CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-κB

Journal of the American Society of Nephrology

Volumn 20, Issue 7, 2009, Pages 1513-1526

  Sánchez López, Elsa ^a   Rayego, Sandra ^a   Rodrigues Díez, Raquel ^a   Rodriguez, Javier Sánchez ^a   Rodrigues Díez, Raúl ^a   Rodríguez Vita, Juan ^a   Carvajal, Gisselle ^b   Aroeira, Luiz Stark ^c   Selgas, Rafael ^c   Mezzano, Sergio A ^b   Ortiz, Alberto ^d   Egido, Jesús ^a   Ruiz Ortega, Marta ^a,d  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PARTHENOLIDE; RANTES;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; INFLAMMATORY CELL; INTERSTITIUM; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

EID: 67649674622     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008090999     Document Type: Article

References (61)

1. Lau LF, Lam SC: The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res 248: 44-57, 1999 (Pubitemid 29393928)
2. Gupta S, Clarkson MR, Duggan J, Brady HR: Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 58: 1389-1399, 2000 (Pubitemid 30739645)
3. Ruperez M, Ruiz-Ortega M, Esteban V, Lorenzo O, Mezzano S, Plaza JJ, Egido J: Angiotensin II increases connective tissue growth factor in the kidney. Am J Pathol 163: 1937-1947, 2003 (Pubitemid 37310024)
4. Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG: Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 11: 25-38, 2000 (Pubitemid 30020423)
5. Burns WC, Twigg SM, Forbes JM, Pete J, Tikellis C, Thallas-Bonke V, Thomas MC, Cooper ME, Kantharidis P: Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: Implications for diabetic renal disease. J Am Soc Nephrol 17: 2484-2494, 2006 (Pubitemid 44300964)
6. Yokoi H, Mukoyama M, Sugawara A, Mori K, Nagae T, Makino H, Suganami T, Yahata K, Fujinaga Y, Tanaka I, Nakao K: Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol 282: F933-F942, 2002 (Pubitemid 34654499)
7. Zhang C, Meng X, Zhu Z, Yang X, Deng A: Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitro. Life Sci 75: 367-379, 2004 (Pubitemid 38591647)
8. Sánchez-López E, Rodriguez-Vita J, Cartier C, Rupérez M, Esteban V, Carvajal G, Rodrígues-Díez R, Plaza JJ, Egido J, Ruiz-Ortega M: Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells. Am J Physiol Renal Physiol 294: F149-F160, 2008
9. Guha M, Xu ZG, Tung D, Lanting L, Natarajan R: Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J 21: 3355-3368, 2007 (Pubitemid 47565554)
10. Chen L, Liu BC, Zhang XL, Zhang, JD, Liu H, Li MX: Influence of connective tissue growth factor antisense oligonucleotide on angio-tensin II-induced epithelial mesenchymal transition in HK2 cells. Acta Pharmacologica Sinica 27: 1029-1036, 2007
11. Szeto CC, Chow KM, Lai KB, Szeto CY, Kwan BC, Li PK: Connective tissue growth factor is responsible for transforming growth factor-beta- induced peritoneal mesothelial cell apoptosis. Nephron Exp Nephrol 103: e166-e174, 2006 (Pubitemid 44114510)
12. Gao R, Brigstock DR: Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining thesurvival of primary rat hepatic stellate cells. Cell Commun Signal 3: 14, 2005 (Pubitemid 44848524)
13. Chien W, Yin D, Gui D, Mori A, Frank JM, Said J, Kusuanco D, Marchevsky A, McKenna R, Koeffler HP: Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells. Mol Cancer Res 4: 591-598, 2006 (Pubitemid 44341368)
14. Aikawa T, Gunn J, Spong SM, Klaus SJ, Korc M: Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 5: 1108-1116, 2006 (Pubitemid 43881302)
15. Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, Goppelt-Struebe M, Garlichs CD: Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol 25: 1008-1013, 2005 (Pubitemid 40627847)
16. Crean JKG, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR: The role of p42/p44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem 277: 44187-44194, 2002 (Pubitemid 36157849)
17. Wu SH, Wu XH, Lu C, Dong L, Zhou GP, Chen ZQ: Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells. Kidney Int 69: 248-256, 2006 (Pubitemid 43323074)
