Design and synthesis of Rho kinase inhibitors (I)

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2115-2137

  Takami, Atsuya ^a   Iwakubo, Masayuki ^a,d   Okada, Yuji ^a   Kawata, Takehisa ^a   Odai, Hideharu ^a   Takahashi, Nobuaki ^a   Shindo, Kazutoshi ^a,e   Kimura, Kaname ^a   Tagami, Yoshimichi ^a   Miyake, Mika ^a   Fukushima, Kayoko ^a   Inagaki, Masaki ^b   Amano, Mutsuki ^c   Kaibuchi, Kozo ^c   Iijima, Hiroshi ^a  

^a KIRIN BREWERY CO LTD   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d DIC CORPORATION   (Japan)

^e JAPAN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Inhibitor; Rho kinase; Structure activity relationship; Structure based drug design

Indexed keywords

INDAZOLE DERIVATIVE; ISOQUINOLINE; LIGAND; PHOSPHOTRANSFERASE INHIBITOR; PHTHALIMIDE; PYRIDINE; RHO KINASE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INFORMATION; LIGAND BINDING; PHARMACOPHORE; PREDICTION; SCREENING; SIMULATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ENZYME INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 11144355930     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.025     Document Type: Article

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