Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts

Molecular Therapy

Volumn 3, Issue 2, 2001, Pages 149-159

  Iwano, Masayuki ^a,b   Fischer, Andreas ^b   Okada, Hirokazu ^b,c   Plieth, David ^a,b   Xue, Chengsen ^a   Danoff, Theodore M ^b   Neilson, Eric G ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Fibroblasts; Fibrosis; FSP1; S100A4; Thymidine kinase

Indexed keywords

COLLAGEN TYPE 1; CYTOPLASM PROTEIN; DNA; FIBROBLAST SPECIFIC PROTEIN 1; GANCICLOVIR; NUCLEOSIDE ANALOG; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIVISION; CELL KILLING; CELL SPECIFICITY; CONTROLLED STUDY; DNA REPLICATION; DNA STRAND BREAKAGE; EPITHELIUM; EXPOSURE; FEMALE; FIBROBLAST; FIBROGENESIS; GENE SEQUENCE; GENETIC CODE; GENETIC SUSCEPTIBILITY; HERPES VIRUS; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; LETHALITY; MALE; MOUSE; NONHUMAN; PHYSIOLOGY; PROMOTER REGION; SCAR FORMATION; TISSUE CULTURE; TISSUE INJURY; TRANSGENIC MOUSE;

ANIMALIA; HERPES; HERPESVIRIDAE; MUS MUSCULUS;

EID: 0034981126     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0251     Document Type: Article

References (60)

1. Fibrosis, a common pathway to organ failure: Angiotensin II and tissue repair
2. Possible mechanisms of renal fibrosis
3. Transdifferentiation: A new angle on renal fibrosis
4. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells
5. Angiotensin in progressive renal diseases: Theory and practice
6. Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells
7. Enalapril decreases nuclear factor κB activation in the kidney with ureteral obstruction
8. Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of ureteral obstruction
9. Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease
10. Angiotensin II in renal fibrosis: Should TGFβ rather than blood pressure be the therapeutic target
11. Production of heparin-binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury
12. The early role of FSP1 in epithelial-mesenchymal transformation
13. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis
14. Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition
15. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis
16. Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis
17. Identification and characterization of a fibroblast marker: FSP1
18. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
19. The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy
20. The myofibroblast
21. Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation
22. Pathological relevance of epithelial and mesenchymal phenotype plasticity
23. Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced
24. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines
25. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
26. Novel cis-acting elements in the FSP1 gene regulate fibroblast-specific transcription
27. The κB and V(D)] recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1
28. A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice
29. Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by gancyclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase
30. Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES
31. Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease
32. Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis
33. Characterization of a cis-acting regulatory element which silences expression of the class II-A beta gene in epithelium
34. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
35. Up-regulation of HSP47 in the mouse kidneys with unilateral ureteral obstruction
36. The Goodpasture autoantigen: Structural delineation of two immunologically privileged epitopes on α3(IV) chain of type IV collagen
37. Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease
38. Angiotensin II receptor antagonists ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction
39. Abnormal growth and clonal proliferation of fibroblasts in an animal model of unilateral ureteral obstruction
40. Mechanisms of interstitial fibrosis in obstructive nephropathy
41. SPARC, a secreted protein associated with morphogenesis and tissue remodelling, induces expression of matrix metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway
42. Molecular insights into renal interstitial fibrosis
43. Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney
44. Myofibroblasts and alpha1(III) collagen expression in experimental tubulointerstitial nephritis
45. Mechanisms of tubulointerstitial fibrosis
46. Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction
47. Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
48. Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix degrading potential in a rat bladder carcinomal cell line
49. Transforming growth factor β in tissue fibrosis
50. The emerging role of transforming growth factor-beta in kidney disease
51. Osteopontin expression in the kidney during unilateral ureteral obstruction
52. Platelet-derived growth factor is chemotactic for fibroblasts
53. Role of basic fibroblast growth factor (FGF-2) in epithelial-mesenchymal transformation
54. Endothelin transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension
55. Involvement of angiotensin II and endothelin in matrix protein production and renal sclerosis
56. Serum- and polypeptide growth factor-inducible gene expression in mouse fibroblasts
57. Gene therapy for cancer
58. Wound healing and collagen formation. VI. The origin of the wound studied in parabiosis
59. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta
60. Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes