Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil

Structure

Volumn 14, Issue 3, 2006, Pages 589-600

  Yamaguchi, Hiroto ^a,b   Kasa, Miyuki ^a,b   Amano, Mutsuki ^c   Kaibuchi, Kozo ^c   Hakoshima, Toshio ^a,b  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FASUDIL; PHOSPHATE; RHO KINASE;

ANIMAL CELL; ARTICLE; CATALYSIS; DIMERIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG CONFORMATION; DRUG INHIBITION; DRUG INTERACTION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; ENZYME REGULATION; NONHUMAN; PLASTICITY; PLIABILITY; PRIORITY JOURNAL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; DIMERIZATION; HYDROPHOBICITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 33644837834     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2005.11.024     Document Type: Article

References (42)

1. M. Amano, M. Ito, K. Kimura, Y. Fukata, K. Chihara, T. Nakano, Y. Matsuura, and K. Kaibuchi Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) J. Biol. Chem. 271 1996 20246 20249
2. M. Amano, K. Chihara, K. Kimura, Y. Fukata, N. Nakamura, Y. Matsuura, and K. Kaibuchi Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase Science 275 1997 1308 1311
3. M. Amano, K. Chihara, N. Nakamura, T. Kaneko, Y. Matsuura, and K. Kaibuchi The COOH terminus of Rho-kinase negatively regulates rho-kinase activity J. Biol. Chem. 274 1999 32418 32424
4. C. Breitenlechner, M. Gassel, H. Hidaka, V. Kinzel, R. Huber, R.A. Engh, and D. Bossemeyer Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity Structure 11 2003 1595 1607
5. A.T. Brünger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.-S. Jiang, J. Kuszewski, M. Nilges, and N.S. Pannu Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54 1998 905 921
6. E.W. Bush, S.M. Helmke, R.A. Birnbaum, and M.B. Perryman Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition Biochemistry 39 2000 8480 8490
7. CCP4 (Collaborative Computational Project, Number 4) The CCP4 suite: programs for protein crystallography Acta Crystallogr. D Biol. Crystallogr. 50 1994 760 763
8. X.Q. Chen, I. Tan, C.H. Ng, C. Hall, L. Lim, and T. Leung Characterization of RhoA-binding kinase ROKα implication of the pleckstrin homology domain in ROKα function using region-specific antibodies J. Biol. Chem. 277 2002 12680 12688
9. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 2000 95 105
10. J.D. Doran, X. Liu, P. Taslimi, A. Saadat, and T. Fox New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications Biochem. J. 384 2004 255 262
11. R. Dvorsky, L. Blumenstein, I.R. Vetter, and M.R. Ahmadian Structural insights into the interaction of ROCKI with the switch regions of RhoA J. Biol. Chem. 279 2004 7098 7104
12. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
13. Y. Fukata, M. Amano, and K. Kaibuchi Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells Trends Pharmacol. Sci. 22 2001 32 39
14. M. Gassel, C.B. Breitenlechner, N. König, R. Huber, R.A. Engh, and D. Bossemeyer The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A J. Biol. Chem. 279 2004 23679 23690
15. E. Hu, and D. Lee Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges Expert Opin. Ther. Targets 9 2005 715 736
16. M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
17. T. Ishizaki, M. Maekawa, K. Fujisawa, K. Okawa, A. Iwamatsu, A. Fujita, N. Watanabe, Y. Saito, A. Kakizuka, N. Morii, and S. Narumiya The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase EMBO J. 15 1996 1885 1893
18. ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions FEBS Lett. 404 1997 118 124
19. K. Kaibuchi, S. Kuroda, and M. Amano Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells Annu. Rev. Biochem. 68 1999 459 486
20. K. Kimura, M. Ito, M. Amano, K. Chihara, Y. Fukata, M. Nakafuku, B. Yamamori, J. Feng, T. Nakano, and K. Okawa Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science 273 1996 245 248
21. G.J. Kleywegt, and T. Jones Model building and refinement practice Methods Enzymol. 277 1997 208 230
22. R.A. Laskowski, M.W. MacArthur, D.S. Moss, and J.M. Thornton PROCHECK: a program to check the stereochemical quality of protein structures J. Appl. Crystallogr. 26 1993 283 291
23. T. Leung, E. Manser, L. Tan, and L. Lim A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes J. Biol. Chem. 270 1995 29051 29054
24. T. Leung, X.Q. Chen, E. Manser, and L. Lim The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton Mol. Cell. Biol. 16 1996 5313 5327
25. P. Madaule, M. Eda, N. Watanabe, K. Fujisawa, T. Matsuoka, H. Bito, T. Ishizaki, and S. Narumiya Role of citron kinase as a target of the small GTPase Rho in cytokinesis Nature 394 1998 491 494
26. T. Matsui, M. Amano, T. Yamamoto, K. Chihara, M. Nakafuku, M. Ito, T. Nakano, K. Okawa, A. Iwamatsu, and K. Kaibuchi Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho EMBO J. 15 1996 2208 2216
27. M. Mohammadi, G. McMahon, L. Sun, C. Tang, P. Hirth, B.K. Yeh, S.R. Hubbard, and J. Schlessinger Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors Science 276 1997 955 960
28. B.K. Mueller, H. Mack, and N. Teusch Rho kinase, a promising drug target for neurological disorders Nat. Rev. Drug Discov. 4 2005 387 398
29. G.N. Murshudov, A.A. Vagin, A. Lebedev, K.S. Wilson, and E.J. Dodson Efficient anisotropic refinement of macromolecular structures using FFT Acta Crystallogr. D Biol. Crystallogr. 55 1999 247 255
30. B. Nagar, O. Hantschel, M.A. Young, K. Scheffzek, D. Veach, W. Bornmann, B. Clarkson, G. Superti-Furga, and J. Kuriyan Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell 112 2003 859 871
31. A.C. Newton Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm Biochem. J. 370 2003 361 371
32. B. Nolen, S. Taylor, and G. Ghosh Regulation of protein kinases: controlling activity through activation segment conformation Mol. Cell 15 2004 661 675
33. N. Ono-Saito, I. Niki, and H. Hidaka H-series protein kinase inhibitors and potential clinical applications Pharmacol. Ther. 82 1999 123 131
34. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326
35. T.D. Parks, K.K. Leuther, E.D. Howard, S.A. Johnston, and W.G. Dougherty Release of proteins and peptides from fusion proteins using a recombinant plant virus proteinase Anal. Biochem. 216 1994 413 417
36. L.H. Pearl, and D. Barford Regulation of protein kinases in insulin, growth factor and Wnt signalling Curr. Opin. Struct. Biol. 12 2002 761 767
37. R.T. Peterson, and S.L. Schreiber Kinase phosphorylation: keeping it all in the family Curr. Biol. 9 1999 R521 R524
38. L. Prade, R.A. Engh, A. Girod, V. Kinzel, R. Huber, and D. Bossemeyer Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential Structure 5 1997 1627 1637
39. K. Riento, and A.J. Ridley Rocks: multifunctional kinases in cell behaviour Nat. Rev. Mol. Cell Biol. 4 2003 446 456
40. T. Shimizu, K. Ihara, R. Maesaki, M. Amano, K. Kaibuchi, and T. Hakoshima Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase J. Biol. Chem. 278 2003 46046 46051
41. I. Tan, K.T. Seow, L. Lim, and T. Leung Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase α Mol. Cell. Biol. 21 2001 2767 2778
42. M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Midori Maekawa, and S. Narumiya Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 1997 990 994