Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase

Cancer Letters

Volumn 219, Issue 1, 2005, Pages 71-81

  Han, Shouwei ^a   Sidell, Neil ^a   Roman, Jesse ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Erk; Fibronectin; Human lung cancer cells; p21; Rho; Sp1

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALPHOSTIN C; COLLAGEN TYPE 1; CYCLIN D1; FIBRONECTIN; GLYCOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OLIGONUCLEOTIDE; PD 98095; PROTEIN P21; RHO KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SP1; WORTMANNIN;

ARTICLE; BINDING AFFINITY; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; GENE EXPRESSION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 13444283563     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.07.040     Document Type: Article

References (50)

1. W.C. Weinberg, and M.F. Denning P21Waf1 control of epithelial cell cycle and cell fate Crit. Rev. Oral Biol. Med. 13 2002 453 464
2. S. Chellappan, A. Giordano, and P.B. Fisher The role of cyclin dependent kinases and their inhibitors in cellular differentiation and development Curr. Top. Immunol. 227 1998 57 103
3. J.S. Kim, S. Lee, T. Lee, Y.W. Lee, and J.B. Trepel Transcriptional activation of p21 (WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor Biochem. Biophys. Res. Commun. 281 2001 866 871
4. J. Niklinski, W. Niklinska, J. Laudanski, E. Chyczewska, and L. Chyczewski Prognostic molecular markers in non-small cell lung cancer Lung Cancer Suppl. 2 2001 S53 S58
5. T. Komiya, Y. Hosono, T. Hirashima, N. Masuda, T. Yasumitsu, and K. Nakagawa p21 expression as a predictor for favorable prognosis in squamous cell carcinoma of the lung Clin. Cancer Res. 3 1997 1831 1835
6. A.H. Limper, and J. Roman Fibronectin. A versatile matrix protein with roles in thoracic development, repair and infection Chest 101 1992 1663 1673
7. J. Labat-Robert Fibronectin in malignancy Semin. Cancer Biol. 12 2002 187 195
8. D.J. Romberger Fibronectin Int. J. Biochem. Cell Biol. 29 1997 939 943
9. F. Oyama, S. Hirohashi, Y. Shimasato, K. Titani, and K. Sekiguchi Qualitative and quantitative changes of human tenascin expression in transformed lung fibroblast and lung tumor tissues: comparison with fibronectin Cancer Res. 51 1991 4876 4881
10. F. Fang, G. Orend, N. Watanabe, T. Hunter, and E. Ruoslahti Dependence of cyclin E-CDK2 kinase activity on cell anchorage Science 271 1996 499 502
11. M. Illario, V. Amideo, A. Casamassima, M. Andreucci, T. di Matola, and C. Miele Integrin-dependent cell growth and survival are mediated by different signals in thyroid cells J. Clin. Endocrinol. Metab. 88 2003 260 269
12. T. Sakai, M. Larsen, and K.M. Yamada Fibronectin requirement in branching morphogenesis Nature 423 2003 876 881
13. J.E. Michaelson, J.D. Ritzenthaler, and J. Roman Regulation of serum-induced fibronectin expression by protein kinases, cytoskeletal integrity, and CREB Am. J. Physiol. Lung Cell Mol. Physiol. 282 2002 L291 L301
14. V.M. Wasenius, S. Hemmer, E. Kettunen, S. Knuutila, K. Franssila, and H. Joensuu Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study Clin. Cancer Res. 9 2003 68 75
15. E. Ioachim, A. Charchanti, E. Briasoulism, V. Karavasilis, H. Tsanoum, and D.L. Arvanitis Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression Eur. J. Cancer 38 2002 2362 2370
16. G. Krupitza, S. Grill, H. Harant, W. Hulla, T. Szekeres, H. Huber, and C. Dittrich Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells Br. J. Cancer 73 1996 433 438
17. N. Nanki, J. Fujita, Y. Yang, S. Hojo, S. Bandoh, Y. Yamaji, and T. Ishida Expression of oncofetal fibronectin and syndecan-1 mRNA in 18 human lung cancer cell lines Tumor Biol. 22 2001 390 396
18. S.B. Jakowlew, J.M. Mariano, L. You, and A. Mathias Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells Biochim. Biophys. Acta 1353 1997 157 170
19. R.C. Rintoul, and T. Sethi Extracellular matrix regulation of drug resistance in small-cell lung cancer Clin. Sci. (Lond.) 102 2002 417 424
20. M.E. Bottazzi, X. Zhu, R.M. Bohmer, and R.K. Assoian Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase J. Cell Biol. 146 1999 1255 1264
21. E.H. Danen, P. Sonneveld, A. Sonnenberg, and K.M. Yamada Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression J. Cell Biol. 151 2000 1413 1422
22. Z.Y. Huang, Y. Wu, N. Hedrick, and D.H. Gutmann T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21 (CIP1/WAF1) expression Mol. Cell Biol. 23 2003 566 578
