-
1
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
DOI 10.1172/JCI200215518
-
Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002 (Pubitemid 34847966)
-
(2002)
Journal of Clinical Investigation
, vol.110
, Issue.3
, pp. 341-350
-
-
Iwano, M.1
Plieth, D.2
Danoff, T.M.3
Xue, C.4
Okada, H.5
Neilson, E.G.6
-
2
-
-
0029091682
-
Identification and characterization of a fibroblast marker: FSP1
-
Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130: 393-405, 1995
-
(1995)
J Cell Biol
, vol.130
, pp. 393-405
-
-
Strutz, F.1
Okada, H.2
Lo, C.W.3
Danoff, T.4
Carone, R.L.5
Tomaszewski, J.E.6
Neilson, E.G.7
-
3
-
-
0034785496
-
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
-
Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159: 1465-1475, 2001 (Pubitemid 32947976)
-
(2001)
American Journal of Pathology
, vol.159
, Issue.4
, pp. 1465-1475
-
-
Yang, J.1
Liu, Y.2
-
4
-
-
0346724511
-
Epithelial-mesenchymal transition and its implications for fibrosis
-
DOI 10.1172/JCI200320530
-
Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003 (Pubitemid 38063698)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1776-1784
-
-
Kalluri, R.1
Neilson, E.G.2
-
5
-
-
0032842887
-
Transforming growth factor-beta regulates tubular epithelial- myofibroblast transdifferentiation in vitro
-
DOI 10.1046/j.1523-1755.1999.00656.x
-
Fan JM, Ng YY, Hill PA, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 56: 1455-1467, 1999 (Pubitemid 29451252)
-
(1999)
Kidney International
, vol.56
, Issue.4
, pp. 1455-1467
-
-
Fan, J.-M.1
Yee-Yung, N.G.2
Hill, P.A.3
Nikolic-Paterson, D.J.4
Mu, W.5
Atkins, R.C.6
Lan, H.Y.7
-
6
-
-
0346727324
-
Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
-
DOI 10.1172/JCI200319270
-
Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A: Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112: 1486-1494, 2003 (Pubitemid 38056275)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.10
, pp. 1486-1494
-
-
Sato, M.1
Muragaki, Y.2
Saika, S.3
Roberts, A.B.4
Ooshima, A.5
-
7
-
-
3242797424
-
Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
-
DOI 10.1111/j.1523-1755.2004.00779.x
-
Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A: Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 66: 597-604, 2004 (Pubitemid 38982001)
-
(2004)
Kidney International
, vol.66
, Issue.2
, pp. 597-604
-
-
Inazaki, K.1
Kanamaru, Y.2
Kojima, Y.3
Sueyoshi, N.4
Okumura, K.5
Kaneko, K.6
Yamashiro, Y.7
Ogawa, H.8
Nakao, A.9
-
8
-
-
65249099522
-
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
-
Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY: Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 24: 1443-1454, 2009
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 1443-1454
-
-
Chung, A.C.1
Huang, X.R.2
Zhou, L.3
Heuchel, R.4
Lai, K.N.5
Lan, H.Y.6
-
9
-
-
2942535966
-
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
-
DOI 10.1073/pnas.0400035101
-
Fukasawa H, Yamamoto T, Togawa A, Ohashi N, Fujigaki Y, Oda T, Uchida C, Kitagawa K, Hattori T, Suzuki S, Kitagawa M, Hishida A: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci U S A 101: 8687-8692, 2004 (Pubitemid 38745832)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.23
, pp. 8687-8692
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
Oda, T.6
Uchida, C.7
Kitagawa, K.8
Hattori, T.9
Suzuki, S.10
Kitagawa, M.11
Hishida, A.12
-
11
-
-
0032442852
-
Smads: Transcriptional activators of TGF-beta responses
-
DOI 10.1016/S0092-8674(00)81696-7
-
