Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis

Journal of the American Society of Nephrology

Volumn 21, Issue 12, 2010, Pages 2047-2052

  Inoue, Tsutomu ^a   Takenaka, Tsuneo ^a   Hayashi, Matsuhiko ^b   Monkawa, Toshiaki ^b   Yoshino, Jun ^b   Shimoda, Kouji ^b   Neilson, Eric G ^c   Suzuki, Hiromichi ^a   Okada, Hirokazu ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALVASCULIN; CRE RECOMBINASE; FIBRONECTIN; GAMMA GLUTAMYLTRANSFERASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROCOLLAGEN; SYNAPTOTAGMIN I;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSGENICS; URETER OBSTRUCTION;

EID: 78149311215     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010010003     Document Type: Article

References (41)

1. Hayden MS, Ghosh S: Shared principles in NF-kB signaling. Cell 132: 344-362, 2008
2. Guijarro C, Egido J: Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 59: 415-424, 2001 (Pubitemid 32157906)
3. Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y: Hepatocyte growth factor exerts its anti-infammatory action by disrupting nuclear factor-kB signaling. Am J Pathol 173: 30-41, 2008 (Pubitemid 351947953)
4. Rodriguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Mezzano SA, Vaziri ND: Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats. J Pharmacol Exp Ther 315: 51-57, 2005
5. Fujihara CK, Antunes GR, Mattar AL, Malheiros, DMAC, Vieira JM, Zatz R: Chronic inhibition of nuclear factor-kB attenutaes renal injury in the 5/6 renal ablation model. Am J Physiol Renal Physiol 292: F92-F99, 2007
6. Gomez-Garre D, Largo R, Tejera N, Fortes J, Manzarbeitia F, Egido J: Activation of NF-kB in tubular epithelial cells of rats with intense proteinuria. Hypertension 37: 1171-1178, 2001
7. Rangan GK, Wang Y, Tay YC, Harris DC: Inhibition of nuclear factor-kB activation reduces cortical tubulointerstitial injury in proteinuric rats. Kidney Int 56: 118-134, 1999
8. Ozawa Y, Kobori H: Crucial role of Rho-nuclear factor-kB axis in angiotensin II-induced renal injury. Am J Physiol Renal Physiol 293: F100-F109, 2007
9. Tamada S, Nakatani T, Asai T, Tashiro K, Komiya T, Sumi T, Okamura M, Kim S, Iwao H, Kishimoto T, Yamanaka S, Miura K: Inhibition of nuclear factor-kB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy. Kidney Int 63: 306-314, 2003 (Pubitemid 35463935)
10. Takase O, Hirahashi J, Takayanagi A, Chkaraishi A, Marumo T, Ozawa Y, Hayashi M, Shimizu N, Saruta T: Gene transfer of truncated IkBa prevents tubulointerstitial injury. Kidney Int 63: 501-513, 2003
11. Ouaaz F, Li M, Beg AA: A critical role for the RelA subunit of nuclear factor kB in regulation of multiple immune-response genes and in Fas-induced cell death. J Exp Med 189: 999-1004, 1999
12. Okada H, Kalluri R: Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis. Curr Mol Med 5: 467-474, 2005
13. Chevalier RL, Forbes MS, Thronhill BA: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 75: 1145-1152, 2009
14. Strutz F, Okada H, Lo CW, Danoff TM, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130: 393-405, 1995
15. Okada H, Danoff TM, Kalluri R, Neilson EG: Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 273: F563-F574, 1997
16. Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS: Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am J Respir Crit Care Med 171: 899-907, 2005
17. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002 (Pubitemid 34847966)
18. Kie JH, Kapturczak MH, Traylor A, Agarwal A, Hill-Kapturczak N: Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis. J Am Soc Nephrol 19: 1681-1691, 2008
19. Kim J, Seok YM, Jung KJ, Park KM: Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Am J Physiol Renal Physiol 297: F461-F470, 2009
20. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, Xu C, Dimitrova YN, Rauscher III, FJ, Neilson EG: A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 117: 482-491, 2007
21. Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH: Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117: 3810-3820, 2007
22. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R: Fibroblasts in kidney fibrosis emerge via endothelial-mesenchymal transition. J Am Soc Nephrol 19: 2282-2287, 2008
23. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R: Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13: 952-961, 2007
24. Liu Y: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222, 2010
25. Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL: TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303: 848-851, 2004
26. Tsutsumi R, Xie C, Wei X, Zhang M, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ: PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. J Bone Miner Res 24: 1753-1762, 2009
27. Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G: Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 461: 1084-1091, 2009
28. Kawamoto S, Niwa H, Tashiro F, Sano S, Kondoh G, Takeda J, Tabayashi K, Miyazaki J: A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett 470: 263-268, 2000
29. Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG: Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 58: 587-597, 2000 (Pubitemid 30620008)
30. Starremans PG, Li X, Finnerty PE, Guo L, Takakura A, Neilson EG, Zhou J: A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5′ end of Pkd1. Kidney Int 73: 1394-1405, 2008
31. Inoue T, Plieth D, Venkov CD, Xu C, Neilson EG: Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int 67: 2488-2493, 2005
32. Vielhauer V, Anders HJ, Mack M, Cihak J, Strutz F, Stangassinger M, Luckow B, Groene HJ, Schlondorff D: Obstructive nephropathy in the mouse: Progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes. J Am Soc Nephrol 12: 1173-1187, 2001
33. Yeh YY, Chiao CC, Kuo WY, Hsiao YC, Chen YJ, Wei YY, Lai TH, Fong YC, Tang CH: TGF-b1 increases motililty and aVb3 integrin up-regulation via PI3K, Akt and NF-kB-dependent pathway in human chondrosarcoma cells. Biochem Pharmocol 75: 1292-1301, 2008
34. Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF, Yan C, Li JD: Synergistic induction of nuclear factor-kB by transforming growth factor-b and tumour necrosis factor-a is mediated by protein kinase A-dependent RelA acetylation. Biochem J 417: 583-591, 2009
35. Chetty A, Cao GJ, Nielsen HC: Insulin-like growth factor-I signaling mechanisms, type I collagen and alpha smooth muscle actin in human fetal lung fibroblasts. Pediatr Res 60: 389-394, 2006
36. Messadi DV, Doung HS, Zhang Q, Kelly AP, Tuan TL, Reichenberger E, Le AD: Activation of NFkB signal pathways in keloid fibroblasts. Arch Dermatol Res 296: 125-133, 2004
37. Theiss AL, Simmons JG, Jobin C, Lund PK: Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 280: 36099-36109, 2005 (Pubitemid 41633881)
38. Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173: 1617-1627, 2008
39. Iwano M, Fischer A, Okada H, Pleith D, Xue C, Danoff T, Neilson E: Conditional abatement of tissue fibrosis using nucleotide analogs to corrupt DNA replication selectively in transgenic fibroblasts. Mol Ther 3: 149-159, 2001
40. Kanegae Y, Takamori K, Sato Y, Lee G, Nakai M, Saito I: Efficient gene activation on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene 181: 207-212, 1996
41. Okada H, Inoue T, Kikuta T, Watabe T, Kanno Y, Ban S, Sugaya T, Horiuchi M, Suzuki H: A possible anti-inflammatory role of angiotensin II type 2 recerptor in immune-mediated glomerulonephritis during type 1 receptor blockade. Am J Pathol 169: 1577-1589, 2006