The aging kidney: Insights from experimental studies

Journal of the American Society of Nephrology

Volumn 9, Issue 4, 1998, Pages 699-709

  Baylis, Chris ^a   Corman, Bruno ^b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ATRIAL NATRIURETIC FACTOR; ENDOTHELIN; MESSENGER RNA; NITRIC OXIDE; PROSTACYCLIN; THROMBOXANE A2;

ADRENERGIC SYSTEM; AGED; AGING; ANIMAL MODEL; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY VASCULAR RESISTANCE; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

EID: 0031901227     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (151)

1. Epstein M: Aging and the kidney. J Am Soc Nephrol 7: 1106-1122, 1996
2. Chou SY, Lindeman RD: Structural and functional changes in the aging kidney. In: The Principles and Practice of Nephrology, 2nd Ed., edited by Jacobson HR, Striker GE, Klahr S, St. Louis, Mosby, 1995, pp 510-514
3. Baylis C, Schmidt RJ: The aging glomerulus. Semin Nephrol 16: 265-276, 1996
4. Levi M, Rowe JW: Renal function and dysfunction in aging. In: The Kidney: Physiology and Pathophysiology, edited by Seldin DW, Giebisch G, New York, Raven, 1992, pp 3433-3456
5. Corman B, Michel JB: Glomerular filtration, renal blood flow, and solute excretion in conscious aging rats. Am J Physiol 253: R555-R560, 1987
6. Corman B, Owen R: Normal development, growth, and aging of the kidney. In: Pathobiology of the Aging Rats, edited by Mohr U, Dungworth DL, Capen CC, Washington, DC, ILSI Press, 1992, pp 195-209
7. Hirokawa K: Characterization of age-associated kidney disease in Wistar rats. Mech Ageing Dev 4: 301-316, 1975
8. Heudes D, Michel O, Chevalier J, Bariety J, Zimmerman A, Corman B: Effect of chronic angiotensin I converting enzyme inhibition on the aging processes. I. Kidney structure and function. Am J Physiol 266: R1038-R1051, 1994
9. Dodane V, Chevalier J, Bariety J, Pratz J, Corman B: Longitudinal study of solute excretion and glomerular ultrastructure in an experimental model of aging rats free of kidney disease. Lab Invest 64: 377-391, 1991
10. Baylis C: Age-dependent glomerular damage in the rat: Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest 94: 1823-1829, 1994
11. Corman B, Pratz J, Poujeol P: Changes in anatomy, glomerular filtration, and solute excretion in aging rat kidney. Am J Physiol 248: R282-287, 1985
12. Owen R, Heywood R: Age-related variation in renal structure and function in Sprague-Dawley rats. Toxicol Pathol 14: 158-167, 1986
13. Yu B, Masoro E, Murata I, Bertrand H, Lynd F: Lifespan study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass, and disease. J Gerontol 37: 130-141, 1982
14. Francois V, Heudes D, Bariety J, Bruneval P, Corman B: Glomerular capillary network of cortical nephron is reduced in male but not in female aging rats. Mech Ageing Dev 91: 11-22, 1996
15. Gray J: Chronic progressive nephrosis in the albino rats. CRC Crit Rev Toxicol 5: 115-143, 1977
16. Gray J, Weaver R, Purmalis A: Ultrastructural observations of chronic progressive nephrosis in the Sprague-Dawley rat. Vet Pathol 11: 153-164, 1974
17. Bolton W, Sturgill B: Ultrastructure of the aging kidney. In: Aging and Cell Structure, Vol. 1, edited by Johnson JE, New York, Plenum, 1981, pp 215-250
18. Li Y, Steffes M, Donelly T, Liu C, Fuh H, Basgen J, Bucala R, Vlassara H: Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine. Proc Natl Acad Sci USA 93: 3902-3907, 1996
