Gene transfer of truncated IκBκ prevents tubulointerstitial injury

Kidney International

Volumn 63, Issue 2, 2003, Pages 501-513

  Takase, Osamu ^a   Hirahashi, Junichi ^a   Takayanagi, Atsushi ^a   Chikaraishi, Akihiro ^a   Marumo, Takeshi ^a   Ozawa, Yuri ^a   Hayashi, Matsuhiko ^a   Shimizu, Nobuyoshi ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenovirus; Inflammation; Nuclear factor B; Progressive renal disease; Proteinuria; Tubulointerstitial injury

Indexed keywords

ADENOVIRUS VECTOR; FIBRONECTIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GENE TRANSFER; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; RENAL ARTERY; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

EID: 0037252370     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00781.x     Document Type: Article

References (47)

1. REMUZZI G, BERTANI T: Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules? Kidney Int 38:384-394, 1990
2. REMUZZI G, RUGGENENTI P, BENIGNI A: Understanding the nature of renal disease progression. Kidney Int 51:2-15, 1997
3. BECKER GJ, HEWITSON TD: The role of tubulointerstitial injury in chronic renal failure. Curr Opin Nephrol Hypertens 9:133-138, 2000
4. REMUZZI G: Abnormal protein traffic through the glomerular barrier induces proximal tubular cell dysfunction and causes renal injury. Curr Opin Nephrol Hypertens 4:339-342, 1995
5. EDDY AA, GIACHELLI CM: Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int 47:1546-1557, 1995
6. WANG Y, RANGAN GK, TAY YC, HARRIS DC: Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor κB in proximal tubule cells. J Am Soc Nephrol 10:1204-1213, 1999
7. ZOJA C, DONADELLI R, COLLEONI S, et al: Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation. Kidney Int 53:1608-1615, 1998
8. RANGAN GK, WANG Y, TAY YC, HARRIS DC: Inhibition of nuclear factor-κB activation reduces cortical tubulointerstitial injury in proteinuric rats. Kidney Int 56:118-134, 1999
9. DONADELLI R, ABBATE M, ZANCHI C, et al: Protein traffic activates NF-κB gene signaling and promotes MCP-1-dependent interstitial inflammation. Am J Kidney Dis 36:1226-1241, 2000
10. GOMEZ-GARRE D, LARGO R, TEJERA N, et al: Activation of NF-κB in tubular epithelial cells of rats with intense proteinuria-Role of angiotensin II and endothelin-1. Hypertension 37:1171-1178, 2001
11. MEZZANO SA, BARRIA M, DROGUETT MA, et al: Tubular NF-κB and AP-1 activation in human proteinuric renal disease. Kidney Int 60:1366-1377, 2001
12. YAMAMOTO Y, GAYNOR RB: Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J Clin Invest 107:135-142, 2001
13. SHA WC, LIOU HC, TUOMANEN EI, BALTIMORE D: Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321-330, 1995
14. OUAAZ F, LI M, BEG AA: A critical role for the RelA subunit of nuclear factor κB in regulation of multiple immune-response genes and in Fas-induced cell death. J Exp Med 189:999-1004, 1999
15. BROWN K, GERSTBERGER S, CARLSON L, et al: Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485-1488, 1995
16. HIRAHASHI J, TAKAYANAGI A, HISHIKAWA K, et al: Overexpression of truncated IκBα potentiates TNF-α-induced apoptosis in mesangial cells. Kidney Int 57:959-968, 2000
17. OBARA H, TAKAYANAGI A, HIRAHASHI J, et al: Overexpression of truncated IκBα induces TNF-α-dependent apoptosis in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20:2198-2204, 2000
18. EDDY AA: Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135:719-733, 1989
19. BARNES PJ, LARIN M: Mechanisms of disease: Nuclear factor-κB -A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071, 1997
20. MOULLIER P, FRIEDLANDER G, CALISE D, et al: Adenoviral-mediated gene transfer to renal tubular cells in vivo. Kidney Int 45:1220-1225, 1994
