Angiotensin II blockade augments renal cortical microvascular pO 2 indicating a novel, potentially renoprotective action

Nephron

Volumn 94, Issue 2, 2003, Pages

  Norman, Jill T ^a   Stidwill, Ray ^a   Singer, Mervyn ^a   Fine, Leon G ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Angiotensin AT1 receptor antagonist; Angiotensin converting enzyme inhibitor; Cortical microvasculature; Hypoxia; Oxygen tension; Porphyrin phosphorescence; Sprague Dawley rats

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; OXYGEN; PROTOPORPHYRIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; PORPHYRIN; TETRAZOLE DERIVATIVE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EXPOSURE; HEALTH STATUS; INSTRUMENTATION; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY INTERSTITIUM; MALE; MICROVASCULATURE; NONHUMAN; OXYGEN TENSION; PHOSPHORESCENCE; PRIORITY JOURNAL; PROTECTION; RAT; RENAL ARTERY; ANIMAL; ANOXIA; CHEMISTRY; DRUG ANTAGONISM; HYPERTENSION; METABOLISM; MICROCIRCULATION; OXYGEN CONSUMPTION; PILOT STUDY; PRESSURE; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANOXIA; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; ENALAPRILAT; HYPERTENSION; KIDNEY CORTEX; MALE; MICROCIRCULATION; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PILOT PROJECTS; PORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; TETRAZOLES;

EID: 0345258415     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071289     Document Type: Article

References (24)

1. Wolf G, Butzmann U, Wenzel UO: Renin-angiotensin system and progression of renal disease: From hemodynamics to cell biology. Nephron Physiol 2003;93:P3-P10.
2. Woolf G, Neilson EG: Angiotensin II as a renal growth factor. J Am Soc Nephrol 1993;3:1531-1540.
3. Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A: Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the antifibrotic effect of renin-angiotensin system. Kidney Int 1997;51:164-172.
4. Moulder JE, Fish BL, Regner KR, Cohen EP: Angiotensin II blockade reduces radiation induced proliferation in experimental radiation nephropathy. Rad Res 2002;157:393-401.
5. Ruiz-Ortega M, Egido J: Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int 1997;52:1497-1510.
6. Taal MT, Brenner BM: Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. Kidney Int 2000;57:1803-1817.
7. Bohle A, Strutz F, Müller G: On the pathogenesis of chronic renal failure in primary glomerulopathies: A view from the interstitium. Exp Nephrol 1994;2:205-210.
8. Mackensen-Haen S, Bohle A, Christensen J, Wehrmann M, Kendziorra H, Kokot F: The consequences for renal function of widening the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases. Clin Nephrol 1992; 37:70-77.
9. Remuzzi G, Ruggenti P, Benigini A: Understanding the nature of renal disease progression. Kidney Int 1997;51:12-15.
10. Fine LG, Bandyopadhay D, Norman JT: Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 2000;57(suppl 75):S22-S26.
11. Orphanides C, Fine LG, Norman JT: Hypoxia stimulates proximal tubular cell matrix production via a TGF-β1 independent mechanism. Kidney Int 1997;52:637-647.
12. Norman JT, Clark IM, Garcia PL: Hypoxia promotes fibrogenesis in renal fibroblasts. Kidney Int 2000;58:2351-2366.
13. Fine LG, Orphanides C, Norman JT: Progressive renal disease: The chronic hypoxia hypothesis. Kidney Int 1998;52(suppl 65):S74-S78.
14. Wada Y, Morioka T, Oyanagi-Tanaka Y, Yao J, Suzuki Y, Geyjo F, Arakawa M, Oite T: Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy-1 glomerulonephritis. Kidney Int 2002;61:432-443.
15. Kang D-H, Joly AH, Oh S-W, Hugo C, Kerjaschki D, Gordon KL, Mazzali M, Jefferson JA, Hughes J, Madsen KM, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 2001;12:1434-1447.
16. Kang D-H, Kanellis J, Hugo C, Truong L, Anderson S, Kerjaschki D, Schreiner GF, Johnson RJ: Role of microvascular endothelium in progressive renal disease. J Am Soc Nephrol 2002;13:806-816.
17. Norman JT, Stidwill R, Cook HT, Singer M, Fine LG: Evidence for a progressive decline in tubulointerstitial oxygenation in a model of rapidly progressive glomerulonephritis. J Am Soc Nephrol 2000;11:625A.
18. Singer M, Stidwill R, Nathan A, Gainer J: Intravenous crocetinate prolongs survival in lethal hypoxemia. Crit Care Med 2000;28:1968-1972.
19. Lo LW, Koch CJ, Wilson DF: Calibration of oxygen-dependent quenching of the phosphorescence of PD-meso-tetra (4-carboxyphenyl) porphyine: A phosphor with general application for measuring oxygen concentration in biological systems. Anal Biochem 1996;236: 153-160.
20. 2 and renal oxygen usage in the hypertensive rat kidney. Kidney Int 2001;59: 230-237.
21. Schurek HJ, Jost U, Baumgartl H, Bertram H, Heckmann U: Evidence for a preglomerular oxygen diffusion shunt in rat renal cortex. Am J Physiol 1990;259:F910-F915.
22. Rosen S, Epstein FH, Brezis M: Determinants of intrarenal oxygenation: Factors in acute renal failure. Renal Failure 1992;14:321-325.
23. Epstein FH, Agmon Y, Brezis M: Physiology of renal hypoxia. Ann NY Acad Sci 1994;718:72-81.
24. 1 receptors. Kidney Int 2003;63:202-208.