19. Reckelhoff JF, Samsell L, Racusen L, Dey R, Baylis C: The effect of aging on glomerular hemodynamics in the Sprague-Dawley rat. Am J Kidney Dis 20: 70-75, 1992
20. Sato F, Tsuchihashi T, Kawashima N: Age changes in number and size of the murine renal glomeruli. Exp Gerontol 10: 325-331, 1975
21. Bertani T, Zoja C, Abbate M, Rossini M, Remuzzi G: Age-related nephropathy and proteinuria in rats with intact kidneys exposed to diets with different protein content. Lab Invest 60: 196-204, 1989
22. Bureck J: Pathology of Aging Rats, Boca Raton, FL, CRC Press, 1979
23. Everitt A, Porter B, Wyndham J: Effect of caloric intake and dietary composition on the development of proteinuria, age associated renal disease and longevity in the male rats. Gerontology 28: 168-173, 1982
24. Kreisberg J, Karnovsky M: Focal glomerular sclerosis in the Fawn-Hooded rat. Am J Pathol 92: 637-652, 1978
25. Maeda H, Gleiser C, Masoro E, Murata I, McMahan C, Yu B: Nutritional influences on aging of Fischer 344 rats. II. Pathology. J Gerontol 40: 671-688, 1985
26. Pollard M, Kajima M: Lesions in aged, germ-free Wistar rats. Am J Pathol 61: 25-36, 1970
27. Short B, Goldstein R: Nonneoplastic lesions in the kidney. In: Pathobiology of the Aging Rats, edited by Mohr U, Dungworth DL, Capen CC, Washington, DC, ILSI Press, 1992, pp 212-225
28. Walker F: The origin, turnover and removal of glomerular basement membrane. J Pathol 110: 233-244, 1973
29. Win Win Y, Takahashi S, Kawashima S: Age-related changes in sex difference in the ultrastructure of renal glomerulus in Wistar/Tw rats. Zool Sci (Tokyo) 6: 777-788, 1989
30. Greenfeld Z, Stillman IE, Brezis M, Rosen S: Medullary injury in the aging rat kidney: Functional-morphometric correlations. Eur J Clin Invest 27: 346-351, 1997
31. Abrass CK, Adcox MJ, Raugi GJ: Age associated changes in renal extracellular matrix. Am J Pathol 146: 742-752, 1995
32. Van Liew JB, Davis FB, Davis PJ, Noble B, Bernardis LL: Calorie restriction decreases microalbuminuria associated with aging in barrier-raised Fischer 344 rats. Am J Physiol 263: F554-F561, 1992
33. Goldstein RS, Tarloff JB, Hook JB: Age-related nephropathy in laboratory rats. FASEB J 2: 2241-2251, 1988
34. Corman B, Chami-Khazraji S, Schaeverbeke J, Michel JB: Effect of feeding on glomerular filtration rate and proteinuria in conscious aging rats. Am J Physiol 255: F250-F256, 1988
35. Baylis C, Fredericks M, Leypoldt K, Frigon R, Wilson C, Henderson L: Mechanisms of proteinuria in aging rats. Mech Ageing Dev 45: 111-126, 1988
36. Neuhaus OW, Flory W: Age-dependent changes in the excretion of urinary proteins by the rat. Nephron 22: 570-576, 1978
37. Alt JM, Hackbarth H, Deerberg F, Stolte H: Proteinuria in rats in relation to age-dependent renal changes. Lab Anim 14: 95-101, 1980
38. Bakala H, Verbeke P, Perichon M, Corman B, Schaeverbeke J: Glycation of albumin with aging and diabetes in rats: Changes in its renal handling. Mech Ageing Dev 78: 63-71, 1995
39. Casadevall G, Piera C, Setoain J, Queralt J: Age-dependent enzymuria, proteinuria and changes in renal blood flow and glomerular filtration rate in rats. Mech Ageing Dev 82: 51-60, 1995
40. Damsgaard EM, Froland A, Jorgensen OD: Microalbuminuria as predictor of increased mortality in elderly people. Br Med J 300: 297-300, 1990
41. Cheignon M, Bakala H, Geloso-Meyer A, Schaeverbeke J: Changes of glomerular filtration barrier related to aging, in the rat. Comptes Rendus de l'Académie des Sciences Paris, t.299, serie III, #9, 379-382, 1984
