Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

EMBO Journal

Volumn 20, Issue 4, 2001, Pages 755-766

  Sahai, E ^a   Olson, M F ^a   Marshall, C J ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

LIM kinase; MAP kinase; p21Waf1; Ras; Rho; ROCK

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; LIM PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL MOTILITY; CELL PROLIFERATION; CELL TRANSFORMATION; ENZYME ACTIVITY; FIBROBLAST; MOLECULAR INTERACTION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; CELL MOVEMENT; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GTP-BINDING PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; MICROINJECTIONS; RAS PROTEINS; RECEPTOR CROSS-TALK;

ANIMALIA;

EID: 0035865137     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.4.755     Document Type: Article

References (43)

1. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
2. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker
3. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
4. Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells
5. Motility and invasion are differentially modulated by Rho family GTPases
6. ras oncogenes in human cancer: A review
7. 1 phase
8. Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
9. Genomic analysis of metastasis reveals an essential role for RhoC
10. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
11. Rho GTPases are over-expressed in human tumors
12. 1 to S phase in growth-stimulated rat FRTL-5 cells
13. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
14. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
15. Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation
16. Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent
17. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
18. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
19. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
20. Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia
21. Rho GTPases control polarity, protrusion and adhesion during cell movement
22. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
23. 1
24. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
25. An essential role for Rac in Ras transformation
26. A role for Rho in Ras transformation
27. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
28. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
29. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
30. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
31. Transformation mediated by RhoA requires activity of ROCK kinases
32. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics
33. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
34. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling
35. Biochemical and biological properties of the human N-ras p21 protein
36. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Db1 oncogenes
37. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
38. 1 progression through the independent regulation of cyclin D1 and p27
39. Multiple Ras functions can contribute to mammalian cell transformation
40. A role for the Ra1 guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
41. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
42. Oncogenic Ras down-regulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
43. A genome-wide survey of RAS transformation targets