Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

Circulation Research

Volumn 88, Issue 11, 2001, Pages 1102-1104

  Sauzeau, Vincent ^a   Le Mellionnec, Erik ^a   Bertoglio, Jacques ^b   Scalbert, Elizabeth ^c   Pacaud, Pierre ^a   Loirand, Gervaise ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b INSERM   (France)

^c IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

G protein; Signal transduction; Vascular

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RHO FACTOR; RHO KINASE; UROTENSIN II;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION;

EID: 0035827716     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1101.092034     Document Type: Article

References (17)

1. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
2. Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
3. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
4. Orphan-receptor ligand human urotensin II: Receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1
5. Contractile responses to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
6. Human urotensin II mediates vasoconstriction via an increase in inositol phosphates
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13. Effect of endothelin-1 (1-31) on extracellular signal-regulated kinase and proliferation of human coronary artery smooth muscle cells
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15. A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle
16. Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries
17. Role of Rho-associated kinase in neointima formation after vascular injury