42. Anderson S, Brenner BM: Effects of aging on the renal glomerulus. Am J Med 80: 435-442, 1986
43. Remuzzi A, Puntorieri S, Mazzoleni A: Sex related differences in glomerular ultrafiltration and proteinuria in Munich Wistar rats. Kidney Int 34: 481-486, 1988
44. Reckelhoff JF, Manning RD Jr: Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats. Am J Physiol 265: R1126-R1131, 1993
45. Fujihara CK, Limongi DMZP, De Oliveira HCF, Zatz R: Absence of focal glomerulosclerosis in aging analbuminemic rats. Am J Physiol 262: R947-R954, 1992
46. Brenner BM: Nephron adaptation to renal injury or ablation. Am J Physiol 249: F324-F328, 1985
47. Yoshida Y, Fogo A, Ichikawa I: Glomerular hemodynamic changes vs hypertrophy in experimental glomerular sclerosis. Kidney Int 35: 654-660, 1989
48. Daniels BS, Hostetter TH: Adverse effects of growth in the glomerular microcirculation. Am J Physiol 258: F1409-F1416, 1990
49. Zatz R, Fujihara CK: Glomerular hypertrophy and progressive glomerulopathy: Is there a definite pathogenetic correlation? Kidney Int Suppl 45: S27-S29, 1994
50. Remuzzi A, Puntorieri S, Alfano M, Maccioni D, Abbate M, Bertani T, Remuzzi G: Pathophysiologic implications of proteinuria in a rat model of progressive glomerular injury. Lab Invest 67: 572-579, 1992
51. Gafter U, Ben-Bassat M, Levi J: Castration inhibits glomerular hypertrophy and proteinuria in uninephrectomized male rats. Eur J Clin Invest 20: 360-365, 1990
52. Gray JE, Van Zwieten MJ, Hollandes CF: Early light microscopic changes of chronic progressive nephrosis in several strains of aging laboratory rats. J Gerontol 37: 142-150, 1982
53. Baylis C, Wilson CB: Sex and the single kidney. Am J Kidney Dis 13: 290-298, 1989
54. Lombet JR, Adler SG, Anderson PS, Nast CC, Olsen DR, Glassock RJ: Sex vulnerability in the subtotal nephrectomy model of glomerulosclerosis in the rat. J Lab Clin Med 114: 66-74, 1989
55. Gretz N, Zeier M, Geberth S, Stranch M, Ritz E: Is gender a determinant for evolution of renal failure? A study of autosomal dominant polycystic kidney disease. Am J Kidney Dis 14: 178-183, 1989
56. West KM, Erdreich L, Stober JA: A detailed study of risk factors for retinopathy and nephropathy in diabetes. Diabetes 29: 501-508, 1980
57. Silbiger SR, Neugarten J: The impact of gender on the progression of chronic renal disease. Am J Kidney Dis 25: 515-533, 1995
58. Floege J, Johnson RJ, Couser WG: Mesangial cells in the pathogenesis of progressive glomerular disease in animal models. Clin Invest 70: 857-864, 1992
59. Couser WG, Stilmant MM: Mesangial lesions and focal glomerular sclerosis in the aging rat. Lab Invest 33: 491-501, 1975
60. Elema JD, Arends A: Focal and segmental glomerular hyalinosis and sclerosis in the rat. Lab Invest 33: 554-561, 1975
61. Corman B, Roinel N: Single nephron filtration rate and proximal reabsorption in aging rats. Am J Physiol 266: F75-F80, 1990
62. Reckelhoff JF, Baylis C: Glomerular metalloprotease activity is suppressed by androgens in the aging kidney. J Am Soc Nephrol 3: 1835-1838, 1993
63. Cohen M, Hud E, Van-Yu W, Ziyadeh N: Albumin modified by Amadori glucose adducts activates mesangial cell type IV collagen gene transcription. Mol Cell Biochem 151: 61-67, 1995
64. Doi T, Vlassara H, Kirstein M, Yamada Y, Striker G, Striker L: Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor. Proc Natl Acad Sci USA 89: 2873-2877, 1992
