메뉴 건너뛰기




Volumn , Issue , 2010, Pages 163-192

The Rho-regulated ROCK kinases in cancer

Author keywords

[No Author keywords available]

Indexed keywords


EID: 78649475276     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-1111-7_11     Document Type: Chapter
Times cited : (7)

References (205)
  • 2
    • 0031724471 scopus 로고    scopus 로고
    • P21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase i inhibitor GGTI-298 through a transforming growth factor beta-and Sp1-responsive element: Involvement of the small GTPase rhoA
    • Adnane J, Bizouarn FA, Qian Y, Hamilton AD, Sebti SM (1998) p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta-and Sp1-responsive element: involvement of the small GTPase rhoA. Mol Cell Biol 18:6962-6970.
    • (1998) Mol Cell Biol , vol.18 , pp. 6962-6970
    • Adnane, J.1    Bizouarn, F.A.2    Qian, Y.3    Hamilton, A.D.4    Sebti, S.M.5
  • 3
    • 0037040984 scopus 로고    scopus 로고
    • P21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    • Alt JR, Gladden AB, Diehl JA (2002) p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J Biol Chem 277:8517-8523.
    • (2002) J Biol Chem , vol.277 , pp. 8517-8523
    • Alt, J.R.1    Gladden, A.B.2    Diehl, J.A.3
  • 7
    • 0035865682 scopus 로고    scopus 로고
    • LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rhoassociated kinase-catalysed phosphorylation at threonine-505
    • Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K (2001) LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rhoassociated kinase-catalysed phosphorylation at threonine-505. Biochem J 354:149-159.
    • (2001) Biochem J , vol.354 , pp. 149-159
    • Amano, T.1    Tanabe, K.2    Eto, T.3    Narumiya, S.4    Mizuno, K.5
  • 8
    • 0027378613 scopus 로고
    • Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils
    • Arai M, Sasaki Y, Nozawa R (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem Pharmacol 46:1487-1490.
    • (1993) Biochem Pharmacol , vol.46 , pp. 1487-1490
    • Arai, M.1    Sasaki, Y.2    Nozawa, R.3
  • 10
    • 0032535711 scopus 로고    scopus 로고
    • Prolonged activation of the mitogen-Activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice
    • Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P (1998) Prolonged activation of the mitogen-Activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. Biochem J 336(Pt 3):551-560.
    • (1998) Biochem J , vol.336 , Issue.PART 3 , pp. 551-560
    • Auer, K.L.1    Park, J.S.2    Seth, P.3    Coffey, R.J.4    Darlington, G.5    Abo, A.6    McMahon, M.7    Depinho, R.A.8    Fisher, P.B.9    Dent, P.10
  • 11
    • 0035168740 scopus 로고    scopus 로고
    • Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation
    • Aznar S, Valeron PF, del Rincon SV, Perez LF, Perona R, Lacal JC (2001) Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Mol Biol Cell 12:3282-3294.
    • (2001) Mol Biol Cell , vol.12 , pp. 3282-3294
    • Aznar, S.1    Valeron, P.F.2    Del Rincon, S.V.3    Perez, L.F.4    Perona, R.5    Lacal, J.C.6
  • 13
    • 9944251987 scopus 로고    scopus 로고
    • Rho GTPases in human cancer: An unresolved link to upstream and downstream transcriptional regulation
    • Benitah SA, Valeron PF, van Aelst L, Marshall CJ, Lacal JC (2004) Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta 1705:121-132.
    • (2004) Biochim Biophys Acta , vol.1705 , pp. 121-132
    • Benitah, S.A.1    Valeron, P.F.2    Van Aelst, L.3    Marshall, C.J.4    Lacal, J.C.5
  • 14
    • 0037325853 scopus 로고    scopus 로고
    • Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    • Bloom J, Pagano M (2003) Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 13:41-47.
    • (2003) Semin Cancer Biol , vol.13 , pp. 41-47
    • Bloom, J.1    Pagano, M.2
  • 15
    • 0030028947 scopus 로고    scopus 로고
    • Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
    • Bohmer RM, Scharf E, Assoian RK (1996) Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mol Biol Cell 7:101-111.
    • (1996) Mol Biol Cell , vol.7 , pp. 101-111
    • Bohmer, R.M.1    Scharf, E.2    Assoian, R.K.3
  • 16
    • 0033588993 scopus 로고    scopus 로고
    • Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase
    • Bottazzi ME, Zhu X, Bohmer RM, Assoian RK (1999) Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol 146:1255-1264.
    • (1999) J Cell Biol , vol.146 , pp. 1255-1264
    • Bottazzi, M.E.1    Zhu, X.2    Bohmer, R.M.3    Assoian, R.K.4
  • 17
    • 34447622126 scopus 로고    scopus 로고
    • The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells
    • Burthem J, Rees-Unwin K, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton AD (2007) The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells. Leukemia 21:1708-1714.
    • (2007) Leukemia , vol.21 , pp. 1708-1714
    • Burthem, J.1    Rees-Unwin, K.2    Mottram, R.3    Adams, J.4    Lucas, G.S.5    Spooncer, E.6    Whetton, A.D.7
  • 18
    • 0021298447 scopus 로고
    • Organization and function of stress fibers in cells in vitro and in situ
    • Byers HR, White GE, Fujiwara K (1984) Organization and function of stress fibers in cells in vitro and in situ. A review. Cell Muscle Motil 5:83-137.
    • (1984) A Review. Cell Muscle Motil , vol.5 , pp. 83-137
    • Byers, H.R.1    White, G.E.2    Fujiwara, K.3
  • 19
    • 34548160002 scopus 로고    scopus 로고
    • Control of actin assembly dynamics in cell motility
    • Carlier MF, Pantaloni D (2007) Control of actin assembly dynamics in cell motility. J Biol Chem 282:23005-23009.
    • (2007) J Biol Chem , vol.282 , pp. 23005-23009
    • Carlier, M.F.1    Pantaloni, D.2
  • 20
    • 23944518640 scopus 로고    scopus 로고
    • Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid
    • Cechin SR, Dunkley PR, Rodnight R (2005) Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid. Neurochem Res 30:603-611.
    • (2005) Neurochem Res , vol.30 , pp. 603-611
    • Cechin, S.R.1    Dunkley, P.R.2    Rodnight, R.3
  • 21
    • 33749233824 scopus 로고    scopus 로고
    • Activation of Rho-Associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
    • Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ (2006) Activation of Rho-Associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A 103:14495-14500.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14495-14500
    • Chang, J.1    Xie, M.2    Shah, V.R.3    Schneider, M.D.4    Entman, M.L.5    Wei, L.6    Schwartz, R.J.7
  • 22
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, Sherr CJ (1999) The p21(Cip1) and p27(Kip1) CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts. Embo J 18:1571-1583.
    • (1999) Embo J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 23
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pbromocinnamylamino) ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
    • Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pbromocinnamylamino) ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272.
    • (1990) J Biol Chem , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5    Inoue, T.6    Naito, K.7    Toshioka, T.8    Hidaka, H.9
  • 24
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
    • Chrzanowska-Wodnicka M, Burridge K (1996) Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 133:1403-1415.