18. Wahab NA, Weston BS, Mason RM: Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 16: 340-351, 2005 (Pubitemid 41725129)
19. Yosimichi G, Kubota S, Nishida T, Kondo S, Yanagita T, Nakao K, Takano-Yamamoto T, Takigawa M: Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes. Bone 38: 853-863, 2006 (Pubitemid 44498592)
20. Guijarro C, Egido J: Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 59: 415-424, 2001 (Pubitemid 32157906)
21. Barnes PJ, Karin M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071, 1997 (Pubitemid 27163860)
22. Esteban V, Lorenzo O, Rupérez M, Suzuki Y, Mezzano S, Blanco J, Kretzler M, Sugaya T, Egido J, Ruiz-Ortega M: Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol 15: 1514-1529, 2004 (Pubitemid 38679676)
23. Tomita N, Morishita R, Lan HY, Yamamoto K, Hashizume M, Notake M, Toyosawa K, Fujitani B, Mu W, Nikolic-Paterson DJ, Atkins RC, Kaneda Y, Higaki J, Ogihara T: In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis. J Am Soc Nephrol 11: 1244-1252, 2000 (Pubitemid 30416220)
24. Mezzano SA, Barria M, Droguett MA, Burgos ME, Ardiles LG, Flores C, Egido J: Tubular NF-κB and AP-1 activation in human proteinuric renal disease. Kidney Int 60: 1366-1377, 2001 (Pubitemid 32960030)
25. Mezzano S, Aros C, Droguett A, Burgos ME, Ardiles L, Flores C, Schneider H, Ruiz-Ortega M, Egido J: NF-kappaB activation and over-expression of regulated genes in human diabetic nephropathy. Nephrol Dial Transplant 19: 2505-2512, 2004 (Pubitemid 39360096)
26. Hehner SP, Hofmann TG, Droge W, Schmitz ML: The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J Immunol 163: 5617-5623, 1999
27. Lopez-Franco O, Suzuki Y, Sanjuan G, Blanco J, Hernandez-Vargas P, Yo Y, Kopp J, Egido J, Gomez-Guerrero C: Nuclear factor kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis. Am J Pathol 161: 1497-1505, 2002
28. van Kooten, Daha MR, van Es LA: Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processes. Exp Nephrol 7: 429-437, 1999 (Pubitemid 29517353)
29. Karger A, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S, Master R: Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells. Cell Signal 20: 1865-1872, 2008
30. Ruster C, Wolf G: The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 13: 944-955, 2008 (Pubitemid 351594739)
31. Lloyd CM, Dorf ME, Proudfoot A, Salant DJ, Gutierrez-Ramos JC: Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis. J Leukoc Biol 62: 676-680, 1997 (Pubitemid 27519779)
32. Uhm WS, Na K, Song GW, Jung SS, Lee T, Park MH, Yoo DH: Cytokine balance in kidney tissue from lupus nephritis patients. Rheumatology (Oxford) 42: 935-938, 2003 (Pubitemid 37220958)
33. Rice EK, Nikolic-Paterson DJ, Hill PA, Metz CN, Bucala R, Atkins RC, Tesch GH: Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells. Nephrology (Carlton) 8: 156-161, 2003 (Pubitemid 36718268)
34. Carvalho-Pinto CE, García MI, Mellado M, Rodríguez-Frade JM, Martín-Caballero J, Flores J, Martínez-A C, Balomenos D: Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169: 1058-1067, 2002 (Pubitemid 34753466)
35. Fukatsu A, Matsuo S, Yuzawa Y, Miyai H, Futenma A, Kato K: Expression of interleukin 6 and major histocompatibility complex molecules in tubular epithelial cells of diseased human kidneys. Lab Invest 69: 58-67, 1993 (Pubitemid 23222247)
36. Herrera-Esparza R, Barbosa-Cisneros O, Villalobos-Hurtado R, Avalos- Díaz E: Renal expression of IL-6 and TNFalpha genes in lupus nephritis. Lupus 7: 154-158, 1998 (Pubitemid 28190678)
37. Patel NS, Chatterjee PK, Di Paola R, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Thiemermann C: Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther 312: 1170-1178, 2005 (Pubitemid 40293778)
38. Sommer M, Eismann U, Gerth J, Stein G: Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblasts. Nephron 92: 868-880, 2002 (Pubitemid 36151370)
39. Deckers JG, De Haij S, van der Woude FJ, van der Kooij SW, Daha MR, van Kooten C: IL-4 and IL-13 augment cytokine- and CD40-induced RANTES production by human renal tubular epithelial cells in vitro. J Am Soc Nephrol 9: 1187-1193, 1998 (Pubitemid 28283881)
40. Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ: IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol 16: 3651-3660, 2005 (Pubitemid 46211286)
41. Kitching AR, Tipping PG, Timoshanko JR, Holdsworth SR: Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. Kidney Int 57: 518-525, 2000 (Pubitemid 30430643)
42. Kingston HG: Mills. Induction, function and regulation of IL-17-producing T cells. Eur J Immunol 38: 2636-2649, 2008
43. Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S: The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol 20: 1361-1368, 2008
44. Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G: p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem 273: 3285-3290, 1998 (Pubitemid 28109741)
45. Yosimichi G, Nakanishi T, Nishida T, Hattori T, Takano-Yamamoto T, Takigawa M: CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem 268: 6058-6065, 2001 (Pubitemid 33132027)
46. Liu XC, Liu BC, Zhang XL, Li MX, Zhang JD: Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells. Clin Chim Acta 382: 89-94, 2007 (Pubitemid 46782742)
47. Tanifuji C, Suzuki Y, Geot WM, Horikoshi S, Sugaya T, Ruiz-Ortega M, Egido J, Tomino Y: Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells. Antioxid Redox Signal 7: 1261-1268, 2005 (Pubitemid 41232523)
48. de Haij S, Bakker AC, van der Geest RN, Haegeman G, Vanden Berghe W, Aarbiou J, Daha MR, van Kooten C: NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase. J Am Soc Nephrol 16: 1603-1611, 2005 (Pubitemid 41716467)
49. Sheryanna A, Bhangal G, McDaid J, Smith J, Manning A, Foxwell BM, Feldmann M, Cook HT, Pusey CD, Tam FW: Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6. J Am Soc Nephrol 18: 1167-1179, 2007 (Pubitemid 46536903)
50. Ho AW, Wong CK, Lam CW: Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways. Immunobiology 213: 533-544, 2008
51. Lin WN, Luo SF, Lee CW, Wang CC, Wang JS, Yang CM: Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. Cell Signal 19: 1258-1267, 2007 (Pubitemid 46561562)
52. Ueno H, Pradhan S, Schlessel D, Hirasawa H, Sumpio BE: Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Cardiovasc Toxicol 6: 39-50, 2006 (Pubitemid 44127951)
53. Okada H, Kikuta T, Kobayashi T, Inoue T, Kanno Y, Takigawa M, Sugaya T, Kopp JB, Suzuki H: Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. J Am Soc Nephrol 16: 133-143, 2005 (Pubitemid 43073165)
54. Li GM, Li DG, Xie Q, Shi Y, Jiang S, Zhou HJ, Lu HM, Jin YX: Effect of silencing connective tissue growth factor on rat liver fibrosis and the accumulation of extracellular matriz. Zhonghua Gan Zang Bing Za Zhi 16: 188-192, 2008
55. Jaffa AA, Usinger WR, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes-Virella M, Luttrell LM, Wilson PW: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Group. Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes. J Clin Endocrinol Metab 93: 1893-1900, 2008
56. Thomson SE, McLennan SV, Kirwan PD, Heffernan SJ, Hennessy A, Yue DK, Twigg SM: Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: Possible predictive marker for incipent diabetic nephropathy. J Diabetes Complications 22: 284-294, 2008 (Pubitemid 351885491)
57. Nguyen TQ, Tarnow L, Jorsal A, Oliver N, Roestenberg P, Ito Y, Parving HH, Rossing P, van Nieuwenhoven FA, Goldschmeding R: Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care 31: 1177-8214, 2008
58. Nonaka Takahashi S, Fujita T, Takahashi T, Wada Y, Fuke Y, Satomura A, Matsumoto K: TGF-beta1 and CTGF mRNAs are correlated with urinary protein level in IgA nephropathy. J Nephrol 21: 53-63, 2008 (Pubitemid 351780574)
59. Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M: Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur J Heart Fail 10: 373-379, 2008
60. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130: 393-405, 1995
61. Esteban V, Ruperez M, Sánchez-López E, Rodríguez- Vita J, Lorenzo O, Demaegdt H, Vanderheyden P, Egido J, Ruiz-Ortega M: Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells. Circ Res 96: 965-973, 2005 (Pubitemid 40712796)