65. Soulis-Liparota T, Cooper M, Papazoglou D, Clarke B, Jerums G: Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozotocin-induced diabetic rat. Diabetes 40: 1328-1334, 1991
66. Vlassara H, Bucala R, Striker L: Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 70: 138-151, 1994
67. Yang C, Vlassara H, Peten E, He C, Striker G, Striker L: Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease. Proc Natl Acad Sci USA 91: 9436-9440, 1994
68. Yang C, Vlassara H, Striker G, Striker L: Administration of AGEs in vivo induces genes implicated in diabetic glomerulosclerosis. Kidney Int Suppl 49: S55-S58, 1995
69. Verbeke P, Perichon M, Borot-Laloi C, Shaeverbeke J, Bakala H: Accumulation of advanced glycation end products in the rat nephron: Link with circulating AGEs during aging. J Histochem Cytochem 45: 1059-1068, 1997
70. Corman B, Duriez M, Poitevin P, Heudes D, Bruneval P, Tedgui A, Levy BI: Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. Proc Natl Acad Sci USA 95: 1301-1306, 1998
71. Saxton J, Kimball G: Relation of nephrosis and other diseases of albino rats to age and to modification of diet. Arch Pathol 32: 951-965, 1942
72. Zawada ET, Alavi FK, Santella RN, Maddox DA: Influence of dietary macronutrients on glomerular senescence. Curr Nephrol 20: 1-47, 1997
73. Corman B, Teillet L: Nutrition and kidney aging. In: Facts and Research in Gerontology, edited by Albarede JL, Veilas P, Garry PJ, Serdi, 1994, pp 127-137
74. Kennedy G: Effect of old age and over-nutrition on the kidney. Br Med Bull 13: 67-81, 1957
75. Masoro E: Food restriction in rodents, an evaluation in its role in the study of aging. J Gerontol 43: 59-64, 1988
76. Masoro E, Yu B: Diet and nephropathy. Lab Invest 60: 165-167, 1989
77. Yu B, Masoro E, McMahan C: Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic, and longevity characteristics. J Gerontol 40: 657-670, 1985
78. Joles JA, Goor H, Van Der Horst LC, Van Toi A, Elema JD, Koomans HA: High lipid levels in very low density lipoprotein and intermediate density lipoprotein may cause proteinuria and glomerulosclerosis in aging female analbuminemic rats. Lab Invest 6: 912-921, 1995
79. Iwaski K, Gleiser C, Masoro E, McMahan C, Seo EJ, Yu B: The influence of dietary protein source on longevity and age-related disease processes of Fischer rats. J Gerontol 43: B5-B12, 1988
80. Kalu D, Masoro E, Yu B, Hardin R, Hollis B: Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction. Endocrinology 122: 1847-1854, 1988
81. Blatherwick N, Medlar E: Chronic nephritis in rats fed high protein diets. Arch Intern Med 59: 572-586, 1937
82. Bras G, Ross H: Kidney disease and nutrition in the rat. Toxicol Appl Pharmacol 6: 247-252, 1964
83. Fujita Y, Ichikawa M, Kurimoto M, Rikimaru T: Effect ot teed restriction and switching the diet on proteinuria in male Wistar rats. J Gerontol 39: 531-537, 1984
84. Tucker S, Mason R, Beauchene R: Influence of diet and feed restriction on kidney function of aging male rats. J Gerontol 31: 264-270, 1976
85. Wyndham J, Everitt A, Everitt S: Effect of isolation and food restriction begun at 50 days on the development of age-associated renal disease in the male Wistar rat. Arch Gerontol Geriatr 2: 317-332, 1983
86. Masoro E, Katz M, McMahan C: Evidence for the glycation hypothesis of aging from the food-restricted rodent model. J Gerontol 44: 20-21, 1989
87. Sterzel RB, Schulze-Lohoff E, Weber M, Goodman SL: Interactions between glomerular mesangial cells, cytokines, and extracellular matrix. J Am Soc Nephrol 2: S126-S131, 1992