    • (1996) J Cell Biol , vol.133 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 25
    • 33646583835 scopus 로고    scopus 로고
    • Stability of p21(Waf1/Cip1) CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton
    • Coleman ML, Densham RM, Croft DR, Olson MF (2006) Stability of p21(Waf1/Cip1) CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton. Oncogene 25:2708-2716.
    • (2006) Oncogene , vol.25 , pp. 2708-2716
    • Coleman, M.L.1    Densham, R.M.2    Croft, D.R.3    Olson, M.F.4
  • 26
    • 0036098594 scopus 로고    scopus 로고
    • Rho GTPase signalling pathways in the morphological changes associated with apoptosis
    • Coleman ML, Olson MF (2002) Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ 9:493-504.
    • (2002) Cell Death Differ , vol.9 , pp. 493-504
    • Coleman, M.L.1    Olson, M.F.2
  • 27
    • 0035072953 scopus 로고    scopus 로고
    • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK i
    • Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF (2001) Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 3:339-345.
    • (2001) Nat Cell Biol , vol.3 , pp. 339-345
    • Coleman, M.L.1    Sahai, E.A.2    Yeo, M.3    Bosch, M.4    Dewar, A.5    Olson, M.F.6
  • 29
    • 32144446158 scopus 로고    scopus 로고
    • Conditional regulation of a ROCK-estrogen receptor fusion protein
    • Croft DR, Olson MF (2006) Conditional regulation of a ROCK-estrogen receptor fusion protein. Methods Enzymol 406:541-553.
    • (2006) Methods Enzymol , vol.406 , pp. 541-553
    • Croft, D.R.1    Olson, M.F.2
  • 30
    • 33745055712 scopus 로고    scopus 로고
    • The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms
    • Croft DR, Olson MF (2006) The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol. Cell. Biol. 26:4612-4627.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 4612-4627
    • Croft, D.R.1    Olson, M.F.2
  • 32
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 33
    • 15944380429 scopus 로고    scopus 로고
    • Anti-Apoptotic effects of muscarinic receptor activation are mediated by Rho kinase
    • De Sarno P, Shestopal SA, Zmijewska AA, Jope RS (2005) Anti-Apoptotic effects of muscarinic receptor activation are mediated by Rho kinase. Brain Research 1041:112-115.
    • (2005) Brain Research , vol.1041 , pp. 112-115
    • De Sarno, P.1    Shestopal, S.A.2    Zmijewska, A.A.3    Jope, R.S.4
  • 34
    • 20444453281 scopus 로고    scopus 로고
    • A role of STAT3 in Rho GTPase-regulated cell migration and proliferation
    • Debidda M, Wang L, Zang H, Poli V, Zheng Y (2005) A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J Biol Chem 280:17275-17285.
    • (2005) J Biol Chem , vol.280 , pp. 17275-17285
    • Debidda, M.1    Wang, L.2    Zang, H.3    Poli, V.4    Zheng, Y.5
  • 35
    • 4444384584 scopus 로고    scopus 로고
    • Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation
    • Dhawan J, Helfman DM (2004) Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation. J Cell Sci 117:3735-3748.
    • (2004) J Cell Sci , vol.117 , pp. 3735-3748
    • Dhawan, J.1    Helfman, D.M.2
  • 36
    • 10644234702 scopus 로고    scopus 로고
    • New insights into the structure-function relationships of Rho-Associated kinase: A thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications
    • Doran JD, Liu X, Taslimi P, Saadat A, Fox T (2004) New insights into the structure-function relationships of Rho-Associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications. Biochem J 384:255-262.
    • (2004) Biochem J , vol.384 , pp. 255-262
    • Doran, J.D.1    Liu, X.2    Taslimi, P.3    Saadat, A.4    Fox, T.5
  • 37
    • 1342304087 scopus 로고    scopus 로고
    • Structural insights into the interaction of ROCKI with the switch regions of RhoA
    • Dvorsky R, Blumenstein L, Vetter IR, Ahmadian MR (2004) Structural insights into the interaction of ROCKI with the switch regions of RhoA. J Biol Chem 279:7098-7104.
    • (2004) J Biol Chem , vol.279 , pp. 7098-7104
    • Dvorsky, R.1    Blumenstein, L.2    Vetter, I.R.3    Ahmadian, M.R.4
  • 38
    • 36348966706 scopus 로고    scopus 로고
    • Rho GTPases: Functions and association with cancer
    • Ellenbroek SI, Collard JG (2007) Rho GTPases: functions and association with cancer. Clin Exp Metastasis 24:657-672.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 657-672
    • Ellenbroek, S.I.1    Collard, J.G.2
  • 39
    • 36649038021 scopus 로고    scopus 로고
    • Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells
    • Endlich N, Otey CA, Kriz W, Endlich K (2007) Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells. Cell Motil Cytoskeleton 64:966-976.
    • (2007) Cell Motil Cytoskeleton , vol.64 , pp. 966-976
    • Endlich, N.1    Otey, C.A.2    Kriz, W.3    Endlich, K.4
  • 40
    • 0041355341 scopus 로고    scopus 로고
    • The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes
    • Fassett JT, Tobolt D, Nelsen CJ, Albrecht JH, Hansen LK (2003) The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J. Biol. Chem. 278:31691-31700.
    • (2003) J. Biol. Chem , vol.278 , pp. 31691-31700
    • Fassett, J.T.1    Tobolt, D.2    Nelsen, C.J.3    Albrecht, J.H.4    Hansen, L.K.5
  • 41
    • 0033601250 scopus 로고    scopus 로고
    • Inhibitory phosphorylation site for Rho-Associated kinase on smooth muscle myosin phosphatase
    • Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T (1999) Inhibitory phosphorylation site for Rho-Associated kinase on smooth muscle myosin phosphatase. J Biol Chem 274:37385-37390.
    • (1999) J Biol Chem , vol.274 , pp. 37385-37390
    • Feng, J.1    Ito, M.2    Ichikawa, K.3    Isaka, N.4    Nishikawa, M.5    Hartshorne, D.J.6    Nakano, T.7
  • 43
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl P, Wolf K (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3:362-374.
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 44
    • 22844433746 scopus 로고    scopus 로고
    • Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells
    • Fukushima M, Nakamuta M, Kohjima M, Kotoh K, Enjoji M, Kobayashi N, Nawata H (2005) Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver International 25:829-838.
    • (2005) Liver International , vol.25 , pp. 829-838
    • Fukushima, M.1    Nakamuta, M.2    Kohjima, M.3    Kotoh, K.4    Enjoji, M.5    Kobayashi, N.6    Nawata, H.7
  • 45
    • 33744734643 scopus 로고    scopus 로고
    • Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits
    • Furuyama T, Komori K, Shimokawa H, Matsumoto Y, Uwatoku T, Hirano K, Maehara Y (2006) Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits. J Vasc Surg 43:1249-1256.