23. S. Han, and N. Sidell RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappaB signaling pathway J. Clin. Endocrinol. Metab. 88 2003 713 719
24. S. Han, and N. Sidell Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid Immunology 106 2002 53 59
25. S. Kawakami, G. Arai, T. Hayashi, Y. Fujii, G. Xia, Y. Kageyama, and K. Kihara PPARgamma ligands suppress proliferation of human urothelial basal cells in vitro J. Cell Physiol. 191 2002 310 319
26. Y. Xiong, T. Connolly, B. Futcher, and D. Beach Human D-type cyclin Cell 65 1991 691 699
27. S.W. Han, H. Inoue, L.C. Flowers, and N. Sidell Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells Clin. Cancer Res. 9 2003 4627 4635
28. S.W. Han, Z.M. Lei, and C.V. Rao Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into deciduas Endocrinology 137 1996 1791 1797
29. J.S. Park, L. Qiao, D. Gilfor, M.Y. Yang, P.B. Hylemon, and C. Benz A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes Mol. Biol. Cell 11 2000 2915 2932
30. S. Han, R.K. Wada, and N. Sidell Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma Cancer Res. 61 2001 3998 4002
31. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res. 11 1983 1475 1489
32. G. Koutsodontis, A. Moustakas, and D. Kardassis The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter Biochemistry 41 2002 12771 12784
33. S. Han, N. Slidell, S. Riser-Pager, and J. Roman Fibronectin stimulates human lung cancer cell growth by inducing cyclooxygenase-2 (COX-2) gene expression Int. J. Cancer 111 2004 322-331
34. W. Bao, M. Thullberg, H. Zhang, A. Onischenko, and S. Stromblad Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling Mol. Cell Biol. 22 2002 4587 4597
35. J. Roman, J.D. Ritzenthaler, M.J. Fenton, S. Roser, and W. Schuyler Transcriptional regulation of the human interleukin 1beta gene by fibronectin: role of protein kinase C and activator protein 1 (AP-1) Cytokine 12 2000 1581 1596
36. K. Larouche, S. Leclerc, C. Salesse, and S.L. Guerin Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro J. Biol. Chem. 275 2000 39182 39192
37. P. Defilippi, M. Venturino, D. Gulino, A. Duperray, P. Boquet, and C. Fiorentini Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation J. Biol. Chem. 272 1997 21726 21734
38. C. Wagner, M. Pioch, C. Meyer, C. Iking-Konert, K. Andrassy, and G.M. Hansch Differentiation of polymorphonuclear neutrophils in patients with systemic infections and chronic inflammatory diseases: evidence of prolonged life span and de novo synthesis of fibronectin J. Mol. Med. 78 2000 337 345
39. N. Cordes, and D. van Beuningen Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro Br. J. Cancer 88 2003 1470 1479
40. S. Martin, L. Favot, R. Matz, C. Lugnier, and R. Andriantsitohaina Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 Biochem. Pharmacol. 65 2003 669 765
41. L. Zhou, A. Tan, S. Iasvovskaia, J. Li, A. Lin, and M.B. Hershenson Ras and mitogen-activated protein kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells Am. J. Respir. Cell Mol. Biol. 28 2003 762 769
42. S. Bourdoulous, G. Orend, D.A. MacKenna, R. Pasqualini, and E. Ruoslahti Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression J. Cell Biol. 143 1998 267 276
43. J. Adnane, F.A. Bizouarn, Y. Qian, A.D. Hamilton, and S.M. Sebti p21 (WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA Mol. Cell Biol. 18 1998 6962 6970
44. J.K. Sax, B.C. Dash, R. Hong, D.T. Dicker, and W.S. El-Deiry The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression) Cell Cycle 1 2002 90 96
45. J.W. Han, S.H. Ahn, Y.K. Kim, G.U. Bae, J.W. Yoon, and S. Hong Activation of p21 (WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C J. Biol. Chem. 276 2001 42084 42090
46. B. Salh, A. Marotta, R. Wagey, M. Sayed, and S. Pelech Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer Int. J. Cancer 98 2002 148 154
47. L. Li, L. Liu, J.N. Rao, A. Esmaili, E.D. Strauch, B.L. Bass, and J.Y. Wang JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion Gastroenterology 123 2002 764 779
48. R. Chinery, J.A. Brockman, M.O. Peeler, Y. Shyr, R.D. Beauchamp, and R.J. Coffey Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta Nat. Med. 3 1997 1233 1241
49. G.Z. Yan, and E.B. Ziff Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor J. Neurosci. 17 1997 6122 6132
50. A.R. Black, J.D. Black, and J. Azizkhan-Clifford Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer J. Cell Physiol. 188 2001 143 160