88. Doi T, Vlassara H, Kirstein M, Yamada Y, Striker G, Striker L: Receptor specific increased mesangial cell extracellular matrix production is mediated by PDGF. Proc Natl Acad Sci USA 89: 2873-2877, 1992
89. Paget G, Lemon P: The interpretation of pathology data. In: The Pathology of Laboratory Animals, Vol. 14, edited by McCoy J, Springfield, IL, Thomas, 1965, pp 382-395
90. Baylis C, Fredericks M, Wilson C, Munger K, Collins R: Renal vasodilatory response to IV glycine in the aging rat kidney. Am J Kidney Dis 15: 244-251, 1990
91. Munger KA, Baylis C: Sex differences in renal hemodynamic in rats. Am J Physiol 254: F223-F231, 1988
92. Belmin J, Lévy BI, Michel JB: Changes in the renin angiotensin-aldosterone axis in the laterlife. Drugs Aging 5: 391-400, 1994
93. Corman B, Michel JB: Renin-angiotensin system, converting-enzyme inhibition, and kidney function in aging female rats. Am J Physiol 251: R450-R455, 1986
94. Hayashi M, Satura T, Nakamura R, Kitajima W, Kato E: Effect of aging on single nephron renin content in rats. Renal Physiol 4: 17-21, 1981
95. Jover B, Dupont M, Geelen G, Wahba W, Mimran A, Corman B: Renal and systemic adaptation to sodium restriction in aging rats. Am J Physiol 264: R833-R838, 1993
96. Magro AM, Rudofsky UH: Plasma renin activity decrease precedes spontaneous focal glomerular sclerosis in aging rats. Nephron 31: 245-253, 1982
97. Michel JB, Heudes D, Michel O, Poitevin P, Philippe M, Scalbert E, Corman B, Levy BI: Effect of chronic angiotensin I converting enzyme inhibition on the aging processes. II. Large arteries. Am J Physiol 267: R124-R135, 1994
98. Corman B, Barrault MB, Klingler C, Houot AM, Michel JB, Della Bruna R, Pinet F, Soubrier F: Renin gene expression in the aging kidney: Effect of sodium restriction. Mech Ageing Dev 84: 1-13, 1995
99. Corman B, Roinel N, Geelen G: Plasma vasopressin and cortical nephron function in aging rats. Mech Ageing Dev 62: 263-277, 1992
100. Docherty JR: Cardiovascular responses in aging: A review. Pharmacol Rev 42: 103-125, 1992
101. Baylis C, Engels K, Hymel A, Navar LG: Plasma renin activity and metabolic clearance rate of angiotensin II in the unstressed aging rat. Mech Ageing Dev 97: 163-171, 1997
102. Baylis C, Engels K, Beierwaltes WH: Airjet stress (AJS) stimulated renin release is blunted in old rats in association with diminished β-adrenoceptor responsiveness [Abstract]. J Am Soc Nephrol 8: 826A, 1997
103. Jung F, Kennefick T, Ingelfinger J, Vora J, Anderson S: Down-regulation of the intrarenal renin-angiotensin system in the aging rat J Am Soc Nephrol 5: 1573-1580, 1995
104. Hung L, Richardson A: The effect of aging on the genetic expression of renin by mouse kidney. Aging (Milano) 5: 193-198, 1993
105. Eggena P, Morin AM, Barett JD, Krall JF: The influence of aging on angiotensinogen production by rat vascular smooth muscle cells in vitro. Clin Exp Hypertens [A] 10: 597-603, 1988
106. Heymes C, Swinghedauw B, Chevalier B: Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats. Circulation 90: 1328-1333, 1994
107. Heudes D, Michel O, Chevalier J, Scalbert J, Ezan E, Bariety J, Zimmerman A, Corman B: Effect of chronic ANG I converting enzyme inhibition on aging processes. I. Kidney structure and function. Am J Physiol 266: R1038-R1051, 1994
108. Mooradian A, Lieberman J: Age-related decrease in serum angiotensin converting enzyme activity: The role of thyroidal status and food intake. J Gerontol 45: B24-B27, 1990