    • (2006) J Vasc Surg , vol.43 , pp. 1249-1256
    • Furuyama, T.1    Komori, K.2    Shimokawa, H.3    Matsumoto, Y.4    Uwatoku, T.5    Hirano, K.6    Maehara, Y.7
  • 46
    • 0032870464 scopus 로고    scopus 로고
    • Cell motility mediated by rho and Rho-Associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma
    • Genda T, Sakamoto M, Ichida T, Asakura H, Kojiro M, Narumiya S, Hirohashi S (1999) Cell motility mediated by rho and Rho-Associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 30:1027-1036.
    • (1999) Hepatology , vol.30 , pp. 1027-1036
    • Genda, T.1    Sakamoto, M.2    Ichida, T.3    Asakura, H.4    Kojiro, M.5    Narumiya, S.6    Hirohashi, S.7
  • 50
    • 13444283563 scopus 로고    scopus 로고
    • Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
    • Han S, Sidell N, Roman J (2005) Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase. Cancer Lett 219:71-81.
    • (2005) Cancer Lett , vol.219 , pp. 71-81
    • Han, S.1    Sidell, N.2    Roman, J.3
  • 51
    • 3142546779 scopus 로고    scopus 로고
    • Downstream effects of ROCK signaling in cultured human corneal stromal cells: Microarray analysis of gene expression
    • Harvey SA, Anderson SC, SundarRaj N (2004) Downstream effects of ROCK signaling in cultured human corneal stromal cells: microarray analysis of gene expression. Invest Ophthalmol Vis Sci 45:2168-2176.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2168-2176
    • Harvey, S.A.1    Anderson, S.C.2    Sundarraj, N.3
  • 52
    • 31544439891 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic strategies of chronic renal injury: Role of rho-kinase in the development of renal injury
    • Hayashi K, Wakino S, Kanda T, Homma K, Sugano N, Saruta T (2006) Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury. J Pharmacol Sci 100:29-33.
    • (2006) J Pharmacol Sci , vol.100 , pp. 29-33
    • Hayashi, K.1    Wakino, S.2    Kanda, T.3    Homma, K.4    Sugano, N.5    Saruta, T.6
  • 53
    • 24044473354 scopus 로고    scopus 로고
    • Glycine-extended gastrin stimulates cell proliferation and migration through a Rho-and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway
    • He H, Pannequin J, Tantiongco JP, Shulkes A, Baldwin GS (2005) Glycine-extended gastrin stimulates cell proliferation and migration through a Rho-and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway. Am J Physiol Gastrointest Liver Physiol 289:G478-G488.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • He, H.1    Pannequin, J.2    Tantiongco, J.P.3    Shulkes, A.4    Baldwin, G.S.5
  • 54
    • 0021751197 scopus 로고
    • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
    • Hidaka H, Inagaki M, Kawamoto S, Sasaki Y (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-5041.
    • (1984) Biochemistry , vol.23 , pp. 5036-5041
    • Hidaka, H.1    Inagaki, M.2    Kawamoto, S.3    Sasaki, Y.4
  • 56
    • 33646386142 scopus 로고    scopus 로고
    • Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
    • Hotulainen P, Lappalainen P (2006) Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol 173:383-394.
    • (2006) J Cell Biol , vol.173 , pp. 383-394
    • Hotulainen, P.1    Lappalainen, P.2
  • 57
    • 0031739360 scopus 로고    scopus 로고
    • Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension
    • Huang S, Chen CS, Ingber DE (1998) Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell 9:3179-3193.
    • (1998) Mol Biol Cell , vol.9 , pp. 3179-3193
    • Huang, S.1    Chen, C.S.2    Ingber, D.E.3
  • 58
    • 0036353562 scopus 로고    scopus 로고
    • A discrete cell cycle checkpoint in late G(1) that is cytoskeletondependent and MAP kinase (Erk)-independent
    • Huang S, Ingber DE (2002) A discrete cell cycle checkpoint in late G(1) that is cytoskeletondependent and MAP kinase (Erk)-independent. Exp Cell Res 275:255-264.
    • (2002) Exp Cell Res , vol.275 , pp. 255-264
    • Huang, S.1    Ingber, D.E.2
  • 59
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse M, Kuriyan J (2002) The conformational plasticity of protein kinases. Cell 109:275-282.
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 60
    • 0032742546 scopus 로고    scopus 로고
    • A major role for the rho-Associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
    • Iizuka K, Yoshii A, Samizo K, Tsukagoshi H, Ishizuka T, Dobashi K, Nakazawa T, Mori M (1999) A major role for the rho-Associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Br J Pharmacol 128:925-933.
    • (1999) Br J Pharmacol , vol.128 , pp. 925-933
    • Iizuka, K.1    Yoshii, A.2    Samizo, K.3    Tsukagoshi, H.4    Ishizuka, T.5    Dobashi, K.6    Nakazawa, T.7    Mori, M.8
  • 62
    • 0036077667 scopus 로고    scopus 로고
    • Inhibition of rhokinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor
    • Ikenoya M, Hidaka H, Hosoya T, Suzuki M, Yamamoto N, Sasaki Y (2002) Inhibition of rhokinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem 81:9-16.
    • (2002) J Neurochem , vol.81 , pp. 9-16
    • Ikenoya, M.1    Hidaka, H.2    Hosoya, T.3    Suzuki, M.4    Yamamoto, N.5    Sasaki, Y.6
  • 63
    • 0037177386 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export
    • Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI (2002) Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 277:14355-14358.
    • (2002) J Biol Chem , vol.277 , pp. 14355-14358
    • Ishida, N.1    Hara, T.2    Kamura, T.3    Yoshida, M.4    Nakayama, K.5    Nakayama, K.I.6
  • 64
    • 0030615004 scopus 로고    scopus 로고
    • P160ROCK, a Rho-Associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
    • Ishizaki T, Naito M, Fujisawa K, Maekawa M, Watanabe N, Saito Y, Narumiya S (1997) p160ROCK, a Rho-Associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett 404:118-124.
    • (1997) FEBS Lett , vol.404 , pp. 118-124
    • Ishizaki, T.1    Naito, M.2    Fujisawa, K.3    Maekawa, M.4    Watanabe, N.5    Saito, Y.6    Narumiya, S.7
  • 67
    • 0032935495 scopus 로고    scopus 로고
    • An essential part for Rho-Associated kinase in the transcellular invasion of tumor cells
    • Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S (1999) An essential part for Rho-Associated kinase in the transcellular invasion of tumor cells. Nat Med 5:221-225.
    • (1999) Nat Med , vol.5 , pp. 221-225
    • Itoh, K.1    Yoshioka, K.2    Akedo, H.3    Uehata, M.4    Ishizaki, T.5    Narumiya, S.6
  • 68
    • 0034118853 scopus 로고    scopus 로고
    • A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth
    • Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, Nawata H (2000) A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth. J Hepatol 32:762-770.
    • (2000) J Hepatol , vol.32 , pp. 762-770
    • Iwamoto, H.1    Nakamuta, M.2    Tada, S.3    Sugimoto, R.4    Enjoji, M.5    Nawata, H.6
  • 70
    • 0036226043 scopus 로고    scopus 로고
    • The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour
    • Kamai T, Arai K, Sumi S, Tsujii T, Honda M, Yamanishi T, Yoshida KI (2002) The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. BJU Int 89:449-453.
