Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress

Current Medicinal Chemistry

Volumn 11, Issue 9, 2004, Pages 1135-1146

  Smith, A R ^b   Shenvi, S V ^b   Widlansky, M ^a   Suh, J H ^b   Hagen, Tory M ^b  

^a BOSTON MEDICAL CENTER   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Antioxidants; Diabetes; Dihydrolipoic acid; Dithiol; Lipoic acid; Metal chelation; Oxidative stress; Polyneuropathy; Redox; Signal transduction

Indexed keywords

ASCORBIC ACID; CADMIUM; COPPER; DITHIOL DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FREE RADICAL; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; IRON; MERCURY; MITOCHONDRIAL ENZYME; PLACEBO; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; THIOCTIC ACID; TRACE ELEMENT; TRANSITION ELEMENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ATHEROSCLEROSIS; BIOCHEMISTRY; BIOENERGY; BLOOD BRAIN BARRIER; CADMIUM POISONING; CHELATION; CHRONIC DISEASE; CLINICAL TRIAL; CYTOSOL; DIABETES MELLITUS; DIABETIC NEUROPATHY; DISEASE ASSOCIATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG PENETRATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FOOD DRUG INTERACTION; HEART DISEASE; HEAVY METAL POISONING; HEMOCHROMATOSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FAILURE; MALIGNANT NEOPLASTIC DISEASE; MERCURIALISM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOPHYSIOLOGY; RAT; REVIEW; SIGNAL TRANSDUCTION; VASODILATATION; WILSON DISEASE;

EID: 2342544918     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043365387     Document Type: Review

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