109. Lu X, Li X, Li L, Li L, Li C, Wang H: Variation of intrarenal angiotensin II and angiotensin II receptors by acute renal ischemia in the aged rats. Renal Failure 18: 19-29, 1996
110. Tank JE, Vora JP, Houghton DC, Anderson S: Altered renal vascular responses in the aging rat kidney. Am J Physiol 266: F942-F948, 1994
111. Baylis C: Renal responses to acute angiotensin II inhibition and administered angiotensin II in the aging, conscious, chronically catheterized rat. Am J Kidney Dis 22: 842-850, 1993
112. Zhang XZ, Qiu C, Baylis C: Glomerular hemodynamic responses to administered angiotensin II in the old rat. Mech Ageing Dev 97: 183-192, 1997
113. Anderson S, Rennke HG, Zatz R: Glomerular adaptations with normal aging and with long-term converting enzyme inhibition in rats. Am J Physiol 267: F35-F43, 1994
114. Ferder L, Inserra F, Romano L, Ercole L, Pszenny V: Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse. Am J Physiol 65: C215-C218, 1993
115. Ferder L, Inserra F, Romano L, Ercole L, Pszenny V: Decrease of glomerulosclerosis in aging by angiotensin-converting-enzyme inhibitions. J Am Soc Nephrol 5: 1147-1152, 1994
116. Hajduczok G, Chapleau MW: Increase in sympathetic activity with age. I. Role of impairment of arterial baroreflexes. Am J Physiol 260: H1113-H1120, 1991
117. Masilamani S, Baylis C: Defective pressure natriuresis in the aging kidney [Abstract]. J Am Soc Nephrol 4: 516A, 1993
118. Kawai Y, Ohhashi T: Age-related changes in relaxant response of vascular smooth muscles to atrial natriuretic peptide. J Pharmacol Exp Ther 252: 1234-1239, 1990
119. Moritoki H, Yoshikawa T, Hisayama T, Takeuchi S: Possible mechanisms of age-associated reduction of vascular relaxation caused by atrial natriuretic peptide. Eur J Pharmacol 210: 61-68, 1992
120. Dunn BR, Ichikawa I, Pfeffer JM, Troy JL, Brenner BM: Renal and systemic hemodynamic effects of synthetic atrial natriuretic peptide in the anesthetized rat. Circ Res 59: 237-246, 1986
121. DePriest D, Zimmermann C, Baylis C: Renal effects of administered atrial natriuretic peptide in the conscious, aging rat. Life Sci 46: 785-792, 1990
122. Tan AC, Jansen TL, Termond EFS: Kinetics of atrial natriuretic peptide in young and elderly subjects. Eur J Clin Pharmacol 42: 449-452, 1992
123. Reckelhoff JF, Baylis C: Proximal tubular metalloprotease activity is decreased in the senescent rat kidney. Life Sci 50: 959-963, 1992
124. Greenfeld Z, Engels K, Samsell L, Baylis C: Aging does not affect the role of endothelin (ET) in the rat kidney [Abstract]. J Am Soc Nephrol 8: 329A 1997
125. Menconi M, Taylor L, Martin B: A review: Prostaglandins, aging, and blood vessels. J Am Geriatr Soc 35: 239-247, 1987
126. Hornych A, Forette F, Bariety J, Krief C, Aumont J, Paris M: The influence of age on renal prostaglandin synthesis in man. Prostaglandins Leukotrienes Essent Fatty Acids 43: 191-195, 1991
127. Rathaus M, Greenfeld Z, Podjarny E, Brezis M, Bernheim J: Sodium loading and renal prostaglandins in old rats. Prostaglandins Leukotrienes Essent Fatty Acids 49: 815-819, 1993
128. Johnson AG, Day RO: The problems and pitfalls of NSAID therapy in the elderly (Part 1). Drugs Aging 1: 130-143, 1991
129. Zager RA, Alpers CE: Effects of aging on expression of ischemic acute renal failure in rats. Lab Invest 3: 290-294, 1989
130. Greenfeld Z, Peleg I, Brezis M, Rosen S, Pisanty S: Potential interaction between prolonged cyclosporin administration and aging in the rat kidney. Ann NY Acad Sci 717: 209-212, 1994