21. SUMITOMO M, TACHIBANA M, OZU C, et al: Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IκBα overexpression. Hum Gene Ther 10:37-47, 1999
22. MIYAKE S, MAKIMURA M, KANEGAE Y, et al: Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 93:1320-1324, 1996
23. KANEGAE Y, MAKIMURA M, SAITO I: A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol 47:157-166, 1994
24. KANEGAE Y, LEE G, SATO Y, et al: Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 23:3816-3821, 1995
25. EL NAHAS AM, BASSETT AH, COPE GH, LE CARPENTIER JE: Role of growth hormone in the development of experimental renal scarring. Kidney Int 40:29-34, 1991
26. JOHNSON TS, GRIFFIN M, THOMAS GL, et al: The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. J Clin Invest 99:2950-2960, 1997
27. OKADA H, MORIWAKI K, KALLURI R, et al: Inhibition of monocyte chemoattractant protein-1 expression in tubular epithelium attenuates tubulointerstitial alteration in rat Goodpasture syndrome. Kidney Int 57:927-936, 2000
28. LARGO R, GOMEZ-GARRE D, SOTO K, et al: Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria. Hypertension 33:732-739, 1999
29. SCHAIER M, LEHRKE I, SCHADE K, et al: Isotretinoin alleviates renal damage in rat chronic glomerulonephritis. Kidney Int 60:2222-2234, 2001
30. KLIEM V, JOHNSON RJ, ALPERS CE, et al: Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int 49:666-678, 1996
31. BARONI EA, COSTA RS, VOLPINI R, COIMBRA TM: Sodium bicarbonate treatment reduces renal injury, renal production of transforming growth factor-β, and urinary transforming growth factor-β excretion in rats with doxorubicin-induced nephropathy. Am J Kidney Dis 34:328-337, 1999
32. LIU SF, YE X, MALIK AB: In vivo inhibition of nuclear factor-κB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J Immunol 159:3976-3983, 1997
33. BRADFORD MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
34. LANE D, PRENTKI P, CHANDLER M: Use of gel retardation to analyze protein-nucleic acid interactions. Microbiol Rev 56:509-528, 1992
35. BOHRER H, QIU F, ZIMMERMANN T, et al: Role of NFκB in the mortality of sepsis. J Clin Invest 100:972-985, 1997
36. ZHU G, NICOLSON AG, COWLEY BD, et al: In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. Gene Ther 3:298-304, 1996
37. CHETBOUL V, KLONJKOWSKI B, LEFEBVRE HP, et al: Short-term efficiency and safety of gene delivery into canine kidneys. Nephrol Dial Transplant 16:608-614, 2001
38. HEIKKILA P, PARPALA T, LUKKARINEN O, et al: Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - First steps towards gene therapy of Alport syndrome. Gene Ther 3:21-27, 1996
39. TU Z, KELLEY VR, COLLINS T, LEE FS: I κB kinase is critical for TNF-α-induced VCAM1 gene expression in renal tubular epithelial cells. J Immunol 166:6839-6846, 2001
40. SCHLEGEL PG, VAYSBURD M, CHEN Y, et al: Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. J Immunol 155:3856-3865, 1995
41. SOLEZ K, RACUSEN LC, ABDULKAREEM F, et al: Adhesion molecules and rejection of renal allografts. Kidney Int 51:1476-1480, 1997
42. ROY-CHAUDHURY P, WU B, KING G, et al: Adhesion molecule interactions in human glomerulonephritis: Importance of the tubulo-interstitium. Kidney Int 49:127-134,
43. RUIZ-ORTEGA M, EGIDO J: Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts. Kidney Int 52:1497-1510, 1997
44. GUIJARRO C, EGIDO J: Transcription factor-κB (NF-κB) and renal disease. Kidney Int 59:415-424, 2001
45. DENEKE SM, FANBURG BL: Regulation of cellular glutathione. Am J Physiol 257:L163-L173, 1989
46. WILD AC, MULCAHY RT: Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases in-tracellular glutathione levels. Biochem J 338:659-665, 1999
47. VERHAEGH GW, RICHARD MJ, HAINAUT P: Regulation of p53 by metal ions and by antioxidants: Dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol Cell Biol 17:5699-5706, 1997