    • (2002) BJU Int , vol.89 , pp. 449-453
    • Kamai, T.1    Arai, K.2    Sumi, S.3    Tsujii, T.4    Honda, M.5    Yamanishi, T.6    Yoshida, K.I.7
  • 71
    • 0037817325 scopus 로고    scopus 로고
    • Significant association of Rho/ ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T, Tsujii T, Arai K, Takagi K, Asami H, Ito Y, Oshima H (2003) Significant association of Rho/ ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 9:2632-2641.
    • (2003) Clin Cancer Res , vol.9 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3    Takagi, K.4    Asami, H.5    Ito, Y.6    Oshima, H.7
  • 72
    • 3242699514 scopus 로고    scopus 로고
    • Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer
    • Kamai T, Yamanishi T, Shirataki H, Takagi K, Asami H, Ito Y, Yoshida K (2004) Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 10:4799-4805.
    • (2004) Clin Cancer Res , vol.10 , pp. 4799-4805
    • Kamai, T.1    Yamanishi, T.2    Shirataki, H.3    Takagi, K.4    Asami, H.5    Ito, Y.6    Yoshida, K.7
  • 73
    • 0041508986 scopus 로고    scopus 로고
    • Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells
    • Kamiyama M, Utsunomiya K, Taniguchi K, Yokota T, Kurata H, Tajima N, Kondo K (2003) Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells. J Atheroscler Thromb 10:117-123.
    • (2003) J Atheroscler Thromb , vol.10 , pp. 117-123
    • Kamiyama, M.1    Utsunomiya, K.2    Taniguchi, K.3    Yokota, T.4    Kurata, H.5    Tajima, N.6    Kondo, K.7
  • 76
    • 0344514708 scopus 로고    scopus 로고
    • Effect of fasudil on Rhokinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats
    • Kanda T, Wakino S, Hayashi K, Homma K, Ozawa Y, Saruta T (2003) Effect of fasudil on Rhokinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 64:2009-2019.
    • (2003) Kidney Int , vol.64 , pp. 2009-2019
    • Kanda, T.1    Wakino, S.2    Hayashi, K.3    Homma, K.4    Ozawa, Y.5    Saruta, T.6
  • 79
    • 22144443812 scopus 로고    scopus 로고
    • The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-Alpha-induced transcriptional repression of cyclin A
    • Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M, Gavin M, Goukassian D, Losordo DW (2005) The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-Alpha-induced transcriptional repression of cyclin A. J Clin Invest 115:1785-1796.
    • (2005) J Clin Invest , vol.115 , pp. 1785-1796
    • Kishore, R.1    Qin, G.2    Luedemann, C.3    Bord, E.4    Hanley, A.5    Silver, M.6    Gavin, M.7    Goukassian, D.8    Losordo, D.W.9
  • 81
    • 0033614371 scopus 로고    scopus 로고
    • Specific accumulation of Rho-Associated kinase at the cleavage furrow during cytokinesis: Cleavage furrow-specific phosphorylation of intermediate filaments
    • Kosako H, Goto H, Yanagida M, Matsuzawa K, Fujita M, Tomono Y, Okigaki T, Odai H, Kaibuchi K, Inagaki M (1999) Specific accumulation of Rho-Associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments. Oncogene 18:2783-2788.
    • (1999) Oncogene , vol.18 , pp. 2783-2788
    • Kosako, H.1    Goto, H.2    Yanagida, M.3    Matsuzawa, K.4    Fujita, M.5    Tomono, Y.6    Okigaki, T.7    Odai, H.8    Kaibuchi, K.9    Inagaki, M.10
  • 82
    • 4143128730 scopus 로고    scopus 로고
    • Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes
    • Koyama Y, Yoshioka Y, Shinde M, Matsuda T, Baba A (2004) Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes. J Neurochem 90:904-912.
    • (2004) J Neurochem , vol.90 , pp. 904-912
    • Koyama, Y.1    Yoshioka, Y.2    Shinde, M.3    Matsuda, T.4    Baba, A.5
  • 83
    • 27644497981 scopus 로고    scopus 로고
    • Statins prevent pulsatile stretchinduced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/ Rho-kinase pathway
    • Kozai T, Eto M, Yang Z, Shimokawa H, Luscher TF (2005) Statins prevent pulsatile stretchinduced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/ Rho-kinase pathway. Cardiovasc Res 68:475-482.
    • (2005) Cardiovasc Res , vol.68 , pp. 475-482
    • Kozai, T.1    Eto, M.2    Yang, Z.3    Shimokawa, H.4    Luscher, T.F.5
  • 85
    • 0036837872 scopus 로고    scopus 로고
    • Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-Associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13-acetate-induced apoptotic cells
    • Lai JM, Wu S, Huang DY, Chang, ZF (2002) Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-Associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13-acetate-induced apoptotic cells. Mol Cell Biol 22:7581-7592.
    • (2002) Mol Cell Biol , vol.22 , pp. 7581-7592
    • Lai, J.M.1    Wu, S.2    Huang, D.Y.3    Chang, Z.F.4
  • 87
    • 0029789678 scopus 로고    scopus 로고
    • The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    • Leung T, Chen XQ, Manser E, Lim L (1996) The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 16:5313-5327.
    • (1996) Mol Cell Biol , vol.16 , pp. 5313-5327
    • Leung, T.1    Chen, X.Q.2    Manser, E.3    Lim, L.4
  • 88
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
    • Leung T, Manser E, Tan L, Lim L (1995) A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem 270:29051-29054.
    • (1995) J Biol Chem , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 89
    • 33846304703 scopus 로고    scopus 로고
    • Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats
    • Li FH, Xia W, Li AW, Zhao CF, Sun RP (2007) Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats. Chin Med J (Engl) 120:22-29.
    • (2007) Chin Med J (Engl , vol.120 , pp. 22-29
    • Li, F.H.1    Xia, W.2    Li, A.W.3    Zhao, C.F.4    Sun, R.P.5
  • 90
    • 0037013293 scopus 로고    scopus 로고
    • Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells
    • Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM (2002) Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J Biol Chem 277:15309-15316.
    • (2002) J Biol Chem , vol.277 , pp. 15309-15316
    • Li, X.1    Liu, L.2    Tupper, J.C.3    Bannerman, D.D.4    Winn, R.K.5    Sebti, S.M.6    Hamilton, A.D.7    Harlan, J.M.8
  • 92
    • 33846013962 scopus 로고    scopus 로고
    • Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase
    • Liu AM, Lo RK, Wong CS, Morris C, Wise H, Wong YH (2006) Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase. J Biol Chem 281:35812-35825.
    • (2006) J Biol Chem , vol.281 , pp. 35812-35825
    • Liu, A.M.1    Lo, R.K.2    Wong, C.S.3    Morris, C.4    Wise, H.5    Wong, Y.H.6
  • 93
    • 0029664395 scopus 로고    scopus 로고
    • Regulation of p21WAF1/CIP1 expression through mitogen-Activated protein kinase signaling pathway
    • Liu Y, Martindale JL, Gorospe M, Holbrook NJ (1996) Regulation of p21WAF1/CIP1 expression through mitogen-Activated protein kinase signaling pathway. Cancer Res 56:31-35.