131. Sabbatini M, Sansone G, Uccello F, De Nicola L, Giliberti A, Sepe V, Magri P, Conte G, Andreucci VE: Functional versus structural changes in the pathophysiology of acute ischemic renal failure in aging rats. Kidney Int 45: 1355-1361, 1994
132. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-141, 1991
133. Kone BC, Baylis C: Biosynthesis and homeostatic roles of nitric oxide in the kidney. Am J Physiol 272: F561-F578, 1997
134. Tominaga M, Fujii K, Abe I, Takata Y, Kobayashi K, Fujishima M: Hypertension and aging impair acetylcholine-induced vasodilation in rats. J Hypertens 12: 259-268, 1994
135. Dohi Y, Thiel MA, Buhler FR, Luscher TF: Activation of endothelial L-arginine pathway in resistance arteries. Hypertension (Dallas) 15: 170-179, 1990
136. Sonaka I, Futami Y, Maki T: L-Arginine-nitric oxide pathway and chronic nephropathy in aged rats. J Gerontol 49: B157-B161, 1990
137. Reckelhoff JF, Kellum JA, Blanchard EJ, Bacon EE, Wesley AJ, Kruckeberg WC: Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. Life Sci 55: 1895-1902, 1994
138. Hill C, Lateef AM, Engels K, Samsell L, Baylis C: Basal and stimulated nitric oxide in control of kidney function in the aging rat. Am J Physiol 41: R1747-R1753, 1997
139. Challah M, Nadaud S, Philippe M, Battle T, Soubrier F, Corman B, Michel JB: Circulating and cellular markers of endothelial dysfunction with aging in rats. Am J Physiol 273: H1941-H1948, 1997
140. Halliwell B: Oxidants and human disease: Some new concepts. FASEB J 1: 358-364, 1987
141. Ruiz-Torres P, Gonzalez-Rubio M, Lucio-Cazana J, Ruiz-Villaespesca A, Rodriguez-Puyol M, Rodriguez-Puyol D: Reactive oxygen species and platelet activating factor synthesis in age-related glomerular sclerosis. J Lab Clin Med 124: 489-495, 1994
142. Greenfeld Z, Dey R, Baylis C: Neuronal nitric oxide synthase (nNOS) level in macula densa (MD) of old rat kidney [Abstract]. J Am Soc Nephrol 8: 329A, 1997
143. Vargas F, Osuna A, Fernandez-Rivas A: Abnormal renal vascular reactivity to acetylcholine and nitroprusside in aging rats. Gen Pharmacol 28: 133-137, 1997
144. Ruilope L, Rodicio J, Garcia Robles R, Sancho J, Miranda B, Granger J, Romero J: Influence of a low sodium diet on the renal response to amino acid infusions in humans. Kidney Int 31: 992-999, 1987
145. Tolins JP, Raij L: Effects of amino acid infusion on renal hemodynamics: Role of endothelium derived relaxing factor. Hypertension (Dallas) 17: 1045-1051, 1991
146. Chorinchath B, Kong LY, Mao L, McCallum R: Age-associated differences in TNF-α and nitric oxide production in endotoxic mice. J Immunol 156: 1525-1530, 1996
147. Chen LC, Pace JL, Russell SW, Morrison DC: Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice. Infect Immun 64: 4288-4297, 1996
148. Johnson A, Lermioglu F, Garg UC, Morgan-Boyd R, Hassid A: A novel biological effect of atrial natriuretic hormone: Inhibition of mesangial cell mitogenesis. Biochem Biophys Res Commun 152: 893-897, 1988
149. Mene P, Dunn MJ: Prostaglandins and rat glomerular mesangial cell proliferation. Kidney Int 37: 1256-1262, 1990
150. Garg UC, Hassid A: Inhibition of rat mesangial cell mitogenesis by nitric oxide generating vasodilators. Am J Physiol 257: F60-F66, 1989
151. Dubey RK: Vasodilator derived nitric oxide inhibits fetal calf serum- and angiotensin-II-induced growth of renal arteriolar smooth muscle cells. J Pharmacol Exp Ther 269: 402-408, 1994