Derynck R, Zhang Y, Feng XH: Smads: Transcriptional activators of TGF-beta responses. Cell 95: 737-740, 1998 (Pubitemid 29014453)
-
(1998)
Cell
, vol.95
, Issue.6
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.-H.3
-
13
-
-
0034065822
-
Ubiquitin-mediated proteolysis: Biological regulation via destruction
-
DOI 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q
-
Ciechanover A, Orian A, Schwartz AL: Ubiquitin-mediated proteolysis: Biological regulation via destruction. Bioessays 22: 442-451, 2000 (Pubitemid 30308270)
-
(2000)
BioEssays
, vol.22
, Issue.5
, pp. 442-451
-
-
Ciechanover, A.1
Orian, A.2
Schwartz, A.L.3
-
14
-
-
10744228283
-
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
-
DOI 10.1093/emboj/cdg632
-
Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. Embo J 22: 6458-6470, 2003 (Pubitemid 38009594)
-
(2003)
EMBO Journal
, vol.22
, Issue.24
, pp. 6458-6470
-
-
Koinuma, D.1
Shinozaki, M.2
Komuro, A.3
Goto, K.4
Saitoh, M.5
Hanyu, A.6
Ebina, M.7
Nukiwa, T.8
Miyazawa, K.9
Imamura, T.10
Miyazono, K.11
-
15
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFbeta receptor for degradation
-
DOI 10.1016/S1097-2765(00)00134-9
-
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 6: 1365-1375, 2000 (Pubitemid 32045929)
-
(2000)
Molecular Cell
, vol.6
, Issue.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
16
-
-
0035918274
-
Smurf1 Interacts with Transforming Growth Factor-beta Type I Receptor through Smad7 and Induces Receptor Degradation
-
DOI 10.1074/jbc.C100008200
-
Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 276: 12477-12480, 2001 (Pubitemid 37385151)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.16
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
Chiba, T.4
Tanaka, K.5
Imamura, T.6
Miyazono, K.7
-
17
-
-
72049089338
-
Trps1 functions downstream of Bmp7 in kidney development
-
Gai Z, Zhou G, Itoh S, Morimoto Y, Tanishima H, Hatamura I, Uetani K, Ito M, Muragaki Y: Trps1 functions downstream of Bmp7 in kidney development. J Am Soc Nephrol 20: 2403-2411, 2009
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2403-2411
-
-
Gai, Z.1
Zhou, G.2
Itoh, S.3
Morimoto, Y.4
Tanishima, H.5
Hatamura, I.6
Uetani, K.7
Ito, M.8
Muragaki, Y.9
-
18
-
-
0034819690
-
Quantification of TGF-beta1 mRNA along rat nephron in obstructive nephropathy
-
Fukuda K, Yoshitomi K, Yanagida T, Tokumoto M, Hirakata H: Quantification of TGF-beta1 mRNA along rat nephron in obstructive nephropathy. Am J Physiol Renal Physiol 281: F513-F521, 2001 (Pubitemid 32885135)
-
(2001)
American Journal of Physiology - Renal Physiology
, vol.281
, Issue.3
-
-
Fukuda, K.1
Yoshitomi, K.2
Yanagida, T.3
Tokumoto, M.4
Hirakata, H.5
-
19
-
-
42649120148
-
Smad7 as a therapeutic agent for chronic kidney diseases
-
DOI 10.2741/3057
-
Lan HY: Smad7 as a therapeutic agent for chronic kidney diseases. Front Biosci 13: 4984-4992, 2008 (Pubitemid 351599652)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.13
, pp. 4984-4992
-
-
Hui, Y.L.1
-
20
-
-
0037498439
-
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
-
DOI 10.1097/01.ASN.0000067632.04658.B8
-
Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ: Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003 (Pubitemid 36687055)
-
(2003)
Journal of the American Society of Nephrology
, vol.14
, Issue.6
, pp. 1535-1548
-
-
Lan, H.Y.1
Mu, W.2
Tomita, N.3
Huang, X.R.4
Li, J.H.5
Zhu, H.-J.6
Morishita, R.7
Johnson, R.J.8
-
21
-
-
23944486004
-
Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7
-
DOI 10.1681/ASN.2004121070
-