    • (1996) Cancer Res , vol.56 , pp. 31-35
    • Liu, Y.1    Martindale, J.L.2    Gorospe, M.3    Holbrook, N.J.4
  • 94
    • 4644248958 scopus 로고    scopus 로고
    • Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
    • Liu Y, Suzuki YJ, Day RM, Fanburg BL (2004) Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 95:579-586.
    • (2004) Circ Res , vol.95 , pp. 579-586
    • Liu, Y.1    Suzuki, Y.J.2    Day, R.M.3    Fanburg, B.L.4
  • 97
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682-688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 98
    • 33845228036 scopus 로고    scopus 로고
    • Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication
    • Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol 26:9016-9034.
    • (2006) Mol Cell Biol , vol.26 , pp. 9016-9034
    • Ma, Z.1    Kanai, M.2    Kawamura, K.3    Kaibuchi, K.4    Ye, K.5    Fukasawa, K.6
  • 102
  • 106
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 108
    • 33746424429 scopus 로고    scopus 로고
    • Dynamics of RhoA and ROKalpha translocation in single living cells
    • Miyazaki K, Komatsu S, Ikebe M (2006) Dynamics of RhoA and ROKalpha translocation in single living cells. Cell Biochem Biophys 45:243-254.
    • (2006) Cell Biochem Biophys , vol.45 , pp. 243-254
    • Miyazaki, K.1    Komatsu, S.2    Ikebe, M.3
  • 110
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • Morgan DO (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Ann Rev Cell Develop Biol 13:261-291.
    • (1997) Ann Rev Cell Develop Biol , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 111
    • 32444440805 scopus 로고    scopus 로고
    • Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: A potential therapeutic approach to rheumatoid arthritis
    • Nagashima T, Okazaki H, Yudoh K, Matsuno H, Minota S (2006) Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. Arthritis Rheum 54:579-586.
    • (2006) Arthritis Rheum , vol.54 , pp. 579-586
    • Nagashima, T.1    Okazaki, H.2    Yudoh, K.3    Matsuno, H.4    Minota, S.5
  • 113
    • 0030603119 scopus 로고    scopus 로고
    • ROCK-I and ROCK-II, two isoforms of Rho-Associated coiled-coil forming protein serine/threonine kinase in mice
    • Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S (1996) ROCK-I and ROCK-II, two isoforms of Rho-Associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett 392:189-193.
    • (1996) FEBS Lett , vol.392 , pp. 189-193
    • Nakagawa, O.1    Fujisawa, K.2    Ishizaki, T.3    Saito, Y.4    Nakao, K.5    Narumiya, S.6
  • 116
    • 0347635451 scopus 로고    scopus 로고
    • A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line
    • Nishimaki H, Kasai K, Kozaki K, Takeo T, Ikeda H, Saga S, Nitta M, Itoh G (2004) A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Commun 314:313-320.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 313-320
    • Nishimaki, H.1    Kasai, K.2    Kozaki, K.3    Takeo, T.4    Ikeda, H.5    Saga, S.6    Nitta, M.7    Itoh, G.8
  • 117
    • 0032489841 scopus 로고    scopus 로고
    • A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion
    • Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (1998) A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol 141:187-197.
    • (1998) J Cell Biol , vol.141 , pp. 187-197
    • Nobes, C.D.1    Lauritzen, I.2    Mattei, M.G.3    Paris, S.4    Hall, A.5    Chardin, P.6
  • 118
    • 0034602959 scopus 로고    scopus 로고
    • Rho-Associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
    • Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K (2000) Rho-Associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275:3577-3582.
    • (2000) J Biol Chem , vol.275 , pp. 3577-3582
    • Ohashi, K.1    Nagata, K.2    Maekawa, M.3    Ishizaki, T.4    Narumiya, S.5    Mizuno, K.6
  • 119
    • 0032537819 scopus 로고    scopus 로고
    • Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
    • Olson MF, Paterson HF, Marshall CJ (1998) Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394:295-299.
    • (1998) Nature , vol.394 , pp. 295-299
    • Olson, M.F.1    Paterson, H.F.2    Marshall, C.J.3
  • 120
    • 33751251037 scopus 로고    scopus 로고
    • Differential involvement of cytoskeleton and rho-guanosine 5-triphosphatases in growth-promoting effects of angiotensin II in rat adrenal glomerulosa cells
    • Otis M, Gallo-Payet N (2006) Differential involvement of cytoskeleton and rho-guanosine 5-triphosphatases in growth-promoting effects of angiotensin II in rat adrenal glomerulosa cells. Endocrinology 147:5460-5469.
    • (2006) Endocrinology , vol.147 , pp. 5460-5469
    • Otis, M.1    Gallo-Payet, N.2
  • 121
    • 34250806729 scopus 로고    scopus 로고
    • Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neurospheres and in PC12 neurite outgrowth
    • Pacary E, Tixier E, Coulet F, Roussel S, Petit E, Bernaudin M (2007) Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neurospheres and in PC12 neurite outgrowth. Mol Cell Neurosci 35:409-423.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 409-423
    • Pacary, E.1    Tixier, E.2    Coulet, F.3    Roussel, S.4    Petit, E.5    Bernaudin, M.6
  • 122
    • 36248969983 scopus 로고    scopus 로고
    • Actin stress fibres
    • Pellegrin S, Mellor H (2007) Actin stress fibres. J Cell Sci 120:3491-3499.
    • (2007) J Cell Sci , vol.120 , pp. 3491-3499
    • Pellegrin, S.1    Mellor, H.2
  • 123
    • 38849185196 scopus 로고    scopus 로고
    • PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
    • Pinner S, Sahai E (2008) PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nature Cell Biology 10
    • (2008) Nature Cell Biology , pp. 10
    • Pinner, S.1    Sahai, E.2
  • 124
    • 33746031475 scopus 로고    scopus 로고
    • An inhibitory role for FAK in regulating proliferation: A link between limited adhesion and RhoA-ROCK signaling
    • Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS (2006) An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J. Cell Biol. 174:277-288.
    • (2006) J. Cell Biol , vol.174 , pp. 277-288
    • Pirone, D.M.1    Liu, W.F.2    Ruiz, S.A.3    Gao, L.4    Raghavan, S.5    Lemmon, C.A.6    Romer, L.H.7    Chen, C.S.8
  • 125
    • 1342302820 scopus 로고    scopus 로고
    • Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA
    • Porter KE, Turner NA, ORegan DJ, Balmforth AJ, Ball SG (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovasc Res 61:745-755.
