJ, Dietze GJ: Effects of stereoisomers of thioctic acid on glucose transport in insulin- resistant rat muscle (Abstract). Diabetologia 37:A59, 1994
31. Slieker LI, Roberts EF, Shaw WW, Johnson WT: Effect of streptozotocin- induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats. Diabetes 39:619-625, 1990
32. King PA, Horton ED, Hirshman MF, Horton ES: Insulin resistance in obese Zucker rat (fa/fa) is associated with a failure of glucose transporter translocation. J Clin Invest 90:1568-1575, 1993
33. Natraj CV, Gandhi VM, Menon KKG: Lipoic acid and diabetes. Effects of dihydrolipoic acid administration in diabetic rats and rabbits. J Biosci 6:37-46, 1984
34. Randle PJ: Alpha-ketoacid dehydrogenase complexes and respiratory fuel utilization in diabetes. Diabetologia 28:479-484, 1985
35. Wagh SS, Natraj CV, Menon KKG: Mode of action of lipoic acid in diabetes. J Biosci 11:59-74, 1987
36. Blumenthal SA: Inhibition of gluconeogenesis in rat liver by lipoic add. Evidence for more than one site of action. Biochem J 219:773-780, 1984
37. Henriksen EJ, Holloszy JO: Effects of phenylarsine oxide on stimulation of glucose transport in rat skeletal muscle. Am J Physiol 258:C648-C653, 1990
38. Wang C, Hsieh C-H, Wu W: Phenylarsine oxide inhibits insulin-dependent glucose transport activity in rat soleus muscle. Biochem Biophys Res Commun 176:202-206, 1991
39. Suzuki YJ, Tsuchiya M, Packer L: Lipoate prevents glucose-induced protein modifications. Free Rad Res Commun 17:211-217, 1992
40. Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-412, 1991
41. Low PA, Nickander KK: Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes 40:873-877, 1991
42. Johnson MB, Heineke EW, Rhinehart BL, Sheetz MJ, Barnhart RL, Robinson KM: MDL 29311: antioxidant with marked lipid and glucose lowering activity in rats and mice. Diabetes 42:1179-1186, 1993