Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

Biochemical Journal

Volumn 378, Issue 3, 2004, Pages 769-778

  Diraison, Frédérique ^a   Parton, Laura ^a   Ferré, Pascal ^b   Foufelle, Fabienne ^b   Briscoe, Celia P ^c   Leclerc, Isabelle ^a   Rutter, Guy A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b INSERM   (France)

^c GLAXOSMITHKLINE   (United States)

Author keywords

5 aminoimidazole 4 carboxamide ribonucleoside (AICAR); AMP activated protein kinase (AMPK); Insulin secretion; Lipotoxicity; Pancreatic islet; Sterol regulatory element binding protein (SREBP)

Indexed keywords

GLUCOSE; INSULIN; LIPIDS; PROTEINS; RNA;

INSULIN SECRETION; TRANSCRIPTION FACTORS;

BIOCHEMISTRY;

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; FATTY ACID SYNTHASE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREPROINSULIN; PROTEIN BCL 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ENZYME REGULATION; GLUCOSE OXIDATION; HOMEOBOX; INSULIN RELEASE; LIPID STORAGE; LIPOGENESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ACETYLTRANSFERASES; ADENOVIRIDAE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION; GENETIC VECTORS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; LIPIDS; MALE; RATS; RATS, WISTAR; RIBONUCLEOTIDES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC; TRIGLYCERIDES;

ADENOVIRIDAE; ANIMALIA;

EID: 1642546212     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031277     Document Type: Article

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