    • (2004) Cardiovasc Res , vol.61 , pp. 745-755
    • Porter, K.E.1    Turner, N.A.2    Oregan, D.J.3    Balmforth, A.J.4    Ball, S.G.5
  • 126
    • 0031028381 scopus 로고    scopus 로고
    • Cell cycle arrest mediated by the MEK/mitogen-Activated protein kinase pathway
    • Pumiglia KM, Decker SJ (1997) Cell cycle arrest mediated by the MEK/mitogen-Activated protein kinase pathway. Proc Natl Acad Sci U S A 94:448-452.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 448-452
    • Pumiglia, K.M.1    Decker, S.J.2
  • 127
    • 33847702961 scopus 로고    scopus 로고
    • Tumor necrosis factor-Alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression
    • Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM, Walsh CT, Brown JH (2007) Tumor necrosis factor-Alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. J Biol Chem 282:863-870.
    • (2007) J Biol Chem , vol.282 , pp. 863-870
    • Radeff-Huang, J.1    Seasholtz, T.M.2    Chang, J.W.3    Smith, J.M.4    Walsh, C.T.5    Brown, J.H.6
  • 128
    • 33845491469 scopus 로고    scopus 로고
    • Caveolin-1 and lipid rafts in confluent BeWo trophoblasts: Evidence for Rock-1 association with caveolin-1
    • Rashid-Doubell F, Tannetta D, Redman CW, Sargent IL, Boyd CA, Linton EA (2007) Caveolin-1 and lipid rafts in confluent BeWo trophoblasts: evidence for Rock-1 association with caveolin-1. Placenta 28:139-151.
    • (2007) Placenta , vol.28 , pp. 139-151
    • Rashid-Doubell, F.1    Tannetta, D.2    Redman, C.W.3    Sargent, I.L.4    Boyd, C.A.5    Linton, E.A.6
  • 129
  • 130
    • 0242608409 scopus 로고    scopus 로고
    • Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells
    • Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Cellek S (2003) Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol 170:2517-2522.
    • (2003) J Urol , vol.170 , pp. 2517-2522
    • Rees, R.W.1    Foxwell, N.A.2    Ralph, D.J.3    Kell, P.D.4    Moncada, S.5    Cellek, S.6
  • 132
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: Multifunctional kinases in cell behaviour
    • Riento K, Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4:446-456.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 133
    • 27744466333 scopus 로고    scopus 로고
    • Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/? haploinsufficient mice
    • Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M, Kim HH, Liao JK (2005) Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/? haploinsufficient mice. Circulation 112:2959-2965.
    • (2005) Circulation , vol.112 , pp. 2959-2965
    • Rikitake, Y.1    Oyama, N.2    Wang, C.Y.3    Noma, K.4    Satoh, M.5    Kim, H.H.6    Liao, J.K.7
  • 134
    • 0035803593 scopus 로고    scopus 로고
    • P27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    • Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S (2001) p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. Embo J 20:6672-6682.
    • (2001) Embo J , vol.20 , pp. 6672-6682
    • Rodier, G.1    Montagnoli, A.2    Di Marcotullio, L.3    Coulombe, P.4    Draetta, G.F.5    Pagano, M.6    Meloche, S.7
  • 135
    • 0032473351 scopus 로고    scopus 로고
    • RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
    • Sahai E, Alberts AS, Treisman R (1998) RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. Embo J 17:1350-1361.
    • (1998) Embo J , vol.17 , pp. 1350-1361
    • Sahai, E.1    Alberts, A.S.2    Treisman, R.3
  • 136
    • 0033545354 scopus 로고    scopus 로고
    • Transformation mediated by RhoA requires activity of ROCK kinases
    • Sahai E, Ishizaki T, Narumiya S, Treisman R (1999) Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol 9:136-145.
    • (1999) Curr Biol , vol.9 , pp. 136-145
    • Sahai, E.1    Ishizaki, T.2    Narumiya, S.3    Treisman, R.4
  • 137
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai E, Marshall CJ (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5:711-719.
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 138
    • 0035865137 scopus 로고    scopus 로고
    • Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
    • Sahai E, Olson MF, Marshall CJ (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. Embo J 20:755-766.
    • (2001) Embo J , vol.20 , pp. 755-766
    • Sahai, E.1    Olson, M.F.2    Marshall, C.J.3
  • 139
    • 0027103067 scopus 로고
    • HA-1077 suppress both proliferation of vascular smooth muscle cells and c-fos mRNA induction
    • Sase K, Yui Y, Hattori R, Shirotani M, Kawai C, Sasayama S (1992) HA-1077 suppress both proliferation of vascular smooth muscle cells and c-fos mRNA induction. Jpn Circ J 56: 1229-1233.
    • (1992) Jpn Circ J , vol.56 , pp. 1229-1233
    • Sase, K.1    Yui, Y.2    Hattori, R.3    Shirotani, M.4    Kawai, C.5    Sasayama, S.6
  • 140
    • 0035827716 scopus 로고    scopus 로고
    • Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase
    • Sauzeau V, Le Mellionnec E, Bertoglio J, Scalbert E, Pacaud P, Loirand G (2001) Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 88:1102-1104.
    • (2001) Circ Res , vol.88 , pp. 1102-1104
    • Sauzeau, V.1    Le Mellionnec, E.2    Bertoglio, J.3    Scalbert, E.4    Pacaud, P.5    Loirand, G.6
  • 142
    • 0033612371 scopus 로고    scopus 로고
    • Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
    • Seasholtz TM, Majumdar M, Kaplan DD, Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84: 1186-1193.
    • (1999) Circ Res , vol.84 , pp. 1186-1193
    • Seasholtz, T.M.1    Majumdar, M.2    Kaplan, D.D.3    Brown, J.H.4
  • 143
    • 13644252220 scopus 로고    scopus 로고
    • Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
    • Sebbagh M, Hamelin J, Bertoglio J, Solary E, Breard J (2005) Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med 201:465-471.
    • (2005) J Exp Med , vol.201 , pp. 465-471
    • Sebbagh, M.1    Hamelin, J.2    Bertoglio, J.3    Solary, E.4    Breard, J.5
  • 144
    • 0035075597 scopus 로고    scopus 로고
    • Caspase-3-mediated cleavage of ROCK i induces MLC phosphorylation and apoptotic membrane blebbing
    • Sebbagh M, Renvoize C, Hamelin J, Riche N, Bertoglio J, Breard J (2001) Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 3:346-352.
    • (2001) Nat Cell Biol , vol.3 , pp. 346-352
    • Sebbagh, M.1    Renvoize, C.2    Hamelin, J.3    Riche, N.4    Bertoglio, J.5    Breard, J.6
  • 145
    • 9644254216 scopus 로고    scopus 로고
    • Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: Role of RhoA
    • Seibold S, Schurle D, Heinloth A, Wolf G, Wagner M, Galle J (2004) Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA. J Am Soc Nephrol 15:3026-3034.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3026-3034
    • Seibold, S.1    Schurle, D.2    Heinloth, A.3    Wolf, G.4    Wagner, M.5    Galle, J.6
  • 146
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing A, Wiseman B, Lloyd AC, Land H (1997) High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 17:5588-5597.
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 147
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr CJ, Roberts JM (2004) Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18:2699-2711.
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 150
  • 152
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL (2002) PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-1152.
