Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes

Diabetologia

Volumn 42, Issue 8, 1999, Pages 949-957

  Rudich, A ^a   Tirosh, A ^a   Potashnik, R ^a   Khamaisi, M ^a   Bashan, N ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

GLUT4 translocation; Insulin resistance; Troglitazone; Vitamin C; Vitamin E

Indexed keywords

ASCORBIC ACID; GLUCOSE; GLUCOSE OXIDASE; GLUCOSE TRANSPORTER; GLUTATHIONE; HYDROGEN PEROXIDE; INSULIN; PROTEIN KINASE B; THIOCTIC ACID; TROGLITAZONE;

ADIPOCYTE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; GLUCOSE TRANSPORT; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0032799487     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051253     Document Type: Article

References (51)

1. Balz F (1994) Natural antioxidants in human health and disease. Academic Press, San Diego, Ca
2. Paolisso G, D'Amore A, Di Maro G et al. (1993) Evidence for a relationship between free radicals and insulin action in the elderly. Metabolism 42: 659-663
3. Nourooz-Zadeh J, Rahimi A, Tajaddini-Sarmadi J et al. (1997) Relationship between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia 40: 647-653
4. Jacob S, Henriksen EJ, Schiemann AL et al. (1995) Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 45: 872-874
5. Caballero B (1993) Vitamin E improves the action of insulin. Nutr Rev 51: 339-340
6. Paolisso G, D'Amore A, Balbi V et al. (1994) Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am J Physiol 266: E261-E268
7. Rudich A, Kozlovsky N, Potashnik R, Bahan N (1997) Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes. Am J Physiol 272: E935-E940
8. Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N (1998) Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 47: 1562-1569
9. Kapur S, Bedard S, Marcotte B, Cote CH, Marette A (1997) Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action. Diabetes 46: 1691-1700
10. Fuchs J, Packer L, Zimmer G (1997) Lipoic acid in Health and Disease. Marcel Dekker, New York Basel Hong Kong
11. Packer L, Witt EH, Tritschler HJ (1995) alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 19: 227-50
12. Kagan VE, Shvedova A, Serbinova E et al. (1992) Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 44: 1637-1649
13. Estrada DE, Ewart HS, Tsakiridis T et al. (1996) Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signalling pathway. Diabetes 45: 1798-1804
14. Yaworsky K, Somwar R, Ramlal T et al. (1998) In vivo activation of the insulin receptor tyrosine kinase and activation of the insulin signalling pathways by a-lipoic acid results in stimulation of glucose uptake in 3T3-L1 adipocytes [Abstract]. Diabetes 47:A277
15. Jacob S, Streeper RS, Fogt DL et al. (1996) The antioxidant alphalipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 45: 1024-1029
16. Khamaisi M, Potashnik R, Tirosh A et al. (1997) Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetes rats. Metabolism 46: 763-768
17. Chen D, Elmendorf JS, Olson AL, Li X, Earp HS, Pessin JE (1997) Osmotic shock stimulates GLUT4 translocation in 3T3-L1 adipocytes by a novel kinase pathway. J Biol Chem 272: 27401-27410
18. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789
19. Beutler E (1975) Reduced glutathione. In: Red cell metabolism. Grune & Stratton, New York San Francisco London, pp 112-114
20. Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602
21. Alessi DR, Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8: 55-62
22. Kohn AD, Kovacina KS, Roth RA (1995) Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14: 4288-4295
23. Kohn AD, Summers SA, Birnbaum MJ, Roth RA (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378
24. Tanti JF, Grillo S, Gremeaux T, Coffer PJ, Van Obberghen E, Le Marchand Brustel Y (1997) Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology 138: 2005-2010
25. Cong LN, Chen H, Li Y et al. (1997) Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 11: 1881-1890
26. Hajduch E, Alessi DR, Hemmings BA, Hundal HS (1998) Constitutive activation of protein kinase Ba by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47: 1006-1013
27. Cominacini L, Garbin U, Pastorino AM et al. (1997) Effects of troglitazone on in vitro oxidation of LDL and HDL induced by copper ions and endothelial cells. Diabetologia 40: 165-172
28. Noguchi N, Sakai H, Kato Y et al. (1996) Inhibition of oxidation of low density lipoprotein by troglitazone. Atherosclerosis 123: 227-234
29. Paolisso G, Balbi V, Volpe C et al. (1995) Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr 14: 387-392
30. Ziegler D, Hanefeld M, Ruhnau KJ et al. (1995) Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia 38: 1425-1433
31. Nagamatsu M, Nickander KK, Schmelzer JD et al. (1995) Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18: 1160-1167
32. Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ (1998) Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia 41: 390-399
33. Wiznitzer A, Ayalon N, Hershkovitz R et al. (1999) Lipoic acid prevention of neural tube defects in offspring of rats with streptozotocin-induced diabetes. Am J Obstet Gynecol 180: 188-193
34. Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer L (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 273:R1771-R1778
35. Begum N (1994) Phenyarsine oxide inhibits insulin-stimulated protein phosphatase 1 activity and GLUT4 translocation. Am J Physiol 267:E14-E23
36. Holman GD, Kasuga M (1997) From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40: 991-1003
37. Rothman JE, Warren G (1994) Implications of the SNARE hypothesis for intracellular membrane topology and dynamics. Curr Biol 4: 220-233
38. Schnitzer JE, Allard J, Oh P (1995) NEM inhibits transcytosis, endocytosis, and capillary permeability: implication of caveolae fusion in endothelia. Am J Physiol 268:H48-H55
39. Rea S, James DE (1997) Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles. Diabetes 46: 1667-1677
40. Han D, Handelman G, Marcocci L et al. (1997) Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6: 321-338
41. Sen CK, Packer L (1996) Antioxidant and redox regulation of gene transcription. FASEB J 10: 709-720
42. Klip A, Volchuk A, Ramlal T, Ackerley C, Mitsumoto Y (1994) Glucose transporters of muscle cells in culture: Developmental regulation and modulation by lipoic acid, an antihyperglycemic agent. In: Draznin B, LeRoith D (eds) Molecular Biology of Diabetes. Humana Press Inc., Totowa, NJ, pp 511-528
43. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ (1997) Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 273:E185-E191
44. Arscott LD, Williams CH Jr (1994) R- and S-dihydrolipoic acid derivatives as substrates of lipoamide dehydrogenase. In: Yagi K (ed) Flavins and flavoproteins 1993, proceedings of the eleventh international symposium. de Gruyter, Berlin New York, pp 527-530
45. Podda M, Traber MG, Packer L (1997) α-Lipoate: Antioxidant properties and effects on skin. In: Fuchs J, Packer L, Zimmer G (eds) Lipoic acid in health and disease. Marcel Dekker, New York, pp 163-180
46. Pick U, Haramaki N, Constantinescu A, Handelman GJ, Tritschler HJ, Packer L (1995) Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for alpha-lipoic acid enantiomers. Biochem Biophys Res Commun 206: 724-730
47. Tirosh A, Potashnik R, Bashan N, Rudich A (1999) Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate 1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem 274:10595-10602
48. Abel ED, Shepherd PR, Kahn BB (1996) Glucose transporters and pathophysiologic states. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus. Lippincott-Raven, Philadelphia New York, pp 530-543
49. Skolnik EY, Marcusohn J (1996) Inhibition of insulin receptor signalling by TNF: potential role in obesity and non-insulin-dependent diabetes mellitus. Cytokine Growth Factor Rev 7: 161-173
50. Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10
51. Paolisso G, Giugliano D (1996) Oxidative stress and insulin action: is there a relationship? Diabetologia 39: 357-363