Cell motility mediated by Rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

Hepatology

Volumn 30, Issue 4, 1999, Pages 1027-1036

  Genoa, Takuya ^a,b   Sakamoto, Michiie ^a   Ichida, Takafumi ^b   Asakura, Hitoshi ^b   Kojiro, Masamichi ^c   Narumiya, Shuh ^d   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; RHO FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CELL MOTILITY; CONTROLLED STUDY; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER METASTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL PROCESSING; TUMOR GROWTH;

ACTINS; ADP RIBOSE TRANSFERASES; ANIMALS; BLOOD PHYSIOLOGY; BOTULINUM TOXINS; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; GENES, DOMINANT; GTP-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PROTEIN-SERINE-THREONINE KINASES; RHOB GTP-BINDING PROTEIN; TUMOR CELLS, CULTURED;

EID: 0032870464     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300420     Document Type: Article

References (5)

1. Nagao T, Inoue S, Goto S, Mizuta T, Omori Y, Kawano N, Morioka Y. Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis. Ann Surg 1987;205:33-40.
2. Nagao T, Inoue S, Yoshimi F, Sodeyama M, Omori Y, Mizuta T, Kawano N, et al. Postoperative recurrence of hepatocellular carcinoma. Ann Surg 1990;211:28-33.
3. Sakamoto M, Hirohashi S, Tsuda H, Shimosato Y, Makuuchi M, Hosoda Y. Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern. Am J Surg Pathol 1989;13:1064-1067.
4. Oda T, Tsuda H, Scarpa A, Sakamoto M, Hirohashi S. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res 1992;52:3674-3678.
5. Tsuda H, Oda T, Sakamoto M, Hirohashi S. Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin. Cancer Res 1992;52:1504-1509.