    • (2002) Nat Med , vol.8 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 154
    • 0026345695 scopus 로고
    • A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture
    • Shirotani M, Yui Y, Hattori R, Kawai C (1991) A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture. J Pharmacol Exp Ther 259:738-744.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 738-744
    • Shirotani, M.1    Yui, Y.2    Hattori, R.3    Kawai, C.4
  • 155
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP, Somlyo AV (2000) Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522(Pt 2):177-185.
    • (2000) J Physiol , vol.522 , Issue.PART 2 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 157
    • 0037310774 scopus 로고    scopus 로고
    • Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants
    • Somlyo AV, Phelps C, Dipierro C, Eto M, Read P, Barrett M, Gibson JJ, Burnitz MC, Myers C, Somlyo AP (2003) Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. Faseb J 17:223-234.
    • (2003) Faseb J , vol.17 , pp. 223-234
    • Somlyo, A.V.1    Phelps, C.2    Dipierro, C.3    Eto, M.4    Read, P.5    Barrett, M.6    Gibson, J.J.7    Burnitz, M.C.8    Myers, C.9    Somlyo, A.P.10
  • 158
    • 33744812402 scopus 로고    scopus 로고
    • Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation
    • Song J, Li J, Lulla A, Evers BM, Chung DH (2006) Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation. Am J Physiol Cell Physiol 290:C1469-C1476.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Song, J.1    Li, J.2    Lulla, A.3    Evers, B.M.4    Chung, D.H.5
  • 160
    • 0035808419 scopus 로고    scopus 로고
    • Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
    • Sumi T, Matsumoto K, Nakamura T (2001) Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem 276:670-676.
    • (2001) J Biol Chem , vol.276 , pp. 670-676
    • Sumi, T.1    Matsumoto, K.2    Nakamura, T.3
  • 161
    • 1542288167 scopus 로고    scopus 로고
    • ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium
    • Svoboda KK, Moessner P, Field T, Acevedo J (2004) ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium. Dev Dyn 229: 579-590.
    • (2004) Dev Dyn , vol.229 , pp. 579-590
    • Svoboda, K.K.1    Moessner, P.2    Field, T.3    Acevedo, J.4
  • 162
    • 20744453672 scopus 로고    scopus 로고
    • Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1
    • Swant JD, Rendon BE, Symons M, Mitchell RA (2005) Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1. J Biol Chem 280:23066-23072.
    • (2005) J Biol Chem , vol.280 , pp. 23066-23072
    • Swant, J.D.1    Rendon, B.E.2    Symons, M.3    Mitchell, R.A.4
  • 164
    • 0035123728 scopus 로고    scopus 로고
    • Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-Associated protein kinase inhibitor Y-27632
    • Takamura M, Sakamoto M, Genda T, Ichida T, Asakura H, Hirohashi S (2001) Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-Associated protein kinase inhibitor Y-27632. Hepatology 33:577-581.
    • (2001) Hepatology , vol.33 , pp. 577-581
    • Takamura, M.1    Sakamoto, M.2    Genda, T.3    Ichida, T.4    Asakura, H.5    Hirohashi, S.6
  • 166
    • 33750468907 scopus 로고    scopus 로고
    • Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
    • Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H (2006) Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am J Respir Cell Mol Biol 35:722-729.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 722-729
    • Takeda, N.1    Kondo, M.2    Ito, S.3    Ito, Y.4    Shimokata, K.5    Kume, H.6
  • 168
  • 171
    • 23844442551 scopus 로고    scopus 로고
    • ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
    • Thumkeo D, Shimizu Y, Sakamoto S, Yamada S, Narumiya S (2005) ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells 10:825-834.
    • (2005) Genes Cells , vol.10 , pp. 825-834
    • Thumkeo, D.1    Shimizu, Y.2    Sakamoto, S.3    Yamada, S.4    Narumiya, S.5
  • 172
    • 0031878095 scopus 로고    scopus 로고
    • Na-H exchange acts downstream of RhoA to regulate integrininduced cell adhesion and spreading
    • Tominaga T, Barber DL (1998) Na-H exchange acts downstream of RhoA to regulate integrininduced cell adhesion and spreading. Mol Biol Cell 9:2287-2303.
    • (1998) Mol Biol Cell , vol.9 , pp. 2287-2303
    • Tominaga, T.1    Barber, D.L.2
  • 173
    • 0015545166 scopus 로고
    • Surface activity and locomotion of Fundulus deep cells during blastula and gastrula stages
    • Trinkaus JP (1973) Surface activity and locomotion of Fundulus deep cells during blastula and gastrula stages. Dev Biol 30:69-103.
    • (1973) Dev Biol , vol.30 , pp. 69-103
    • Trinkaus, J.P.1
  • 174
    • 34250223071 scopus 로고    scopus 로고
    • The Rho-kinase inhibitor H-1152P suppresses the wound-healing activities of human Tenons capsule fibroblasts in vitro
    • Tura A, Grisanti S, Petermeier K, Henke-Fahle S (2007) The Rho-kinase inhibitor H-1152P suppresses the wound-healing activities of human Tenons capsule fibroblasts in vitro. Invest Ophthalmol Vis Sci 48:2152-2161.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2152-2161
    • Tura, A.1    Grisanti, S.2    Petermeier, K.3    Henke-Fahle, S.4
  • 177
    • 33646876458 scopus 로고    scopus 로고
    • Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells
    • Van Kolen K, Slegers H (2006) Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells. Febs J 273:1843-1854.
    • (2006) Febs J , vol.273 , pp. 1843-1854
    • Van Kolen, K.1    Slegers, H.2
  • 178
    • 0037063362 scopus 로고    scopus 로고
    • Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin
    • Velasco G, Armstrong C, Morrice N, Frame S, Cohen P (2002) Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. FEBS Lett 527:101-104.
    • (2002) FEBS Lett , vol.527 , pp. 101-104
    • Velasco, G.1    Armstrong, C.2    Morrice, N.3    Frame, S.4    Cohen, P.5
  • 179
    • 10444265891 scopus 로고    scopus 로고
    • Two different pathways link G-protein-coupled receptors with tyrosine kinases for the modulation of growth and survival in human hematopoietic progenitor cells
    • Vichalkovski A, Baltensperger K, Thomann D, Porzig H (2005) Two different pathways link G-protein-coupled receptors with tyrosine kinases for the modulation of growth and survival in human hematopoietic progenitor cells. Cell Signal 17:447-459.
    • (2005) Cell Signal , vol.17 , pp. 447-459
    • Vichalkovski, A.1    Baltensperger, K.2    Thomann, D.3    Porzig, H.4
  • 181
    • 34247253325 scopus 로고    scopus 로고
    • ERK activity and G1 phase progression: Identifying dispensable versus essential activities and primary versus secondary targets
    • Villanueva J, Yung Y, Walker JL, Assoian RK (2007) ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets. Mol. Biol. Cell 18:1457-1463.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1457-1463
    • Villanueva, J.1    Yung, Y.2    Walker, J.L.3    Assoian, R.K.4
  • 182
    • 35348997467 scopus 로고    scopus 로고
    • ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging
    • Vishnubhotla R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC (2007) ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab Invest 87:1149-1158.