Wang W, Huang XR, Li AG, Liu F, Li JH, Truong LD, Wang XJ, Lan HY: Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7. J Am Soc Nephrol 16: 1371-1383, 2005 (Pubitemid 41716521)
-
(2005)
Journal of the American Society of Nephrology
, vol.16
, Issue.5
, pp. 1371-1383
-
-
Wang, W.1
Huang, X.R.2
Li, A.G.3
Liu, F.4
Li, J.-H.5
Truong, L.D.6
Wang, X.J.7
Lan, H.Y.8
-
22
-
-
0034799176
-
Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation
-
Zeisberg M, Bonner G, Maeshima Y, Colorado P, Muller GA, Strutz F, Kalluri R: Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am J Pathol 159: 1313-1321, 2001 (Pubitemid 32947961)
-
(2001)
American Journal of Pathology
, vol.159
, Issue.4
, pp. 1313-1321
-
-
Zeisberg, M.1
Bonner, G.2
Maeshima, Y.3
Colorado, P.4
Muller, G.A.5
Strutz, F.6
Kalluri, R.7
-
23
-
-
2542609844
-
Smad3 as a mediator of the fibrotic response
-
Flanders KC: Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 85: 47-64, 2004
-
(2004)
Int J Exp Pathol
, vol.85
, pp. 47-64
-
-
Flanders, K.C.1
-
24
-
-
0036014928
-
Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation
-
Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY: Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13: 1464-1472, 2002
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1464-1472
-
-
Li, J.H.1
Zhu, H.J.2
Huang, X.R.3
Lai, K.N.4
Johnson, R.J.5
Lan, H.Y.6
-
25
-
-
0034646674
-
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta
-
DOI 10.1074/jbc.275.15.11320
-
von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Bottinger EP: Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem 275: 11320-11326, 2000 (Pubitemid 30212781)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.15
, pp. 11320-11326
-
-
Von Gersdorff, G.1
Susztak, K.2
Rezvani, F.3
Bitzer, M.4
Liang, D.5
Bottinger, E.P.6
-
26
-
-
0033584854
-
Regulation of Smad7 promoter by direct association with Smad3 and Smad4
-
Nagarajan RP, Zhang J, Li W, Chen Y: Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J Biol Chem 274: 33412-33418, 1999 (Pubitemid 129511646)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.47
, pp. 33412-33418
-
-
Nagarajan, R.P.1
Zhang, J.2
Li, W.3
Chen, Y.4
-
27
-
-
39349094176
-
Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition
-
DOI 10.1038/sj.ki.5002713, PII 5002713
-
Liu FY, Li XZ, Peng YM, Liu H, Liu YH: Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition. Kidney Int 73: 588-594, 2008 (Pubitemid 351264107)
-
(2008)
Kidney International
, vol.73
, Issue.5
, pp. 588-594
-
-
Liu, F.-Y.1
Li, X.-Z.2
Peng, Y.-M.3
Liu, H.4
Liu, Y.-H.5
-
28
-
-
34247098372
-
Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis
-
DOI 10.1159/000100518
-
Liu FY, Li XZ, Peng YM, Liu H, Liu YH: Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis. Am J Nephrol 27: 176-183, 2007 (Pubitemid 46588184)
-
(2007)
American Journal of Nephrology
, vol.27
, Issue.2
, pp. 176-183
-
-
Liu, F.-Y.1
Li, X.-Z.2
Peng, Y.-M.3
Liu, H.4
Liu, Y.-H.5
-
29
-
-
17544379605
-
Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction
-
Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey J: Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 279: F130-F143, 2000 (Pubitemid 30619554)
-
(2000)
American Journal of Physiology - Renal Physiology
, vol.279
, Issue.1
-
-
Hruska, K.A.1
Guo, G.2
Wozniak, M.3
Martin, D.4
Miller, S.5
Liapis, H.6
Loveday, K.7
Klahr, S.8
Sampath, T.K.9
Morrissey, J.10
-
30
-
-
0038717407
-
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
-
DOI 10.1038/nm888
-
Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003 (Pubitemid 36889942)
