Therapeutic Effect of Y-27632 on Chronic Allograft Nephropathy in Rats

Journal of Surgical Research

Volumn 157, Issue 1, 2009, Pages

  Liu, Min ^a   Gu, Min ^a   Wu, Yichao ^b   Zhu, Pengcheng ^b   Zhang, Wei ^a   Yin, Changjun ^a  

^a j)   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

chronic allograft nephropathy; kidney transplantation; Rho kinase; Y 27632, fibrosis

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA SMOOTH MUSCLE ACTIN; CHEMOKINE; CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; RHO FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; FISCHER 344 RAT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; LEWIS RAT; MALE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; RAT;

ACTINS; AMIDES; ANIMALS; CHEMOKINE CCL2; CHEMOKINE CCL5; CHRONIC DISEASE; DELAYED GRAFT FUNCTION; ENZYME INHIBITORS; FIBROSIS; KIDNEY TRANSPLANTATION; MALE; NEPHRITIS; NF-KAPPA B; PYRIDINES; RATS; RATS, INBRED F344; RATS, INBRED LEW; RHO-ASSOCIATED KINASES; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTATION, HOMOLOGOUS;

EID: 70349792513     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.10.018     Document Type: Article

References (33)

1. Paul L.C. Chronic allograft nephropathy: An update. Kidney Int 56 (1999) 783
2. Mannon R.B. Therapeutic targets in the treatment of allograft fibrosis. Am J Transplant 6 (2006) 867
3. Shimizu A., Yamada K., Sachs D.H., et al. Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine. Lab Invest 82 (2002) 673
4. Bedi S., Vidysagar A., and Djamali A. Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev 22 (2008) 1
5. Hertog A., Verine J., Mougenot B., et al. Risk factors for early epithelial to mesenchymal transition in renal grafts. Am J Transplant 6 (2006) 2937
6. Madaule P., and Axel R. A novel ras-related gene family. Cell 41 (1985) 31
7. Pawlak G., and Helfman D.M. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. J Biol Chem 277 (2002) 26927
8. Cho H.J., and Yoo J. Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cells. Cell Biol Int 31 (2007) 1225
9. Teraishi K., Kurata H., Nakajima A., et al. Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal failure in rats. Eur J Pharmacol 505 (2004) 205
10. Lai A., and Frishman W.H. Rho-kinase inhibition in the therapy of cardiovascular disease. Cardiol Rev 13 (2005) 285
11. Kitamura K., Tada S., Nakamoto N., et al. Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis. J Gastroenterol Hepatol 22 (2007) 2022
12. Zhang W., Liu M., Wu Y., et al. Protective effects of atorvastatin on chronic allograft nephropathy in rats. J Surg Res 143 (2007) 428
13. Uehata M., Ishizaki T., Satoh H., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein. Nature 389 (1997) 990
14. Ishizaki T., Uehata M., Tamechika I., et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57 (2000) 976
15. Wang J., Geissler E.K., Fechner Jr. J.H., et al. Use of donor serum to prevent passive transfer of hyperacute rejection. J Surg Res 57 (1994) 150
16. Racusen L.C., Solez K., Colvin R.B., et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 55 (1999) 713
17. McCarthy G.P., and Roberts I.S. Diagnosis of acute renal allograft rejection: Evaluation of the Banff 97 Guidelines for Slide Preparation. Transplantation 73 (2002) 1518
18. Liu M., Zhang W., Gu M., et al. Protective effects of sirolimus by attenuating connective tissue growth factor expression in human chronic allograft nephropathy. Transplant Proc 39 (2007) 1410
19. Griffin B.D., and Moynagh P.N. In vivo binding of NF-κB to the I-κBβ promoter is insufficient for transcriptional activation. Biochem J 400 (2006) 115
20. Versteilen A.M., Korstjens I.J., Musters R.J., et al. Rho kinase regulates renal blood flow by modulating eNOS activity in ischemia-reperfusion of the rat kidney. Am J Physiol Renal Physiol 291 (2006) F606
21. Seko T., Ito M., Kureishi Y., et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 92 (2003) 411
22. Fu P., Liu F., Su S., et al. Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol 17 (2006) 3105
23. Gao B.H., Zhao S.T., Meng F.W., et al. Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways. Andrologia 39 (2007) 146
24. Murata T., Arii S., Mori A., et al. Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis. J Surg Res 114 (2003) 64
25. Katsuyuki N., Toshiki M., Noritaka K., et al. Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kid Int 61 (2002) 1684
26. Vongwiwatana A., Tasanarong A., Rayner D.C., et al. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis. Am J Transplant 5 (2005) 1367
27. Burns W.C., Kantharidis P., and Thomas M.C. The role of tubular epithelial-mesenchymal transition in progressive kidney disease. Cells Tissues Organs 185 (2007) 222
28. van den Boom F., Düssmann H., Uhlenbrock K., et al. The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization. Mol Biol Cell 18 (2007) 1507
29. Cavarape A., Bauer J., Bartoli E., et al. Effects of angiotensin II, arginine vasopressin and thromboxane A2 in renal vascular bed. Nephrol Dial Transplant 18 (2003) 1764
30. Walsh S.V., Hopkins A.M., Chen J., et al. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 121 (2001) 566
31. Chen S., Crawford M., Day R.M., et al. RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation. J Biol Chem 281 (2006) 1765
32. Deaton R.A., Su C., Valencia T.G., et al. Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK. J Biol Chem 280 (2005) 31172
33. Nishimura G., Manabe I., Tsushima K., et al. DeltaEF1 mediates TGF-β signaling in vascular smooth muscle cell differentiation. Dev Cell 11 (2006) 93