    • (2007) Lab Invest , vol.87 , pp. 1149-1158
    • Vishnubhotla, R.1    Sun, S.2    Huq, J.3    Bulic, M.4    Ramesh, A.5    Guzman, G.6    Cho, M.7    Glover, S.C.8
  • 183
    • 1842581698 scopus 로고    scopus 로고
    • RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation
    • Wang G, Woods A, Sabari S, Pagnotta L, Stanton LA, Beier F (2004) RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J Biol Chem 279:13205-13214.
    • (2004) J Biol Chem , vol.279 , pp. 13205-13214
    • Wang, G.1    Woods, A.2    Sabari, S.3    Pagnotta, L.4    Stanton, L.A.5    Beier, F.6
  • 184
  • 186
    • 0033160196 scopus 로고    scopus 로고
    • Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
    • Watanabe N, Kato T, Fujita A, Ishizaki T, Narumiya S (1999) Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol 1:136-143.
    • (1999) Nat Cell Biol , vol.1 , pp. 136-143
    • Watanabe, N.1    Kato, T.2    Fujita, A.3    Ishizaki, T.4    Narumiya, S.5
  • 187
    • 33751563869 scopus 로고    scopus 로고
    • Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: Comparison with other vasoactive agents and hydrogen peroxide
    • Watanabe T, Takahashi K, Kanome T, Hongo S, Miyazaki A, Koba S, Katagiri T, Pakara R, Benedict CR (2006) Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: comparison with other vasoactive agents and hydrogen peroxide. Hypertens Res 29:821-831.
    • (2006) Hypertens Res , vol.29 , pp. 821-831
    • Watanabe, T.1    Takahashi, K.2    Kanome, T.3    Hongo, S.4    Miyazaki, A.5    Koba, S.6    Katagiri, T.7    Pakara, R.8    Benedict, C.R.9
  • 188
    • 14744304060 scopus 로고    scopus 로고
    • Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
    • Wilkinson S, Paterson HF, Marshall CJ (2005) Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol 7:255-261.
    • (2005) Nat Cell Biol , vol.7 , pp. 255-261
    • Wilkinson, S.1    Paterson, H.F.2    Marshall, C.J.3
  • 189
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17:5598-5611.
    • (1997) Mol Cell Biol , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 190
    • 33746562929 scopus 로고    scopus 로고
    • ROCK-and myosindependent matrix deformation enables protease-independent tumor-cell invasion in vivo
    • Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E (2006) ROCK-and myosindependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol 16:1515-1523.
    • (2006) Curr Biol , vol.16 , pp. 1515-1523
    • Wyckoff, J.B.1    Pinner, S.E.2    Gschmeissner, S.3    Condeelis, J.S.4    Sahai, E.5
  • 191
    • 33644997214 scopus 로고    scopus 로고
    • Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells
    • Yahiaoui L, Villeneuve A, Valderrama-Carvajal H, Burke F, Fixman ED (2006) Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Cell Physiol Biochem 17:37-46.
    • (2006) Cell Physiol Biochem , vol.17 , pp. 37-46
    • Yahiaoui, L.1    Villeneuve, A.2    Valderrama-Carvajal, H.3    Burke, F.4    Fixman, E.D.5
  • 192
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada KM, Cukierman E (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130:601-610.
    • (2007) Cell , vol.130 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 193
    • 33644837834 scopus 로고    scopus 로고
    • Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil
    • Yamaguchi H, Kasa M, Amano M, Kaibuchi K, Hakoshima T (2006) Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. Structure 14:589-600.
    • (2006) Structure , vol.14 , pp. 589-600
    • Yamaguchi, H.1    Kasa, M.2    Amano, M.3    Kaibuchi, K.4    Hakoshima, T.5
  • 194
    • 23844488162 scopus 로고    scopus 로고
    • Regulation of cancer cell motility through actin reorganization
    • Yamazaki D, Kurisu S, Takenawa T (2005) Regulation of cancer cell motility through actin reorganization. Cancer Sci 96:379-386.
    • (2005) Cancer Sci , vol.96 , pp. 379-386
    • Yamazaki, D.1    Kurisu, S.2    Takenawa, T.3
  • 195
    • 0037040943 scopus 로고    scopus 로고
    • Rho/ ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy
    • Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S (2002) Rho/ ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem 277:8618-8625.
    • (2002) J Biol Chem , vol.277 , pp. 8618-8625
    • Yanazume, T.1    Hasegawa, K.2    Wada, H.3    Morimoto, T.4    Abe, M.5    Kawamura, T.6    Sasayama, S.7
  • 196
    • 15744382282 scopus 로고    scopus 로고
    • Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor
    • Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ (2005) Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol 12:385-395.
    • (2005) Chem Biol , vol.12 , pp. 385-395
    • Yarrow, J.C.1    Totsukawa, G.2    Charras, G.T.3    Mitchison, T.J.4
  • 198
    • 14244251720 scopus 로고    scopus 로고
    • Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: Possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM
    • Yokoyama T, Goto H, Izawa I, Mizutani H, Inagaki M (2005) Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM). Genes Cells 10:127-137.
    • (2005) Genes Cells , vol.10 , pp. 127-137
    • Yokoyama, T.1    Goto, H.2    Izawa, I.3    Mizutani, H.4    Inagaki, M.5
  • 199
    • 23744480002 scopus 로고    scopus 로고
    • The Rho kinases i and II regulate different aspects of myosin II activity
    • Yoneda A, Multhaupt HA, Couchman JR (2005) The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol 170:443-453.
    • (2005) J Cell Biol , vol.170 , pp. 443-453
    • Yoneda, A.1    Multhaupt, H.A.2    Couchman, J.R.3
  • 202
    • 30044434693 scopus 로고    scopus 로고
    • Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2
    • Zhao M, Discipio RG, Wimmer AG, Schraufstatter IU (2006) Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2. Mol Pharmacol 69:66-75.
    • (2006) Mol Pharmacol , vol.69 , pp. 66-75
    • Zhao, M.1    Discipio, R.G.2    Wimmer, A.G.3    Schraufstatter, I.U.4
  • 203
    • 0037217745 scopus 로고    scopus 로고
    • Rho-Associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation
    • Zhao Z, Rivkees SA (2003) Rho-Associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation. Dev Dyn 226:24-32.
    • (2003) Dev Dyn , vol.226 , pp. 24-32
    • Zhao, Z.1    Rivkees, S.A.2
  • 204
    • 0041920695 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis
    • Zhong W-B, Wang C-Y, Chang T-C, Lee W-S (2003) Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology 144:3852-3859.
    • (2003) Endocrinology , vol.144 , pp. 3852-3859
    • Zhong, W.-B.1    Wang, C.-Y.2    Chang, T.-C.3    Lee, W.-S.4
  • 205
    • 0042934304 scopus 로고    scopus 로고
    • RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression
    • Zuckerbraun BS, Shapiro RA, Billiar TR, Tzeng E (2003) RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression. Circulation 108:876-881.
    • (2003) Circulation , vol.108 , pp. 876-881
    • Zuckerbraun, B.S.1    Shapiro, R.A.2    Billiar, T.R.3    Tzeng, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.