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 964-968
-
-
Zeisberg, M.1
Hanai, J.-I.2
Sugimoto, H.3
Mammoto, T.4
Charytan, D.5
Strutz, F.6
Kalluri, R.7
-
31
-
-
34248191263
-
Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: Role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition
-
Park SH, Choi MJ, Song IK, Choi SY, Nam JO, Kim CD, Lee BH, Park RW, Park KM, Kim YJ, Kim IS, Kwon TH, Kim YL: Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: Role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. J Am Soc Nephrol 18: 1497-1507, 2007
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1497-1507
-
-
Park, S.H.1
Choi, M.J.2
Song, I.K.3
Choi, S.Y.4
Nam, J.O.5
Kim, C.D.6
Lee, B.H.7
Park, R.W.8
Park, K.M.9
Kim, Y.J.10
Kim, I.S.11
Kwon, T.H.12
Kim, Y.L.13
-
32
-
-
54749083116
-
Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis
-
Kie JH, Kapturczak MH, Traylor A, Agarwal A, Hill-Kapturczak N: Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis. J Am Soc Nephrol 19: 1681-1691, 2008
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 1681-1691
-
-
Kie, J.H.1
Kapturczak, M.H.2
Traylor, A.3
Agarwal, A.4
Hill-Kapturczak, N.5
-
33
-
-
39049125285
-
Latent TGF-beta1 protects against crescentic glomerulonephritis
-
DOI 10.1681/ASN.2007040484
-
Huang XR, Chung AC, Zhou L, Wang XJ, Lan HY: Latent TGF-beta1 protects against crescentic glomerulonephritis. J Am Soc Nephrol 19: 233-242, 2008 (Pubitemid 351240645)
-
(2008)
Journal of the American Society of Nephrology
, vol.19
, Issue.2
, pp. 233-242
-
-
Huang, X.R.1
Chung, A.C.K.2
Zhou, L.3
Wang, X.J.4
Lan, H.Y.5
-
34
-
-
0030000689
-
A novel method of microwave treatment for detection of cytoplasmic and nuclear antigens by flow cytometry
-
DOI 10.1016/0022-1759(95)00233-2
-
Lan HY, Hutchinson P, Tesch GH, Mu W, Atkins RC: A novel method of microwave treatment for detection of cytoplasmic and nuclear antigens by flow cytometry. J Immunol Methods 190: 1-10, 1996 (Pubitemid 26099973)
-
(1996)
Journal of Immunological Methods
, vol.190
, Issue.1
, pp. 1-10
-
-
Lan, H.Y.1
Hutchinson, P.2
Tesch, G.H.3
Mu, W.4
Atkins, R.C.5
-
35
-
-
41149103627
-
Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells
-
DOI 10.1111/j.1365-2443.2008.01170.x
-
Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y: Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 13: 355-363, 2008 (Pubitemid 351437022)
-
(2008)
Genes to Cells
, vol.13
, Issue.4
, pp. 355-363
-
-
Itoh, S.1
Kanno, S.2
Gai, Z.3
Suemoto, H.4
Kawakatsu, M.5
Tanishima, H.6
Morimoto, Y.7
Nishioka, K.8
Hatamura, I.9
Yoshida, M.10
Muragaki, Y.11
-
36
-
-
33750693942
-
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
-
DOI 10.1681/ASN.2005121366
-
Fu P, Liu F, Su S, Wang W, Huang XR, Entman ML, Schwartz RJ, Wei L, Lan HY: Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol 17: 3105-3114, 2006 (Pubitemid 44707770)
-
(2006)
Journal of the American Society of Nephrology
, vol.17
, Issue.11
, pp. 3105-3114
-
-
Fu, P.1
Liu, F.2
Su, S.3
Wang, W.4
Huang, X.R.5
Entman, M.L.6
Schwartz, R.J.7
Wei, L.8
Lan, H.Y.9
-
37
-
-
33645652695
-
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction
-
Cochrane AL, Kett MM, Samuel CS, Campanale NV, Anderson WP, Hume DA, Little MH, Bertram JF, Ricardo SD: Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. J Am Soc Nephrol 16: 3623-3630, 2005
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3623-3630
-
-
Cochrane, A.L.1
Kett, M.M.2
Samuel, C.S.3
Campanale, N.V.4
Anderson, W.P.5
Hume, D.A.6
Little, M.H.7
Bertram, J.F.8
Ricardo, S.D.9
|